Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
HICKSON, Ian, YAN ZHAO, RICHARDSON, Caroline J, GREEN, Sharon J, MARTIN, Niall M. B, ORR, Alisdair I, REAPER, Philip M, JACKSON, Stephen P, CURTIN, Nicola J, SMITH, Graeme C. M
Published in Cancer research (Chicago, Ill.) (15.12.2004)
Published in Cancer research (Chicago, Ill.) (15.12.2004)
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Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
Saalau-Bethell, Susanne M, Woodhead, Andrew J, Chessari, Gianni, Carr, Maria G, Coyle, Joseph, Graham, Brent, Hiscock, Steven D, Murray, Christopher W, Pathuri, Puja, Rich, Sharna J, Richardson, Caroline J, Williams, Pamela A, Jhoti, Harren
Published in Nature chemical biology (01.11.2012)
Published in Nature chemical biology (01.11.2012)
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Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K
Munck, Joanne M, Batey, Michael A, Zhao, Yan, Jenkins, Helen, Richardson, Caroline J, Cano, Celine, Tavecchio, Michele, Barbeau, Jody, Bardos, Julia, Cornell, Liam, Griffin, Roger J, Menear, Keith, Slade, Andrew, Thommes, Pia, Martin, Niall M B, Newell, David R, Smith, Graeme C M, Curtin, Nicola J
Published in Molecular cancer therapeutics (01.08.2012)
Published in Molecular cancer therapeutics (01.08.2012)
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ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK
Munck, Joanne M, Berdini, Valerio, Bevan, Luke, Brothwood, Jessica L, Castro, Juan, Courtin, Aurélie, East, Charlotte, Ferraldeschi, Roberta, Heightman, Tom D, Hindley, Christopher J, Kucia-Tran, Justyna, Lyons, John F, Martins, Vanessa, Muench, Sandra, Murray, Christopher W, Norton, David, O'Reilly, Marc, Reader, Michael, Rees, David C, Rich, Sharna J, Richardson, Caroline J, Shah, Alpesh D, Stanczuk, Lukas, Thompson, Neil T, Wilsher, Nicola E, Woolford, Alison J-A, Wallis, Nicola G
Published in Molecular cancer therapeutics (01.10.2021)
Published in Molecular cancer therapeutics (01.10.2021)
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Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1
VEUGER, Stephany J, CURTIN, Nicola J, RICHARDSON, Caroline J, SMITH, Graeme C. M, DURKACZ, Barbara W
Published in Cancer research (Chicago, Ill.) (15.09.2003)
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Published in Cancer research (Chicago, Ill.) (15.09.2003)
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1‑Substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino‑4H‑chromen-4-ones Endowed with Dual DNA-PK/PI3‑K Inhibitory Activity
Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J, Frigerio, Mark, Golding, Bernard T, Hardcastle, Ian R, Hummersone, Marc G, Menear, Keith A, Newell, David R, Richardson, Caroline J, Shea, K, Smith, Graeme C. M, Thommes, Pia, Ting, Attilla, Griffin, Roger J
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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Contribution of dietary protein to sulfide production in the large intestine : an in vitro and a controlled feeding study in humans
MAGEE, Elizabeth A, RICHARDSON, Caroline J, HUGHES, Roisin, CUMMINGS, John H
Published in The American journal of clinical nutrition (01.12.2000)
Published in The American journal of clinical nutrition (01.12.2000)
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AT9283, a potent inhibitor of the Aurora kinases and Jak2, has therapeutic potential in myeloproliferative disorders
Dawson, Mark A., Curry, Jayne E., Barber, Kelly, Beer, Philip A., Graham, Brent, Lyons, John F., Richardson, Caroline J., Scott, Mike A., Smyth, Tomoko, Squires, Matthew S., Thompson, Neil T., Green, Anthony R., Wallis, Nicola G.
Published in British journal of haematology (01.07.2010)
Published in British journal of haematology (01.07.2010)
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DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype
Cano, Céline, Barbeau, Olivier R, Bailey, Christine, Cockcroft, Xiao-Ling, Curtin, Nicola J, Duggan, Heather, Frigerio, Mark, Golding, Bernard T, Hardcastle, Ian R, Hummersone, Marc G, Knights, Charlotte, Menear, Keith A, Newell, David R, Richardson, Caroline J, Smith, Graeme C. M, Spittle, Ben, Griffin, Roger J
Published in Journal of medicinal chemistry (23.12.2010)
Published in Journal of medicinal chemistry (23.12.2010)
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Pyranone, Thiopyranone, and Pyridone Inhibitors of Phosphatidylinositol 3-Kinase Related Kinases. Structure−Activity Relationships for DNA-Dependent Protein Kinase Inhibition, and Identification of the First Potent and Selective Inhibitor of the Ataxia Telangiectasia Mutated Kinase
Hollick, Jonathan J, Rigoreau, Laurent J. M, Cano-Soumillac, Celine, Cockcroft, Xiaoling, Curtin, Nicola J, Frigerio, Mark, Golding, Bernard T, Guiard, Sophie, Hardcastle, Ian R, Hickson, Ian, Hummersone, Marc G, Menear, Keith A, Martin, Niall M. B, Matthews, Ian, Newell, David R, Ord, Rachel, Richardson, Caroline J, Smith, Graeme C. M, Griffin, Roger J
Published in Journal of medicinal chemistry (19.04.2007)
Published in Journal of medicinal chemistry (19.04.2007)
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1-Substituted (Dibenzo[ b,d ]thiophen-4-yl)-2-morpholino-4 H -chromen-4-ones Endowed with Dual DNA-PK/PI3-K Inhibitory Activity
Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J., Frigerio, Mark, Golding, Bernard T., Hardcastle, Ian R., Hummersone, Marc G., Menear, Keith A., Newell, David R., Richardson, Caroline J., Shea, K., Smith, Graeme C. M., Thommes, Pia, Ting, Attilla, Griffin, Roger J.
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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Abstract B154: Characterization of a novel ERK1/2 inhibitor, which modulates the phosphorylation and catalytic activity of ERK1/2
Munck, Joanne M., Berdini, Valerio, Bevan, Luke D., Braithwaite, Hannah, Buck, Ildiko M., Cassidy, Megan, Castro, Juan, Courtin, Aurelie, Day, James E., East, Charlotte, Fazal, Lynsey, Graham, Brent, Griffiths-Jones, Charlotte M., Heightman, Tom D., Hindley, Chris J., Kidane, Birikiti, Kucia-Tran, Justyna, Lyons, John F., Martins, Vanessa, Muench, Sandra, Murray, Chris W., Norton, David, O'Reilly, Marc, Palmer, Nick, Pathuri, Puja, Reader, Mike, Rees, David C., Rich, Sharna J., Richardson, Caroline J., Saini, Harpreet K., Shah, Alpesh, Stanczuk, Lukas, Thompson, Neil T., Walton, Hugh, Wilsher, Nicola E., Woolford, Alison J., Wallis, Nicola G.
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Identification of novel allosteric inhibitors through fragment-based drug discovery and X-ray crystallography
Pathuri, Puja, Saalau-Bethell, Susanne M., Woodhead, Andrew J., Berdini, Valerio, Carr, Maria G., Chessari, Gianni, Cleasby, Anne, Congreve, Miles, Coyle, Joseph E., Graham, Brent, Hiscock, Steven D., Lock, Victoria, Murray, Christopher W., O'Brien, M. Alistair, Rich, Sharna J., Richardson, Caroline J., Sambrook, Tracey, Vinkovic, Mladen, Williams, Pamela A., Yon, Jeff R., Jhoti, Harren
Published in Acta crystallographica. Section A, Foundations and advances (23.08.2015)
Published in Acta crystallographica. Section A, Foundations and advances (23.08.2015)
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Chemosensitisation of cancer cells by KU-0060648; a dual inhibitor of DNA-PK and PI-3K
Munck, Joanne M., Batey, Michael A., Zhao, Yan, Jenkins, Helen, Richardson, Caroline J., Cano, Celine, Tavecchio, Michele, Barbeau, Jody, Bardos, Julia, Cornell, Liam, Griffin, Roger J., Menear, Keith, Slade, Andrew, Thommes, Pia, Martin, Niall MB, Newell, David R, Smith, Graeme CM, Curtin, Nicola J
Published in Molecular cancer therapeutics (10.05.2012)
Published in Molecular cancer therapeutics (10.05.2012)
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Abstract A1: The physiological form of MetAP2 can be inhibited through binding to either of the two active-site metals
Wallis, Nicola G., Berdini, Valerio, Besong, Gilbert, Chessari, Gianni, Coyle, Joe, Graham, Brent, Madin, Andrew, O'Brien, Alistair, Richardson, Caroline J., Smith, Kirsten, Thompson, Neil T., Vinkovic, Mladen, Williams, Pamela A.
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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Contribution of dietary protein to sulfide production in the large intestine: an in vitro and a controlled feeding study in humans123
Magee, Elizabeth A, Richardson, Caroline J, Hughes, Róisín, Cummings, John H
Published in The American journal of clinical nutrition (01.12.2000)
Published in The American journal of clinical nutrition (01.12.2000)
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