Synthesis, structure–property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor
Bach, Peter, Boström, Jonas, Brickmann, Kay, van Giezen, J.J.J., Groneberg, Robert D., Harvey, Darren M., O'Sullivan, Michael, Zetterberg, Fredrik
Published in European journal of medicinal chemistry (01.07.2013)
Published in European journal of medicinal chemistry (01.07.2013)
Get full text
Journal Article
Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors
Eary, C. Todd, Jones, Zachary S., Groneberg, Robert D., Burgess, Laurence E., Mareska, David A., Drew, Mark D., Blake, James F., Laird, Ellen R., Balachari, Devan, O’Sullivan, Michael, Allen, Andrew, Marsh, Vivienne
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Get full text
Journal Article
5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor
Bach, Peter, Boström, Jonas, Brickmann, Kay, Burgess, Laurence E, Clarke, David, Groneberg, Robert D, Harvey, Darren M, Laird, Ellen R, O'Sullivan, Michael, Zetterberg, Fredrik
Published in Future medicinal chemistry (01.11.2013)
Published in Future medicinal chemistry (01.11.2013)
Get more information
Journal Article
Identification of a Nonpeptidic and Conformationally Restricted Bradykinin B1 Receptor Antagonist with Anti-Inflammatory Activity
D'Amico, Derin C, Aya, Toshi, Human, Jason, Fotsch, Christopher, Chen, Jian Jeffrey, Biswas, Kaustav, Riahi, Bobby, Norman, Mark H, Willoughby, Christopher A, Hungate, Randall, Reider, Paul J, Biddlecome, Gloria, Lester-Zeiner, Dianna, Van Staden, Carlo, Johnson, Eileen, Kamassah, Augustus, Arik, Leyla, Wang, Judy, Viswanadhan, Vellarkad N, Groneberg, Robert D, Zhan, James, Suzuki, Hideo, Toro, Andras, Mareska, David A, Clarke, David E, Harvey, Darren M, Burgess, Laurence E, Laird, Ellen R, Askew, Benny, Ng, Gordon
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
Get full text
Journal Article
Potent Nonpeptide Antagonists of the Bradykinin B1 Receptor: Structure−Activity Relationship Studies with Novel Diaminochroman Carboxamides
Biswas, Kaustav, Li, Aiwen, Chen, Jian Jeffrey, D'Amico, Derin C, Fotsch, Christopher, Han, Nianhe, Human, Jason, Liu, Qingyian, Norman, Mark H, Riahi, Bobby, Yuan, Chester, Suzuki, Hideo, Mareska, David A, Zhan, James, Clarke, David E, Toro, Andras, Groneberg, Robert D, Burgess, Laurence E, Lester-Zeiner, Dianna, Biddlecome, Gloria, Manning, Barton H, Arik, Leyla, Dong, Hong, Huang, Ming, Kamassah, Augustus, Loeloff, Richard, Sun, Hong, Hsieh, Feng-Yin, Kumar, Gondi, Ng, Gordon Y, Hungate, Randall W, Askew, Benny C, Johnson, Eileen
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
Get full text
Journal Article
A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core
Fotsch, Christopher, Biddlecome, Gloria, Biswas, Kaustav, Chen, Jian Jeff, D’Amico, Derin C., Groneberg, Robert D., Han, Nianhe Bruce, Hsieh, Feng-Yin, Kamassah, Augustus, Kumar, Gondi, Lester-Zeiner, Dianna, Liu, Qingyian, Mareska, David A., Riahi, Babak Bobby, Wang, Yueh-Ju Judy, Yang, Kevin, Zhan, James, Zhu, Joe, Johnson, Eileen, Ng, Gordon, Askew, Benny C.
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Get full text
Journal Article
Dual Inhibition of Phosphodiesterase 4 and Matrix Metalloproteinases by an (Arylsulfonyl)hydroxamic Acid Template
Groneberg, Robert D, Burns, Christopher J, Morrissette, Matthew M, Ullrich, John W, Morris, Robert L, Darnbrough, Shelley, Djuric, Stevan W, Condon, Stephen M, McGeehan, Gerard M, Labaudiniere, Richard, Neuenschwander, Kent, Scotese, Anthony C, Kline, Jane A
Published in Journal of medicinal chemistry (25.02.1999)
Published in Journal of medicinal chemistry (25.02.1999)
Get full text
Journal Article
Solid-phase synthesis of an arylsulfone hydroxamate library
Salvino, Joseph M, Mathew, Rose, Kiesow, Terence, Narensingh, Ramesh, Mason, Helen J, Dodd, Amy, Groneberg, Robert, Burns, Christopher J, McGeehan, Gerald, Kline, Jane, Orton, Edward, Tang, Sheng-Yuh, Morrisette, Mathew, Labaudininiere, Richard
Published in Bioorganic & medicinal chemistry letters (07.08.2000)
Published in Bioorganic & medicinal chemistry letters (07.08.2000)
Get full text
Journal Article
Synthesis, structure-property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y(12) receptor
Bach, Peter, Bostrom, Jonas, Brickmann, Kay, van Giezen, J. J. J., Groneberg, Robert D., Harvey, Darren M., O'Sullivan, Michael, Zetterberg, Fredrik
Published in European journal of medicinal chemistry (01.07.2013)
Published in European journal of medicinal chemistry (01.07.2013)
Get full text
Journal Article
Spirocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species
Hunt, Kevin W, Cook, Adam W, Watts, Ryan J, Clark, Christopher T, Vigers, Guy, Smith, Darin, Metcalf, Andrew T, Gunawardana, Indrani W, Burkard, Michael, Cox, April A, Geck Do, Mary K, Dutcher, Darrin, Thomas, Allen A, Rana, Sumeet, Kallan, Nicholas C, DeLisle, Robert K, Rizzi, James P, Regal, Kelly, Sammond, Douglas, Groneberg, Robert, Siu, Michael, Purkey, Hans, Lyssikatos, Joseph P, Marlow, Allison, Liu, Xingrong, Tang, Tony P
Published in Journal of medicinal chemistry (25.04.2013)
Published in Journal of medicinal chemistry (25.04.2013)
Get full text
Journal Article
Nanomolar Inhibitors for Two Distinct Biological Target Families from a Single Synthetic Sequence: A Next Step in Combinatorial Library Design?
Burns, Christopher J., Groneberg, Robert D., Salvino, Joseph M., McGeehan, Gerard, Condon, Stephen M., Morris, Robert, Morrissette, Matthew, Mathew, Rose, Darnbrough, Shelley, Neuenschwander, Kent, Scotese, Anthony, Djuric, Stevan W., Ullrich, John, Labaudiniere, Richard
Published in Angewandte Chemie (International ed.) (02.11.1998)
Published in Angewandte Chemie (International ed.) (02.11.1998)
Get full text
Journal Article
Discovery of 7‑Tetrahydropyran-2-yl Chromans: β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β‑Protein (Aβ) in the Central Nervous System
Thomas, Allen A, Hunt, Kevin W, Volgraf, Matthew, Watts, Ryan J, Liu, Xingrong, Vigers, Guy, Smith, Darin, Sammond, Douglas, Tang, Tony P, Rhodes, Susan P, Metcalf, Andrew T, Brown, Karin D, Otten, Jennifer N, Burkard, Michael, Cox, April A, Do, Mary K. Geck, Dutcher, Darrin, Rana, Sumeet, DeLisle, Robert K, Regal, Kelly, Wright, Albion D, Groneberg, Robert, Scearce-Levie, Kimberly, Siu, Michael, Purkey, Hans E, Lyssikatos, Joseph P, Gunawardana, Indrani W
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
Get full text
Journal Article
8‑Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors
Thomas, Allen A, Hunt, Kevin W, Newhouse, Brad, Watts, Ryan J, Liu, Xingrong, Vigers, Guy, Smith, Darin, Rhodes, Susan P, Brown, Karin D, Otten, Jennifer N, Burkard, Michael, Cox, April A, Geck Do, Mary K, Dutcher, Darrin, Rana, Sumeet, DeLisle, Robert K, Regal, Kelly, Wright, Albion D, Groneberg, Robert, Liao, Jiangpeng, Scearce-Levie, Kimberly, Siu, Michael, Purkey, Hans E, Lyssikatos, Joseph P
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
Get full text
Journal Article
Total synthesis of the oligosaccharide fragment of calicheamicin .gamma.1I
Nicolaou, K. C, Groneberg, Robert D, Miyazaki, T, Stylianides, N. A, Schulze, T. J, Stahl, W
Published in Journal of the American Chemical Society (01.10.1990)
Published in Journal of the American Chemical Society (01.10.1990)
Get full text
Journal Article
8-SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS
GRONEBERG, ROBERT D, DOHERTY, GEORGE A, EARY, C. TODD, JONES, ZACHARY
Year of Publication 12.06.2018
Get full text
Year of Publication 12.06.2018
Patent
SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS
DIETSCH, GREGORY, GRONEBERG, ROBERT D, DOHERTY, GEORGE A, HERSHBERG, ROBERT, BURGESS, LAURENCE E, HOWBERT, JAMES JEFFRY, EARY, C. TODD, JONES, ZACHARY
Year of Publication 15.01.2019
Get full text
Year of Publication 15.01.2019
Patent