CD8 epitope escape and reversion in acute HCV infection
Timm, Joerg, Lauer, Georg M, Kavanagh, Daniel G, Sheridan, Isabelle, Kim, Arthur Y, Lucas, Michaela, Pillay, Thillagavathie, Ouchi, Kei, Reyor, Laura L, Schulze zur Wiesch, Julian, Gandhi, Rajesh T, Chung, Raymond T, Bhardwaj, Nina, Klenerman, Paul, Walker, Bruce D, Allen, Todd M
Published in The Journal of experimental medicine (20.12.2004)
Published in The Journal of experimental medicine (20.12.2004)
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Journal Article
Improving the Diagnosis of Acute Hepatitis C Virus Infection with Expanded Viral Load Criteria
McGovern, Barbara H., Birch, Christopher E., Bowen, Melinda J., Reyor, Laura L., Nagami, Ellen H., Chung, Raymond T., Kim, Arthur Y.
Published in Clinical infectious diseases (01.10.2009)
Published in Clinical infectious diseases (01.10.2009)
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Journal Article
High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome
KASPROWICZ, Victoria, SCHULZE ZUR WIESCH, Julian, KWOK, William W, MCGOVERN, Barbara G, FREEMAN, Gordon, CHUNG, Raymond T, KLENERMAN, Paul, LEWIS-XIMENEZ, Lia, WALKER, Bruce D, ALLEN, Todd M, KIM, Arthur Y, LAUER, Georg M, KUNTZEN, Thomas, NOLAN, Brian E, LONGWORTH, Steven, BERICAL, Andrew, BLUM, Jenna, MCMAHON, Cory, REYOR, Laura L, ELIAS, Nahel
Published in Journal of Virology (01.03.2008)
Published in Journal of Virology (01.03.2008)
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Journal Article
De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection
ALLEN, Todd M, YU, Xu G, ALTER, Galit, BROWN, Nancy V, JOHNSTON, Mary N, ROSENBERG, Eric S, MALLAL, Simon A, BRANDER, Christian, WALKER, Bruce D, ALTFELD, Marcus, KALIFE, Elizabeth T, REYOR, Laura L, LICHTERFELD, Mathias, JOHN, Mina, CHENG, Michael, ALLGAIER, Rachel L, MUI, Stanley, FRAHM, Nicole
Published in Journal of Virology (01.10.2005)
Published in Journal of Virology (01.10.2005)
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Journal Article
Compensatory Mutations Restore the Replication Defects Caused by Cytotoxic T Lymphocyte Escape Mutations in Hepatitis C Virus Polymerase
ONIANGUE-NDZA, Cesar, KUNTZEN, Thomas, GLADDEN, Adrianne D, BLOOM, Allyson K, POWER, Karen A, THIMME, Robert, LAUER, Georg M, HENN, Matthew R, KIM, Arthur Y, ALLEN, Todd M, KEMPER, Michael, BERICAL, Andrew, WANG, Yaoyu E, NEUMANN-HAEFELIN, Christoph, KRISTIAN FOOTE, Peter, HILLS-EVANS, Kelsey, REYOR, Laura L, KANE, Katherine
Published in Journal of Virology (01.11.2011)
Published in Journal of Virology (01.11.2011)
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Journal Article
Transmission and Long-Term Stability of Compensated CD8 Escape Mutations
Schneidewind, Arne, Brumme, Zabrina L, Brumme, Chanson J, Power, Karen A, Reyor, Laura L, O'Sullivan, Kristin, Gladden, Adrianne, Hempel, Ursula, Kuntzen, Thomas, Wang, Yaoyu E, Oniangue-Ndza, Cesar, Jessen, Heiko, Markowitz, Martin, Rosenberg, Eric S, Sékaly, Rafick-Pierre, Kelleher, Anthony D, Walker, Bruce D, Allen, Todd M
Published in Journal of Virology (15.04.2009)
Published in Journal of Virology (15.04.2009)
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Journal Article
Rate of Sustained Virologic Response in Relation to Baseline Hepatitis C Virus (HCV) RNA Level and Rapid Virologic Clearance in Persons with Acute HCV Infection
McGovern, Barbara H., Nagami, Ellen H., Birch, Christopher E., Bowen, Melinda J., Reyor, Laura L., Chung, Raymond T., Kim, Arthur Y.
Published in The Journal of infectious diseases (15.09.2009)
Published in The Journal of infectious diseases (15.09.2009)
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Journal Article
Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence
Schulze Zur Wiesch, Julian, Ciuffreda, Donatella, Lewis-Ximenez, Lia, Kasprowicz, Victoria, Nolan, Brian E, Streeck, Hendrik, Aneja, Jasneet, Reyor, Laura L, Allen, Todd M, Lohse, Ansgar W, McGovern, Barbara, Chung, Raymond T, Kwok, William W, Kim, Arthur Y, Lauer, Georg M
Published in The Journal of experimental medicine (16.01.2012)
Published in The Journal of experimental medicine (16.01.2012)
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Journal Article
The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design
ALTFELD, Marcus, ALLEN, Todd M, PERKINS, Beth, ROBINSON, Loren K, SIDNEY, John, ALTER, Galit, LICHTERFELD, Mathias, SETTE, Alessandro, ROSENBERG, Eric S, GOULDER, Philip J. R, BRANDER, Christian, WALKER, Bruce D, KALIFE, Elizabeth T, FRAHM, Nicole, ADDO, Marylyn M, MOTHE, Bianca R, RATHOD, Almas, REYOR, Laura L, HARLOW, Jason, YU, Xu G
Published in Journal of Virology (01.04.2005)
Published in Journal of Virology (01.04.2005)
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Journal Article
Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance
Alter, Galit, Jost, Stephanie, Rihn, Suzannah, Reyor, Laura L, Nolan, Brian E, Ghebremichael, Musie, Bosch, Ronald, Altfeld, Marcus, Lauer, Georg M
Published in Journal of hepatology (01.08.2011)
Published in Journal of hepatology (01.08.2011)
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Journal Article
Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes
Kim, Arthur Y, Kuntzen, Thomas, Timm, Joerg, Nolan, Brian E, Baca, Melanie A, Reyor, Laura L, Berical, Andrew C, Feller, Andrea J, Johnson, Kristin L, Schulze zur Wiesch, Julian, Robbins, Gregory K, Chung, Raymond T, Walker, Bruce D, Carrington, Mary, Allen, Todd M, Lauer, Georg M
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2011)
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2011)
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Journal Article
Spontaneous Control of HCV Is Associated With Expression of HLA-B57 and Preservation of Targeted Epitopes
Kim, Arthur Y, Kuntzen, Thomas, Timm, Joerg, Nolan, Brian E, Baca, Melanie A, Reyor, Laura L, Berical, Andrew C, Feller, Andrea J, Johnson, Kristin L, Wiesch, Julian Schulze Zur, Robbins, Gregory K, Chung, Raymond T, Walker, Bruce D, Carrington, Mary, Allen, Todd M, Lauer, Georg M
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2011)
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2011)
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Journal Article
Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations
Neumann‐Haefelin, Christoph, Oniangue‐Ndza, Cesar, Kuntzen, Thomas, Schmidt, Julia, Nitschke, Katja, Sidney, John, Caillet‐Saguy, Célia, Binder, Marco, Kersting, Nadine, Kemper, Michael W., Power, Karen A., Ingber, Susan, Reyor, Laura L., Hills‐Evans, Kelsey, Kim, Arthur Y., Lauer, Georg M., Lohmann, Volker, Sette, Alessandro, Henn, Matthew R., Bressanelli, Stéphane, Thimme, Robert, Allen, Todd M.
Published in Hepatology (Baltimore, Md.) (01.10.2011)
Published in Hepatology (Baltimore, Md.) (01.10.2011)
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Journal Article
Human leukocyte antigen–associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution
Timm, Joerg, Li, Bin, Daniels, Marcus G., Bhattacharya, Tanmoy, Reyor, Laura L., Allgaier, Rachel, Kuntzen, Thomas, Fischer, Will, Nolan, Brian E., Duncan, Jared, Schulze zur Wiesch, Julian, Kim, Arthur Y., Frahm, Nicole, Brander, Christian, Chung, Raymond T., Lauer, Georg M., Korber, Bette T., Allen, Todd M.
Published in Hepatology (Baltimore, Md.) (01.08.2007)
Published in Hepatology (Baltimore, Md.) (01.08.2007)
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Journal Article
Temporal Dynamics of a Predominant Protease Inhibitor–Resistance Mutation in a Treatment-Naive, Hepatitis C Virus–Infected Individual
Kim, Arthur Y., Timm, Joerg, Nolan, Brian E., Reyor, Laura L., Kane, Katherine, Berical, Andrew C., Zachary, Kimon C., Lauer, Georg M., Kuntzen, Thomas, Allen, Todd M.
Published in The Journal of infectious diseases (01.03.2009)
Published in The Journal of infectious diseases (01.03.2009)
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Journal Article
Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution
ALLEN, Todd M, ALTFELD, Marcus, KAUFMANN, Daniel E, LAHAIE, Matthew P, REYOR, Laura, TANZI, Giancarlo, JOHNSTON, Mary N, BRANDER, Christian, DRAENERT, Rika, ROCKSTROH, Jurgen K, JESSEN, Heiko, ROSENBERG, Eric S, GEER, Shaun C, MALLAL, Simon A, WALKER, Bruce D, KALIFE, Elizabeth T, MOORE, Corey, O'SULLIVAN, Kristin M, DESOUZA, Ivna, FEENEY, Margaret E, ELDRIDGE, Robert L, MAIER, Erica L
Published in Journal of Virology (01.11.2005)
Published in Journal of Virology (01.11.2005)
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Journal Article
Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment‐naïve patients
Kuntzen, Thomas, Timm, Joerg, Berical, Andrew, Lennon, Niall, Berlin, Aaron M., Young, Sarah K., Lee, Bongshin, Heckerman, David, Carlson, Jonathan, Reyor, Laura L., Kleyman, Marianna, McMahon, Cory M., Birch, Christopher, Schulze zur Wiesch, Julian, Ledlie, Timothy, Koehrsen, Michael, Kodira, Chinnappa, Roberts, Andrew D., Lauer, Georg M., Rosen, Hugo R., Bihl, Florian, Cerny, Andreas, Spengler, Ulrich, Liu, Zhimin, Kim, Arthur Y., Xing, Yanming, Schneidewind, Arne, Madey, Margaret A., Fleckenstein, Jaquelyn F., Park, Vicki M., Galagan, James E., Nusbaum, Chad, Walker, Bruce D., Lake‐Bakaar, Gerond V., Daar, Eric S., Jacobson, Ira M., Gomperts, Edward D., Edlin, Brian R., Donfield, Sharyne M., Chung, Raymond T., Talal, Andrew H., Marion, Tony, Birren, Bruce W., Henn, Matthew R., Allen, Todd M.
Published in Hepatology (Baltimore, Md.) (01.12.2008)
Published in Hepatology (Baltimore, Md.) (01.12.2008)
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Journal Article
HLA-associated sequence polymorphisms in HCV reveal the reproducibility of immune responses and constraints on viral evolution
Timm, J, Li, B, Bhattacharya, T, Daniels, M G, Reyor, L L, Allgaier, R, Kuntzen, T, Fischer, W, Duncan, J, Schulze zur Wiesch, J, Kim, A, Frahm, N, Brander, C, Chung, R T, Lauer, G M, Korber, B T, Walker, B D, Allen, T M
Published in Journal of clinical virology (01.01.2006)
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Published in Journal of clinical virology (01.01.2006)
Journal Article
HLA-A1 assoziierter Selektionsdruck beeinflusst die Evolution des Hepatitis C Virus
Timm, J, Reiser, M, Brechmann, T, Reyor, L, Schmiegel, W, Walker, B, Allen, T
Published in Zeitschrift für Gastroenterologie (10.04.2006)
Published in Zeitschrift für Gastroenterologie (10.04.2006)
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Conference Proceeding
HLA-B27 Selects for Rare Escape Mutations that Significantly Impair Hepatitis C Virus Replication and Require Compensatory Mutations
Neumann-Haefelin, Christoph, Oniangue-Ndza, Cesar, Kuntzen, Thomas, Schmidt, Julia, Nitschke, Katja, Sidney, John, Caillet-Saguy, Célia, Binder, Marco, Kersting, Nadine, Kemper, Michael W., Power, Karen A., Ingber, Susan, Reyor, Laura L., Hills-Evans, Kelsey, Kim, Arthur Y., Lauer, Georg M., Lohmann, Volker, Sette, Alessandro, Henn, Matthew R., Bressanelli, Stéphane, Thimme, Robert, Allen, Todd M.
Published in Hepatology (Baltimore, Md.) (01.10.2011)
Published in Hepatology (Baltimore, Md.) (01.10.2011)
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Journal Article