Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels
Riddell, David R, Zhou, Hua, Atchison, Kevin, Warwick, Helen K, Atkinson, Peter J, Jefferson, Julius, Xu, Lin, Aschmies, Suzan, Kirksey, Yolanda, Hu, Yun, Wagner, Erik, Parratt, Adrienne, Xu, Jane, Li, Zhuting, Zaleska, Margaret M, Jacobsen, J. Steve, Pangalos, Menelas N, Reinhart, Peter H
Published in The Journal of neuroscience (05.11.2008)
Published in The Journal of neuroscience (05.11.2008)
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Journal Article
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors
Zuhl, Andrea M, Nolan, Charles E, Brodney, Michael A, Niessen, Sherry, Atchison, Kevin, Houle, Christopher, Karanian, David A, Ambroise, Claude, Brulet, Jeffrey W, Beck, Elizabeth M, Doran, Shawn D, O'Neill, Brian T, Am Ende, Christopher W, Chang, Cheng, Geoghegan, Kieran F, West, Graham M, Judkins, Joshua C, Hou, Xinjun, Riddell, David R, Johnson, Douglas S
Published in Nature communications (11.10.2016)
Published in Nature communications (11.10.2016)
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Journal Article
Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor
Stepan, Antonia F, Subramanyam, Chakrapani, Efremov, Ivan V, Dutra, Jason K, O’Sullivan, Theresa J, DiRico, Kenneth J, McDonald, W. Scott, Won, Annie, Dorff, Peter H, Nolan, Charles E, Becker, Stacey L, Pustilnik, Leslie R, Riddell, David R, Kauffman, Gregory W, Kormos, Bethany L, Zhang, Liming, Lu, Yasong, Capetta, Steven H, Green, Michael E, Karki, Kapil, Sibley, Evelyn, Atchison, Kevin P, Hallgren, Andrew J, Oborski, Christine E, Robshaw, Ashley E, Sneed, Blossom, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Systemic immune‐checkpoint blockade with anti‐PD1 antibodies does not alter cerebral amyloid‐β burden in several amyloid transgenic mouse models
Latta‐Mahieu, Martine, Elmer, Bradford, Bretteville, Alexis, Wang, Yaming, Lopez‐Grancha, Mati, Goniot, Philippe, Moindrot, Nicolas, Ferrari, Paul, Blanc, Véronique, Schussler, Nathalie, Brault, Emmanuel, Roudières, Valérie, Blanchard, Véronique, Yang, Zhi‐Yong, Barneoud, Pascal, Bertrand, Philippe, Roucourt, Bart, Carmans, Sofie, Bottelbergs, Astrid, Mertens, Liesbeth, Wintmolders, Cindy, Larsen, Peter, Hersley, Caroline, McGathey, Tyler, Racke, Margaret M., Liu, Ling, Lu, Jirong, O'Neill, Michael J., Riddell, David R., Ebneth, Andreas, Nabel, Gary J., Pradier, Laurent
Published in Glia (01.03.2018)
Published in Glia (01.03.2018)
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Journal Article
Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies
Shineman, Diana W, Basi, Guriqbal S, Bizon, Jennifer L, Colton, Carol A, Greenberg, Barry D, Hollister, Beth A, Lincecum, John, Leblanc, Gabrielle G, Lee, Linda Bobbi H, Luo, Feng, Morgan, Dave, Morse, Iva, Refolo, Lorenzo M, Riddell, David R, Scearce-Levie, Kimberly, Sweeney, Patrick, Yrjänheikki, Juha, Fillit, Howard M
Published in Alzheimer's research & therapy (28.09.2011)
Published in Alzheimer's research & therapy (28.09.2011)
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Journal Article
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease
Martone, Robert L, Zhou, Hua, Atchison, Kevin, Comery, Thomas, Xu, Jane Z, Huang, Xinyi, Gong, Xioahai, Jin, Mei, Kreft, Anthony, Harrison, Boyd, Mayer, Scott C, Aschmies, Suzan, Gonzales, Cathleen, Zaleska, Margaret M, Riddell, David R, Wagner, Erik, Lu, Peimin, Sun, Shaiu-Ching, Sonnenberg-Reines, June, Oganesian, Aram, Adkins, Karissa, Leach, Michael W, Clarke, David W, Huryn, Donna, Abou-Gharbia, Magid, Magolda, Ronald, Bard, Jonathan, Frick, Glen, Raje, Sangeeta, Forlow, S Bradley, Balliet, Carrie, Burczynski, Michael E, Reinhart, Peter H, Wan, Hong I, Pangalos, Menelas N, Jacobsen, J Steven
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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Journal Article
Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design
Butler, Christopher R, Brodney, Michael A, Beck, Elizabeth M, Barreiro, Gabriela, Nolan, Charles E, Pan, Feng, Vajdos, Felix, Parris, Kevin, Varghese, Alison H, Helal, Christopher J, Lira, Ricardo, Doran, Shawn D, Riddell, David R, Buzon, Leanne M, Dutra, Jason K, Martinez-Alsina, Luis A, Ogilvie, Kevin, Murray, John C, Young, Joseph M, Atchison, Kevin, Robshaw, Ashley, Gonzales, Cathleen, Wang, Jinlong, Zhang, Yong, O’Neill, Brian T
Published in Journal of medicinal chemistry (26.03.2015)
Published in Journal of medicinal chemistry (26.03.2015)
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Journal Article
Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates
Berger, Zdenek, Perkins, Sarah, Ambroise, Claude, Oborski, Christine, Calabrese, Matthew, Noell, Stephen, Riddell, David, Hirst, Warren D
Published in PloS one (12.03.2015)
Published in PloS one (12.03.2015)
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Journal Article
Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade
Jacobsen, J. Steven, Comery, Thomas A, Martone, Robert L, Elokdah, Hassan, Crandall, David L, Oganesian, Aram, Aschmies, Suzan, Kirksey, Yolanda, Gonzales, Cathleen, Xu, Jane, Zhou, Hua, Atchison, Kevin, Wagner, Erik, Zaleska, Margaret M, Das, Indranil, Arias, Robert L, Bard, Jonathan, Riddell, David, Gardell, Stephen J, Abou-Gharbia, Magid, Robichaud, Albert, Magolda, Ronald, Vlasuk, George P, Bjornsson, Thorir, Reinhart, Peter H, Pangalos, Menelas N
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
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Journal Article
Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease
Mayer, Scott C, Kreft, Anthony F, Harrison, Boyd, Abou-Gharbia, Magid, Antane, Madelene, Aschmies, Suzan, Atchison, Kevin, Chlenov, Michael, Cole, Derek C, Comery, Thomas, Diamantidis, George, Ellingboe, John, Fan, Kristi, Galante, Rocco, Gonzales, Cathleen, Ho, Douglas M, Hoke, Molly E, Hu, Yun, Huryn, Donna, Jain, Uday, Jin, Mei, Kremer, Kenneth, Kubrak, Dennis, Lin, Melissa, Lu, Peimin, Magolda, Ron, Martone, Robert, Moore, William, Oganesian, Aram, Pangalos, Menelas N, Porte, Alex, Reinhart, Peter, Resnick, Lynn, Riddell, David R, Sonnenberg-Reines, June, Stock, Joseph R, Sun, Shaiu-Ching, Wagner, Erik, Wang, Ting, Woller, Kevin, Xu, Zheng, Zaleska, Margaret M, Zeldis, Joseph, Zhang, Minsheng, Zhou, Hua, Jacobsen, J. Steven
Published in Journal of medicinal chemistry (11.12.2008)
Published in Journal of medicinal chemistry (11.12.2008)
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Journal Article
The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
Riddell, David R., Zhou, Hua, Comery, Thomas A., Kouranova, Evguenia, Lo, C. Frederick, Warwick, Helen K., Ring, Robert H., Kirksey, Yolanda, Aschmies, Suzan, Xu, Jane, Kubek, Katie, Hirst, Warren D., Gonzales, Catherine, Chen, Yi, Murphy, Erin, Leonard, Sarah, Vasylyev, Dmytro, Oganesian, Aram, Martone, Robert L., Pangalos, Menelas N., Reinhart, Peter H., Jacobsen, J. Steve
Published in Molecular and cellular neuroscience (01.04.2007)
Published in Molecular and cellular neuroscience (01.04.2007)
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Journal Article
Characterization of the Ectodomain Shedding of the β-Site Amyloid Precursor Protein-cleaving Enzyme 1 (BACE1)
Hussain, Ishrut, Hawkins, Julie, Shikotra, Aarti, Riddell, David R., Faller, Andrew, Dingwall, Colin
Published in The Journal of biological chemistry (19.09.2003)
Published in The Journal of biological chemistry (19.09.2003)
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Journal Article
BACE-1 inhibitors Part 1: Identification of novel hydroxy ethylamines (HEAs)
Clarke, Brian, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Faller, Andrew, Hawkins, Julie, Hussain, Ishrut, MacPherson, David, Maile, Graham, Matico, Rosalie, Milner, Peter, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Riddell, David, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Stanway, Steven, Stemp, Geoffrey, Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Ward, John, Wayne, Gareth
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Journal Article
Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons
Vinson, Mary, Rausch, Oliver, Maycox, Peter R, Prinjha, Rab K, Chapman, Debra, Morrow, Rachel, Harper, Alex J, Dingwall, Colin, Walsh, Frank S, Burbidge, Stephen A, Riddell, David R
Published in Molecular and cellular neuroscience (01.03.2003)
Published in Molecular and cellular neuroscience (01.03.2003)
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Journal Article
Behavioral responses to sublethal cadmium exposure within an experimental aquatic food web
Riddell, David J., Culp, Joseph M., Baird, Donald J.
Published in Environmental toxicology and chemistry (01.02.2005)
Published in Environmental toxicology and chemistry (01.02.2005)
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Journal Article
Identification and characterization of LRP8 (apoER2) in human blood platelets
Riddell, D R, Vinogradov, D V, Stannard, A K, Chadwick, N, Owen, J S
Published in Journal of lipid research (01.10.1999)
Published in Journal of lipid research (01.10.1999)
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Journal Article
( S) -N-(5-Chlorothiophene-2-sulfonyl)-β,β-diethylalaninol a Notch-1-sparing γ-secretase inhibitor
Cole, Derek C., Stock, Joseph R., Kreft, Anthony F., Antane, Madelene, Aschmies, Suzan H., Atchison, Kevin P., Casebier, David S., Comery, Thomas A., Diamantidis, George, Ellingboe, John W., Harrison, Boyd L., Hu, Yun, Jin, Mei, Kubrak, Dennis M., Lu, Peimin, Mann, Charles W., Martone, Robert L., Moore, William J., Oganesian, Aram, Riddell, David R., Sonnenberg-Reines, June, Sun, Shaiu-Ching, Wagner, Erik, Wang, Zheng, Woller, Kevin R., Xu, Zheng, Zhou, Hua, Jacobsen, J. Steven
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Journal Article
The Power of Seeing: Experiences using video as a deep-sea engagement and education tool
Hoeberechts, Maia, Owens, Dwight, Riddell, David J., Robertson, Andrew D.
Published in OCEANS 2015 - MTS/IEEE Washington (01.10.2015)
Published in OCEANS 2015 - MTS/IEEE Washington (01.10.2015)
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Conference Proceeding
Soluble Aβ from PSAPP mice is different to that extracted from Alzheimer patients
Hirst, Warren D, Needle, Elie, Staal, Roland G.W, Crozier, Robert, Breysse, Nathalie, Nagy, Reka, Sung, Amy, Monaghan, Michael, Riddell, David R, Chin, Jeannie, Walsh, Dominic M, Pangalos, Menelas N, Reinhart, Peter H, Jacobsen, J.S
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane
Riddell, D R, Sun, X M, Stannard, A K, Soutar, A K, Owen, J S
Published in Journal of lipid research (01.06.2001)
Published in Journal of lipid research (01.06.2001)
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Journal Article