Mechanism-based inhibition of cytochrome P450 enzymes: An evaluation of early decision making in vitro approaches and drug–drug interaction prediction methods
Grime, Kenneth H., Bird, James, Ferguson, Douglas, Riley, Robert J.
Published in European journal of pharmaceutical sciences (15.02.2009)
Published in European journal of pharmaceutical sciences (15.02.2009)
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Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo
SOARS, Matthew G, GRIME, Ken, SPROSTON, Joanne L, WEBBORN, Peter J. H, RILEY, Robert J
Published in Drug metabolism and disposition (01.06.2007)
Published in Drug metabolism and disposition (01.06.2007)
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The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
AUSTIN, Rupert P, BARTON, Patrick, COCKROFT, Scott L, WENLOCK, Mark C, RILEY, Robert J
Published in Drug metabolism and disposition (01.12.2002)
Published in Drug metabolism and disposition (01.12.2002)
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Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes
PAINE, Stuart W, PARKER, Alison J, GARDINER, Philip, WEBBORN, Peter J. H, RILEY, Robert J
Published in Drug metabolism and disposition (01.07.2008)
Published in Drug metabolism and disposition (01.07.2008)
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From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis
SPRINGTHORPE, Brian, BAILEY, Andrew, HUNT, Simon F, INCE, Francis, INGALL, Anthony H, KIRK, Ian P, LEESON, Paul D, LEFF, Paul, LEWIS, Richard J, MARTIN, Barrie P, MCGINNITY, Dermot F, MORTIMORE, Michael P, BARTON, Patrick, PAINE, Stuart W, PAIRAUDEAU, Garry, PATEL, Anil, RIGBY, Aaron J, RILEY, Robert J, TEOBALD, Barry J, TOMLINSON, Wendy, WEBBORN, Peter J. H, WILLIS, Paul A, BIRKINSHAW, Timothy N, BONNERT, Roger V, BROWN, Roger C, CHAPMAN, David, DIXON, John, GUILE, Simon D, HUMPHRIES, Robert G
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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The pivotal role of hepatocytes in drug discovery
Soars, Matthew G., McGinnity, Dermot F., Grime, Ken, Riley, Robert J.
Published in Chemico-biological interactions (20.05.2007)
Published in Chemico-biological interactions (20.05.2007)
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Evaluation of Multiple in Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery: Human Hepatocytes, Pregnane X Receptor Reporter Gene, and Fa2N-4 and HepaRG Cells
MCGINNITY, Dermot F, ZHANG, George, KENNY, Jane R, HAMILTON, Geraldine A, OTMANI, Sara, STAMS, Karen R, HANEY, Suzzette, BRASSIL, Patrick, STRESSER, David M, RILEY, Robert J
Published in Drug metabolism and disposition (01.06.2009)
Published in Drug metabolism and disposition (01.06.2009)
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EVALUATION OF TIME-DEPENDENT CYTOCHROME P450 INHIBITION USING CULTURED HUMAN HEPATOCYTES
MCGINNITY, Dermot F, BERRY, Amanda J, KENNY, Jane R, GRIME, Ken, RILEY, Robert J
Published in Drug metabolism and disposition (01.08.2006)
Published in Drug metabolism and disposition (01.08.2006)
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Evaluation of a novel PXR‐knockout in HepaRG™ cells
Williamson, Beth, Lorbeer, Mathias, Mitchell, Michael D., Brayman, Timothy G., Riley, Robert J.
Published in Pharmacology research & perspectives (01.10.2016)
Published in Pharmacology research & perspectives (01.10.2016)
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Studying the right transporter at the right time: an in vitro strategy for assessing drug-drug interaction risk during drug discovery and development
Elsby, Robert, Atkinson, Hayley, Butler, Philip, Riley, Robert J.
Published in Expert opinion on drug metabolism & toxicology (03.10.2022)
Published in Expert opinion on drug metabolism & toxicology (03.10.2022)
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