Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor
Thoma, Gebhard, Miltz, Wolfgang, Srinivas, Honnappa, Penno, Carlos A., Kiffe, Michael, Gajewska, Monika, Klein, Kai, Evans, Amanda, Beerli, Christian, Röhn, Till A.
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
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Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase
Thoma, Gebhard, Markert, Christian, Lueoend, Rainer, Miltz, Wolfgang, Spanka, Carsten, Bollbuck, Birgit, Wolf, Romain M., Srinivas, Honnappa, Penno, Carlos A., Kiffe, Michael, Gajewska, Monika, Bednarczyk, Dallas, Wieczorek, Grazyna, Evans, Amanda, Beerli, Christian, Röhn, Till A.
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Lipidomics Profiling of Hidradenitis Suppurativa Skin Lesions Reveals Lipoxygenase Pathway Dysregulation and Accumulation of Proinflammatory Leukotriene B4
Penno, Carlos A., Jäger, Petra, Laguerre, Claire, Hasler, Franziska, Hofmann, Andreas, Gass, Stephanie K., Wettstein-Ling, Barbara, Schaefer, Dirk J., Avrameas, Alexandre, Raulf, Friedrich, Wieczorek, Grazyna, Lehmann, Joachim C.U., Loesche, Christian, Roth, Lukas, Röhn, Till A.
Published in Journal of investigative dermatology (01.12.2020)
Published in Journal of investigative dermatology (01.12.2020)
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Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice
Uluckan, Özge, Bruno, Sandro, Wang, Yichen, Wack, Nathalie, Wilzopolski, Jenny, Goetschy, Jean-Francois, Delucis-Bronn, Corinne, Urban, Beatrice, Fehlmann, Dominique, Stark, Holger, Hauchard, Alice, Roussel, Elsa, Kempf, Dominique, Kaupmann, Klemens, Raulf, Friedrich, Bäumer, Wolfgang, Röhn, Till A., Zerwes, Hans Günter
Published in European journal of pharmacology (15.04.2023)
Published in European journal of pharmacology (15.04.2023)
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LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial
Loesche, Christian, Picard, Damien, Van Hoorick, Benjamin, Schuhmann, Imelda, Jäger, Petra, Klein, Kai, Schuhler, Carole, Thoma, Gebhard, Markert, Christian, Poller, Birk, Zamurovic, Natasa, Weiss, H. Markus, Otto, Heike, Fink, Martin, Röhn, Till A.
Published in Clinical and translational science (01.02.2024)
Published in Clinical and translational science (01.02.2024)
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Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors
Numao, Shin, Hasler, Franziska, Laguerre, Claire, Srinivas, Honnappa, Wack, Nathalie, Jäger, Petra, Schmid, Andres, Osmont, Arnaud, Röthlisberger, Patrik, Houguenade, Jeremy, Bergsdorf, Christian, Dawson, Janet, Carte, Nathalie, Hofmann, Andreas, Markert, Christian, Hardaker, Liz, Billich, Andreas, Wolf, Romain M., Penno, Carlos A., Bollbuck, Birgit, Miltz, Wolfgang, Röhn, Till A.
Published in Scientific reports (19.10.2017)
Published in Scientific reports (19.10.2017)
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A virus-like particle-based anti-nerve growth factor vaccine reduces inflammatory hyperalgesia: potential long-term therapy for chronic pain
Röhn, Till A, Ralvenius, William T, Paul, Jolly, Borter, Petra, Hernandez, Marcela, Witschi, Robert, Grest, Paula, Zeilhofer, Hanns Ulrich, Bachmann, Martin F, Jennings, Gary T
Published in The Journal of immunology (1950) (01.02.2011)
Published in The Journal of immunology (1950) (01.02.2011)
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IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium
Songhet, Pascal, Barthel, Manja, Röhn, Till A, Van Maele, Laurye, Cayet, Delphine, Sirard, Jean-Claude, Bachmann, Martin, Kopf, Manfred, Hardt, Wolf-Dietrich
Published in PloS one (23.11.2010)
Published in PloS one (23.11.2010)
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A novel strategy for the discovery of MHC class II-restricted tumor antigens : Identification of a melanotransferrin helper T-cell epitope
RÖHN, Till A, REITZ, Annette, PASCHEN, Annette, NGUYEN, Xuan D, SCHADENDORF, Dirk, VOGT, Anne B, KROPSHOFER, Harald
Published in Cancer research (Chicago, Ill.) (01.11.2005)
Published in Cancer research (Chicago, Ill.) (01.11.2005)
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What causes hidradenitis suppurativa ?—15 years after
Zouboulis, Christos C., Benhadou, Farida, Byrd, Angel S., Chandran, Nisha S., Giamarellos‐Bourboulis, Evangelos J., Fabbrocini, Gabriella, Frew, John W., Fujita, Hideki, González‐López, Marcos A., Guillem, Philippe, Gulliver, Wayne P. F., Hamzavi, Iltefat, Hayran, Yildiz, Hórvath, Barbara, Hüe, Sophie, Hunger, Robert E., Ingram, John R., Jemec, Gregor B.E., Ju, Qiang, Kimball, Alexa B., Kirby, Joslyn S., Konstantinou, Maria P., Lowes, Michelle A., MacLeod, Amanda S., Martorell, Antonio, Marzano, Angelo V., Matusiak, Łukasz, Nassif, Aude, Nikiphorou, Elena, Nikolakis, Georgios, Nogueira da Costa, André, Okun, Martin M., Orenstein, Lauren A.V., Pascual, José Carlos, Paus, Ralf, Perin, Benjamin, Prens, Errol P., Röhn, Till A., Szegedi, Andrea, Szepietowski, Jacek C., Tzellos, Thrasyvoulos, Wang, Baoxi, van der Zee, Hessel H.
Published in Experimental dermatology (01.12.2020)
Published in Experimental dermatology (01.12.2020)
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Journal Article
Drug discovery strategies for novel leukotriene A4 hydrolase inhibitors
Röhn, Till A, Numao, Shin, Otto, Heike, Loesche, Christian, Thoma, Gebhard
Published in Expert opinion on drug discovery (02.12.2021)
Published in Expert opinion on drug discovery (02.12.2021)
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Journal Article
IL-26 Potentiates Type 2 Skin Inflammation in the Presence of IL-1β
Bier, Katharina, Senajova, Zuzana, Henrion, Fanny, Wang, Yichen, Bruno, Sandro, Rauld, Celine, Hörmann, Lisa C., Barske, Carmen, Delucis-Bronn, Corinne, Bergling, Sebastian, Altorfer, Marc, Hägele, Jasmin, Knehr, Judith, Junt, Tobias, Roediger, Ben, Röhn, Till A., Kolbinger, Frank
Published in Journal of investigative dermatology (01.07.2024)
Published in Journal of investigative dermatology (01.07.2024)
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Journal Article
Vaccination against IL‐17 suppresses autoimmune arthritis and encephalomyelitis
Röhn, Till A., Jennings, Gary T., Hernandez, Marcela, Grest, Paula, Beck, Markus, Zou, Yu, Kopf , Manfred, Bachmann, Martin F.
Published in European Journal of Immunology (01.11.2006)
Published in European Journal of Immunology (01.11.2006)
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Disease Association of Anti‒Carboxyethyl Lysine Autoantibodies in Hidradenitis Suppurativa
Macchiarella, Giulio, Cornacchione, Vanessa, Cojean, Celine, Riker, Julia, Wang, Yichen, Te, Helene, Ceci, Melanie, Gudjonsson, Johann E., Gaulis, Swann, Goetschy, Jean François, Wollschlegel, Audrey, Gass, Stephanie K., Oetliker-Contin, Sofia, Wettstein-Ling, Barbara, Schaefer, Dirk J., Meschberger, Pascale, de Roche, Roland, Osinga, Rik, Wieczorek, Grazyna, Naumann, Ulrike, Lehmann, Joachim C.U., Schubart, Anna, Hofmann, Andreas, Roth, Lukas, Florencia, Edwin F., Loesche, Christian, Traggiai, Elisabetta, Avrameas, Alexandre, Prens, Errol P., Röhn, Till A., Roediger, Ben
Published in Journal of investigative dermatology (01.02.2023)
Published in Journal of investigative dermatology (01.02.2023)
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Modelling atopic dermatitis in healthy human skin for the characterization of topical compounds
Hacini‐Rachinel, Feriel, Hauchard, Alice, Bruno, Sandro, Paulat, Guido, Cojean, Celine, Loesle, Perrine, Schneider, Martin Alexander, Bourne, Marta, Elain, Gaelle, Roth, Lukas, Urban, Beatrice, Viebrock, Sabine, Leon, Anette Orjuela, Roehn, Till A., Loesche, Christian, Werfel, Thomas, Thoma, Gebhard, Zerwes, Hans‐Günter
Published in Experimental dermatology (01.05.2024)
Published in Experimental dermatology (01.05.2024)
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Transport of Streptococcus pneumoniae capsular polysaccharide in MHC Class II tubules
Stephen, Tom Li, Fabri, Mario, Groneck, Laura, Röhn, Till A, Hafke, Helena, Robinson, Nirmal, Rietdorf, Jens, Schrama, David, Becker, Jürgen C, Plum, Georg, Krönke, Martin, Kropshofer, Harald, Kalka-Moll, Wiltrud M
Published in PLoS pathogens (01.03.2007)
Published in PLoS pathogens (01.03.2007)
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Journal Article
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase
Markert, Christian, Thoma, Gebhard, Srinivas, Honnappa, Bollbuck, Birgit, Lüönd, Rainer M, Miltz, Wolfgang, Wälchli, Rudolf, Wolf, Romain, Hinrichs, Jürgen, Bergsdorf, Christian, Azzaoui, Kamal, Penno, Carlos A, Klein, Kai, Wack, Nathalie, Jäger, Petra, Hasler, Franziska, Beerli, Christian, Loetscher, Pius, Dawson, Janet, Wieczorek, Grazyna, Numao, Shin, Littlewood-Evans, Amanda, Röhn, Till A
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Journal Article
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase
Markert, Christian, Thoma, Gebhard, Srinivas, Honnappa, Bollbuck, Birgit, Lüönd, Rainer M, Miltz, Wolfgang, Wälchli, Rudolf, Wolf, Romain, Hinrichs, Jürgen, Bergsdorf, Christian, Azzaoui, Kamal, Penno, Carlos A, Klein, Kai, Wack, Nathalie, Jäger, Petra, Hasler, Franziska, Beerli, Christian, Loetscher, Pius, Dawson, Janet, Wieczorek, Grazyna, Numao, Shin, Littlewood-Evans, Amanda, Röhn, Till A
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Neutralization of IL‐17 by active vaccination inhibits IL‐23‐dependent autoimmune myocarditis
Sonderegger, Ivo, Röhn, Till A., Kurrer, Michael O., Iezzi, Giandomenica, Zou, Yu, Kastelein, Robert A., Bachmann, Martin F., Kopf, Manfred
Published in European Journal of Immunology (01.11.2006)
Published in European Journal of Immunology (01.11.2006)
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