Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor
Palmer, Wylie S, Poncet-Montange, Guillaume, Liu, Gang, Petrocchi, Alessia, Reyna, Naphtali, Subramanian, Govindan, Theroff, Jay, Yau, Anne, Kost-Alimova, Maria, Bardenhagen, Jennifer P, Leo, Elisabetta, Shepard, Hannah E, Tieu, Trang N, Shi, Xi, Zhan, Yanai, Zhao, Shuping, Barton, Michelle C, Draetta, Giulio, Toniatti, Carlo, Jones, Philip, Geck Do, Mary, Andersen, Jannik N
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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Journal Article
Identification of potent and selective MTH1 inhibitors
Petrocchi, Alessia, Leo, Elisabetta, Reyna, Naphtali J., Hamilton, Matthew M., Shi, Xi, Parker, Connor A., Mseeh, Faika, Bardenhagen, Jennifer P., Leonard, Paul, Cross, Jason B., Huang, Sha, Jiang, Yongying, Cardozo, Mario, Draetta, Giulio, Marszalek, Joseph R., Toniatti, Carlo, Jones, Philip, Lewis, Richard T.
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
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Journal Article
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme
Hamilton, Matthew M, Mseeh, Faika, McAfoos, Timothy J, Leonard, Paul G, Reyna, Naphtali J, Harris, Angela L, Xu, Alan, Han, Michelle, Soth, Michael J, Czako, Barbara, Theroff, Jay P, Mandal, Pijus K, Burke, Jason P, Virgin-Downey, Brett, Petrocchi, Alessia, Pfaffinger, Dana, Rogers, Norma E, Parker, Connor A, Yu, Simon S, Jiang, Yongying, Krapp, Stephan, Lammens, Alfred, Trevitt, Graham, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Cross, Jason B, Jones, Philip, Marszalek, Joseph R, Lewis, Richard T
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Abstract 3277: IACS-9779, a development candidate that inhibits 2,3-dioxygenase (IDO) activity by blocking heme incorporation into IDO apoenzyme
Mseeh, Faika, Hamilton, Matthew M., Marszalek, Joseph R., Rogers, Norma E., Parker, Connor A., Yu, Simon S., Liu, Zhen, Reyna, Naphtali J., McAfoos, Timothy, Virgin-Downey, Brett W., Leonard, Paul G., Cross, Jason B., Feng, Ningping, Harris, Angela L., Zuniga, Andy M., Mikule, Keith, Tremblay, Martin, Jiang, Yongying, Mahendra, Mikhila, Pang, Jihai, Wu, Qi, Xu, Quanyun, Heffernan, Timothy P., Jones, Philip, Lewis, Richard T.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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질병 치료용 수용체 상호작용 단백질 키나아제 I 의 억제제
RAY WILLIAM, RAMASWAMY SUYAMBU KESAVA VIJAYAN, PFAFFINGER DANA, ALVAREZ FERNANDO, LEWIS RICHARD, HAMILTON MATTHEW, CROSS JASON, REYNA NAPHTALI
Year of Publication 02.06.2022
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Year of Publication 02.06.2022
Patent
Abstract LB-071: Discovery of an imidazopyridine series of potent human IDO1 inhibitors with robust target engagement in a preclinical tumor model
Petrocchi, Alessia, Reyna, Naphtali J., Mseeh, Faika, Parker, Connor A., Yu, Simon, Xu, Quanyun, Feng, Ningping, Leonard, Paul, Rogers, Norma, Cross, Jason B., Harris, Angela L., Jiang, Yongying, Khor, Tin Oo, Mahendra, Mikhila G., Pang, Jihai, Wu, Qi, Zuniga, Andy M., McAfoos, Timothy, Hamilton, Matthew M., Marszalek, Joe R., Mikule, Keith, Vancutsem, Paul, Wilcoxen, Keith, Tremblay, Martin, Jones, Philip, Lewis, Richard T.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract B48: Identification of potent, cell active MTH1 inhibitors and their use in target validation studies
Leo, Elisabetta, Petrocchi, Alessia, Bardenhagen, Jennifer, Alimova, Maria, Shi, Xi, Parker, Connor, Reyna, Naphtali, Hamilton, Matthew, Felix, Edward, Mazan, Andrzej, Dillon, Christian, Mseeh, Faika, Marszalek, Joseph R., Toniatti, Carlo, Draetta, Giulio, Jones, Phil, Lewis, Richard T.
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
HETEROCYCLIC COMPOUNDS AS NRAS INHIBITORS
REYNA, Naphtali J, COX, Joshua, MANDAL, Pijus K, JONES, Philip, CROSS, Jason B, MCAFOOS, Timothy J, NAGY, Edith, SOTH, Michael J, TRAN, Tuyen Ngoc Phuong
Year of Publication 17.10.2024
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Year of Publication 17.10.2024
Patent
Inhibitors of receptor interacting protein kinase i for the treatment of disease
Suyambu Kesava Vijayan RAMASWAMY, William RAY, Matthew HAMILTON, Richard LEWIS, Naphtali REYNA, Fernando ALVAREZ
Year of Publication 01.10.2022
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Year of Publication 01.10.2022
Patent