Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase
Rizo, Alexandrea N., Lin, JiaBei, Gates, Stephanie N., Tse, Eric, Bart, Stephen M., Castellano, Laura M., DiMaio, Frank, Shorter, James, Southworth, Daniel R.
Published in Nature communications (03.06.2019)
Published in Nature communications (03.06.2019)
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Structures of the holo CRISPR RNA-guided transposon integration complex
Park, Jung-Un, Tsai, Amy Wei-Lun, Rizo, Alexandrea N., Truong, Vinh H., Wellner, Tristan X., Schargel, Richard D., Kellogg, Elizabeth H.
Published in Nature (London) (26.01.2023)
Published in Nature (London) (26.01.2023)
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Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104
Gates, Stephanie N., Yokom, Adam L., Lin, JiaBei, Jackrel, Meredith E., Rizo, Alexandrea N., Kendsersky, Nathan M., Buell, Courtney E., Sweeny, Elizabeth A., Mack, Korrie L., Chuang, Edward, Torrente, Mariana P., Su, Min, Shorter, James, Southworth, Daniel R.
Published in Science (American Association for the Advancement of Science) (21.07.2017)
Published in Science (American Association for the Advancement of Science) (21.07.2017)
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Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis
Lopez, Kyle E., Rizo, Alexandrea N., Tse, Eric, Lin, JiaBei, Scull, Nathaniel W., Thwin, Aye C., Lucius, Aaron L., Shorter, James, Southworth, Daniel R.
Published in Nature structural & molecular biology (01.05.2020)
Published in Nature structural & molecular biology (01.05.2020)
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Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2
Bracken, Colton J., Lim, Shion A., Solomon, Paige, Rettko, Nicholas J., Nguyen, Duy P., Zha, Beth Shoshana, Schaefer, Kaitlin, Byrnes, James R., Zhou, Jie, Lui, Irene, Liu, Jia, Pance, Katarina, Zhou, Xin X., Leung, Kevin K., Wells, James A.
Published in Nature chemical biology (01.01.2021)
Published in Nature chemical biology (01.01.2021)
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Journal Article
Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3
Cupo, Ryan R., Rizo, Alexandrea N., Braun, Gabriel A., Tse, Eric, Chuang, Edward, Gupta, Kushol, Southworth, Daniel R., Shorter, James
Published in Cell reports (Cambridge) (27.09.2022)
Published in Cell reports (Cambridge) (27.09.2022)
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Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps
Remesh, Soumya G., Merz, Gregory E., Brilot, Axel F., Chio, Un Seng, Rizo, Alexandrea N., Pospiech, Thomas H., Lui, Irene, Laurie, Mathew T., Glasgow, Jeff, Le, Chau Q., Zhang, Yun, Diwanji, Devan, Hernandez, Evelyn, Lopez, Jocelyne, Mehmood, Hevatib, Pawar, Komal Ishwar, Pourmal, Sergei, Smith, Amber M., Zhou, Fengbo, DeRisi, Joseph, Kortemme, Tanja, Rosenberg, Oren S., Glasgow, Anum, Leung, Kevin K., Wells, James A., Verba, Kliment A.
Published in Structure (London) (02.03.2023)
Published in Structure (London) (02.03.2023)
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An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
Schoof, Michael, Faust, Bryan, Saunders, Reuben A, Sangwan, Smriti, Rezelj, Veronica, Hoppe, Nick, Boone, Morgane, Billesbølle, Christian B, Puchades, Cristina, Azumaya, Caleigh M, Kratochvil, Huong T, Zimanyi, Marcell, Deshpande, Ishan, Liang, Jiahao, Dickinson, Sasha, Nguyen, Henry C, Chio, Cynthia M, Merz, Gregory E, Thompson, Michael C, Diwanji, Devan, Schaefer, Kaitlin, Anand, Aditya A, Dobzinski, Niv, Zha, Beth Shoshana, Simoneau, Camille R, Leon, Kristoffer, White, Kris M, Chio, Un Seng, Gupta, Meghna, Jin, Mingliang, Li, Fei, Liu, Yanxin, Zhang, Kaihua, Bulkley, David, Sun, Ming, Smith, Amber M, Rizo, Alexandrea N, Moss, Frank, Brilot, Axel F, Pourmal, Sergei, Trenker, Raphael, Pospiech, Thomas, Gupta, Sayan, Barsi-Rhyne, Benjamin, Belyy, Vladislav, Barile-Hill, Andrew W, Nock, Silke, Liu, Yuwei, Krogan, Nevan J, Ralston, Corie Y, Swaney, Danielle L, García-Sastre, Adolfo, Ott, Melanie, Vignuzzi, Marco, Walter, Peter, Manglik, Aashish
Published in Science (18.12.2020)
Published in Science (18.12.2020)
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Design principles to tailor Hsp104 therapeutics
Lin, JiaBei, Carman, Peter J, Gambogi, Craig W, Kendsersky, Nathan M, Chuang, Edward, Gates, Stephanie N, Yokom, Adam L, Rizo, Alexandrea N, Southworth, Daniel R, Shorter, James
Published in bioRxiv (28.04.2024)
Published in bioRxiv (28.04.2024)
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Journal Article
Conformational Plasticity of the Clpap Aaa+ Protease Couples Protein Unfolding and Proteolysis
Rizo, Alexandrea N., Eric Lopez, Kyle, Shorter, James, Southworth, Daniel R.
Published in Biophysical journal (12.02.2021)
Published in Biophysical journal (12.02.2021)
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Journal Article
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps
Remesh, Soumya G, Merz, Gregory E, Brilot, Axel F, Chio, Un Seng, Rizo, Alexandrea N, Pospiech, Jr, Thomas H, Lui, Irene, Laurie, Mathew T, Glasgow, Jeff, Le, Chau Q, Zhang, Yun, Diwanji, Devan, Hernandez, Evelyn, Lopez, Jocelyne, Pawar, Komal Ishwar, Pourmal, Sergei, Smith, Amber M, Zhou, Fengbo, DeRisi, Joseph, Kortemme, Tanja, Rosenberg, Oren S, Glasgow, Anum, Leung, Kevin K, Wells, James A, Verba, Kliment A
Published in bioRxiv (10.08.2022)
Published in bioRxiv (10.08.2022)
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Paper
Development of potent dimeric inhibitors of GAS41 YEATS domain
Listunov, Dymytrii, Linhares, Brian M., Kim, EunGi, Winkler, Alyssa, Simes, Miranda L., Weaver, Sidney, Cho, Hyo Je, Rizo, Alexandrea, Zolov, Sergey, Keshamouni, Venkateshwar G., Grembecka, Jolanta, Cierpicki, Tomasz
Published in Cell chemical biology (16.12.2021)
Published in Cell chemical biology (16.12.2021)
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An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation
Schoof, Michael, Faust, Bryan, Saunders, Reuben A, Sangwan, Smriti, Rezelj, Veronica, Hoppe, Nick, Boone, Morgane, Billesbølle, Christian B, Puchades, Cristina, Azumaya, Caleigh M, Kratochvil, Huong T, Zimanyi, Marcell, Deshpande, Ishan, Liang, Jiahao, Dickinson, Sasha, Nguyen, Henry C, Chio, Cynthia M, Merz, Gregory E, Thompson, Michael C, Diwanji, Devan, Schaefer, Kaitlin, Anand, Aditya A, Dobzinski, Niv, Zha, Beth Shoshana, Simoneau, Camille R, Leon, Kristoffer, White, Kris M, Chio, Un Seng, Gupta, Meghna, Jin, Mingliang, Li, Fei, Liu, Yanxin, Zhang, Kaihua, Bulkley, David, Sun, Ming, Smith, Amber M, Rizo, Alexandrea N, Moss, Frank, Brilot, Axel F, Pourmal, Sergei, Trenker, Raphael, Pospiech, Thomas, Gupta, Sayan, Barsi-Rhyne, Benjamin, Belyy, Vladislav, Barile-Hill, Andrew W, Nock, Silke, Liu, Yuwei, Krogan, Nevan J, Ralston, Corie Y, Swaney, Danielle L, García-Sastre, Adolfo, Ott, Melanie, Vignuzzi, Marco, Walter, Peter, Manglik, Aashish
Published in bioRxiv : the preprint server for biology (17.08.2020)
Published in bioRxiv : the preprint server for biology (17.08.2020)
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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
Gordon, David E, Hiatt, Joseph, Bouhaddou, Mehdi, Rezelj, Veronica V, Ulferts, Svenja, Braberg, Hannes, Jureka, Alexander S, Obernier, Kirsten, Guo, Jeffrey Z, Batra, Jyoti, Kaake, Robyn M, Weckstein, Andrew R, Owens, Tristan W, Gupta, Meghna, Pourmal, Sergei, Titus, Erron W, Cakir, Merve, Soucheray, Margaret, McGregor, Michael, Cakir, Zeynep, Jang, Gwendolyn, O'Meara, Matthew J, Tummino, Tia A, Zhang, Ziyang, Foussard, Helene, Rojc, Ajda, Zhou, Yuan, Kuchenov, Dmitry, Hüttenhain, Ruth, Xu, Jiewei, Eckhardt, Manon, Swaney, Danielle L, Fabius, Jacqueline M, Ummadi, Manisha, Tutuncuoglu, Beril, Rathore, Ujjwal, Modak, Maya, Haas, Paige, Haas, Kelsey M, Naing, Zun Zar Chi, Pulido, Ernst H, Shi, Ying, Barrio-Hernandez, Inigo, Memon, Danish, Petsalaki, Eirini, Dunham, Alistair, Marrero, Miguel Correa, Burke, David, Koh, Cassandra, Vallet, Thomas, Silvas, Jesus A, Azumaya, Caleigh M, Billesbølle, Christian, Brilot, Axel F, Campbell, Melody G, Diallo, Amy, Dickinson, Miles Sasha, Diwanji, Devan, Herrera, Nadia, Hoppe, Nick, Kratochvil, Huong T, Liu, Yanxin, Merz, Gregory E, Moritz, Michelle, Nguyen, Henry C, Nowotny, Carlos, Puchades, Cristina, Rizo, Alexandrea N, Schulze-Gahmen, Ursula, Smith, Amber M, Sun, Ming, Young, Iris D, Zhao, Jianhua, Asarnow, Daniel, Biel, Justin, Bowen, Alisa, Braxton, Julian R, Chen, Jen, Chio, Cynthia M, Chio, Un Seng, Deshpande, Ishan, Doan, Loan, Faust, Bryan, Flores, Sebastian, Jin, Mingliang, Kim, Kate, Lam, Victor L, Li, Fei, Li, Junrui, Li, Yen-Li, Li, Yang, Liu, Xi, Lo, Megan, Lopez, Kyle E, Melo, Arthur A, Moss, 3rd, Frank R, Nguyen, Phuong, Paulino, Joana, Pawar, Komal Ishwar, Peters, Jessica K
Published in Science (04.12.2020)
Published in Science (04.12.2020)
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Design principles to tailor Hsp104 therapeutics
Lin, JiaBei, Carman, Peter J., Gambogi, Craig W., Kendsersky, Nathan M., Chuang, Edward, Gates, Stephanie N., Yokom, Adam L., Rizo, Alexandrea N., Southworth, Daniel R., Shorter, James
Published in Cell reports (Cambridge)
Published in Cell reports (Cambridge)
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CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes
Gupta, Meghna, Azumaya, Caleigh M, Moritz, Michelle, Pourmal, Sergei, Diallo, Amy, Merz, Gregory E, Jang, Gwendolyn, Bouhaddou, Mehdi, Fossati, Andrea, Brilot, Axel F, Diwanji, Devan, Hernandez, Evelyn, Herrera, Nadia, Kratochvil, Huong T, Lam, Victor L, Li, Fei, Li, Yang, Nguyen, Henry C, Nowotny, Carlos, Owens, Tristan W, Peters, Jessica K, Rizo, Alexandrea N, Schulze-Gahmen, Ursula, Smith, Amber M, Young, Iris D, Yu, Zanlin, Asarnow, Daniel, Billesbølle, Christian, Campbell, Melody G, Chen, Jen, Chen, Kuei-Ho, Chio, Un Seng, Dickinson, Miles Sasha, Doan, Loan, Jin, Mingliang, Kim, Kate, Li, Junrui, Li, Yen-Li, Linossi, Edmond, Liu, Yanxin, Lo, Megan, Lopez, Jocelyne, Lopez, Kyle E, Mancino, Adamo, Moss, 3rd, Frank R, Paul, Michael D, Pawar, Komal Ishwar, Pelin, Adrian, Pospiech, Jr, Thomas H, Puchades, Cristina, Remesh, Soumya Govinda, Safari, Maliheh, Schaefer, Kaitlin, Sun, Ming, Tabios, Mariano C, Thwin, Aye C, Titus, Erron W, Trenker, Raphael, Tse, Eric, Tsui, Tsz Kin Martin, Wang, Feng, Zhang, Kaihua, Zhang, Yang, Zhao, Jianhua, Zhou, Fengbo, Zhou, Yuan, Zuliani-Alvarez, Lorena, Agard, David A, Cheng, Yifan, Fraser, James S, Jura, Natalia, Kortemme, Tanja, Manglik, Aashish, Southworth, Daniel R, Stroud, Robert M, Swaney, Danielle L, Krogan, Nevan J, Frost, Adam, Rosenberg, Oren S, Verba, Kliment A
Published in Research square (19.05.2021)
Published in Research square (19.05.2021)
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CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes
Gupta, Meghna, Azumaya, Caleigh M, Moritz, Michelle, Pourmal, Sergei, Diallo, Amy, Merz, Gregory E, Jang, Gwendolyn, Bouhaddou, Mehdi, Fossati, Andrea, Brilot, Axel F, Diwanji, Devan, Hernandez, Evelyn, Herrera, Nadia, Kratochvil, Huong T, Lam, Victor L, Li, Fei, Li, Yang, Nguyen, Henry C, Nowotny, Carlos, Owens, Tristan W, Peters, Jessica K, Rizo, Alexandrea N, Schulze-Gahmen, Ursula, Smith, Amber M, Young, Iris D, Yu, Zanlin, Asarnow, Daniel, Billesbølle, Christian, Campbell, Melody G, Chen, Jen, Chen, Kuei-Ho, Chio, Un Seng, Dickinson, Miles Sasha, Doan, Loan, Jin, Mingliang, Kim, Kate, Li, Junrui, Li, Yen-Li, Linossi, Edmond, Liu, Yanxin, Lo, Megan, Lopez, Jocelyne, Lopez, Kyle E, Mancino, Adamo, Moss, 3rd, Frank R, Paul, Michael D, Pawar, Komal Ishwar, Pelin, Adrian, Pospiech, Jr, Thomas H, Puchades, Cristina, Remesh, Soumya Govinda, Safari, Maliheh, Schaefer, Kaitlin, Sun, Ming, Tabios, Mariano C, Thwin, Aye C, Titus, Erron W, Trenker, Raphael, Tse, Eric, Tsui, Tsz Kin Martin, Wang, Feng, Zhang, Kaihua, Zhang, Yang, Zhao, Jianhua, Zhou, Fengbo, Zhou, Yuan, Zuliani-Alvarez, Lorena, Agard, David A, Cheng, Yifan, Fraser, James S, Jura, Natalia, Kortemme, Tanja, Manglik, Aashish, Southworth, Daniel R, Stroud, Robert M, Swaney, Danielle L, Krogan, Nevan J, Frost, Adam, Rosenberg, Oren S, Verba, Kliment A
Published in bioRxiv : the preprint server for biology (11.05.2021)
Published in bioRxiv : the preprint server for biology (11.05.2021)
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