Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning
Echle, Amelie, Grabsch, Heike Irmgard, Quirke, Philip, van den Brandt, Piet A., West, Nicholas P., Hutchins, Gordon G.A., Heij, Lara R., Tan, Xiuxiang, Richman, Susan D., Krause, Jeremias, Alwers, Elizabeth, Jenniskens, Josien, Offermans, Kelly, Gray, Richard, Brenner, Hermann, Chang-Claude, Jenny, Trautwein, Christian, Pearson, Alexander T., Boor, Peter, Luedde, Tom, Gaisa, Nadine Therese, Hoffmeister, Michael, Kather, Jakob Nikolas
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2020)
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2020)
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Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies
Venderbosch, Sabine, Nagtegaal, Iris D, Maughan, Tim S, Smith, Christopher G, Cheadle, Jeremy P, Fisher, David, Kaplan, Richard, Quirke, Philip, Seymour, Matthew T, Richman, Susan D, Meijer, Gerrit A, Ylstra, Bauke, Heideman, Danielle A M, de Haan, Anton F J, Punt, Cornelis J A, Koopman, Miriam
Published in Clinical cancer research (15.10.2014)
Published in Clinical cancer research (15.10.2014)
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Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning
Sirinukunwattana, Korsuk, Domingo, Enric, Richman, Susan D, Redmond, Keara L, Blake, Andrew, Verrill, Clare, Leedham, Simon J, Chatzipli, Aikaterini, Hardy, Claire, Whalley, Celina M, Wu, Chieh-hsi, Beggs, Andrew D, McDermott, Ultan, Dunne, Philip D, Meade, Angela, Walker, Steven M, Murray, Graeme I, Samuel, Leslie, Seymour, Matthew, Tomlinson, Ian, Quirke, Phil, Maughan, Timothy, Rittscher, Jens, Koelzer, Viktor H
Published in Gut (01.03.2021)
Published in Gut (01.03.2021)
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KRAS and BRAF Mutations in Advanced Colorectal Cancer Are Associated With Poor Prognosis but Do Not Preclude Benefit From Oxaliplatin or Irinotecan: Results From the MRC FOCUS Trial
Richman, Susan D, Seymour, Matthew T, Chambers, Philip, Elliott, Faye, Daly, Catherine L, Meade, Angela M, Taylor, Graham, Barrett, Jennifer H, Quirke, Philip
Published in Journal of clinical oncology (10.12.2009)
Published in Journal of clinical oncology (10.12.2009)
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HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials
Richman, Susan D, Southward, Katie, Chambers, Philip, Cross, Debra, Barrett, Jennifer, Hemmings, Gemma, Taylor, Morag, Wood, Henry, Hutchins, Gordon, Foster, Joseph M, Oumie, Assa, Spink, Karen G, Brown, Sarah R, Jones, Marc, Kerr, David, Handley, Kelly, Gray, Richard, Seymour, Matthew, Quirke, Philip
Published in The Journal of pathology (01.03.2016)
Published in The Journal of pathology (01.03.2016)
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Value of Mismatch Repair, KRAS, and BRAF Mutations in Predicting Recurrence and Benefits From Chemotherapy in Colorectal Cancer
HUTCHINS, Gordon, SOUTHWARD, Katie, GRAY, Richard, QUIRKE, Philip, HANDLEY, Kelly, MAGILL, Laura, BEAUMONT, Claire, STAHLSCHMIDT, Jens, RICHMAN, Susan, CHAMBERS, Philip, SEYMOUR, Matthew, KERR, David
Published in Journal of clinical oncology (01.04.2011)
Published in Journal of clinical oncology (01.04.2011)
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A robust multiplex immunofluorescence and digital pathology workflow for the characterisation of the tumour immune microenvironment
Viratham Pulsawatdi, Amélie, Craig, Stephanie G., Bingham, Victoria, McCombe, Kris, Humphries, Matthew P., Senevirathne, Seedevi, Richman, Susan D., Quirke, Phil, Campo, Leticia, Domingo, Enric, Maughan, Timothy S., James, Jacqueline A., Salto‐Tellez, Manuel
Published in Molecular oncology (01.10.2020)
Published in Molecular oncology (01.10.2020)
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Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia
Craig, Stephanie G, Humphries, Matthew P, Alderdice, Matthew, Bingham, Victoria, Richman, Susan D, Loughrey, Maurice B, Coleman, Helen G, Viratham-Pulsawatdi, Amelie, McCombe, Kris, Murray, Graeme I, Blake, Andrew, Domingo, Enric, Robineau, James, Brown, Louise, Fisher, David, Seymour, Matthew T, Quirke, Phil, Bankhead, Peter, McQuaid, Stephen, Lawler, Mark, McArt, Darragh G, Maughan, Tim S, James, Jacqueline A, Salto-Tellez, Manuel
Published in British journal of cancer (13.10.2020)
Published in British journal of cancer (13.10.2020)
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Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial
Seymour, Matthew T, Prof, Brown, Sarah R, PhD, Middleton, Gary, Prof, Maughan, Timothy, Prof, Richman, Susan, PhD, Gwyther, Stephen, FRCR, Lowe, Catherine, MA, Seligmann, Jennifer F, MBChB, Wadsley, Jonathan, MBBChir, Maisey, Nick, MD, Chau, Ian, MD, Hill, Mark, MD, Dawson, Lesley, MBChB, Falk, Stephen, MD, O'Callaghan, Ann, MBB Ch BAO, Benstead, Kim, MD, Chambers, Philip, PhD, Oliver, Alfred, LLB, Marshall, Helen, MSc, Napp, Vicky, BSc, Quirke, Phil, Prof
Published in The lancet oncology (01.07.2013)
Published in The lancet oncology (01.07.2013)
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Prospective patient stratification into robust cancer‐cell intrinsic subtypes from colorectal cancer biopsies
Alderdice, Matthew, Richman, Susan D, Gollins, Simon, Stewart, James P, Hurt, Chris, Adams, Richard, McCorry, Amy MB, Roddy, Aideen C, Vimalachandran, Dale, Isella, Claudio, Medico, Enzo, Maughan, Tim, McArt, Darragh G, Lawler, Mark, Dunne, Philip D
Published in The Journal of pathology (01.05.2018)
Published in The Journal of pathology (01.05.2018)
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Inhibition of WEE1 Is Effective in TP53 - and RAS -Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring
Seligmann, Jenny F, Fisher, David J, Brown, Louise C, Adams, Richard A, Graham, Janet, Quirke, Philip, Richman, Susan D, Butler, Rachel, Domingo, Enric, Blake, Andrew, Yates, Emma, Braun, Michael, Collinson, Fiona, Jones, Rob, Brown, Ewan, de Winton, Emma, Humphrey, Timothy C, Parmar, Mahesh, Kaplan, Richard, Wilson, Richard H, Seymour, Matthew, Maughan, Timothy S
Published in Journal of clinical oncology (20.11.2021)
Published in Journal of clinical oncology (20.11.2021)
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FOCUS4 biomarker laboratories: from the benefits to the practical and logistical issues faced during 6 years of centralised testing
Richman, Susan D, Hemmings, Gemma, Roberts, Helen, Gallop, Niall, Dodds, Rachel, Wilkinson, Lyndsay, Davis, Jonathan, White, Rhian, Yates, Emma, Jasani, Bharat, Brown, Louise, Maughan, Tim S, Butler, Rachel, Quirke, Philip, Adams, Richard
Published in Journal of clinical pathology (01.08.2023)
Published in Journal of clinical pathology (01.08.2023)
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RAS screening in colorectal cancer: a comprehensive analysis of the results from the UK NEQAS colorectal cancer external quality assurance schemes (2009–2016)
Richman, Susan D., Fairley, Jennifer, Butler, Rachel, Deans, Zandra C.
Published in Virchows Archiv : an international journal of pathology (01.12.2017)
Published in Virchows Archiv : an international journal of pathology (01.12.2017)
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Predictive Biomarkers of Chemotherapy Efficacy in Colorectal Cancer: Results From the UK MRC FOCUS Trial
Braun, Michael S, Richman, Susan D, Quirke, Philip, Daly, Catherine, Adlard, Julian W, Elliott, Faye, Barrett, Jennifer H, Selby, Peter, Meade, Angela M, Stephens, Richard J, Parmar, Mahesh K B, Seymour, Matthew T
Published in Journal of clinical oncology (01.06.2008)
Published in Journal of clinical oncology (01.06.2008)
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Evaluation of CD3 and CD8 T-Cell Immunohistochemistry for Prognostication and Prediction of Benefit From Adjuvant Chemotherapy in Early-Stage Colorectal Cancer Within the QUASAR Trial
Williams, Christopher J.M., Gray, Richard, Hills, Robert K., Shires, Michael, Zhang, Liping, Zhao, Zuo, Gardner, Tracie, Sapanara, Nancy, Xu, Xiao-Meng, Bai, Isaac, Yan, Dongyao, Muranyi, Andrea, Dance, Sarah, Aghaei, Faranak, Hemmings, Gemma, Hale, Michael, Kurkure, Uday, Guetter, Christoph, Richman, Susan D., Hutchins, Gordon, Seligmann, Jenny F., West, Nicholas P., Singh, Shalini, Shanmugam, Kandavel, Quirke, Philip
Published in Journal of clinical oncology (31.07.2024)
Published in Journal of clinical oncology (31.07.2024)
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Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification
Dunne, Philip D, Alderdice, Matthew, O'Reilly, Paul G, Roddy, Aideen C, McCorry, Amy M B, Richman, Susan, Maughan, Tim, McDade, Simon S, Johnston, Patrick G, Longley, Daniel B, Kay, Elaine, McArt, Darragh G, Lawler, Mark
Published in Nature communications (31.05.2017)
Published in Nature communications (31.05.2017)
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EGFR Amplification in Metastatic Colorectal Cancer
Randon, Giovanni, Yaeger, Rona, Hechtman, Jaclyn F, Manca, Paolo, Fucà, Giovanni, Walch, Henry, Lee, Jeeyun, Élez, Elena, Seligmann, Jenny, Mussolin, Benedetta, Pagani, Filippo, Germani, Marco Maria, Ambrosini, Margherita, Rossini, Daniele, Ratti, Margherita, Salvà, Francesc, Richman, Susan D, Wood, Henry, Nanjangud, Gouri, Gloghini, Annunziata, Milione, Massimo, Bardelli, Alberto, de Braud, Filippo, Morano, Federica, Cremolini, Chiara, Pietrantonio, Filippo
Published in JNCI : Journal of the National Cancer Institute (02.11.2021)
Published in JNCI : Journal of the National Cancer Institute (02.11.2021)
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Molecular subtype-specific efficacy of anti-EGFR therapy in colorectal cancer is dependent on the chemotherapy backbone
Ten Hoorn, Sanne, Sommeijer, Dirkje W, Elliott, Faye, Fisher, David, de Back, Tim R, Trinh, Anne, Koens, Lianne, Maughan, Tim, Seligmann, Jenny, Seymour, Matthew T, Quirke, Phil, Adams, Richard, Richman, Susan D, Punt, Cornelis J A, Vermeulen, Louis
Published in British journal of cancer (12.10.2021)
Published in British journal of cancer (12.10.2021)
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How close are we to standardised extended RAS gene mutation testing? The UK NEQAS evaluation
Richman, Susan D, Fairley, Jennifer, Butler, Rachel, Deans, Zandra C
Published in Journal of clinical pathology (01.01.2017)
Published in Journal of clinical pathology (01.01.2017)
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Capecitabine Versus Active Monitoring in Stable or Responding Metastatic Colorectal Cancer After 16 Weeks of First-Line Therapy: Results of the Randomized FOCUS4-N Trial
Adams, Richard A, Fisher, David J, Graham, Janet, Seligmann, Jenny F, Seymour, Matthew, Kaplan, Richard, Yates, Emma, Parmar, Mahesh, Richman, Susan D, Quirke, Philip, Butler, Rachel, Brown, Ewan, Collinson, Fiona, Falk, Stephen, Wasan, Harpreet, Shiu, Kai-Keen, Middleton, Gary, Samuel, Leslie, Wilson, Richard H, Brown, Louise C, Maughan, Timothy S
Published in Journal of clinical oncology (20.11.2021)
Published in Journal of clinical oncology (20.11.2021)
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