Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models
Chan-Penebre, Elayne, Armstrong, Kelli, Drew, Allison, Grassian, Alexandra R, Feldman, Igor, Knutson, Sarah K, Kuplast-Barr, Kristy, Roche, Maria, Campbell, John, Ho, Peter, Copeland, Robert A, Chesworth, Richard, Smith, Jesse J, Keilhack, Heike, Ribich, Scott A
Published in Molecular cancer therapeutics (01.05.2017)
Published in Molecular cancer therapeutics (01.05.2017)
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EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL
Brach, Dorothy, Johnston-Blackwell, Danielle, Drew, Allison, Lingaraj, Trupti, Motwani, Vinny, Warholic, Natalie M, Feldman, Igor, Plescia, Christopher, Smith, Jesse J, Copeland, Robert A, Keilhack, Heike, Chan-Penebre, Elayne, Knutson, Sarah K, Ribich, Scott A, Raimondi, Alejandra, Thomenius, Michael J
Published in Molecular cancer therapeutics (01.11.2017)
Published in Molecular cancer therapeutics (01.11.2017)
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Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss
Fedoriw, Andrew, Rajapurkar, Satyajit R., O'Brien, Shane, Gerhart, Sarah V., Mitchell, Lorna H., Adams, Nicholas D., Rioux, Nathalie, Lingaraj, Trupti, Ribich, Scott A., Pappalardi, Melissa B., Shah, Niyant, Laraio, Jenny, Liu, Yan, Butticello, Michael, Carpenter, Chris L., Creasy, Caretha, Korenchuk, Susan, McCabe, Michael T., McHugh, Charles F., Nagarajan, Raman, Wagner, Craig, Zappacosta, Francesca, Annan, Roland, Concha, Nestor O., Thomas, Roberta A., Hart, Timothy K., Smith, Jesse J., Copeland, Robert A., Moyer, Mikel P., Campbell, John, Stickland, Kim, Mills, James, Jacques-O’Hagan, Suzanne, Allain, Christina, Johnston, Danielle, Raimondi, Alejandra, Porter Scott, Margaret, Waters, Nigel, Swinger, Kerren, Boriack-Sjodin, Ann, Riera, Tom, Shapiro, Gideon, Chesworth, Richard, Prinjha, Rabinder K., Kruger, Ryan G., Barbash, Olena, Mohammad, Helai P.
Published in Cancer cell (08.07.2019)
Published in Cancer cell (08.07.2019)
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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
Chan-Penebre, Elayne, Kuplast, Kristy G, Majer, Christina R, Boriack-Sjodin, P Ann, Wigle, Tim J, Johnston, L Danielle, Rioux, Nathalie, Munchhof, Michael J, Jin, Lei, Jacques, Suzanne L, West, Kip A, Lingaraj, Trupti, Stickland, Kimberly, Ribich, Scott A, Raimondi, Alejandra, Scott, Margaret Porter, Waters, Nigel J, Pollock, Roy M, Smith, Jesse J, Barbash, Olena, Pappalardi, Melissa, Ho, Thau F, Nurse, Kelvin, Oza, Khyati P, Gallagher, Kathleen T, Kruger, Ryan, Moyer, Mikel P, Copeland, Robert A, Chesworth, Richard, Duncan, Kenneth W
Published in Nature chemical biology (01.06.2015)
Published in Nature chemical biology (01.06.2015)
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Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
Drew, Allison E, Moradei, Oscar, Jacques, Suzanne L, Rioux, Nathalie, Boriack-Sjodin, Ann P, Allain, Christina, Scott, Margaret Porter, Jin, Lei, Raimondi, Alejandra, Handler, Jessica L, Ott, Heidi M, Kruger, Ryan G, McCabe, Michael T, Sneeringer, Christopher, Riera, Thomas, Shapiro, Gideon, Waters, Nigel J, Mitchell, Lorna H, Duncan, Kenneth W, Moyer, Mikel P, Copeland, Robert A, Smith, Jesse, Chesworth, Richard, Ribich, Scott A
Published in Scientific reports (21.12.2017)
Published in Scientific reports (21.12.2017)
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Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound
Mitchell, Lorna H., Drew, Allison E., Ribich, Scott A., Rioux, Nathalie, Swinger, Kerren K., Jacques, Suzanne L., Lingaraj, Trupti, Boriack-Sjodin, P. Ann, Waters, Nigel J., Wigle, Tim J., Moradei, Oscar, Jin, Lei, Riera, Tom, Porter-Scott, Margaret, Moyer, Mikel P., Smith, Jesse J., Chesworth, Richard, Copeland, Robert A.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Promoter Choice Determines Splice Site Selection in Protocadherin α and γ Pre-mRNA Splicing
Tasic, Bosiljka, Nabholz, Christoph E., Baldwin, Kristin K., Kim, Youngwook, Rueckert, Erroll H., Ribich, Scott A., Cramer, Paula, Wu, Qiang, Axel, Richard, Maniatis, Tom
Published in Molecular cell (01.07.2002)
Published in Molecular cell (01.07.2002)
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Abstract 312: Evidence of EZH2 dependent and independent mechanisms of tazemetostat treatment emergent resistance in models of diffuse large B cell lymphoma
Campbell, Carly T., Jasper, Jeff S., Daigle, Scott R., Ribich, Scott A., Keilhack, Heike, Smith, Jesse S., Ho, Peter T., Blakemore, Stephen J.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract B130: Elevated cancer-intrinsic type I interferon signaling confers a dependency on the RNA editor ADAR1
Gardino, Alexandra K., Collins, Cindy, Lynes, Maureen S., Boriack-Sjodin, P. Ann, Copeland, Robert A., Ribich, Scott A.
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Abstract 3345: Selective killing of SMARCA2- and SMARCA4-deficient tumors by inhibition of EZH2: In vitro and in vivo preclinical models
Chan-Penebre, Elayne, Armstrong, Kelli, Drew, Allison, Grassian, Alexandra R., Feldman, Igor, Roche, Maria, Ho, Peter, Brach, Dorothy, Raimondi, Alejandra, Copeland, Robert A., Chesworth, Richard, Smith, Jesse J., Ribich, Scott A.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Reawakening of Human Fetal Hemoglobin and an Epigenetic Path to the Clinic for Sickle Cell Disease and Beta-Thalassemia: Identification of an Orally-Available, Potent, and Selective Euchromatic Histone Lysine Methyltransferase 1 and 2 (EHMT1/2) Inhibitor
Chan-Penebre, Elayne, Gibaja, Veronica, Campbell, John, Olu, Ogunbodede, Admirand, Elizabeth, Brach, Dorothy, Tang, Cuyue, Raimondi, Alejandra, Hood, Tami, Cocozaki, Alexis, Karaman, Sule, Stickland, Kimberly, Plescia, Christopher, Munchhof, Michael, Armstrong, Kelli, Riera, Thomas, Orkin, Stuart, Boriack-Sjodin, Ann, Janzen, William, Blakemore, Stephen, Ribich, Scott A, Chesworth, Richard, Smith, Jesse J, Duncan, Kenneth W
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Identification of a First-in-Class PRMT5 Inhibitor with Potent in Vitro and in Vivo Activity in Preclinical Models of Mantle Cell Lymphoma
Penebre, Elayne, Kuplast, Kristy G, Majer, Christina R, Johnston, L. Danielle, Rioux, Nathalie, Munchhof, Michael, Jin, Lei, Boriak-Sjodin, P. Ann, Wigle, Tim J, Jacques, Suzanne L, West, Kip A, Lingaraj, Trupti, Stickland, Kimberly, Ribich, Scott A, Raimondi, Alejandra, Porter-Scott, Margaret, Waters, Nigel J, Pollock, Roy M, Smith, Jesse J, Barbash, Olena, Kruger, Ryan G., Copeland, Robert A, Moyer, Mikel P, Chesworth, Richard, Duncan, Kenneth W
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Inhibitors of RNA helicase DHX9 and uses thereof
SPARLING, BRIAN ANDREW, CASTRO, JENNIFER, JENNINGS, ANDREW J, DUNCAN, KENNETH W, WHITLOCK, GAVIN, TASKER, ANDREW STEWART, LEE, YOUG-TAE, RIBICH, SCOTT, MILLS, JAMES EDWARD JOHN, SICKMIER, ERNEST ALLEN, DANIELS, MATTHEW H
Year of Publication 01.11.2023
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Year of Publication 01.11.2023
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