Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
Knutson, Sarah K., Warholic, Natalie M., Wigle, Tim J., Klaus, Christine R., Allain, Christina J., Raimondi, Alejandra, Scott, Margaret Porter, Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M., Kuntz, Kevin W., Keilhack, Heike
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2013)
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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
Sneeringer, Christopher J., Scott, Margaret Porter, Kuntz, Kevin W., Knutson, Sarah K., Pollock, Roy M., Richon, Victoria M., Copeland, Robert A., Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (07.12.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (07.12.2010)
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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
Knutson, Sarah K, Wigle, Tim J, Warholic, Natalie M, Sneeringer, Christopher J, Allain, Christina J, Klaus, Christine R, Sacks, Joelle D, Raimondi, Alejandra, Majer, Christina R, Song, Jeffrey, Scott, Margaret Porter, Jin, Lei, Smith, Jesse J, Olhava, Edward J, Chesworth, Richard, Moyer, Mikel P, Richon, Victoria M, Copeland, Robert A, Keilhack, Heike, Pollock, Roy M, Kuntz, Kevin W
Published in Nature chemical biology (01.11.2012)
Published in Nature chemical biology (01.11.2012)
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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
Daigle, Scott R., Olhava, Edward J., Therkelsen, Carly A., Basavapathruni, Aravind, Jin, Lei, Boriack-Sjodin, P. Ann, Allain, Christina J., Klaus, Christine R., Raimondi, Alejandra, Scott, Margaret Porter, Waters, Nigel J., Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M.
Published in Blood (08.08.2013)
Published in Blood (08.08.2013)
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The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat
Kuntz, Kevin W, Campbell, John E, Keilhack, Heike, Pollock, Roy M, Knutson, Sarah K, Porter-Scott, Margaret, Richon, Victoria M, Sneeringer, Chris J, Wigle, Tim J, Allain, Christina J, Majer, Christina R, Moyer, Mikel P, Copeland, Robert A, Chesworth, Richard
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
Daigle, Scott R., Olhava, Edward J., Therkelsen, Carly A., Majer, Christina R., Sneeringer, Christopher J., Song, Jeffrey, Johnston, L. Danielle, Scott, Margaret Porter, Smith, Jesse J., Xiao, Yonghong, Jin, Lei, Kuntz, Kevin W., Chesworth, Richard, Moyer, Mikel P., Bernt, Kathrin M., Tseng, Jen-Chieh, Kung, Andrew L., Armstrong, Scott A., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M.
Published in Cancer cell (12.07.2011)
Published in Cancer cell (12.07.2011)
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Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l
Deshpande, Aniruddha J., Chen, Liying, Fazio, Maurizio, Sinha, Amit U., Bernt, Kathrin M., Banka, Deepti, Dias, Stuart, Chang, Jenny, Olhava, Edward J., Daigle, Scott R., Richon, Victoria M., Pollock, Roy M., Armstrong, Scott A.
Published in Blood (28.03.2013)
Published in Blood (28.03.2013)
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A687V EZH2 is a gain-of-function mutation found in lymphoma patients
Majer, Christina R., Jin, Lei, Scott, Margaret Porter, Knutson, Sarah K., Kuntz, Kevin W., Keilhack, Heike, Smith, Jesse J., Moyer, Mikel P., Richon, Victoria M., Copeland, Robert A., Wigle, Tim J.
Published in FEBS letters (21.09.2012)
Published in FEBS letters (21.09.2012)
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Chemogenetic Analysis of Human Protein Methyltransferases
Richon, Victoria M., Johnston, Danielle, Sneeringer, Christopher J., Jin, Lei, Majer, Christina R., Elliston, Keith, Jerva, L. Fred, Scott, Margaret Porter, Copeland, Robert A.
Published in Chemical biology & drug design (01.08.2011)
Published in Chemical biology & drug design (01.08.2011)
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Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid, in Patients With Advanced Cancer
KELLY, William Kevin, O'CONNOR, Owen A, RICHARDSON, Stacy, CHU, Elaina, OLGAC, Semra, MARKS, Paul A, SCHER, Howard, RICHON, Victoria M, KRUG, Lee M, CHIAO, Judy H, HEANEY, Mark, CURLEY, Tracy, MACGREGORE-CORTELLI, Barbara, TONG, William, SECRIST, J. Paul, SCHWARTZ, Lawrence
Published in Journal of clinical oncology (10.06.2005)
Published in Journal of clinical oncology (10.06.2005)
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Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study
GALANIS, Evanthia, JAECKLE, Kurt A, RICHON, Victoria M, SCHEITHAUER, Bernd, GIANNINI, Caterina, FLYNN, Patrick J, MOORE, Dennis F, ZWIEBEL, James, BUCKNER, Jan C, MAURER, Matthew J, REID, Joel M, AMES, Matthew M, HARDWICK, James S, REILLY, John F, LOBODA, Andrey, NEBOZHYN, Michael, FANTIN, Valeria R
Published in Journal of clinical oncology (20.04.2009)
Published in Journal of clinical oncology (20.04.2009)
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The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
Wigle, Tim J., Knutson, Sarah K., Jin, Lei, Kuntz, Kevin W., Pollock, Roy M., Richon, Victoria M., Copeland, Robert A., Scott, Margaret Porter
Published in FEBS letters (03.10.2011)
Published in FEBS letters (03.10.2011)
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Identification and Functional Significance of Genes Regulated by Structurally Different Histone Deacetylase Inhibitors
Peart, Melissa J., Smyth, Gordon K., van Laar, Ryan K., Bowtell, David D., Richon, Victoria M., Marks, Paul A., Holloway, Andrew J., Johnstone, Ricky W.
Published in Proceedings of the National Academy of Sciences - PNAS (08.03.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (08.03.2005)
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Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of γ-H2AX foci
Munshi, Anupama, Tanaka, Toshimitsu, Hobbs, Marvette L, Tucker, Susan L, Richon, Victoria M, Meyn, Raymond E
Published in Molecular cancer therapeutics (01.08.2006)
Published in Molecular cancer therapeutics (01.08.2006)
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MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
Bernt, Kathrin M., Zhu, Nan, Sinha, Amit U., Vempati, Sridhar, Faber, Joerg, Krivtsov, Andrei V., Feng, Zhaohui, Punt, Natalie, Daigle, Amanda, Bullinger, Lars, Pollock, Roy M., Richon, Victoria M., Kung, Andrew L., Armstrong, Scott A.
Published in Cancer cell (12.07.2011)
Published in Cancer cell (12.07.2011)
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Vorinostat in solid and hematologic malignancies
Siegel, David, Hussein, Mohamad, Belani, Chandra, Robert, Francisco, Galanis, Evanthia, Richon, Victoria M, Garcia-Vargas, José, Sanz-Rodriguez, Cesar, Rizvi, Syed
Published in Journal of hematology and oncology (27.07.2009)
Published in Journal of hematology and oncology (27.07.2009)
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Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks
PALMIERI, Diane, LOCKMAN, Paul R, TASKAR, Kunal S, RUDRARAJU, Vinay, MITTAPALLI, Rajendar K, GAASCH, Julie A, BOHN, Kaci A, THORSHEIM, Helen R, LIEWEHR, David J, DAVIS, Sean, REILLY, John F, WALKER, Robert, THOMAS, Fancy C, BRONDER, Julie L, FEIGENBAUM, Lionel, STEINBERG, Seth M, CAMPHAUSEN, Kevin, MELTZER, Paul S, RICHON, Victoria M, SMITH, Quentin R, STEEG, Patricia S, HUA, Emily, HERRING, Jeanne, HARGRAVE, Elizabeth, JOHNSON, Matthew, FLORES, Natasha, YONGZHEN QIAN, VEGA-VALLE, Eleazar
Published in Clinical cancer research (01.10.2009)
Published in Clinical cancer research (01.10.2009)
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Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Ameliorates Motor Deficits in a Mouse Model of Huntington's Disease
Hockly, Emma, Richon, Victoria M., Woodman, Benjamin, Smith, Donna L., Zhou, Xianbo, Rosa, Eddie, Sathasivam, Kirupa, Ghazi-Noori, Shabnam, Mahal, Amarbirpal, Philip A. S. Lowden, Steffan, Joan S., Marsh, J. Lawrence, Thompson, Leslie M., Lewis, Cathryn M., Marks, Paul A., Bates, Gillian P.
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2003)
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The Histone Deacetylase Inhibitor SAHA Arrests Cancer Cell Growth, Up-Regulates Thioredoxin-Binding Protein-2, and Down-Regulates Thioredoxin
Butler, Lisa M., Zhou, Xianbo, Xu, Wei-Sheng, Scher, Howard I., Rifkind, Richard A., Marks, Paul A., Richon, Victoria M.
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2002)
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