Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons
Guo, Jing L., Covell, Dustin J., Daniels, Joshua P., Iba, Michiyo, Stieber, Anna, Zhang, Bin, Riddle, Dawn M., Kwong, Linda K., Xu, Yan, Trojanowski, John Q., Lee, Virginia M.Y.
Published in Cell (03.07.2013)
Published in Cell (03.07.2013)
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Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
Volpicelli-Daley, Laura A., Luk, Kelvin C., Patel, Tapan P., Tanik, Selcuk A., Riddle, Dawn M., Stieber, Anna, Meaney, David F., Trojanowski, John Q., Lee, Virginia M.-Y.
Published in Neuron (Cambridge, Mass.) (06.10.2011)
Published in Neuron (Cambridge, Mass.) (06.10.2011)
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Human tau pathology transmits glial tau aggregates in the absence of neuronal tau
Narasimhan, Sneha, Changolkar, Lakshmi, Riddle, Dawn M, Kats, Alexandra, Stieber, Anna, Weitzman, Sarah A, Zhang, Bin, Li, Zhiyong, Roberson, Erik D, Trojanowski, John Q, Lee, Virginia M Y
Published in The Journal of experimental medicine (03.02.2020)
Published in The Journal of experimental medicine (03.02.2020)
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Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology
Bassil, Fares, Brown, Hannah J., Pattabhiraman, Shankar, Iwasyk, Joe E., Maghames, Chantal M., Meymand, Emily S., Cox, Timothy O., Riddle, Dawn M., Zhang, Bin, Trojanowski, John Q., Lee, Virginia M.-Y.
Published in Neuron (Cambridge, Mass.) (22.01.2020)
Published in Neuron (Cambridge, Mass.) (22.01.2020)
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α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons
Wu, Qihui, Takano, Hajime, Riddle, Dawn M, Trojanowski, John Q, Coulter, Douglas A, Lee, Virginia M-Y
Published in The Journal of neuroscience (26.06.2019)
Published in The Journal of neuroscience (26.06.2019)
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Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult
Henderson, Michael X., Sedor, Samantha, McGeary, Ian, Cornblath, Eli J., Peng, Chao, Riddle, Dawn M., Li, Howard L., Zhang, Bin, Brown, Hannah J., Olufemi, Modupe F., Bassett, Danielle S., Trojanowski, John Q., Lee, Virginia M.Y.
Published in Neuron (Cambridge, Mass.) (04.03.2020)
Published in Neuron (Cambridge, Mass.) (04.03.2020)
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Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes
Volpicelli-Daley, Laura A, Gamble, Karen L, Schultheiss, Christine E, Riddle, Dawn M, West, Andrew B, Lee, Virginia M-Y
Published in Molecular biology of the cell (15.12.2014)
Published in Molecular biology of the cell (15.12.2014)
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Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity
Luna, Esteban, Decker, Samantha C., Riddle, Dawn M., Caputo, Anna, Zhang, Bin, Cole, Tracy, Caswell, Carrie, Xie, Sharon X., Lee, Virginia M. Y., Luk, Kelvin C.
Published in Acta neuropathologica (01.06.2018)
Published in Acta neuropathologica (01.06.2018)
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Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies
Gibbons, Garrett S, Banks, Rachel A, Kim, Bumjin, Changolkar, Lakshmi, Riddle, Dawn M, Leight, Susan N, Irwin, David J, Trojanowski, John Q, Lee, Virginia M Y
Published in Journal of neuropathology and experimental neurology (01.03.2018)
Published in Journal of neuropathology and experimental neurology (01.03.2018)
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Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease
Henderson, Michael X., Covell, Dustin J., Chung, Charlotte Hiu-Yan, Pitkin, Rose M., Sandler, Raizel M., Decker, Samantha C., Riddle, Dawn M., Zhang, Bin, Gathagan, Ronald J., James, Michael J., Trojanowski, John Q., Brunden, Kurt R., Lee, Virginia M.Y., Luk, Kelvin C.
Published in Neurobiology of disease (01.03.2020)
Published in Neurobiology of disease (01.03.2020)
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Journal Article
Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology
Bassil, Fares, Brown, Hannah J, Pattabhiraman, Shankar, Iwasyk, Joe E, Maghames, Chantal M, Meymand, Emily S, Cox, Timothy O, Riddle, Dawn M, Zhang, Bin, Trojanowski, John Q, Lee, Virginia M-Y
Published in Neuron (Cambridge, Mass.) (15.11.2023)
Published in Neuron (Cambridge, Mass.) (15.11.2023)
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Journal Article
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics
Xu, Hong, O’Reilly, Mia, Gibbons, Garrett S., Changolkar, Lakshmi, McBride, Jennifer D., Riddle, Dawn M., Zhang, Bin, Stieber, Anna, Nirschl, Jeffrey, Kim, Soo-Jung, Hoxha, Kevt-her, Brunden, Kurt R., Schellenberg, Gerard D., Trojanowski, John Q., Lee, Virginia M.-Y.
Published in Acta neuropathologica (01.02.2021)
Published in Acta neuropathologica (01.02.2021)
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Journal Article
GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
Gibbons, Garrett S, Banks, Rachel A, Kim, Bumjin, Xu, Hong, Changolkar, Lakshmi, Leight, Susan N, Riddle, Dawn M, Li, Chi, Gathagan, Ronald J, Brown, Hannah J, Zhang, Bin, Trojanowski, John Q, Lee, Virginia M-Y
Published in The Journal of neuroscience (22.11.2017)
Published in The Journal of neuroscience (22.11.2017)
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Journal Article
Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies
Henderson, Michael X, Chung, Charlotte Hiu-Yan, Riddle, Dawn M, Zhang, Bin, Gathagan, Ronald J, Seeholzer, Steven H, Trojanowski, John Q, Lee, Virginia M Y
Published in The Journal of neuroscience (14.06.2017)
Published in The Journal of neuroscience (14.06.2017)
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Journal Article
Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer's disease
Gibbons, Garrett S, Kim, Soo-Jung, Wu, Qihui, Riddle, Dawn M, Leight, Susan N, Changolkar, Lakshmi, Xu, Hong, Meymand, Emily S, O'Reilly, Mia, Zhang, Bin, Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M Y
Published in Molecular neurodegeneration (04.11.2020)
Published in Molecular neurodegeneration (04.11.2020)
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Journal Article
Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization
Marshall, Courtney A, McBride, Jennifer D, Changolkar, Lakshmi, Riddle, Dawn M, Trojanowski, John Q, Lee, Virginia M-Y
Published in Acta neuropathologica communications (04.03.2022)
Published in Acta neuropathologica communications (04.03.2022)
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A Team Training Field Research Study: Extending a Theory of Team Development
Johnston, Joan H, Phillips, Henry L, Milham, Laura M, Riddle, Dawn L, Townsend, Lisa N, DeCostanza, Arwen H, Patton, Debra J, Cox, Katherine R, Fitzhugh, Sean M
Published in Frontiers in psychology (26.06.2019)
Published in Frontiers in psychology (26.06.2019)
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Journal Article
Exogenous [alpha]-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
Volpicelli-Daley, Laura A, Luk, Kelvin C, Patel, Tapan P, Tanik, Selcuk A, Riddle, Dawn M, Stieber, Anna, Meaney, David F, Trojanowski, John Q, Lee, Virginia M-Y
Published in Neuron (Cambridge, Mass.) (06.10.2011)
Published in Neuron (Cambridge, Mass.) (06.10.2011)
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