ABCB1 attenuates brain exposure to the KRASG12C inhibitor opnurasib whereas binding to mouse carboxylesterase 1c influences its plasma exposure
Rijmers, Jamie, Retmana, Irene A., Bui, Viët, Arguedas, Davinia, Lebre, Maria C., Sparidans, Rolf W., Beijnen, Jos H., Schinkel, Alfred H.
Published in Biomedicine & pharmacotherapy (01.06.2024)
Published in Biomedicine & pharmacotherapy (01.06.2024)
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Pharmacokinetics of the KRASG12C inhibitor adagrasib is limited by CYP3A and ABCB1, and influenced by binding to mouse plasma carboxylesterase 1c
Loos, Nancy H.C., Retmana, Irene A., Rijmers, Jamie, Wang, Yaogeng, Gan, Changpei, Lebre, Maria C., Sparidans, Rolf W., Beijnen, Jos H., Schinkel, Alfred H.
Published in Biomedicine & pharmacotherapy (01.10.2023)
Published in Biomedicine & pharmacotherapy (01.10.2023)
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P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) limit brain accumulation of the FLT3 inhibitor quizartinib in mice
Wang, Jing, Gan, Changpei, Retmana, Irene A., Sparidans, Rolf W., Li, Wenlong, Lebre, Maria C., Beijnen, Jos H., Schinkel, Alfred H.
Published in International journal of pharmaceutics (10.02.2019)
Published in International journal of pharmaceutics (10.02.2019)
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Development and validation of an LC-MS/MS method for the quantification of KRASG12C inhibitor opnurasib in several mouse matrices and its application in a pharmacokinetic mouse study
Retmana, Irene A., Çelebi, Nefise, Rijmers, Jamie, Schinkel, Alfred H., Beijnen, Jos H., Sparidans, Rolf W.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.01.2024)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.01.2024)
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Validated LC-MS/MS method for simultaneous quantification of KRASG12C inhibitor sotorasib and its major circulating metabolite (M24) in mouse matrices and its application in a mouse pharmacokinetic study
Retmana, Irene A., Loos, Nancy H.C., Schinkel, Alfred H., Beijnen, Jos H., Sparidans, Rolf W.
Published in Journal of pharmaceutical and biomedical analysis (25.10.2023)
Published in Journal of pharmaceutical and biomedical analysis (25.10.2023)
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Quantification of KRAS inhibitor sotorasib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry
Retmana, Irene A., Loos, Nancy H.C., Schinkel, Alfred H., Beijnen, Jos H., Sparidans, Rolf W.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.06.2021)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.06.2021)
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Journal Article
Variability of in vivo potency tests of Diphtheria, Tetanus and acellular Pertussis (DTaP) vaccines
Stalpers, Coen A.L., Retmana, Irene A., Pennings, Jeroen L.A., Vandebriel, Rob J., Hendriksen, Coenraad F.M., Akkermans, Arnoud M., Hoefnagel, Marcel H.N.
Published in Vaccine (28.04.2021)
Published in Vaccine (28.04.2021)
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Development and validation of an HPLC–MS/MS method to quantify the KRAS inhibitor adagrasib in mouse plasma and tissue‐related matrices
Retmana, Irene A., Loos, Nancy H. C., Schinkel, Alfred H., Beijnen, Jos H., Sparidans, Rolf W.
Published in Biomedical chromatography (01.11.2023)
Published in Biomedical chromatography (01.11.2023)
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Corrigendum to “Variability of in vivo potency tests of Diphtheria, Tetanus and acellular Pertussis (DTaP) vaccines” [Vaccine 39(18) (2021) 2506–2516]
Stalpers, Coen A.L., Retmana, Irene A., Pennings, Jeroen L.A., Vandebriel, Rob J., Hendriksen, Coenraad F.M., Akkermans, Arnoud M., Hoefnagel, Marcel H.N.
Published in Vaccine (20.05.2022)
Published in Vaccine (20.05.2022)
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Journal Article
ABCB1 limits brain exposure of the KRASG12C inhibitor sotorasib, whereas ABCB1, CYP3A, and possibly OATP1a/1b restrict its oral availability
Loos, Nancy H.C., Retmana, Irene A., Li, Wenlong, Martins, Margarida L.F., Lebre, Maria C., Sparidans, Rolf W., Beijnen, Jos H., Schinkel, Alfred H.
Published in Pharmacological research (01.04.2022)
Published in Pharmacological research (01.04.2022)
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Journal Article
Liquid chromatography-tandem mass spectrometric assay for the quantitative determination of the tyrosine kinase inhibitor quizartinib in mouse plasma using salting-out liquid-liquid extraction
Retmana, Irene A., Wang, Jing, Schinkel, Alfred H., Schellens, Jan H.M., Beijnen, Jos H., Sparidans, Rolf W.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.09.2017)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.09.2017)
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Journal Article
Development and validation of an LC-MS/MS method for the quantification of KRAS G12C inhibitor opnurasib in several mouse matrices and its application in a pharmacokinetic mouse study
Retmana, Irene A, Çelebi, Nefise, Rijmers, Jamie, Schinkel, Alfred H, Beijnen, Jos H, Sparidans, Rolf W
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.01.2024)
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Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.01.2024)
Journal Article
Validated LC-MS/MS method for simultaneous quantification of KRAS G12C inhibitor sotorasib and its major circulating metabolite (M24) in mouse matrices and its application in a mouse pharmacokinetic study
Retmana, Irene A, Loos, Nancy H C, Schinkel, Alfred H, Beijnen, Jos H, Sparidans, Rolf W
Published in Journal of pharmaceutical and biomedical analysis (31.07.2023)
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Published in Journal of pharmaceutical and biomedical analysis (31.07.2023)
Journal Article
ABCB1 attenuates brain exposure to the KRAS G12C inhibitor opnurasib whereas binding to mouse carboxylesterase 1c influences its plasma exposure
Rijmers, Jamie, Retmana, Irene A, Bui, Viët, Arguedas, Davinia, Lebre, Maria C, Sparidans, Rolf W, Beijnen, Jos H, Schinkel, Alfred H
Published in Biomedicine & pharmacotherapy (01.06.2024)
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Published in Biomedicine & pharmacotherapy (01.06.2024)
Journal Article
ABCB1 limits brain exposure of the KRAS G12C inhibitor sotorasib, whereas ABCB1, CYP3A, and possibly OATP1a/1b restrict its oral availability
Loos, Nancy H C, Retmana, Irene A, Li, Wenlong, Martins, Margarida L F, Lebre, Maria C, Sparidans, Rolf W, Beijnen, Jos H, Schinkel, Alfred H
Published in Pharmacological research (01.04.2022)
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Published in Pharmacological research (01.04.2022)
Journal Article