In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance
Checkmahomed, Liva, Carbonneau, Julie, Du Pont, Venice, Riola, Nicholas C, Perry, Jason K, Li, Jiani, Paré, Bastien, Simpson, Shawn M, Smith, Martin A, Porter, Danielle P, Boivin, Guy
Published in Antimicrobial agents and chemotherapy (19.07.2022)
Published in Antimicrobial agents and chemotherapy (19.07.2022)
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Journal Article
Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys
Mackman, Richard L., Kalla, Rao V., Babusis, Darius, Pitts, Jared, Barrett, Kimberly T., Chun, Kwon, Du Pont, Venice, Rodriguez, Lauren, Moshiri, Jasmine, Xu, Yili, Lee, Michael, Lee, Gary, Bleier, Blake, Nguyen, Anh-Quan, O’Keefe, B. Michael, Ambrosi, Andrea, Cook, Meredith, Yu, Joy, Dempah, Kassibla Elodie, Bunyan, Elaine, Riola, Nicholas C., Lu, Xianghan, Liu, Renmeng, Davie, Ashley, Hsiang, Tien-Ying, Dearing, Justin, Vermillion, Meghan, Gale, Michael, Niedziela-Majka, Anita, Feng, Joy Y., Hedskog, Charlotte, Bilello, John P., Subramanian, Raju, Cihlar, Tomas
Published in Journal of medicinal chemistry (14.09.2023)
Published in Journal of medicinal chemistry (14.09.2023)
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Journal Article
Discovery of GS-7682, a Novel 4′-Cyano-Modified C‑Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys
Siegel, Dustin S., Hui, Hon C., Pitts, Jared, Vermillion, Meghan S., Ishida, Kazuya, Rautiola, Davin, Keeney, Michael, Irshad, Hammad, Zhang, Lijun, Chun, Kwon, Chin, Gregory, Goyal, Bindu, Doerffler, Edward, Yang, Hai, Clarke, Michael O., Palmiotti, Chris, Vijjapurapu, Arya, Riola, Nicholas C., Stray, Kirsten, Murakami, Eisuke, Ma, Bin, Wang, Ting, Zhao, Xiaofeng, Xu, Yili, Lee, Gary, Marchand, Bruno, Seung, Minji, Nayak, Arabinda, Tomkinson, Adrian, Kadrichu, Nani, Ellis, Scott, Barauskas, Ona, Feng, Joy Y., Perry, Jason K., Perron, Michel, Bilello, John P., Kuehl, Philip J., Subramanian, Raju, Cihlar, Tomas, Mackman, Richard L.
Published in Journal of medicinal chemistry (08.08.2024)
Published in Journal of medicinal chemistry (08.08.2024)
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Journal Article
Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants
Pitts, Jared, Li, Jiani, Perry, Jason K, Du Pont, Venice, Riola, Nicholas, Rodriguez, Lauren, Lu, Xianghan, Kurhade, Chaitanya, Xie, Xuping, Camus, Gregory, Manhas, Savrina, Martin, Ross, Shi, Pei-Yong, Cihlar, Tomas, Porter, Danielle P, Mo, Hongmei, Maiorova, Evguenia, Bilello, John P
Published in Antimicrobial agents and chemotherapy (21.06.2022)
Published in Antimicrobial agents and chemotherapy (21.06.2022)
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Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection
Pitts, Jared, Babusis, Darius, Vermillion, Meghan S., Subramanian, Raju, Barrett, Kim, Lye, Diane, Ma, Bin, Zhao, Xiaofeng, Riola, Nicholas, Xie, Xuping, Kajon, Adriana, Lu, Xianghan, Bannister, Roy, Shi, Pei-Yong, Toteva, Maria, Porter, Danielle P., Smith, Bill J., Cihlar, Tomas, Mackman, Richard, Bilello, John P.
Published in Antiviral research (01.07.2022)
Published in Antiviral research (01.07.2022)
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539. Efficacy in Multiple SARS-CoV-2 Animal Models Supports Phase 3 Dose Selection for Obeldesivir
Pitts, Jared, Babusis, Darius, Humeniuk, Rita, Martinez, David, Cox, Robert M, Schäfer, Alexandra, Riola, Nicholas C, Feng, Joy, Du Pont, Venice, Anoshchenko, Olena, Vermillion, Meghan, Abdelghany, Mazin, Hyland, Robert H, Girish, Sandhya, Sheahan, Timothy P, Plemper, Richard K, Baric, Ralph S, Cihlar, Tomas, Llewellyn, Joe, Winter, Helen, Bannister, Roy, Subramanian, Raju, Mackman, Richard L, Bilello, John P
Published in Open forum infectious diseases (27.11.2023)
Published in Open forum infectious diseases (27.11.2023)
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Journal Article
Remdesivir and GS-441524 retain antiviral activity against Delta, Omicron, and other emergent SARS-CoV-2 variants
Pitts, Jared, Li, Jiani, Perry, Jason, Venice Du Pont, Riola, Nicholas, Rodriguez, Lauren, Lu, Xianghan, Kurhade, Chaitanya, Xie, Xuping, Camus, Gregory, Manhas, Savrina, Ross, Martin, Pei-Yong, Shi, Cihlar, Tomas, Danielle Poulin Porter, Mo, Hongmei, Maiorova, Evguenia S, Bilello, John P
Published in bioRxiv (10.02.2022)
Published in bioRxiv (10.02.2022)
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