The first potent inhibitor of squalene synthase: a profound contribution of an ether oxygen to inhibitor-enzyme interaction
Biller, Scott A, Sofia, Michael J, DeLange, Barbara, Forster, Cornelia, Gordon, Eric M, Harrity, Thomas, Rich, Lois C, Ciosek, Carl P
Published in Journal of the American Chemical Society (01.10.1991)
Published in Journal of the American Chemical Society (01.10.1991)
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Journal Article
α-Phosphonosulfonic Acids: Potent and Selective Inhibitors of Squalene Synthase
Magnin, David R, Biller, Scott A, Chen, Ying, Dickson, John K, Fryszman, Olga M, Lawrence, R. Michael, Logan, Janette V. H, Sieber-McMaster, Ellen S, Sulsky, Richard B, Traeger, Sarah C, Hsieh, Dolly C, Lan, Shih-Jung, Rinehart, J. Kent, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Rich, Lois C, Slusarchyk, Dorothy A, Ciosek, Carl P
Published in Journal of medicinal chemistry (02.02.1996)
Published in Journal of medicinal chemistry (02.02.1996)
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Journal Article
1,1-Bisphosphonate Squalene Synthase Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate
Magnin, David R, Dickson, John K, Logan, Janette V, Lawrence, R. Michael, Chen, Ying, Sulsky, Richard B, Ciosek, Carl P, Biller, Scott A, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Rich, Lois C, Slusarchyk, Dorothy A
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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Journal Article
Isoprenyl phosphinylformates: new inhibitors of squalene synthetase
Biller, Scott A, Forster, Cornelia, Gordon, Eric M, Harrity, Thomas, Rich, Lois C, Marretta, Joseph, Ciosek, Carl P
Published in Journal of medicinal chemistry (01.06.1991)
Published in Journal of medicinal chemistry (01.06.1991)
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Journal Article
Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety
Robl, Jeffrey A, Duncan, Laurelee A, Pluscec, Jelka, Karanewsky, Donald S, Gordon, Eric M, Ciosek, Carl P, Rich, Lois C, Dehmel, Viviane C, Slusarchyk, Dorothy A
Published in Journal of medicinal chemistry (01.09.1991)
Published in Journal of medicinal chemistry (01.09.1991)
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Journal Article
Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo
Ciosek, C P, Magnin, D R, Harrity, T W, Logan, J V, Dickson, J K, Gordon, E M, Hamilton, K A, Jolibois, K G, Kunselman, L K, Lawrence, R M
Published in The Journal of biological chemistry (25.11.1993)
Published in The Journal of biological chemistry (25.11.1993)
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Journal Article
Aromatic isosteres as conformational probes for an isoprenyl subunit: application to inhibitors of squalene synthase
Biller, Scott A., Abt, Jeffrey W., Pudzianowski, Andrew T., Rich, Lois C., Slusarchyk, Dorothy A., Ciosek, Carl.P.
Published in Bioorganic & medicinal chemistry letters (01.04.1993)
Published in Bioorganic & medicinal chemistry letters (01.04.1993)
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