Phase I Study of ARN-509, a Novel Antiandrogen, in the Treatment of Castration-Resistant Prostate Cancer
RATHKOPF, Dana E, MORRIS, Michael J, FLEISHER, Martin, LARSON, Steven M, SAWYERS, Charles L, SCHER, Howard I, FOX, Josef J, DANILA, Daniel C, SLOVIN, Susan F, HAGER, Jeffrey H, RIX, Peter J, CHOW ANEVAL, Edna, CHEN, Isan, GÖNEN, Mithat
Published in Journal of clinical oncology (01.10.2013)
Published in Journal of clinical oncology (01.10.2013)
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ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment
CLEGG, Nicola J, WONGVIPAT, John, APARICIO, Anna, DOROW, Steven, ARORA, Vivek, GANG SHAO, JING QIAN, HONG ZHAO, GUANGBIN YANG, CHUNYAN CAO, SENSINTAFFAR, John, WASIELEWSKA, Teresa, JOSEPH, James D, HERBERT, Mark R, BONNEFOUS, Celine, DARIMONT, Beatrice, SCHER, Howard I, SMITH-JONES, Peter, KLANG, Mark, SMITH, Nicholas D, DE STANCHINA, Elisa, NIAN WU, OUERFELLI, Ouathek, TRAN, Chris, RIX, Peter J, HEYMAN, Richard A, JUNG, Michael E, SAWYERS, Charles L, HAGER, Jeffrey H, OUK, Samedy, DILHAS, Anna, YU CHEN, GRILLOT, Kate, BISCHOFF, Eric D, LING CAI
Published in Cancer research (Chicago, Ill.) (15.03.2012)
Published in Cancer research (Chicago, Ill.) (15.03.2012)
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Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Nebulized Sodium Nitrite (AIR001) Following Repeat-Dose Inhalation in Healthy Subjects
Rix, Peter J., Vick, Andrew, Attkins, Neil J., Barker, Geoffrey E., Bott, Adrian W., Alcorn, Harry, Gladwin, Mark T., Shiva, Sruti, Bradley, Stephen, Hussaini, Azra, Hoye, William L., Parsley, Ed L., Masamune, Hiroko
Published in Clinical pharmacokinetics (01.03.2015)
Published in Clinical pharmacokinetics (01.03.2015)
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Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts
Lai, Andiliy, Kahraman, Mehmet, Govek, Steven, Nagasawa, Johnny, Bonnefous, Celine, Julien, Jackie, Douglas, Karensa, Sensintaffar, John, Lu, Nhin, Lee, Kyoung-jin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Moon, Michael J, Joseph, James D, Darimont, Beatrice, Brigham, Daniel, Grillot, Kate, Heyman, Richard, Rix, Peter J, Hager, Jeffrey H, Smith, Nicholas D
Published in Journal of medicinal chemistry (25.06.2015)
Published in Journal of medicinal chemistry (25.06.2015)
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Substituted 6-(1-Pyrrolidine)quinolin-2(1H)-ones as Novel Selective Androgen Receptor Modulators
Martinborough, Esther, Shen, Yixing, van Oeveren, Arjan, Long, Yun Oliver, Lau, Thomas L. S, Marschke, Keith B, Chang, William Y, López, Francisco J, Vajda, Eric G, Rix, Peter J, Viveros, O. Humberto, Negro-Vilar, Andrés, Zhi, Lin
Published in Journal of medicinal chemistry (18.10.2007)
Published in Journal of medicinal chemistry (18.10.2007)
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Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer
Nagasawa, Johnny, Govek, Steven, Kahraman, Mehmet, Lai, Andiliy, Bonnefous, Celine, Douglas, Karensa, Sensintaffar, John, Lu, Nhin, Lee, KyoungJin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Joseph, James D, Darimont, Beatrice, Brigham, Daniel, Maheu, Kate, Heyman, Richard, Rix, Peter J, Hager, Jeffrey H, Smith, Nicholas D
Published in Journal of medicinal chemistry (13.09.2018)
Published in Journal of medicinal chemistry (13.09.2018)
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The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer
Joseph, James D, Darimont, Beatrice, Zhou, Wei, Arrazate, Alfonso, Young, Amy, Ingalla, Ellen, Walter, Kimberly, Blake, Robert A, Nonomiya, Jim, Guan, Zhengyu, Kategaya, Lorna, Govek, Steven P, Lai, Andiliy G, Kahraman, Mehmet, Brigham, Dan, Sensintaffar, John, Lu, Nhin, Shao, Gang, Qian, Jing, Grillot, Kate, Moon, Michael, Prudente, Rene, Bischoff, Eric, Lee, Kyoung-Jin, Bonnefous, Celine, Douglas, Karensa L, Julien, Jackaline D, Nagasawa, Johnny Y, Aparicio, Anna, Kaufman, Josh, Haley, Benjamin, Giltnane, Jennifer M, Wertz, Ingrid E, Lackner, Mark R, Nannini, Michelle A, Sampath, Deepak, Schwarz, Luis, Manning, Henry Charles, Tantawy, Mohammed Noor, Arteaga, Carlos L, Heyman, Richard A, Rix, Peter J, Friedman, Lori, Smith, Nicholas D, Metcalfe, Ciara, Hager, Jeffrey H
Published in eLife (13.07.2016)
Published in eLife (13.07.2016)
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Maximizing ER‑α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927
Kahraman, Mehmet, Govek, Steven P, Nagasawa, Johnny Y, Lai, Andiliy, Bonnefous, Celine, Douglas, Karensa, Sensintaffar, John, Liu, Nhin, Lee, KyoungJin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Joseph, James D, Darimont, Beatrice, Brigham, Daniel, Heyman, Richard, Rix, Peter J, Hager, Jeffrey H, Smith, Nicholas D
Published in ACS medicinal chemistry letters (10.01.2019)
Published in ACS medicinal chemistry letters (10.01.2019)
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Optimization of an indazole series of selective estrogen receptor degraders: Tumor regression in a tamoxifen-resistant breast cancer xenograft
Govek, Steven P., Nagasawa, Johnny Y., Douglas, Karensa L., Lai, Andiliy G., Kahraman, Mehmet, Bonnefous, Celine, Aparicio, Anna M., Darimont, Beatrice D., Grillot, Katherine L., Joseph, James D., Kaufman, Joshua A., Lee, Kyoung-Jin, Lu, Nhin, Moon, Michael J., Prudente, Rene Y., Sensintaffar, John, Rix, Peter J., Hager, Jeffrey H., Smith, Nicholas D.
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft
Govek, Steven P., Bonnefous, Celine, Julien, Jackaline D., Nagasawa, Johnny Y., Kahraman, Mehmet, Lai, Andiliy G., Douglas, Karensa L., Aparicio, Anna M., Darimont, Beatrice D., Grillot, Katherine L., Joseph, James D., Kaufman, Joshua A., Lee, Kyoung-Jin, Lu, Nhin, Moon, Michael J., Prudente, Rene Y., Sensintaffar, John, Rix, Peter J., Hager, Jeffrey H., Smith, Nicholas D.
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
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Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases
Symons, Kent T, Nguyen, Phan M, Massari, Mark E, Anzola, John V, Staszewski, Lena M, Wang, Li, Yazdani, Nahid, Dorow, Steven, Muhammad, Jerry, Sablad, Marciano, Rozenkrants, Natasha, Bonefous, Celine, Payne, Joseph E, Rix, Peter J, Shiau, Andrew K, Noble, Stewart A, Smith, Nicholas D, Hassig, Christian A, Zhang, Yan, Rao, Tadimeti S
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
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Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927
Kahraman, Mehmet, Govek, Steven P., Nagasawa, Johnny Y., Lai, Andiliy, Bonnefous, Celine, Douglas, Karensa, Sensintaffar, John, Lu, Nhin, Lee, KyoungJin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Joseph, James D., Darimont, Beatrice, Brigham, Daniel, Heyman, Richard, Rix, Peter J., Hager, Jeffrey H., Smith, Nicholas D., Blake, Robert A., Chang, Jae, Choo, Edna, Daemen, Anneleen, Friedman, Lori S., Guan, Jane, Hartman, Steven, Ingalla, Ellen, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada, Metcalfe, Ciara, Mody, Vidhi, Nannini, Michelle, Sampath, Deepak, Young, Amy, Vinogradova, Maia, Zhou, Wei, Liang, Jun, Wang, Xiaojing
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer
Joseph, James D, Darimont, Beatrice, Zhou, Wei, Arrazate, Alfonso, Young, Amy, Ingalla, Ellen, Walter, Kimberly, Blake, Robert A, Nonomiya, Jim, Guan, Zhengyu, Kategaya, Lorna, Govek, Steven P, Lai, Andiliy G, Kahraman, Mehmet, Brigham, Dan, Sensintaffar, John, Lu, Nhin, Shao, Gang, Qian, Jing, Grillot, Kate, Moon, Michael, Prudente, Rene, Bischoff, Eric, Lee, Kyoung-Jin, Bonnefous, Celine, Douglas, Karensa L, Julien, Jackaline D, Nagasawa, Johnny Y, Aparicio, Anna, Kaufman, Josh, Haley, Benjamin, Giltnane, Jennifer M, Wertz, Ingrid E, Lackner, Mark R, Nannini, Michelle A, Sampath, Deepak, Schwarz, Luis, Manning, Henry Charles, Tantawy, Mohammed Noor, Arteaga, Carlos L, Heyman, Richard A, Rix, Peter J, Friedman, Lori, Smith, Nicholas D, Metcalfe, Ciara, Hager, Jeffrey H
Published in eLife (07.01.2019)
Published in eLife (07.01.2019)
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A phase I study of the androgen signaling inhibitor ARN-509 in patients with metastatic castration-resistant prostate cancer (mCRPC)
Rathkopf, Dana E., Morris, Michael J., Danila, Daniel Costin, Slovin, Susan F., Steinbrecher, Jill Elise, Arauz, Gabrielle, Curley, Tracy, Rix, Peter J., Chow Maneval, Edna, Chen, Isan, Fleisher, Martin, Landa, Jonathan, Fox, Josef J., Larson, Steven M., Scher, Howard I.
Published in Journal of clinical oncology (20.05.2012)
Published in Journal of clinical oncology (20.05.2012)
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Phase I/II safety and pharmacokinetic (PK) study of ARN-509 in patients with metastatic castration-resistant prostate cancer (mCRPC): Phase I results of a Prostate Cancer Clinical Trials Consortium study
Rathkopf, Dana E., Danila, Daniel Costin, Morris, Michael J., Slovin, Susan F., Steinbrecher, Jill Elise, Arauz, Gabrielle, Rix, Peter J., Chow Maneval, Edna, Chen, Isan, Fox, Josef J., Fleisher, Martin, Larson, Steven M., Scher, Howard I.
Published in Journal of clinical oncology (10.02.2012)
Published in Journal of clinical oncology (10.02.2012)
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A phase II study of the androgen signaling inhibitor ARN-509 in patients with castration-resistant prostate cancer (CRPC)
Rathkopf, Dana E., Shore, Neal, Antonarakis, Emmanuel S., Berry, William R., Alumkal, Joshi J., Tutrone, Ronald, Saleh, Mansoor N., Redfern, Charles H., Hauke, Ralph J., Liu, Glenn, Steinbrecher, Jill Elise, Danila, Daniel Costin, Curley, Tracy, Arauz, Gabrielle, Rix, Peter J., Maneval, Edna Chow, Chen, Isan, Scher, Howard I.
Published in Journal of clinical oncology (20.05.2012)
Published in Journal of clinical oncology (20.05.2012)
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Journal Article
ARN-509: a novel anti-androgen for prostate cancer treatment
Clegg, Nicola J., Wongvipat, John, Joseph, Jim, Tran, Chris, Ouk, Samedy, Dilhas, Anna, Chen, Yu, Grillot, Kate, Bischoff, Eric D., Cai, Ling, Aparicio, Anna, Dorow, Steven, Arora, Vivek, Shao, Gang, Qian, Jing, Zhao, Hong, Yang, Guangbin, Cao, Chunyan, Sensintaffar, John, Wasielewska, Teresa, Herbert, Mark R., Bonnefous, Celine, Darimont, Beatrice, Scher, Howard I., Smith-Jones, Peter, Klang, Mark, Smith, Nicholas D., De Stanchina, Elisa, Wu, Nian, Ouerfelli, Ouathek, Rix, Peter J., Heyman, Richard A., Jung, Michael E., Sawyers, Charles L., Hager, Jeffrey H.
Published in Cancer research (Chicago, Ill.) (20.01.2012)
Published in Cancer research (Chicago, Ill.) (20.01.2012)
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Effect of Benzalkonium Chloride/EDTA on the Ocular Bioavailability of Ketorolac Tromethamine following Ocular Instillation to Normal and De-epithelialized Corneas of Rabbits
Madhu, Cherukury, Rix, Peter J., Shackleton, Martha J., Nguyen, Thai G., Tang-Liu, Diane D.-S.
Published in Journal of pharmaceutical sciences (01.04.1996)
Published in Journal of pharmaceutical sciences (01.04.1996)
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