Search Results - "René Wyler" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery

MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery

by Brocklehurst, Cara E., Altmann, Eva, Bon, Corentin, Davis, Holly, Dunstan, David, Ertl, Peter, Ginsburg-Moraff, Carol, Grob, Jonathan, Gosling, Daniel J., Lapointe, Guillaume, Marziale, Alexander N., Mues, Heinrich, Palmieri, Marco, Racine, Sophie, Robinson, Richard I., Springer, Clayton, Tan, Kian, Ulmer, William, Wyler, René
Published in Journal of medicinal chemistry (08.02.2024)

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Safety screening in early drug discovery: An optimized assay panel

Safety screening in early drug discovery: An optimized assay panel

by Bendels, Stefanie, Bissantz, Caterina, Fasching, Bernhard, Gerebtzoff, Grégori, Guba, Wolfgang, Kansy, Manfred, Migeon, Jacques, Mohr, Susanne, Peters, Jens-Uwe, Tillier, Fabien, Wyler, René, Lerner, Christian, Kramer, Christian, Richter, Hans, Roberts, Sonia
Published in Journal of pharmacological and toxicological methods (01.09.2019)

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Correction to “MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery”

Correction to “MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery”

by Brocklehurst, Cara E., Altmann, Eva, André, Jérôme, Bon, Corentin, Caya, Thomas, Davis, Holly, Decoret, Odile, Dunstan, David, Ertl, Peter, Ginsburg-Moraff, Carol, Grob, Jonathan, Gosling, Daniel J., Lapointe, Guillaume, Majumdar, Dyuti, Marziale, Alexander N., Mues, Heinrich, Palmieri, Marco, Racine, Sophie, Robinson, Richard I., Springer, Clayton, Tan, Kian, Ulmer, William, West, Laura, Wyler, René
Published in Journal of medicinal chemistry (28.03.2024)

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Integrated and automated high-throughput purification of libraries on microscale

Integrated and automated high-throughput purification of libraries on microscale

by Ginsburg-Moraff, Carol, Grob, Jonathan, Chin, Karl, Eastman, Grant, Wildhaber, Sandra, Bayliss, Mark, Mues, Heinrich M., Palmieri, Marco, Poirier, Jennifer, Reck, Marcel, Luneau, Alexandre, Rodde, Stephane, Reilly, John, Wagner, Trixie, Brocklehurst, Cara E., Wyler, René, Dunstan, David, Marziale, Alexander N.
Published in SLAS technology (01.12.2022)

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Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer’s Disease

Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer’s Disease

by Borroni, Edilio, Bohrmann, Bernd, Grueninger, Fiona, Prinssen, Eric, Nave, Stephane, Loetscher, Hansruedi, Chinta, Shankar J, Rajagopalan, Subramanian, Rane, Anand, Siddiqui, Almas, Ellenbroek, Bart, Messer, Juerg, Pähler, Axel, Andersen, Julie K, Wyler, Rene, Cesura, Andrea M
Published in The Journal of pharmacology and experimental therapeutics (01.09.2017)

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Lead Generation: Sowing the Seeds for Future Success

Lead Generation: Sowing the Seeds for Future Success

by Konrad H. Bleicher, Matthias Nettekoven, Jens-Uwe Peters, René Wyler
Published in Chimia (01.09.2004)

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2-(3,4-Dihydro-1 H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

2-(3,4-Dihydro-1 H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

by Büttelmann, Bernd, Alanine, Alexander, Bourson, Anne, Gill, Ramanjit, Heitz, Marie-Paule, Mutel, Vincent, Pinard, Emmanuel, Trube, Gerhard, Wyler, René
Published in Bioorganic & medicinal chemistry letters (10.03.2003)

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1-Benzyloxy-4,5-dihydro- 1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

1-Benzyloxy-4,5-dihydro- 1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

by Alanine, Alexander, Bourson, Anne, Büttelmann, Bernd, Gill, Ramanjit, Heitz, Marie-Paule, Mutel, Vincent, Pinard, Emmanuel, Trube, Gerhard, Wyler, René
Published in Bioorganic & medicinal chemistry letters (06.10.2003)

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4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

by Pinard, Emmanuel, Alanine, Alexander, Bourson, Anne, Büttelmann, Bernd, Heitz, Marie-Paule, Mutel, a Ramanjit Gill, Vincent, Trube, Gerhard, Wyler, René
Published in Bioorganic & medicinal chemistry letters (16.09.2002)

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4-(3,4-Dihydro-1 H-isoquinolin-2yl)-pyridines and 4-(3,4-Dihydro-1 H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists

4-(3,4-Dihydro-1 H-isoquinolin-2yl)-pyridines and 4-(3,4-Dihydro-1 H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists

by Büttelmann, Bernd, Alanine, Alexander, Bourson, Anne, Gill, Ramanjit, Heitz, Marie-Paule, Mutel, Vincent, Pinard, Emmanuel, Trube, Gerhard, Wyler, René
Published in Bioorganic & medicinal chemistry letters (19.05.2003)

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Preclinical characterization of RO4602522, a novel, selective and orally active monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease

Preclinical characterization of RO4602522, a novel, selective and orally active monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease

by Borroni, Edilio, Wyler, Rene, Messer, Juergen, Nave, Stephane, Cesura, Andrea
Published in Alzheimer's & dementia (01.07.2013)

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P4–312: Preclinical characterization of RO4602522, a novel, selective and orally active monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease

P4–312: Preclinical characterization of RO4602522, a novel, selective and orally active monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease

by Borroni, Edilio, Wyler, Rene, Messer, Juergen, Nave, Stephane, Cesura, Andrea
Published in Alzheimer's & dementia (01.07.2013)

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A SYNTHETIC CAVITY ASSEMBLES THROUGH SELF-COMPLEMENTARY HYDROGEN-BONDS

A SYNTHETIC CAVITY ASSEMBLES THROUGH SELF-COMPLEMENTARY HYDROGEN-BONDS

by WYLER, R, DEMENDOZA, J, REBEK, J
Published in Angewandte Chemie International Edition (01.12.1993)

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Discovery of ( R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist

Discovery of ( R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist

by Pinard, Emmanuel, Alanine, Alexander, Bourson, Anne, Büttelmann, Bernd, Gill, Ramanjit, Heitz, Marie-Paule, Jaeschke, Georg, Mutel, Vincent, Trube, Gerhard, Wyler, René
Published in Bioorganic & medicinal chemistry letters (20.08.2001)

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2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines as potent NR1/2B subtype selective NMDA receptor antagonists

2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines as potent NR1/2B subtype selective NMDA receptor antagonists

by Buettelmann, B, Alanine, A, Bourson, A, Gill, R, Heitz, MP, Mutel, Pinard, E, Trube, G, Wyler, R
Published in Chimia (01.01.2004)

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Reversal of a Vigilance Decrement in the Aged Rat by Subtype-Selective Nicotinic Ligands

Reversal of a Vigilance Decrement in the Aged Rat by Subtype-Selective Nicotinic Ligands

by GROTTICK, Andrew J, HAMAN, Marie, WYLER, Rene, HIGGINS, Guy A
Published in Neuropsychopharmacology (01.05.2003)

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Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease

Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease

by Borroni, Edilio, Bohrmann, Bernd, Grueninger, Fiona, Prinssen, Eric, Nave, Stephane, Loetscher, Hansruedi, Chinta, Shankar J, Rajagopalan, Subramanian, Rane, Anand, Siddiqui, Almas, Ellenbroek, Bart, Messer, Juerg, Pähler, Axel, Andersen, Julie K, Wyler, Rene, Cesura, Andrea M
Published in The Journal of pharmacology and experimental therapeutics (01.09.2017)

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2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)pyridines as Potent NR1/2B Subtype Selective NMDA Receptor Antagonists

2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)pyridines as Potent NR1/2B Subtype Selective NMDA Receptor Antagonists

by Bernd Buettelmann, Alexander Alanine, Anne Bourson, Ramanjit Gill, Marie-Paule Heitz, Vincent Mutel, Emmanuel Pinard, Gerhard Trube, René Wyler
Published in Chimia (01.09.2004)

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Synthesis and rearrangement of 6H-imidazo[1,2-c]-quinazolin-5-ones

Synthesis and rearrangement of 6H-imidazo[1,2-c]-quinazolin-5-ones

by Arnold, W, Buttelmann, B, Heitz, MP, Wyler, R
Published in Heterocycles (1996)

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Replication and assembly

Replication and assembly

by Andreu, Cecilia, Beerli, René, Branda, Neil R., Conn, Morgan, de Mendoza, J., Galán, A., Huc, Ivan, Kato, Y., Tymoschenko, M., Valdez, C., Wintner, E., Wyler, R., Rebek, J.
Published in Pure and applied chemistry (01.01.1993)

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