Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development
Reijns, Martin A.M., Rabe, Björn, Rigby, Rachel E., Mill, Pleasantine, Astell, Katy R., Lettice, Laura A., Boyle, Shelagh, Leitch, Andrea, Keighren, Margaret, Kilanowski, Fiona, Devenney, Paul S., Sexton, David, Grimes, Graeme, Holt, Ian J., Hill, Robert E., Taylor, Martin S., Lawson, Kirstie A., Dorin, Julia R., Jackson, Andrew P.
Published in Cell (25.05.2012)
Published in Cell (25.05.2012)
Get full text
Journal Article
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling
Hansen, Anne Louise, Buchan, Gregory J., Rühl, Michael, Mukai, Kojiro, Salvatore, Sonia R., Ogawa, Emari, Andersen, Sidsel D., Iversen, Marie B., Thielke, Anne L., Gunderstofte, Camilla, Motwani, Mona, Møller, Charlotte T., Jakobsen, Andreas S., Fitzgerald, Katherine A., Roos, Jessica, Lin, Rongtuan, Maier, Thorsten J., Goldbach-Mansky, Raphaela, Miner, Cathrine A., Qian, Wei, Miner, Jonathan J., Rigby, Rachel E., Rehwinkel, Jan, Jakobsen, Martin R., Arai, Hiroyuki, Taguchi, Tomohiko, Schopfer, Francisco J., Olagnier, David, Holm, Christian K.
Published in Proceedings of the National Academy of Sciences - PNAS (14.08.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (14.08.2018)
Get full text
Journal Article
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response
Mackenzie, Karen J, Carroll, Paula, Lettice, Laura, Tarnauskaitė, Žygimantė, Reddy, Kaalak, Dix, Flora, Revuelta, Ailsa, Abbondati, Erika, Rigby, Rachel E, Rabe, Björn, Kilanowski, Fiona, Grimes, Graeme, Fluteau, Adeline, Devenney, Paul S, Hill, Robert E, Reijns, Martin AM, Jackson, Andrew P
Published in The EMBO journal (15.04.2016)
Published in The EMBO journal (15.04.2016)
Get full text
Journal Article
Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype
Fraser, Emily, Denney, Laura, Antanaviciute, Agne, Blirando, Karl, Vuppusetty, Chaitanya, Zheng, Yuejuan, Repapi, Emmanouela, Iotchkova, Valentina, Taylor, Stephen, Ashley, Neil, St Noble, Victoria, Benamore, Rachel, Hoyles, Rachel, Clelland, Colin, Rastrick, Joseph M D, Hardman, Clare S, Alham, Nasullah K, Rigby, Rachel E, Simmons, Alison, Rehwinkel, Jan, Ho, Ling-Pei
Published in Frontiers in immunology (05.03.2021)
Published in Frontiers in immunology (05.03.2021)
Get full text
Journal Article
Mammalian Mitochondrial DNA Replication Intermediates Are Essentially Duplex but Contain Extensive Tracts of RNA/DNA Hybrid
Pohjoismäki, Jaakko L.O., Holmes, J. Bradley, Wood, Stuart R., Yang, Ming-Yao, Yasukawa, Takehiro, Reyes, Aurelio, Bailey, Laura J., Cluett, Tricia J., Goffart, Steffi, Willcox, Smaranda, Rigby, Rachel E., Jackson, Andrew P., Spelbrink, Johannes N., Griffith, Jack D., Crouch, Robert J., Jacobs, Howard T., Holt, Ian J.
Published in Journal of molecular biology (16.04.2010)
Published in Journal of molecular biology (16.04.2010)
Get full text
Journal Article
Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses
Tang, Qiannan, Rigby, Rachel E., Young, George R., Hvidt, Astrid Korning, Davis, Tanja, Tan, Tiong Kit, Bridgeman, Anne, Townsend, Alain R., Kassiotis, George, Rehwinkel, Jan
Published in Immunity (Cambridge, Mass.) (14.09.2021)
Published in Immunity (Cambridge, Mass.) (14.09.2021)
Get full text
Journal Article
Deoxyguanosine is a TLR7 agonist
Davenne, Tamara, Bridgeman, Anne, Rigby, Rachel E., Rehwinkel, Jan
Published in European journal of immunology (01.01.2020)
Published in European journal of immunology (01.01.2020)
Get full text
Journal Article
Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling
Hertzog, Jonny, Dias Junior, Antonio Gregorio, Rigby, Rachel E., Donald, Claire L., Mayer, Alice, Sezgin, Erdinc, Song, Chaojun, Jin, Boquan, Hublitz, Philip, Eggeling, Christian, Kohl, Alain, Rehwinkel, Jan
Published in European journal of immunology (01.07.2018)
Published in European journal of immunology (01.07.2018)
Get full text
Journal Article
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS
Hertzog, Jonny, Zhou, Wen, Fowler, Gerissa, Rigby, Rachel E, Bridgeman, Anne, Blest, Henry TW, Cursi, Chiara, Chauveau, Lise, Davenne, Tamara, Warner, Benjamin E, Kinchington, Paul R, Kranzusch, Philip J, Rehwinkel, Jan
Published in The EMBO journal (18.07.2022)
Published in The EMBO journal (18.07.2022)
Get full text
Journal Article
RNA:DNA hybrids are a novel molecular pattern sensed by TLR9
Rigby, Rachel E, Webb, Lauren M, Mackenzie, Karen J, Li, Yue, Leitch, Andrea, Reijns, Martin A M, Lundie, Rachel J, Revuelta, Ailsa, Davidson, Donald J, Diebold, Sandra, Modis, Yorgo, MacDonald, Andrew S, Jackson, Andrew P
Published in The EMBO journal (18.03.2014)
Published in The EMBO journal (18.03.2014)
Get full text
Journal Article
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP
Davenne, Tamara, Klintman, Jenny, Sharma, Sushma, Rigby, Rachel E., Blest, Henry T.W., Cursi, Chiara, Bridgeman, Anne, Dadonaite, Bernadeta, De Keersmaecker, Kim, Hillmen, Peter, Chabes, Andrei, Schuh, Anna, Rehwinkel, Jan
Published in Cell reports (Cambridge) (12.05.2020)
Published in Cell reports (Cambridge) (12.05.2020)
Get full text
Journal Article
Accurate and reliable high-throughput detection of copy number variation in the human genome
Fiegler, Heike, Redon, Richard, Andrews, Dan, Scott, Carol, Andrews, Robert, Carder, Carol, Clark, Richard, Dovey, Oliver, Ellis, Peter, Feuk, Lars, French, Lisa, Hunt, Paul, Kalaitzopoulos, Dimitrios, Larkin, James, Montgomery, Lyndal, Perry, George H, Plumb, Bob W, Porter, Keith, Rigby, Rachel E, Rigler, Diane, Valsesia, Armand, Langford, Cordelia, Humphray, Sean J, Scherer, Stephen W, Lee, Charles, Hurles, Matthew E, Carter, Nigel P
Published in Genome Research (01.12.2006)
Published in Genome Research (01.12.2006)
Get full text
Journal Article
89 Analysis of extensive RNA/DNA hybrids in the replicating mammalian mitochondrial genome
Holmes, J. Bradley, Pohjoismäki, Jaakko L.O., Yang, Ming-Yao, Yasukawa, Takehiro, Cluett, Tricia J., Reyes, Aurelio, Goffart, Steffi, Willcox, Smaranda, Rigby, Rachel E., Jackson, Andrew P., Spelbrink, Johannes N., Griffith, Jack D., Crouch, Robert J., Jacobs, Howard T., Holt, Ian J.
Published in Mitochondrion (01.03.2010)
Published in Mitochondrion (01.03.2010)
Get full text
Journal Article