Brain Tumor Stem Cell Dependence on Glutaminase Reveals a Metabolic Vulnerability through the Amino Acid Deprivation Response Pathway
Restall, Ian J, Cseh, Orsolya, Richards, Laura M, Pugh, Trevor J, Luchman, H Artee, Weiss, Samuel
Published in Cancer research (Chicago, Ill.) (15.12.2020)
Published in Cancer research (Chicago, Ill.) (15.12.2020)
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Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells
MacLeod, Graham, Bozek, Danielle A., Rajakulendran, Nishani, Monteiro, Vernon, Ahmadi, Moloud, Steinhart, Zachary, Kushida, Michelle M., Yu, Helen, Coutinho, Fiona J., Cavalli, Florence M.G., Restall, Ian, Hao, Xiaoguang, Hart, Traver, Luchman, H. Artee, Weiss, Samuel, Dirks, Peter B., Angers, Stephane
Published in Cell reports (Cambridge) (16.04.2019)
Published in Cell reports (Cambridge) (16.04.2019)
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PRMT5 inhibition disrupts splicing and stemness in glioblastoma
Sachamitr, Patty, Ho, Jolene C., Ciamponi, Felipe E., Ba-Alawi, Wail, Coutinho, Fiona J., Guilhamon, Paul, Kushida, Michelle M., Cavalli, Florence M. G., Lee, Lilian, Rastegar, Naghmeh, Vu, Victoria, Sánchez-Osuna, María, Coulombe-Huntington, Jasmin, Kanshin, Evgeny, Whetstone, Heather, Durand, Mathieu, Thibault, Philippe, Hart, Kirsten, Mangos, Maria, Veyhl, Joseph, Chen, Wenjun, Tran, Nhat, Duong, Bang-Chi, Aman, Ahmed M., Che, Xinghui, Lan, Xiaoyang, Whitley, Owen, Zaslaver, Olga, Barsyte-Lovejoy, Dalia, Richards, Laura M., Restall, Ian, Caudy, Amy, Röst, Hannes L., Bonday, Zahid Quyoom, Bernstein, Mark, Das, Sunit, Cusimano, Michael D., Spears, Julian, Bader, Gary D., Pugh, Trevor J., Tyers, Mike, Lupien, Mathieu, Haibe-Kains, Benjamin, Artee Luchman, H., Weiss, Samuel, Massirer, Katlin B., Prinos, Panagiotis, Arrowsmith, Cheryl H., Dirks, Peter B.
Published in Nature communications (12.02.2021)
Published in Nature communications (12.02.2021)
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Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia
Cole, Alicia, Wang, Zezhou, Coyaud, Etienne, Voisin, Veronique, Gronda, Marcela, Jitkova, Yulia, Mattson, Rachel, Hurren, Rose, Babovic, Sonja, Maclean, Neil, Restall, Ian, Wang, Xiaoming, Jeyaraju, Danny V., Sukhai, Mahadeo A., Prabha, Swayam, Bashir, Shaheena, Ramakrishnan, Ashwin, Leung, Elisa, Qia, Yi Hua, Zhang, Nianxian, Combes, Kevin R., Ketela, Troy, Lin, Fengshu, Houry, Walid A., Aman, Ahmed, Al-awar, Rima, Zheng, Wei, Wienholds, Erno, Xu, Chang Jiang, Dick, John, Wang, Jean C.Y., Moffat, Jason, Minden, Mark D., Eaves, Connie J., Bader, Gary D., Hao, Zhenyue, Kornblau, Steven M., Raught, Brian, Schimmer, Aaron D.
Published in Cancer cell (08.06.2015)
Published in Cancer cell (08.06.2015)
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Chemical genomics reveals targetable programs of human cancers rooted in pluripotency
Orlando, Luca, Benoit, Yannick D., Reid, Jennifer C., Nakanishi, Mio, Boyd, Allison L., García-Rodriguez, Juan L., Tanasijevic, Borko, Doyle, Meaghan S., Luchman, Artee, Restall, Ian J., Bergin, Christopher J., Masibag, Angelique N., Aslostovar, Lili, Di Lu, Justin, Laronde, Sarah, Collins, Tony J., Weiss, Samuel, Bhatia, Mickie
Published in Cell chemical biology (20.07.2023)
Published in Cell chemical biology (20.07.2023)
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PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma
Restall, Ian J, Parolin, Doris A E, Daneshmand, Manijeh, Hanson, Jennifer E L, Simard, Manon A, Fitzpatrick, Megan E, Kumar, Ritesh, Lavictoire, Sylvie J, Lorimer, Ian A J
Published in Cell cycle (Georgetown, Tex.) (2015)
Published in Cell cycle (Georgetown, Tex.) (2015)
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PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1
Gont, Alexander, Hanson, Jennifer E L, Lavictoire, Sylvie J, Parolin, Doris A, Daneshmand, Manijeh, Restall, Ian J, Soucie, Mathieu, Nicholas, Garth, Woulfe, John, Kassam, Amin, Da Silva, Vasco F, Lorimer, Ian A J
Published in Oncotarget (01.08.2013)
Published in Oncotarget (01.08.2013)
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Isolation and Culture of Glioblastoma Brain Tumor Stem Cells
Chesnelong, Charles, Restall, Ian, Weiss, Samuel
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2019)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2019)
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Abstract 1968: Inactivation of the tumor suppressor Lgl via PTEN loss promotes the invasiveness of glioblastoma multiforme
Gont, Alexander, Hanson, Jennifer, Soucie, Mathieu, Kassam, Amin, DaSilva, Vasco, Woulfe, John, Nicholas, Garth, Lavictoire, Sylvie, Restall, Ian, Lorimer, Ian A.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Abstract 1224: Repression of cancer cell senescence by PKCι
Restall, Ian J., Paget, Judith A., Daneshmand, Manijeh, Amin, Md. Shahrier, Islam, Shahidul, Lorimer, Ian A.J.
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leuekmia
Cole, Alicia, Wang, Zezhou, Coyaud, Etienne, Voisin, Veronique, Gronda, Marcela, Jitkova, Yulia, Mattson, Rachel, Hurren, Rose, Babovic, Sonja, Maclean, Neil, Restall, Ian, Wang, Xiaoming, Jeyaraju, Danny V., Sukhai, Mahadeo A., Prabha, Swayam, Bashir, Shaheena, Ramakrishnan, Ashwin, Leung, Elisa, Qia, Yi Hua, Zhang, Nianxian, Combes, Kevin R., Ketela, Troy, Lin, Fengshu, Houry, Walid A., Aman, Ahmed, Al-awar, Rima, Zheng, Wei, Wienholds, Erno, Xu, Chang Jiang, Dick, John, Wang, Jean C.Y., Moffat, Jason, Minden, Mark D., Eaves, Connie J., Bader, Gary D., Hao, Zhenyue, Kornblau, Steven M., Raught, Brian, Schimmer, Aaron D.
Published in Cancer cell (08.06.2015)
Published in Cancer cell (08.06.2015)
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The functional genomic circuitry of human glioblastoma stem cells
Macleod, Graham, Bozek, Danielle A, Rajakulendran, Nishani, Monteiro, Vernon, Ahmadi, Moloud, Steinhart, Zachary, Kushida, Michelle M, Yu, Helen, Coutinho, Fiona J, Restall, Ian, Hao, Xiaoguang, Hart, Traver, Luchman, H Artee, Weiss, Samuel, Dirks, Peter B, Angers, Stephane
Published in bioRxiv (28.06.2018)
Published in bioRxiv (28.06.2018)
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PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma
Restall, Ian J, Parolin, Doris A E, Daneshmand, Manijeh, Hanson, Jennifer E L, Simard, Manon A, Fitzpatrick, Megan E, Kumar, Ritesh, Lavictoire, Sylvie J, Lorimer, Ian A J
Published in Cell Cycle (17.09.2015)
Published in Cell Cycle (17.09.2015)
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