REGULATED GENE EXPRESSION IN STREPTOMYCETES
MUTH, GUENTER, RIESS, GUNTHER JOHANNES, PUEHLER, ALFRED, WOHLLEBEN, WOLFGANG
Year of Publication 15.01.1999
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Year of Publication 15.01.1999
Patent
Retention of marked sensitivity to ( S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-Dihydroquinoxaline-2(1H)-Thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2′,3′-dideoxy-3′-thiacytidine (Lamivudine)
Balzarini, Jan, Pelemans, Heidi, Riess, Gunther, Roesner, Manfred, Winkler, Irvin, De Ckrcq, Erik, Kleim, Jörg-Peter
Published in Biochemical pharmacology (01.03.1998)
Published in Biochemical pharmacology (01.03.1998)
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Journal Article
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance
Hsiou, Y, Das, K, Ding, J, Clark, Jr, A D, Kleim, J P, Rösner, M, Winkler, I, Riess, G, Hughes, S H, Arnold, E
Published in Journal of molecular biology (27.11.1998)
Published in Journal of molecular biology (27.11.1998)
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Journal Article
Selective Pressure of a Quinoxaline Nonnucleoside Inhibitor of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase (RT) on HIV-1 Replication Results in the Emergence of Nucleoside RT-Inhibitor-Specific (RT Leu-74 → Val or Ile and Val-75 → Leu or Ile) HIV-1 mutants
Kleim, Jörg-Peter, Rösner, Manfred, Winkler, Irvin, Paessens, Arno, Kirsch, Reinhard, Hsiou, Yu, Arnold, Edward, Riess, Günther
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.1996)
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Journal Article