Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
Watson, Peter J., Millard, Christopher J., Riley, Andrew M., Robertson, Naomi S., Wright, Lyndsey C., Godage, Himali Y., Cowley, Shaun M., Jamieson, Andrew G., Potter, Barry V. L., Schwabe, John W. R.
Published in Nature communications (25.04.2016)
Published in Nature communications (25.04.2016)
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A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop
Wang, Huanchen, Perera, Lalith, Jork, Nikolaus, Zong, Guangning, Riley, Andrew M., Potter, Barry V. L., Jessen, Henning J., Shears, Stephen B.
Published in Nature communications (25.04.2022)
Published in Nature communications (25.04.2022)
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Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
Márquez-Moñino, María Ángeles, Ortega-García, Raquel, Whitfield, Hayley, Riley, Andrew M., Infantes, Lourdes, Garrett, Shane W., Shipton, Megan L., Brearley, Charles A., Potter, Barry V. L., González, Beatriz
Published in Nature communications (19.02.2024)
Published in Nature communications (19.02.2024)
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Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling
Qi, Ji, Cheng, Weiwei, Gao, Zhe, Chen, Yuanyuan, Shipton, Megan L., Furkert, David, Chin, Alfred C., Riley, Andrew M., Fiedler, Dorothea, Potter, Barry V.L., Fu, Chenglai
Published in Biomedicine & pharmacotherapy (01.05.2023)
Published in Biomedicine & pharmacotherapy (01.05.2023)
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Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response
Pulloor, Niyas Kudukkil, Nair, Sajith, McCaffrey, Kathleen, Kostic, Aleksandar D, Bist, Pradeep, Weaver, Jeremy D, Riley, Andrew M, Tyagi, Richa, Uchil, Pradeep D, York, John D, Snyder, Solomon H, García-Sastre, Adolfo, Potter, Barry V L, Lin, Rongtuan, Shears, Stephen B, Xavier, Ramnik J, Krishnan, Manoj N
Published in PLoS pathogens (01.02.2014)
Published in PLoS pathogens (01.02.2014)
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Designer small molecules to target calcium signalling
Swarbrick, Joanna M, Riley, Andrew M, Mills, Stephen J, Potter, Barry V L
Published in Biochemical Society transactions (01.06.2015)
Published in Biochemical Society transactions (01.06.2015)
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Synthetic partial agonists reveal key steps in IP3 receptor activation
Rossi, Ana M, Riley, Andrew M, Tovey, Stephen C, Rahman, Taufiq, Dellis, Olivier, Taylor, Emily J A, Veresov, Valery G, Potter, Barry V L, Taylor, Colin W
Published in Nature chemical biology (01.09.2009)
Published in Nature chemical biology (01.09.2009)
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Inhibition of the phosphatidylinositol 3-kinase/akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects
MAFFUCCI, Tania, PICCOLO, Enza, POTTER, Barry V. L, INNOCENTI, Paolo, FALASCA, Marco, CUMASHI, Albana, IEZZI, Manuela, RILEY, Andrew M, SAIARDI, Adolfo, GODAGE, H. Yasmin, ROSSI, Cosmo, BROGGINI, Massimo, IACOBELLI, Stefano
Published in Cancer research (Chicago, Ill.) (15.09.2005)
Published in Cancer research (Chicago, Ill.) (15.09.2005)
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Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by adenophostin A and its analogues
Saleem, Huma, Tovey, Stephen C, Riley, Andrew M, Potter, Barry V L, Taylor, Colin W
Published in PloS one (28.02.2013)
Published in PloS one (28.02.2013)
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Identification of Mammalian Vps24p as an Effector of Phosphatidylinositol 3,5-Bisphosphate-dependent Endosome Compartmentalization
Whitley, Paul, Reaves, Barbara J., Hashimoto, Makoto, Riley, Andrew M., Potter, Barry V.L., Holman, Geoffrey D.
Published in The Journal of biological chemistry (03.10.2003)
Published in The Journal of biological chemistry (03.10.2003)
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An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels
Whitfield, Hayley, White, Gaye, Sprigg, Colleen, Riley, Andrew M, Potter, Barry V L, Hemmings, Andrew M, Brearley, Charles A
Published in Biochemical journal (31.07.2020)
Published in Biochemical journal (31.07.2020)
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Inositol pentakisphosphate promotes apoptosis through the PI 3-K Akt pathway
PICCOLO, Enza, VIGNATI, Sara, FALASCA, Marco, MAFFUCCI, Tania, INNOMINATO, Pasquale F, RILEY, Andrew M, POTTER, Barry V. L, PANDOLFI, Pier Paolo, BROGGINI, Massimo, IACOBELLI, Stefano, INNOCENTI, Paolo
Published in Oncogene (04.03.2004)
Published in Oncogene (04.03.2004)
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Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs
Hostachy, Sarah, Wang, Huanchen, Zong, Guangning, Franke, Katy, Riley, Andrew M., Schmieder, Peter, Potter, Barry V. L., Shears, Stephen B., Fiedler, Dorothea
Published in Chemistry : a European journal (01.12.2023)
Published in Chemistry : a European journal (01.12.2023)
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Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP
Shipton, Megan L, Jamion, Fathima A, Wheeler, Simon, Riley, Andrew M, Plasser, Felix, Potter, Barry V. L, Butler, Stephen J
Published in Chemical science (Cambridge) (17.05.2023)
Published in Chemical science (Cambridge) (17.05.2023)
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Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin
Fu, Lin, Du, Jimin, Furkert, David, Shipton, Megan L, Liu, Xiaoqi, Aguirre, Tim, Chin, Alfred C, Riley, Andrew M, Potter, Barry V L, Fiedler, Dorothea, Zhang, Xu, Zhu, Yi, Fu, Chenglai
Published in Cardiovascular research (02.07.2024)
Published in Cardiovascular research (02.07.2024)
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Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier AtITPK4
Whitfield, Hayley L, He, Sining, Gu, Yinghong, Sprigg, Colleen, Kuo, Hui-Fen, Chiou, Tzyy-Jen, Riley, Andrew M, Potter, Barry V L, Hemmings, Andrew M, Brearley, Charles A
Published in Biochemical journal (29.03.2023)
Published in Biochemical journal (29.03.2023)
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Crystal Structure and Enzymology of Solanum tuberosum Inositol Tris/Tetrakisphosphate Kinase 1 (StITPK1)
Whitfield, Hayley L., Rodriguez, Raquel Faba, Shipton, Megan L., Li, Arthur W.H., Riley, Andrew M., Potter, Barry V.L., Hemmings, Andrew M., Brearley, Charles A.
Published in Biochemistry (Easton) (02.01.2024)
Published in Biochemistry (Easton) (02.01.2024)
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