Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development
Sun, Daqing, Li, Zhihong, Rew, Yosup, Gribble, Michael, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chen, Xiaoqi, Chow, David, Deignan, Jeffrey, Duquette, Jason, Eksterowicz, John, Fisher, Benjamin, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Gonzalez-Lopez De Turiso, Felix, Houze, Jonathan B, Huang, Xin, Jiang, Min, Jin, Lixia, Kayser, Frank, Liu, Jiwen (Jim), Lo, Mei-Chu, Long, Alexander M, Lucas, Brian, McGee, Lawrence R, McIntosh, Joel, Mihalic, Jeff, Oliner, Jonathan D, Osgood, Tao, Peterson, Matthew L, Roveto, Philip, Saiki, Anne Y, Shaffer, Paul, Toteva, Maria, Wang, Yingcai, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Yu, Ming, Zhao, Xiaoning, Zhou, Jing, Zhu, Jiang, Olson, Steven H, Medina, Julio C
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Journal Article
Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction
Rew, Yosup, Sun, Daqing, Gonzalez-Lopez De Turiso, Felix, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Deignan, Jeffrey, Fox, Brian M, Gustin, Darin, Huang, Xin, Jiang, Min, Jiao, Xianyun, Jin, Lixia, Kayser, Frank, Kopecky, David J, Li, Yihong, Lo, Mei-Chu, Long, Alexander M, Michelsen, Klaus, Oliner, Jonathan D, Osgood, Tao, Ragains, Mark, Saiki, Anne Y, Schneider, Steve, Toteva, Maria, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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Journal Article
Ordering of the N‑Terminus of Human MDM2 by Small Molecule Inhibitors
Michelsen, Klaus, Jordan, John B, Lewis, Jeffrey, Long, Alexander M, Yang, Evelyn, Rew, Yosup, Zhou, Jing, Yakowec, Peter, Schnier, Paul D, Huang, Xin, Poppe, Leszek
Published in Journal of the American Chemical Society (17.10.2012)
Published in Journal of the American Chemical Society (17.10.2012)
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Journal Article
Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101)
Rew, Yosup, Du, Xiaohui, Eksterowicz, John, Zhou, Haiying, Jahchan, Nadine, Zhu, Liusheng, Yan, Xuelei, Kawai, Hiroyuki, McGee, Lawrence R, Medina, Julio C, Huang, Tom, Chen, Chelsea, Zavorotinskaya, Tatiana, Sutimantanapi, Dena, Waszczuk, Joanna, Jackson, Erica, Huang, Elizabeth, Ye, Qiuping, Fantin, Valeria R, Sun, Daqing
Published in Journal of medicinal chemistry (13.09.2018)
Published in Journal of medicinal chemistry (13.09.2018)
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Journal Article
Abstract 3822: ORIC-101 reverses a GR-driven EMT-like phenotype and sensitizes TNBC cells to chemotherapy
Zhou, Haiying, Sun, Jessica, Kong, Wayne, Rew, Yosup, Du, Xiaohui, Eksterowicz, John, Sun, Daqing, Ye, Qiuping, Kabbarah, Omar, Fantin, Valeria R.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Discovery and in Vivo Evaluation of Macrocyclic Mcl‑1 Inhibitors Featuring an α‑Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere
Rescourio, Gwenaella, Gonzalez, Ana Z, Jabri, Salman, Belmontes, Brian, Moody, Gordon, Whittington, Doug, Huang, Xin, Caenepeel, Sean, Cardozo, Mario, Cheng, Alan C, Chow, David, Dou, Hannah, Jones, Adrie, Kelly, Ron C, Li, Yihong, Lizarzaburu, Mike, Lo, Mei-Chu, Mallari, Rommel, Meleza, Cesar, Rew, Yosup, Simonovich, Scott, Sun, Daqing, Turcotte, Simon, Yan, Xuelei, Wong, Simon G, Yanez, Evelyn, Zancanella, Manuel, Houze, Jonathan, Medina, Julio C, Hughes, Paul E, Brown, Sean P
Published in Journal of medicinal chemistry (27.11.2019)
Published in Journal of medicinal chemistry (27.11.2019)
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Journal Article
Abstract LB-115: An orally bioavailable inhibitor of CD73 reverts intratumoral immunosuppression and promotes anti-tumor responses
Metzger, Todd, Blank, Brian, Chan, Brenda, Chen, Chelsea, Chen, Yuping, Du, Xiaohui, Duong, Frank, Friedman, Lori, Junttila, Melissa, Kawai, Hiro, Kong, Wayne, Moore, Jared, Pham, Johnny, Rew, Yosup, Sun, Daqing, Sun, Jessica, Sutimantanapi, Dena, Wu, Kejia, Yeh, Chien-Hung, Yuen, Natalie, Zavorotinskaya, Tatiana
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction
Gonzalez, Ana Z, Eksterowicz, John, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Duquette, Jason, Fox, Brian M, Fu, Jiasheng, Huang, Xin, Houze, Jonathan B, Jin, Lixia, Li, Yihong, Li, Zhihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, McMinn, Dustin L, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Medina, Julio C, Sun, Daqing
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Journal Article
Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633)
Du, Xiaohui, Eksterowicz, John, Zhou, Haiying, Rew, Yosup, Zhu, Liusheng, Yan, Xuelei, Medina, Julio C, Huang, Tom, Chen, Xi, Sutimantanapi, Dena, Jahchan, Nadine, Kong, Wayne, Sun, Jessica, Zavorotinskaya, Tatiana, Ye, Qiuping, Fantin, Valeria R, Sun, Daqing
Published in Journal of medicinal chemistry (25.07.2019)
Published in Journal of medicinal chemistry (25.07.2019)
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Journal Article
Abstract A133: Development of murine models to evaluate the impact of glucocorticoid receptor (GR) inhibition on chemotherapy response
Jahchan, Nadine, Zhou, Haiying, Stice, James, Kong, Wayne, McWeeney, Dan, Sun, Daqing, Rew, Yosup, Du, Xiaohui, Zhu, Liusheng, Ye, Qiuping, Jackson, Erica L., Fantin, Valeria
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
Abstract 1968: A novel glucocorticoid receptor (GR) antagonist overcomes GR-mediated chemoresistance in triple-negative breast cancer
Jahchan, Nadine, Zhou, Haiying, Kong, Wayne, Weeney, Dan Mc, Tracy, Ted, Stice, James, Sutimantanapi, Dena, Chen, Chelsea, Huang, Tom, Rew, Yosup, Du, Xiauhui, Zavorotinskaya, Tatiana, Sun, Daqing, Ye, Qiuping, Jackson, Erica, Fantin, Valeria
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors
Gonzalez-Lopez de Turiso, Felix, Sun, Daqing, Rew, Yosup, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Correll, Tiffany L, Huang, Xin, Julian, Lisa D, Kayser, Frank, Lo, Mei-Chu, Long, Alexander M, McMinn, Dustin, Oliner, Jonathan D, Osgood, Tao, Powers, Jay P, Saiki, Anne Y, Schneider, Steve, Shaffer, Paul, Xiao, Shou-Hua, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H
Published in Journal of medicinal chemistry (23.05.2013)
Published in Journal of medicinal chemistry (23.05.2013)
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Journal Article
Discovery of AM-7209, a Potent and Selective 4‑Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction
Rew, Yosup, Sun, Daqing, Yan, Xuelei, Beck, Hilary P, Canon, Jude, Chen, Ada, Duquette, Jason, Eksterowicz, John, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Houze, Jonathan, Huang, Xin, Jiang, Min, Jin, Lixia, Li, Yihong, Li, Zhihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, Oliner, Jonathan D, Osgood, Tao, Saiki, Anne Y, Shaffer, Paul, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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Journal Article
Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres
Gonzalez, Ana Z, Li, Zhihong, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Duquette, Jason, Eksterowicz, John, Fox, Brian M, Fu, Jiasheng, Huang, Xin, Houze, Jonathan, Jin, Lixia, Li, Yihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Sun, Daqing, Medina, Julio C
Published in Journal of medicinal chemistry (10.04.2014)
Published in Journal of medicinal chemistry (10.04.2014)
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Abstract 4172: Activation of AR signaling by mifepristone enhances prostate cancer growth and impairs enzalutamide response
Zhou, Haiying, Jachan, Nadine, Singh, Mallika, Tran, Chris, McWeeney, Dan, Balbas, Minna, Schenkein, Emily, Zovorotinskaya, Tatiana, Jackson, Erica L., Medina, Julio, Sun, Daqing, Rew, Yosup, Du, Xiaohui, Eksterowicz, John, Yan, Xuelei, Zhu, Liusheng, Ye, Qiuping, Fantin, Valeria
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
CD73 CD73 INHIBITORS
EKSTEROWICZ JOHN, YEH CHIEN HUNG, SUN DAQING, PHAM JOHNNY, FANTIN VALERIA R, ZAVOROTINSKAYA TATIANA, DU XIAOHUI, BLANK BRIAN R, WU KEJIA, KAWAI HIROYUKI, YE QIUPING, ZHU LIUSHENG, MOORE JARED, REW YOSUP
Year of Publication 02.04.2024
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Year of Publication 02.04.2024
Patent
Alanine Scan of [l-Dap2]Ramoplanin A2 Aglycon: Assessment of the Importance of Each Residue
Nam, Joonwoo, Shin, Dongwoo, Rew, Yosup, Boger, Dale L
Published in Journal of the American Chemical Society (18.07.2007)
Published in Journal of the American Chemical Society (18.07.2007)
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극성기를 갖는 독소를 포함하는 항체 약물 접합체 및 이의 용도
CHOI JIHYE, SEO DONGHOON, JEON CHEOLMIN, LEE HYANG SOOK, YOO JAE DO, LEE SANGKWANG, KIM HYEWON, LEE CHOHEE, HA JIHYEON, JUNG DOOHWAN, SONG JINA, JEONG MYEONGHWA, KIM YA GOB, PARK TAEKYO, KIM SUNYOUNG, YANG EUN HYE, SEO BEOMSEOK, KIM SENA, REW YOSUP
Year of Publication 22.08.2024
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Year of Publication 22.08.2024
Patent