A Novel Dual Drug Approach That Combines Ivermectin and Dihydromyricetin (DHM) to Reduce Alcohol Drinking and Preference in Mice
Silva, Joshua, Carry, Eileen, Xue, Chen, Zhang, Jifeng, Liang, Jing, Roberge, Jacques Y, Davies, Daryl L
Published in Molecules (Basel, Switzerland) (22.03.2021)
Published in Molecules (Basel, Switzerland) (22.03.2021)
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Design, Synthesis, and Biological Evaluation of Deuterated C‑Aryl Glycoside as a Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes
Xu, Ge, Lv, Binhua, Roberge, Jacques Y, Xu, Baihua, Du, Jiyan, Dong, Jiajia, Chen, Yuanwei, Peng, Kun, Zhang, Lili, Tang, Xinxing, Feng, Yan, Xu, Min, Fu, Wei, Zhang, Wenbin, Zhu, Liangcheng, Deng, Zhongping, Sheng, Zelin, Welihinda, Ajith, Sun, Xun
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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A FtsZ Inhibitor That Can Utilize Siderophore-Ferric Iron Uptake Transporter Systems for Activity against Gram-Negative Bacterial Pathogens
Bryan, Eric J, Qiao, Qi, Wang, Yuxuan, Roberge, Jacques Y, LaVoie, Edmond J, Pilch, Daniel S
Published in Antibiotics (Basel) (22.02.2024)
Published in Antibiotics (Basel) (22.02.2024)
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TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens
Bryan, Eric J, Sagong, Hye Yeon, Parhi, Ajit K, Grier, Mark C, Roberge, Jacques Y, LaVoie, Edmond J, Pilch, Daniel S
Published in Antibiotics (Basel) (20.05.2022)
Published in Antibiotics (Basel) (20.05.2022)
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C-Aryl glucosides substituted at the 4′-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
Xu, Baihua, Feng, Yan, Cheng, Huawei, Song, Yanli, Lv, Binhua, Wu, Yuelin, Wang, Congna, Li, Shengbin, Xu, Min, Du, Jiyan, Peng, Kun, Dong, Jiajia, Zhang, Wenbin, Zhang, Ting, Zhu, Liangcheng, Ding, Haifeng, Sheng, Zelin, Welihinda, Ajith, Roberge, Jacques Y., Seed, Brian, Chen, Yuanwei
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
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EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA1c levels in db/db mice and prolongs the survival of stroke-prone rats
Zhang, Wenbin, Welihinda, Ajith, Mechanic, Jordan, Ding, Haifeng, Zhu, Liangcheng, Lu, Yuan, Deng, Zhongping, Sheng, Zelin, Lv, Binhua, Chen, Yuanwei, Roberge, Jacques Y., Seed, Brian, Wang, Yong-Xiang
Published in Pharmacological research (01.04.2011)
Published in Pharmacological research (01.04.2011)
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Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53
Gilleran, John A, Yu, Xin, Blayney, Alan J, Bencivenga, Anthony F, Na, Bing, Augeri, David J, Blanden, Adam R, Kimball, S. David, Loh, Stewart N, Roberge, Jacques Y, Carpizo, Darren R
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin
Rudolph, Michael J., Dutta, Arkajyoti, Tsymbal, Anastasiia M., McLaughlin, John E., Chen, Yang, Davis, Simon A., Theodorous, Sophia A., Pierce, Michael, Algava, Benjamin, Zhang, Xiaoyu, Szekely, Zoltan, Roberge, Jacques Y., Li, Xiao-Ping, Tumer, Nilgun E.
Published in Bioorganic & medicinal chemistry (15.02.2024)
Published in Bioorganic & medicinal chemistry (15.02.2024)
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Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials
Gilleran, John A., Ashraf, Kutub, Delvillar, Melvin, Eck, Tyler, Fondekar, Raheel, Miller, Edward B., Hutchinson, Ashley, Dong, Aiping, Seitova, Alma, De Souza, Mariana Laureano, Augeri, David, Halabelian, Levon, Siekierka, John, Rotella, David P., Gordon, John, Childers, Wayne E., Grier, Mark C., Staker, Bart L., Roberge, Jacques Y., Bhanot, Purnima
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Correction to “Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials”
Gilleran, John A., Ashraf, Kutub, Delvillar, Melvin, Eck, Tyler, Fondekar, Raheel, Miller, Edward B., Hutchinson, Ashley, Dong, Aiping, Seitova, Alma, De Souza, Mariana Laureano, Augeri, David, Halabelian, Levon, Siekierka, John, Rotella, David P., Gordon, John, Childers, Wayne E., Grier, Mark C., Staker, Bart L., Roberge, Jacques Y., Bhanot, Purnima
Published in Journal of medicinal chemistry (25.07.2024)
Published in Journal of medicinal chemistry (25.07.2024)
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Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design
Li, Xiao-Ping, Harijan, Rajesh K, Cao, Bin, Kahn, Jennifer N, Pierce, Michael, Tsymbal, Anastasiia M, Roberge, Jacques Y, Augeri, David, Tumer, Nilgun E
Published in Journal of medicinal chemistry (28.10.2021)
Published in Journal of medicinal chemistry (28.10.2021)
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Fragment Screening to Identify Inhibitors Targeting Ribosome Binding of Shiga Toxin 2
Rudolph, Michael J., Tsymbal, Anastasiia M., Dutta, Arkajyoti, Davis, Simon A., Algava, Benjamin, Roberge, Jacques Y., Tumer, Nilgun E., Li, Xiao-Ping
Published in ACS infectious diseases (09.08.2024)
Published in ACS infectious diseases (09.08.2024)
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Discovery and structure–activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists
Yang, Wu, Wang, Yufeng, Roberge, Jacques Y., Ma, Zhengping, Liu, Yalei, Michael Lawrence, R., Rotella, David P., Seethala, Ramakrishna, Feyen, Jean H.M., Dickson, John K.
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
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EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats
Zhang, Wenbin, Welihinda, Ajith, Mechanic, Jordan, Ding, Haifeng, Zhu, Liangcheng, Lu, Yuan, Deng, Zhongping, Sheng, Zelin, Lv, Binhua, Chen, Yuanwei, Roberge, Jacques Y, Seed, Brian, Wang, Yong-Xiang
Published in Pharmacological research (01.04.2011)
Published in Pharmacological research (01.04.2011)
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Acylpyrazoline-Based Third-Generation Selective Antichlamydial Compounds with Enhanced Potency
Lu, Bin, Qiao, Qi, Park, Elizabeth R., Wang, Yuxuan, Gilleran, John A., Pan, Matthew, Pilch, Daniel S., Wu, Xiang, Roberge, Jacques Y., Fan, Huizhou
Published in ACS omega (21.02.2023)
Published in ACS omega (21.02.2023)
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Identification of purine inhibitors of phosphodiesterase 7 (PDE7)
Pitts, William J., Vaccaro, Wayne, Huynh, Tram, Leftheris, Katerina, Roberge, Jacques Y., Barbosa, Joseph, Guo, Junqing, Brown, Baerbel, Watson, Andrew, Donaldson, Karen, Starling, Gary C., Kiener, Peter A., Poss, Michael A., Dodd, John H., Barrish, Joel C.
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
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Characterization of a new class of selective nonsteroidal progesterone receptor agonists
Dong, Yu, Roberge, Jacques Y, Wang, Zhaoqing, Wang, Xiaodong, Tamasi, Joseph, Dell, Vanessa, Golla, Rajasree, Corte, James R, Liu, Yalei, Fang, Tianan, Anthony, Monique N, Schnur, Dora M, Agler, Michele L, Dickson, John K, Lawrence, R.Michael, Prack, Margaret M, Seethala, Ramakrishna, Feyen, Jean H.M
Published in Steroids (01.03.2004)
Published in Steroids (01.03.2004)
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Convergent Synthesis of N-Linked Glycopeptides on a Solid Support
Roberge, J. Y, Beebe, X, Danishefsky, S. J
Published in Journal of the American Chemical Society (29.04.1998)
Published in Journal of the American Chemical Society (29.04.1998)
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