Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release
Foster, Daniel J., Wilson, Jermaine M., Remke, Daniel H., Mahmood, M. Suhaib, Uddin, M. Jashim, Wess, Jürgen, Patel, Sachin, Marnett, Lawrence J., Niswender, Colleen M., Jones, Carrie K., Xiang, Zixiu, Lindsley, Craig W., Rook, Jerri M., Conn, P. Jeffrey
Published in Neuron (Cambridge, Mass.) (21.09.2016)
Published in Neuron (Cambridge, Mass.) (21.09.2016)
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M 1 -positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition
Moran, Sean P, Dickerson, Jonathan W, Cho, Hyekyung P, Xiang, Zixiu, Maksymetz, James, Remke, Daniel H, Lv, Xiaohui, Doyle, Catherine A, Rajan, Deepa H, Niswender, Colleen M, Engers, Darren W, Lindsley, Craig W, Rook, Jerri M, Conn, P Jeffrey
Published in Neuropsychopharmacology (New York, N.Y.) (01.07.2018)
Published in Neuropsychopharmacology (New York, N.Y.) (01.07.2018)
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Journal Article
M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition
Moran, Sean P., Dickerson, Jonathan W., Cho, Hyekyung P., Xiang, Zixiu, Maksymetz, James, Remke, Daniel H., Lv, Xiaohui, Doyle, Catherine A., Rajan, Deepa H., Niswender, Colleen M., Engers, Darren W., Lindsley, Craig W., Rook, Jerri M., Conn, P. Jeffrey
Published in Neuropsychopharmacology (New York, N.Y.) (01.07.2018)
Published in Neuropsychopharmacology (New York, N.Y.) (01.07.2018)
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Journal Article
Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M 4 Muscarinic Receptor
Moehle, Mark S, Pancani, Tristano, Byun, Nellie, Yohn, Samantha E, Wilson, 3rd, George H, Dickerson, Johnathan W, Remke, Daniel H, Xiang, Zixiu, Niswender, Colleen M, Wess, Jürgen, Jones, Carrie K, Lindsley, Craig W, Rook, Jerri M, Conn, P Jeffrey
Published in Neuron (Cambridge, Mass.) (20.12.2017)
Published in Neuron (Cambridge, Mass.) (20.12.2017)
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Journal Article
Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M4 Muscarinic Receptor
Moehle, Mark S., Pancani, Tristano, Byun, Nellie, Yohn, Samantha E., Wilson, George H., Dickerson, Johnathan W., Remke, Daniel H., Xiang, Zixiu, Niswender, Colleen M., Wess, Jürgen, Jones, Carrie K., Lindsley, Craig W., Rook, Jerri M., Conn, P. Jeffrey
Published in Neuron (Cambridge, Mass.) (20.12.2017)
Published in Neuron (Cambridge, Mass.) (20.12.2017)
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A Novel M 1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity
Rook, Jerri M, Bertron, Jeanette L, Cho, Hyekyung P, Garcia-Barrantes, Pedro M, Moran, Sean P, Maksymetz, James T, Nance, Kellie D, Dickerson, Jonathan W, Remke, Daniel H, Chang, Sichen, Harp, Joel M, Blobaum, Anna L, Niswender, Colleen M, Jones, Carrie K, Stauffer, Shaun R, Conn, P Jeffrey, Lindsley, Craig W
Published in ACS chemical neuroscience (19.09.2018)
Published in ACS chemical neuroscience (19.09.2018)
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PF-06827443 Displays Robust Allosteric Agonist and Positive Allosteric Modulator Activity in High Receptor Reserve and Native Systems
Moran, Sean P, Cho, Hyekyung P, Maksymetz, James, Remke, Daniel H, Hanson, Ryan M, Niswender, Colleen M, Lindsley, Craig W, Rook, Jerri M, Conn, P. Jeffrey
Published in ACS chemical neuroscience (19.09.2018)
Published in ACS chemical neuroscience (19.09.2018)
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Journal Article
Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs
Rook, Jerri M, Abe, Masahito, Cho, Hyekyung P, Nance, Kellie D, Luscombe, Vincent B, Adams, Jeffrey J, Dickerson, Jonathan W, Remke, Daniel H, Garcia-Barrantes, Pedro M, Engers, Darren W, Engers, Julie L, Chang, Sichen, Foster, Jarrett J, Blobaum, Anna L, Niswender, Colleen M, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W
Published in ACS chemical neuroscience (19.04.2017)
Published in ACS chemical neuroscience (19.04.2017)
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VU6010608, a Novel mGlu7 NAM from a Series of N‑(2-(1H‑1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides
Reed, Carson W, McGowan, Kevin M, Spearing, Paul K, Stansley, Branden J, Roenfanz, Hanna F, Engers, Darren W, Rodriguez, Alice L, Engelberg, Eileen M, Luscombe, Vincent B, Loch, Matthew T, Remke, Daniel H, Rook, Jerri M, Blobaum, Anna L, Conn, P. Jeffrey, Niswender, Colleen M, Lindsley, Craig W
Published in ACS medicinal chemistry letters (14.12.2017)
Published in ACS medicinal chemistry letters (14.12.2017)
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Journal Article
Antipsychotic-like Effects of M 4 Positive Allosteric Modulators Are Mediated by CB 2 Receptor-Dependent Inhibition of Dopamine Release
Foster, Daniel J., Wilson, Jermaine M., Remke, Daniel H., Mahmood, M. Suhaib, Uddin, M. Jashim, Wess, Jürgen, Patel, Sachin, Marnett, Lawrence J., Niswender, Colleen M., Jones, Carrie K., Xiang, Zixiu, Lindsley, Craig W., Rook, Jerri M., Conn, P. Jeffrey
Published in Neuron (Cambridge, Mass.) (01.09.2016)
Published in Neuron (Cambridge, Mass.) (01.09.2016)
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Journal Article
A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity
Rook, Jerri M, Bertron, Jeanette L, Cho, Hyekyung P, Garcia-Barrantes, Pedro M, Moran, Sean P, Maksymetz, James T, Nance, Kellie D, Dickerson, Jonathan W, Remke, Daniel H, Chang, Sichen, Harp, Joel M, Blobaum, Anna L, Niswender, Colleen M, Jones, Carrie K, Stauffer, Shaun R, Conn, P. Jeffrey, Lindsley, Craig W
Published in ACS chemical neuroscience (19.09.2018)
Published in ACS chemical neuroscience (19.09.2018)
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Journal Article
VU6010608, a Novel mGlu 7 NAM from a Series of N -(2-(1 H -1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides
Reed, Carson W, McGowan, Kevin M, Spearing, Paul K, Stansley, Branden J, Roenfanz, Hanna F, Engers, Darren W, Rodriguez, Alice L, Engelberg, Eileen M, Luscombe, Vincent B, Loch, Matthew T, Remke, Daniel H, Rook, Jerri M, Blobaum, Anna L, Conn, P Jeffrey, Niswender, Colleen M, Lindsley, Craig W
Published in ACS medicinal chemistry letters (14.12.2017)
Published in ACS medicinal chemistry letters (14.12.2017)
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Journal Article
Cholinergic projections to the substantia nigra reticulata inhibit dopamine modulation of basal ganglia through the M4 muscarinic receptor
Moehle, Mark S., Pancani, Tristano, Byun, Nellie, Yohn, Samantha E., Wilson, George H., Dickerson, Johnathan W., Remke, Daniel H., Xiang, Zixiu, Niswender, Colleen M., Wess, Jurgen, Jones, Carrie K., Lindsley, Craig W., Rook, Jerri M., Conn, P. Jeffrey
Published in Neuron (Cambridge, Mass.) (20.12.2017)
Published in Neuron (Cambridge, Mass.) (20.12.2017)
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Journal Article
Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M4Muscarinic Receptor
Moehle, Mark S, Tristano Pancani, Byun, Nellie, Yohn, Samantha E, Wilson, George H, Dickerson, Johnathan W, Remke, Daniel H, Xiang, Zixiu, Niswender, Colleen M, Wess, Jürgen, Jones, Carrie K, Lindsley, Craig W, Rook, Jerri M, Conn, P Jeffrey
Published in Neuron (Cambridge, Mass.) (20.12.2017)
Published in Neuron (Cambridge, Mass.) (20.12.2017)
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Journal Article
Antipsychotic-like Effects of M4Positive Allosteric Modulators Are Mediated by CB2Receptor-Dependent Inhibition of Dopamine Release
Foster, Daniel J, Wilson, Jermaine M, Remke, Daniel H, Mahmood, M Suhaib, Uddin, M Jashim, Wess, Jürgen, Patel, Sachin, Marnett, Lawrence J, Niswender, Colleen M, Jones, Carrie K, Xiang, Zixiu, Lindsley, Craig W, Rook, Jerri M, Conn, P Jeffrey
Published in Neuron (Cambridge, Mass.) (21.09.2016)
Published in Neuron (Cambridge, Mass.) (21.09.2016)
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Journal Article
Antipsychotic-like effects of M4 positive allosteric modulators are mediated by CB2 cannabinoid receptor-dependent inhibition of dopamine release
Foster, Daniel J., Wilson, Jermaine M., Remke, Daniel H., Muhammad, M. Suhaib, Uddin, M. Jashim, Wess, Jürgen, Patel, Sachin, Marnett, Lawrence J., Niswender, Colleen M., Jones, Carrie K., Xiang, Zixiu, Lindsley, Craig W., Rook, Jerri M., Conn, P. Jeffrey
Published in Neuron (Cambridge, Mass.) (08.09.2016)
Published in Neuron (Cambridge, Mass.) (08.09.2016)
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Journal Article
VU6010608, a Novel mGlu(7) NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides
Reed, Carson W., McGowan, Kevin M., Spearing, Paul K., Stansley, Branden J., Roenfanz, Hanna F., Engers, Darren W., Rodriguez, Alice L., Engelberg, Eileen M., Luscombe, Vincent B., Loch, Matthew T., Remke, Daniel H., Rook, Jerri M., Blobaum, Anna L., Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W.
Published in ACS medicinal chemistry letters (01.12.2017)
Published in ACS medicinal chemistry letters (01.12.2017)
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Journal Article