Discovery of N‑(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro‑1H‑pyrrolo[2,3‑c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor
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Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Enabling, Decagram-Scale Synthesis of Macrocyclic MCL‑1 Inhibitor ABBV-467
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Published in Journal of organic chemistry (17.11.2023)
Published in Journal of organic chemistry (17.11.2023)
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Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors
Wang, Le, Pratt, John K, Soltwedel, Todd, Sheppard, George S, Fidanze, Steven D, Liu, Dachun, Hasvold, Lisa A, Mantei, Robert A, Holms, James H, McClellan, William J, Wendt, Michael D, Wada, Carol, Frey, Robin, Hansen, T. Matthew, Hubbard, Robert, Park, Chang H, Li, Leiming, Magoc, Terrance J, Albert, Daniel H, Lin, Xiaoyu, Warder, Scott E, Kovar, Peter, Huang, Xiaoli, Wilcox, Denise, Wang, Rongqi, Rajaraman, Ganesh, Petros, Andrew M, Hutchins, Charles W, Panchal, Sanjay C, Sun, Chaohong, Elmore, Steven W, Shen, Yu, Kati, Warren M, McDaniel, Keith F
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors
Fidanze, Steven D., Liu, Dachun, Mantei, Robert A., Hasvold, Lisa A., Pratt, John K., Sheppard, George S., Wang, Le, Holms, James H., Dai, Yujia, Aguirre, Ana, Bogdan, Andrew, Dietrich, Justin D., Marjanovic, Jasmina, Park, Chang H., Hutchins, Charles W., Lin, Xiaoyu, Bui, Mai H., Huang, Xiaoli, Wilcox, Denise, Li, Leiming, Wang, Rongqi, Kovar, Peter, Magoc, Terrance J., Rajaraman, Ganesh, Albert, Daniel H., Shen, Yu, Kati, Warren M., McDaniel, Keith F.
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
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Methylpyrrole inhibitors of BET bromodomains
Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., McDaniel, Keith F.
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
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Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases
WANG, Gary T, MANTEI, Robert A, BOUSKA, Jennifer, JIEYI WANG, DAVIDSEN, Steven K, BELL, Randy L, SHEPPARD, George S, HUBBARD, Robert D, WILSBACHER, Julie L, QIAN ZHANG, TUCKER, Lora, XIAOMING HU, KOVAR, Peter, JOHNSON, Eric F, OSTERLING, Donald J
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
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Discovery and Optimization of Anthranilic Acid Sulfonamides as Inhibitors of Methionine Aminopeptidase-2: A Structural Basis for the Reduction of Albumin Binding
Sheppard, George S, Wang, Jieyi, Kawai, Megumi, Fidanze, Steve D, BaMaung, Nwe Y, Erickson, Scott A, Barnes, David M, Tedrow, Jason S, Kolaczkowski, Lawrence, Vasudevan, Anil, Park, David C, Wang, Gary T, Sanders, William J, Mantei, Robert A, Palazzo, Fabio, Tucker-Garcia, Lora, Lou, Pingping, Zhang, Qian, Park, Chang H, Kim, Ki H, Petros, Andrew, Olejniczak, Edward, Nettesheim, David, Hajduk, Phillip, Henkin, Jack, Lesniewski, Richard, Davidsen, Steven K, Bell, Randy L
Published in Journal of medicinal chemistry (29.06.2006)
Published in Journal of medicinal chemistry (29.06.2006)
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1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyano- pyrazi-2-yl)ureas as Potent and Selective Inhibitors of Chk1 Kinase: Synthesis, Preliminary SAR, and Biological Activities
Wang, Gary T, Li, Gaoquan, Mantei, Robert A, Chen, Zehan, Kovar, Peter, Gu, Wendy, Xiao, Zhan, Zhang, Haiying, Sham, Hing L, Sowin, Thomas, Rosenberg, Saul H, Lin, Nan-Horng
Published in Journal of medicinal chemistry (05.05.2005)
Published in Journal of medicinal chemistry (05.05.2005)
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Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
Wang, Gary T., Mantei, Robert A., Kawai, Megumi, Tedrow, Jason S., Barnes, David M., Wang, Jieyi, Zhang, Qian, Lou, Pingping, Garcia, Lora A., Bouska, Jennifer, Yates, Melinda, Park, Chang, Judge, Russell A., Lesniewski, Richard, Sheppard, George S., Bell, Randy L.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ETA Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722
Winn, Martin, von Geldern, Thomas W, Opgenorth, Terry J, Jae, Hwan-Soo, Tasker, Andrew S, Boyd, Steven A, Kester, Jeffrey A, Mantei, Robert A, Bal, Radhika, Sorensen, Bryan K, Wu-Wong, Jinshyun R, Chiou, William J, Dixon, Douglas B, Novosad, Eugene I, Hernandez, Lisa, Marsh, Kennan C
Published in Journal of medicinal chemistry (01.03.1996)
Published in Journal of medicinal chemistry (01.03.1996)
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Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation
Hasvold, Lisa A., Wang, Weibo, Gwaltney, Stephen L., Rockway, Todd W., Nelson, Lissa T.J., Mantei, Robert A., Fakhoury, Stephen A., Sullivan, Gerard M., Li, Qun, Lin, Nan-Horng, Wang, Le, Zhang, Haiying, Cohen, Jerome, Gu, Wen-Zhen, Marsh, Kennan, Bauch, Joy, Rosenberg, Saul, Sham, Hing L.
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases
Michaelides, Michael R, Kluge, Arthur, Patane, Michael, Van Drie, John H, Wang, Ce, Hansen, T. Matthew, Risi, Roberto M, Mantei, Robert, Hertel, Carmen, Karukurichi, Kannan, Nesterov, Alexandre, McElligott, David, de Vries, Peter, Langston, J. William, Cole, Philip A, Marmorstein, Ronen, Liu, Hong, Lasko, Loren, Bromberg, Kenneth D, Lai, Albert, Kesicki, Edward A
Published in ACS medicinal chemistry letters (11.01.2018)
Published in ACS medicinal chemistry letters (11.01.2018)
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Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET A receptor selectivity
Boyd, Steven A, Mantei, Robert A, Tasker, Andrew S, Liu, Gang, Sorensen, Bryan K, Henry Jr, Kenneth J, von Geldern, Thomas W, Winn, Martin, Wu-Wong, Jinshyun R, Chiou, William J, Dixon, Douglas B, Hutchins, Charles W, Marsh, Kennan C, Nguyen, Bach, Opgenorth, Terry J
Published in Bioorganic & medicinal chemistry (01.06.1999)
Published in Bioorganic & medicinal chemistry (01.06.1999)
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Nonpeptide Renin Inhibitors with Good Intraduodenal Bioavailability and Efficacy in Dog
Boyd, Steven A, Fung, Anthony K. L, Baker, William R, Mantei, Robert A, Stein, Herman H, Cohen, Jerome, Barlow, Jennifer L, Klinghofer, Vered, Wessale, Jerry L
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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Abstract 4695: Functional group elaboration of a low molecular weight fragment to yield the novel BET family bromodomain inhibitor ABBV-075
McDaniel, Keith, Wang, Le, Sheppard, George, Fidanze, Steve, Pratt, John, Liu, Dachun, Hasvold, Lisa, Mantei, Robert, Park, Chang, Sarthy, Aparna, Li, Leiming, Albert, Daniel H., Lin, Xiaoyu, Warder, Scott, Faivre, Emily, Bui, Mai H., Huang, Xiaoli, Wilcox, Denise, Wang, Rongqi, Magoc, Terry, Rajaraman, Ganesh, Petros, Andrew, Panchal, Sanjay, Sun, Chaohong, Fang, Guowei, Elmore, Steven W., Rosenberg, Saul, Shen, Yu, Kati, Warren
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Methylpyrrole inhibitors of BET bromodomains
Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., McDaniel, Keith F.
Published in Bioorganic & medicinal chemistry letters (01.05.2017)
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Published in Bioorganic & medicinal chemistry letters (01.05.2017)
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Imidazo[2,1- b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases
Fidanze, Steve D., Erickson, Scott A., Wang, Gary T., Mantei, Robert, Clark, Richard F., Sorensen, Bryan K., Bamaung, Nwe Y., Kovar, Peter, Johnson, Eric F., Swinger, Kerren K., Stewart, Kent D., Zhang, Qian, Tucker, Lora A., Pappano, William N., Wilsbacher, Julie L., Wang, Jieyi, Sheppard, George S., Bell, Randy L., Davidsen, Steven K., Hubbard, Robert D.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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C-Terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties
Boyd, Steven A, Fung, Anthony K. L, Baker, William R, Mantei, Robert A, Armiger, Yoek Lin, Stein, Herman H, Cohen, Jerome, Egan, David A, Barlow, Jennifer L
Published in Journal of medicinal chemistry (01.05.1992)
Published in Journal of medicinal chemistry (01.05.1992)
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Stereoselective syntheses of hydroxyethylene dipeptide isosteres
Boyd, Steven A, Mantei, Robert A, Hsiao, Chi Nung, Baker, William R
Published in Journal of organic chemistry (01.01.1991)
Published in Journal of organic chemistry (01.01.1991)
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Year of Publication 13.02.2020
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Year of Publication 13.02.2020
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