The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes – Implications for osteoarthritis
Imagawa, Kei, de Andrés, MC, Hashimoto, Ko, Pitt, Dominic, Itoi, Eiji, Goldring, Mary B., Roach, Helmtrud I., Oreffo, Richard O.C.
Published in Biochemical and biophysical research communications (18.02.2011)
Published in Biochemical and biophysical research communications (18.02.2011)
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Synthesis of scaffold-free, three dimensional, osteogenic constructs following culture of skeletal osteoprogenitor cells on glass surfaces
Alghfeli, Latifa, Parambath, Divyasree, Manzoor, Shaista, Roach, Helmtrud I., Oreffo, Richard O.C., El-Serafi, Ahmed T.
Published in Bone Reports (01.12.2021)
Published in Bone Reports (01.12.2021)
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Journal Article
Tissue engineering strategies for cartilage generation—Micromass and three dimensional cultures using human chondrocytes and a continuous cell line
Tare, Rahul S., Howard, Daniel, Pound, Jodie C., Roach, Helmtrud I., Oreffo, Richard O.C.
Published in Biochemical and biophysical research communications (29.07.2005)
Published in Biochemical and biophysical research communications (29.07.2005)
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Journal Article
Epigenetic regulation during fetal femur development: DNA methylation matters
de Andrés, María C, Kingham, Emmajayne, Imagawa, Kei, Gonzalez, Antonio, Roach, Helmtrud I, Wilson, David I, Oreffo, Richard O C
Published in PloS one (28.01.2013)
Published in PloS one (28.01.2013)
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Journal Article
Improved Quantification of DNA Methylation Using Methylation-Sensitive Restriction Enzymes and Real-Time PCR
Hashimoto, Ko, Kokubun, Shoichi, Itoi, Eiji, Roach, Helmtrud I.
Published in Epigenetics (01.04.2007)
Published in Epigenetics (01.04.2007)
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Journal Article
Induction of Human Osteoprogenitor Chemotaxis, Proliferation, Differentiation, and Bone Formation by Osteoblast Stimulating Factor‐1/Pleiotrophin: Osteoconductive Biomimetic Scaffolds for Tissue Engineering
Yang, Xuebin, Tare, Rahul S, Partridge, Kris A, Roach, Helmtrud I, Clarke, Nicholas MP, Howdle, Steven M, Shakesheff, Kevin M, Oreffo, Richard OC
Published in Journal of bone and mineral research (01.01.2003)
Published in Journal of bone and mineral research (01.01.2003)
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Journal Article
Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites
Hashimoto, Ko, Otero, Miguel, Imagawa, Kei, de Andrés, María C., Coico, Jonathan M., Roach, Helmtrud I., Oreffo, Richard O.C., Marcu, Kenneth B., Goldring, Mary B.
Published in The Journal of biological chemistry (05.04.2013)
Published in The Journal of biological chemistry (05.04.2013)
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Journal Article
Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation
Imagawa, Kei, Andrés, María C., Hashimoto, Ko, Itoi, Eiji, Otero, Miguel, Roach, Helmtrud I., Goldring, Mary B., Oreffo, Richard O. C.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2014)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2014)
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Journal Article
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis
Goldring, Mary B, Otero, Miguel, Plumb, Darren A, Dragomir, Cecilia, Favero, Marta, El Hachem, Karim, Hashimoto, Ko, Roach, Helmtrud I, Olivotto, Eleonora, Borzì, Rosa Maria, Marcu, Kenneth B
Published in European cells & materials (24.02.2011)
Published in European cells & materials (24.02.2011)
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Journal Article
Loss of methylation in CpG sites in the NF-[kappa]B enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes
de Andrés, María C, Imagawa, Kei, Hashimoto, Ko, Gonzalez, Antonio, Roach, Helmtrud I, Goldring, Mary B, Oreffo, Richard O. C
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.03.2013)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.03.2013)
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Journal Article
Changes in the antiangiogenic properties of articular cartilage in osteoarthritis
Smith, James O., Oreffo, Richard O.C., Clarke, Nicholas M.P., Roach, Helmtrud I.
Published in Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association (01.11.2003)
Published in Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association (01.11.2003)
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Journal Article
Normal Bone Growth Requires Optimal Estrogen Levels: Negative Effects of Both High and Low Dose Estrogen on the Number of Growth Plate Chondrocytes
Takano, Hiroyuki, Aizawa, Toshimi, Irie, Taichi, Itoi, Eiji, Kokubun, Shoichi, Roach, Helmtrud I.
Published in The Tohoku Journal of Experimental Medicine (01.03.2008)
Published in The Tohoku Journal of Experimental Medicine (01.03.2008)
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Journal Article
Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage
da Silva, Marco A., Yamada, Norikazu, Clarke, Nicholas M.P., Roach, Helmtrud I.
Published in Journal of orthopaedic research (01.05.2009)
Published in Journal of orthopaedic research (01.05.2009)
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Journal Article
Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis
de Andrés, María C., Imagawa, Kei, Hashimoto, Ko, Gonzalez, Antonio, Goldring, Mary B., Roach, Helmtrud I., Oreffo, Richard O.C.
Published in Biochemical and biophysical research communications (01.04.2011)
Published in Biochemical and biophysical research communications (01.04.2011)
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Journal Article
Bone‐like Resorbable Silk‐based Scaffolds for Load‐bearing Osteoregenerative Applications
Collins, Andrew M., Skaer, Nick J. V., Gheysens, Tom, Knight, David, Bertram, Caroline, Roach, Helmtrud I., Oreffo, Richard O. C., Von‐Aulock, Sonja, Baris, Teodora, Skinner, John, Mann, Stephen
Published in Advanced materials (Weinheim) (05.01.2009)
Published in Advanced materials (Weinheim) (05.01.2009)
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Journal Article
DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes
Hashimoto, Ko, Oreffo, Richard O. C., Gibson, Marc B., Goldring, Mary B., Roach, Helmtrud I.
Published in Arthritis and rheumatism (01.11.2009)
Published in Arthritis and rheumatism (01.11.2009)
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Journal Article
Apoptosis in osteoarthritis
Aigner, Thomas, Kim, Hyun A, Roach, Helmtrud I
Published in Rheumatic diseases clinics of North America (01.08.2004)
Published in Rheumatic diseases clinics of North America (01.08.2004)
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