Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice
Blaney Davidson, Esmeralda N, Remst, Dennis F. G, Vitters, Elly L, van Beuningen, Henk M, Blom, Arjen B, Goumans, Marie-Jose, van den Berg, Wim B, van der Kraan, Peter M
Published in The Journal of immunology (1950) (15.06.2009)
Published in The Journal of immunology (1950) (15.06.2009)
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TGF-ß induces Lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling
Remst, Dennis F. G, Blaney Davidson, Esmeralda N, Vitters, Elly L, Bank, Ruud A, van den Berg, Wim B, van der Kraan, Peter M
Published in Cell and tissue research (2014)
Published in Cell and tissue research (2014)
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Inhibition of SUMOylation enhances DNA hypomethylating drug efficacy to reduce outgrowth of hematopoietic malignancies
Kroonen, Jessie S., de Graaf, Ilona J., Kumar, Sumit, Remst, Dennis F. G., Wouters, Anne K., Heemskerk, Mirjam H. M., Vertegaal, Alfred C. O.
Published in Leukemia (01.04.2023)
Published in Leukemia (01.04.2023)
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Journal Article
Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure
Wachsmann, Tassilo L. A., Wouters, Anne K., Remst, Dennis F. G., Hagedoorn, Renate S., Meeuwsen, Miranda H., van Diest, Eline, Leusen, Jeanette, Kuball, Jürgen, Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.
Published in Oncoimmunology (31.12.2022)
Published in Oncoimmunology (31.12.2022)
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Journal Article
Antibody-mediated delivery of viral epitopes to redirect EBV-specific CD8+ T-cell immunity towards cancer cells
van der Wulp, Willemijn, Remst, Dennis F. G., Kester, Michel G. D., Hagedoorn, Renate S., Parren, Paul W. H. I., van Kasteren, Sander I., Schuurman, Janine, Hoeben, Rob C., Ressing, Maaike E., Bleijlevens, Boris, Heemskerk, Mirjam H. M.
Published in Cancer gene therapy (01.01.2024)
Published in Cancer gene therapy (01.01.2024)
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Journal Article
Self-sufficient primary natural killer cells engineered to express T cell receptors and interleukin-15 exhibit improved effector function and persistence
van Hees, Els P, Morton, Laura T, Remst, Dennis F G, Wouters, Anne K, Van den Eynde, Astrid, Falkenburg, J H Frederik, Heemskerk, Mirjam H M
Published in Frontiers in immunology (16.04.2024)
Published in Frontiers in immunology (16.04.2024)
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Journal Article
PRAME and CTCFL-reactive TCRs for the treatment of ovarian cancer
van Amerongen, Rosa A, Tuit, Sander, Wouters, Anne K, van de Meent, Marian, Siekman, Sterre L, Meeuwsen, Miranda H, Wachsmann, Tassilo L A, Remst, Dennis F G, Hagedoorn, Renate S, van der Steen, Dirk M, de Ru, Arnoud H, Verdegaal, Els M E, van Veelen, Peter A, Falkenburg, J H Frederik, Heemskerk, Mirjam H M
Published in Frontiers in immunology (21.03.2023)
Published in Frontiers in immunology (21.03.2023)
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Journal Article
Broadly applicable TCR-based therapy for multiple myeloma targeting the immunoglobulin J chain
Meeuwsen, Miranda H, Wouters, Anne K, Wachsmann, Tassilo L A, Hagedoorn, Renate S, Kester, Michel G D, Remst, Dennis F G, van der Steen, Dirk M, de Ru, Arnoud H, van Hees, Els P, Kremer, Martijn, Griffioen, Marieke, van Veelen, Peter A, Falkenburg, J H Frederik, Heemskerk, Mirjam H M
Published in Journal of hematology and oncology (27.02.2023)
Published in Journal of hematology and oncology (27.02.2023)
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Journal Article
T cell receptor engineering of primary NK cells to therapeutically target tumors and tumor immune evasion
Morton, Laura T, Wachsmann, Tassilo L A, Meeuwsen, Miranda H, Wouters, Anne K, Remst, Dennis F G, van Loenen, Marleen M, Falkenburg, J H Frederik, Heemskerk, Mirjam H M
Published in Journal for immunotherapy of cancer (01.03.2022)
Published in Journal for immunotherapy of cancer (01.03.2022)
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Journal Article
WT1-specific TCRs directed against newly identified peptides install antitumor reactivity against acute myeloid leukemia and ovarian carcinoma
van Amerongen, Rosa A, Hagedoorn, Renate S, Remst, Dennis F G, Assendelft, Danique C, van der Steen, Dirk M, Wouters, Anne K, van de Meent, Marian, Kester, Michel G D, de Ru, Arnoud H, Griffioen, Marieke, van Veelen, Peter A, Falkenburg, J H Frederik, Heemskerk, Mirjam H M
Published in Journal for immunotherapy of cancer (01.06.2022)
Published in Journal for immunotherapy of cancer (01.06.2022)
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Journal Article
Targeting epigenetic regulation and post-translational modification with 5-Aza-2’ deoxycytidine and SUMO E1 inhibition augments T-cell receptor therapy
Kroonen, Jessie S, Wouters, Anne K, de Graaf, Ilona J, Remst, Dennis F G, Kumar, Sumit, Wachsmann, Tassilo L A, Teunisse, Amina F A S, Roelands, Jessica P, de Miranda, Noel F C C, Griffioen, Marieke, Heemskerk, Mirjam H M, Vertegaal, Alfred C O
Published in Journal for immunotherapy of cancer (26.09.2024)
Published in Journal for immunotherapy of cancer (26.09.2024)
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Journal Article
Simultaneous Deletion of Endogenous TCRαβ for TCR Gene Therapy Creates an Improved and Safe Cellular Therapeutic
Morton, Laura T., Reijmers, Rogier M., Wouters, Anne K., Kweekel, Christiaan, Remst, Dennis F.G., Pothast, Cilia R., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.
Published in Molecular therapy (08.01.2020)
Published in Molecular therapy (08.01.2020)
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A broad and systematic approach to identify B cell malignancy-targeting TCRs for multi-antigen-based T cell therapy
Meeuwsen, Miranda H., Wouters, Anne K., Jahn, Lorenz, Hagedoorn, Renate S., Kester, Michel G.D., Remst, Dennis F.G., Morton, Laura T., van der Steen, Dirk M., Kweekel, Christiaan, de Ru, Arnoud H., Griffioen, Marieke, van Veelen, Peter A., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.
Published in Molecular therapy (02.02.2022)
Published in Molecular therapy (02.02.2022)
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Journal Article
Cutting Edge: Unconventional CD8 + T Cell Recognition of a Naturally Occurring HLA-A02:01-Restricted 20mer Epitope
Meeuwsen, Miranda H, Wouters, Anne K, Hagedoorn, Renate S, Kester, Michel G D, Remst, Dennis F G, van der Steen, Dirk M, de Ru, Arnoud, van Veelen, Peter A, Rossjohn, Jamie, Gras, Stephanie, Falkenburg, J H Frederik, Heemskerk, Mirjam H M
Published in The Journal of immunology (1950) (15.04.2022)
Published in The Journal of immunology (1950) (15.04.2022)
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Combining BCMA-targeting CAR T cells with TCR-engineered T-cell therapy to prevent immune escape of multiple myeloma
Wachsmann, Tassilo L. A., Meeuwsen, Miranda H., Remst, Dennis F. G., Buchner, Karen, Wouters, Anne K., Hagedoorn, Renate S., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.
Published in Blood advances (24.10.2023)
Published in Blood advances (24.10.2023)
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Journal Article
Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential
van Amerongen, Rosa A., Morton, Laura T., Chaudhari, Umesh G., Remst, Dennis F.G., Hagedoorn, Renate S., van den Berg, Cathelijne W., Freund, Christian, Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.
Published in Molecular therapy. Methods & clinical development (09.03.2023)
Published in Molecular therapy. Methods & clinical development (09.03.2023)
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Journal Article
A library of cancer testis specific T cell receptors for T cell receptor gene therapy
de Rooij, Marije A.J., Remst, Dennis F.G., van der Steen, Dirk M., Wouters, Anne K., Hagedoorn, Renate S., Kester, Michel G.D., Meeuwsen, Miranda H., Wachsmann, Tassilo L.A., de Ru, Arnoud H., van Veelen, Peter A., Verdegaal, Els M.E., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.
Published in Molecular therapy. Oncolytics (16.03.2023)
Published in Molecular therapy. Oncolytics (16.03.2023)
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Journal Article
An HLA-A11:01-Binding Neoantigen from Mutated NPM1 as Target for TCR Gene Therapy in AML
van der Lee, Dyantha I, Koutsoumpli, Georgia, Reijmers, Rogier M, Honders, M Willy, de Jong, Rob C M, Remst, Dennis F G, Wachsmann, Tassilo L A, Hagedoorn, Renate S, Franken, Kees L M C, Kester, Michel G D, Harber, Karl J, Roelofsen, Lisanne M, Schouten, Annemiek M, Mulder, Arend, Drijfhout, Jan W, Veelken, Hendrik, van Veelen, Peter A, Heemskerk, Mirjam H M, Falkenburg, J H Frederik, Griffioen, Marieke
Published in Cancers (27.10.2021)
Published in Cancers (27.10.2021)
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Journal Article
Combining BCMA-targeting CAR-T with TCR-engineered T-cell therapy to prevent immune escape of multiple myeloma
Wachsmann, Tassilo L A, Meeuwsen, Miranda H, Remst, Dennis F G, Buchner, Karen, Wouters, Anne K, Hagedoorn, Renate, Falkenburg, J H Frederik, Heemskerk, Mirjam H M
Published in Blood advances (11.08.2023)
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Published in Blood advances (11.08.2023)
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