Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody
Geiger, Martina, Stubenrauch, Kay-Gunnar, Sam, Johannes, Richter, Wolfgang F, Jordan, Gregor, Eckmann, Jan, Hage, Carina, Nicolini, Valeria, Freimoser-Grundschober, Anne, Ritter, Mirko, Lauer, Matthias E, Stahlberg, Henning, Ringler, Philippe, Patel, Jigar, Sullivan, Eric, Grau-Richards, Sandra, Endres, Stefan, Kobold, Sebastian, Umaña, Pablo, Brünker, Peter, Klein, Christian
Published in Nature communications (24.06.2020)
Published in Nature communications (24.06.2020)
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RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis
Brünker, Peter, Wartha, Katharina, Friess, Thomas, Grau-Richards, Sandra, Waldhauer, Inja, Koller, Claudia Ferrara, Weiser, Barbara, Majety, Meher, Runza, Valeria, Niu, Huifeng, Packman, Kathryn, Feng, Ningping, Daouti, Sherif, Hosse, Ralf J, Mössner, Ekkehard, Weber, Thomas G, Herting, Frank, Scheuer, Werner, Sade, Hadassah, Shao, Cuiying, Liu, Bin, Wang, Peng, Xu, Gary, Vega-Harring, Suzana, Klein, Christian, Bosslet, Klaus, Umaña, Pablo
Published in Molecular cancer therapeutics (01.05.2016)
Published in Molecular cancer therapeutics (01.05.2016)
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Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions
Schlothauer, Tilman, Herter, Sylvia, Koller, Claudia Ferrara, Grau-Richards, Sandra, Steinhart, Virginie, Spick, Christian, Kubbies, Manfred, Klein, Christian, Umaña, Pablo, Mössner, Ekkehard
Published in Protein engineering, design and selection (01.10.2016)
Published in Protein engineering, design and selection (01.10.2016)
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A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
Bacac, Marina, Fauti, Tanja, Sam, Johannes, Colombetti, Sara, Weinzierl, Tina, Ouaret, Djamila, Bodmer, Walter, Lehmann, Steffi, Hofer, Thomas, Hosse, Ralf J, Moessner, Ekkehard, Ast, Oliver, Bruenker, Peter, Grau-Richards, Sandra, Schaller, Teilo, Seidl, Annette, Gerdes, Christian, Perro, Mario, Nicolini, Valeria, Steinhoff, Nathalie, Dudal, Sherri, Neumann, Sebastian, von Hirschheydt, Thomas, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umaña, Pablo
Published in Clinical cancer research (01.07.2016)
Published in Clinical cancer research (01.07.2016)
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Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy
Claus, Christina, Ferrara, Claudia, Xu, Wei, Sam, Johannes, Lang, Sabine, Uhlenbrock, Franziska, Albrecht, Rosmarie, Herter, Sylvia, Schlenker, Ramona, Hüsser, Tamara, Diggelmann, Sarah, Challier, John, Mössner, Ekkehard, Hosse, Ralf J, Hofer, Thomas, Brünker, Peter, Joseph, Catherine, Benz, Jörg, Ringler, Philippe, Stahlberg, Henning, Lauer, Matthias, Perro, Mario, Chen, Stanford, Küttel, Christine, Bhavani Mohan, Preethi L, Nicolini, Valeria, Birk, Martina Carola, Ongaro, Amandine, Prince, Christophe, Gianotti, Reto, Dugan, Gregory, Whitlow, Christopher T, Solingapuram Sai, Kiran Kumar, Caudell, David L, Burgos-Rodriguez, Armando G, Cline, J Mark, Hettich, Michael, Ceppi, Maurizio, Giusti, Anna Maria, Crameri, Flavio, Driessen, Wouter, Morcos, Peter N, Freimoser-Grundschober, Anne, Levitsky, Victor, Amann, Maria, Grau-Richards, Sandra, von Hirschheydt, Thomas, Tournaviti, Stella, Mølhøj, Michael, Fauti, Tanja, Heinzelmann-Schwarz, Viola, Teichgräber, Volker, Colombetti, Sara, Bacac, Marina, Zippelius, Alfred, Klein, Christian, Umaña, Pablo
Published in Science translational medicine (12.06.2019)
Published in Science translational medicine (12.06.2019)
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Abstract 3634: A novel tumor-targeted 4-1BB agonist and its combination with T-cell bispecific antibodies: an off-the-shelf cancer immunotherapy alternative to CAR T-cells
Claus, Christina, Ferrara, Claudia, Lang, Sabine, Albrecht, Rosmarie, Herter, Sylvia, Amann, Maria, Richards-Grau, Sandra, Sam, Johannes, Colombetti, Sara, Bacac, Marina, Klein, Christian, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Bispecific antigen binding molecule for a costimulatory TNF receptor
Amann, Maria, Pousse, Laurene, Klein, Christian, Umaña, Pablo, Grau-Richards, Sandra
Year of Publication 02.05.2023
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Year of Publication 02.05.2023
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Cell based assay for determining antibody or ligand binding and function
Amann, Maria, Claus, Christina, Albrecht, Rosmarie, Zielonka, Joerg, Grau-Richards, Sandra
Year of Publication 27.12.2022
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Year of Publication 27.12.2022
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Bispecific antigen binding molecule for a costimulatory TNF receptor
Amann, Maria, Pincha, Mudita, Klein, Christian, Umaña, Pablo, Grau-Richards, Sandra
Year of Publication 27.09.2022
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Year of Publication 27.09.2022
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BISPECIFIC ANTIBODIES SPECIFIC FOR A COSTIMULATORY TNF RECEPTOR
GRAU-RICHARDS Sandra, UMAÑA Pablo, CLAUS Christina, HOSSE Ralf, LEVITSKI Viktor, BRUENKER Peter, AMANN Maria, KLEIN Christian, FERRARA KOLLER Claudia
Year of Publication 20.06.2023
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Year of Publication 20.06.2023
Patent
Bispecific antibodies specific for a costimulatory TNF receptor
Amann, Maria, Levitski, Viktor, Claus, Christina, Hosse, Ralf, Bruenker, Peter, Ferrara Koller, Claudia, Klein, Christian, Umaña, Pablo, Grau-Richards, Sandra
Year of Publication 13.04.2023
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Year of Publication 13.04.2023
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Antigen binding molecules comprising a tnf family ligand trimer
Moessner, Ekkehard, Regula, Joerg Thomas, Amann, Maria, Levitski, Viktor, Claus, Christina, Ferrara Koller, Claudia, Klein, Christian, Bruenker, Peter, Umaña, Pablo, Grau-Richards, Sandra
Year of Publication 23.02.2024
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Year of Publication 23.02.2024
Patent
Antigen binding molecules comprising a tnf family ligand trimer
Moessner, Ekkehard, Regula, Joerg Thomas, Amann, Maria, Levitski, Viktor, Claus, Christina, Ferrara Koller, Claudia, Klein, Christian, Bruenker, Peter, Umaña, Pablo, Grau-Richards, Sandra
Year of Publication 23.02.2024
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Year of Publication 23.02.2024
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Antigen Binding Molecules comprising a TNF family ligand trimer and PD1 binding moiety
Koller, Claudia Ferrara, Umana, Pablo, Moessner, Ekkehard, Amann, Maria, Levitski, Viktor, Seeber, Stefan, Claus, Christina, Klein, Christian, Bruenker, Peter, Grau-Richards, Sandra
Year of Publication 20.04.2023
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Year of Publication 20.04.2023
Patent