Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666
Duncan, Kenneth W, Rioux, Nathalie, Boriack-Sjodin, P. Ann, Munchhof, Michael J, Reiter, Lawrence A, Majer, Christina R, Jin, Lei, Johnston, L. Danielle, Chan-Penebre, Elayne, Kuplast, Kristy G, Porter Scott, Margaret, Pollock, Roy M, Waters, Nigel J, Smith, Jesse J, Moyer, Mikel P, Copeland, Robert A, Chesworth, Richard
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
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Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation
Matthews, Erin E, Thévenin, Damien, Rogers, Julia M, Gotow, Lisa, Lira, Paul D, Reiter, Lawrence A, Brissette, William H, Engelman, Donald M
Published in The FASEB journal (01.07.2011)
Published in The FASEB journal (01.07.2011)
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An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer
Shah, Manisha, Huang, Dexing, Blick, Tony, Connor, Andrea, Reiter, Lawrence A, Hardink, Joel R, Lynch, Conor C, Waltham, Mark, Thompson, Erik W
Published in PloS one (11.01.2012)
Published in PloS one (11.01.2012)
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Journal Article
Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs
Golder, Matthew R, Liu, Jenny, Andersen, Jannik N, Shipitsin, Michail V, Vohidov, Farrukh, Nguyen, Hung V-T, Ehrlich, Deborah C, Huh, Sung Jin, Vangamudi, Bhavatarini, Economides, Kyriakos D, Neenan, Allison M, Ackley, James C, Baddour, Joelle, Paramasivan, Sattanathan, Brady, Samantha W, Held, Eric J, Reiter, Lawrence A, Saucier-Sawyer, Jennifer K, Kopesky, Paul W, Chickering, Donald E, Blume-Jensen, Peter, Johnson, Jeremiah A
Published in Nature biomedical engineering (01.11.2018)
Published in Nature biomedical engineering (01.11.2018)
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Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities
Vohidov, Farrukh, Andersen, Jannik N, Economides, Kyriakos D, Shipitsin, Michail V, Burenkova, Olga, Ackley, James C, Vangamudi, Bhavatarini, Nguyen, Hung V.-T, Gallagher, Nolan M, Shieh, Peyton, Golder, Matthew R, Liu, Jenny, Dahlberg, William K, Ehrlich, Deborah J. C, Kim, Julie, Kristufek, Samantha L, Huh, Sung Jin, Neenan, Allison M, Baddour, Joelle, Paramasivan, Sattanathan, de Stanchina, Elisa, KC, Gaurab, Turnquist, David J, Saucier-Sawyer, Jennifer K, Kopesky, Paul W, Brady, Samantha W, Jessel, Michael J, Reiter, Lawrence A, Chickering, Donald E, Johnson, Jeremiah A, Blume-Jensen, Peter
Published in Journal of the American Chemical Society (31.03.2021)
Published in Journal of the American Chemical Society (31.03.2021)
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Correction to Discovery of the Hemifumarate and (α‑l‑Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole: Prodrugs for the Enolic OH Group
Robinson, Ralph P, Reiter, Lawrence A, Barth, Wayne E, Campeta, Anthony M, Cooper, Kelvin, Cronin, Brian J, Destito, Rosalina, Donahue, Kathleen M, Falkner, Fred C, Fiese, Eugene F, Johnson, Diane L, Kuperman, Alexander V, Liston, Theodore E, Malloy, Deborah, Martin, John J, Mitchell, David Y, Rusek, Frank W, Shamblin, Sheri L, Wright, Charles F
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Journal Article
Discovery of the Hemifumarate and (α-l-Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole: Prodrugs for the Enolic OH Group
Robinson, Ralph P, Reiter, Lawrence A, Barth, Wayne E, Campeta, Anthony M, Cooper, Kelvin, Cronin, Brian J, Destito, Rosalina, Donahue, Kathleen M, Falkner, Fred C, Fiese, Eugene F, Johnson, Diane L, Kuperman, Alexander V, Liston, Theodore E, Malloy, Deborah, Martin, John J, Mitchell, David Y, Rusek, Frank W, Shamblin, Sheri L, Wright, Charles F
Published in Journal of medicinal chemistry (05.01.1996)
Published in Journal of medicinal chemistry (05.01.1996)
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A Rational Chemical Intervention Strategy To Circumvent Bioactivation Liabilities Associated with a Nonpeptidyl Thrombopoietin Receptor Agonist Containing a 2-Amino-4-arylthiazole Motif
Kalgutkar, Amit S, Driscoll, James, Zhao, Sabrina X, Walker, Gregory S, Shepard, Richard M, Soglia, John R, Atherton, James, Yu, Linning, Mutlib, Abdul E, Munchhof, Michael J, Reiter, Lawrence A, Jones, Christopher S, Doty, Johnathan L, Trevena, Kristen A, Shaffer, Christopher L, Ripp, Sharon L
Published in Chemical research in toxicology (01.12.2007)
Published in Chemical research in toxicology (01.12.2007)
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Publisher Correction: Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs
Golder, Matthew R, Liu, Jenny, Andersen, Jannik N, Shipitsin, Michail V, Vohidov, Farrukh, Nguyen, Hung V-T, Ehrlich, Deborah C, Huh, Sung Jin, Vangamudi, Bhavatarini, Economides, Kyriakos D, Neenan, Allison M, Ackley, James C, Baddour, Joelle, Paramasivan, Sattanathan, Brady, Samantha W, Held, Eric J, Reiter, Lawrence A, Saucier-Sawyer, Jennifer K, Kopesky, Paul W, Chickering, Donald E, Blume-Jensen, Peter, Johnson, Jeremiah A
Published in Nature biomedical engineering (01.09.2018)
Published in Nature biomedical engineering (01.09.2018)
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Structure–activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor
Antipas, Amy S., Blumberg, Laura C., Brissette, William H., Brown, Matthew F., Casavant, Jeffrey M., Doty, Jonathan L., Driscoll, James, Harris, Thomas M., Jones, Christopher S., McCurdy, Sandra P., McElroy, Eric, Mitton-Fry, Mark, Munchhof, Michael J., Reim, David A., Reiter, Lawrence A., Ripp, Sharon L., Shavnya, Andrei, Smeets, Marc I., Trevena, Kristen A.
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
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Journal Article
Potent, selective pyrimidinetrione-based inhibitors of MMP-13
Reiter, Lawrence A., Freeman-Cook, Kevin D., Jones, Christopher S., Martinelli, Gary J., Antipas, Amy S., Berliner, Martin A., Datta, Kaushik, Downs, James T., Eskra, James D., Forman, Michael D., Greer, Elaine M., Guzman, Roberto, Hardink, Joel R., Janat, Fouad, Keene, Nandell F., Laird, Ellen R., Liras, Jennifer L., Lopresti-Morrow, Lori L., Mitchell, Peter G., Pandit, Jayvardhan, Robertson, Donald, Sperger, Diana, Vaughn-Bowser, Marcie L., Waller, Darra M., Yocum, Sue A.
Published in Bioorganic & medicinal chemistry letters (15.11.2006)
Published in Bioorganic & medicinal chemistry letters (15.11.2006)
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Journal Article
Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists
Reiter, Lawrence A., Jones, Christopher S., Brissette, William H., McCurdy, Sandra P., Abramov, Yuriy A., Bordner, Jon, DiCapua, Frank M., Munchhof, Michael J., Rescek, Diane M., Samardjiev, Ivan J., Withka, Jane M.
Published in Bioorganic & medicinal chemistry (01.05.2008)
Published in Bioorganic & medicinal chemistry (01.05.2008)
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Journal Article
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14
Blagg, Julian A., Noe, Mark C., Wolf-Gouveia, Lilli A., Reiter, Lawrence A., Laird, Ellen R., Chang, Shang-Poa P., Danley, Dennis E., Downs, James T., Elliott, Nancy C., Eskra, James D., Griffiths, Richard J., Hardink, Joel R., Haugeto, Amber I., Jones, Christopher S., Liras, Jennifer L., Lopresti-Morrow, Lori L., Mitchell, Peter G., Pandit, Jayvardhan, Robinson, Ralph P., Subramanyam, Chakrapani, Vaughn-Bowser, Marcie L., Yocum, Sue A.
Published in Bioorganic & medicinal chemistry letters (01.04.2005)
Published in Bioorganic & medicinal chemistry letters (01.04.2005)
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Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13
Freeman-Cook, Kevin D., Reiter, Lawrence A., Noe, Mark C., Antipas, Amy S., Danley, Dennis E., Datta, Kaushik, Downs, James T., Eisenbeis, Shane, Eskra, James D., Garmene, David J., Greer, Elaine M., Griffiths, Richard J., Guzman, Roberto, Hardink, Joel R., Janat, Fouad, Jones, Christopher S., Martinelli, Gary J., Mitchell, Peter G., Laird, Ellen R., Liras, Jennifer L., Lopresti-Morrow, Lori L., Pandit, Jayvardhan, Reilly, Usa D., Robertson, Donald, Vaughn-Bowser, Marcie L., Wolf-Gouviea, Lilli A., Yocum, Sue A.
Published in Bioorganic & medicinal chemistry (01.12.2007)
Published in Bioorganic & medicinal chemistry (01.12.2007)
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Journal Article
Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1
Reiter, Lawrence A., Robinson, Ralph P., McClure, Kim F., Jones, Christopher S., Reese, Matthew R., Mitchell, Peter G., Otterness, Ivan G., Bliven, Marcia L., Liras, Jennifer, Cortina, Santo R., Donahue, Kathleen M., Eskra, James D., Griffiths, Richard J., Lame, Mary E., Lopez-Anaya, Arturo, Martinelli, Gary J., McGahee, Shunda M., Yocum, Sue A., Lopresti-Morrow, Lori L., Tobiassen, Lisa M., Vaughn-Bowser, Marcie L.
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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Journal Article
The identification of orally bioavailable thrombopoietin agonists
Munchhof, Michael J., Antipas, Amy S., Blumberg, Laura C., Brissette, William H., Brown, Matthew F., Casavant, Jeffrey M., Doty, Jonathan L., Driscoll, James, Harris, Thomas M., Wolf-Gouveia, Lilli A., Jones, Christopher S., Li, Qifang, Linde, Robert G., Lira, Paul D., Marfat, Anthony, McElroy, Eric, Mitton-Fry, Mark, McCurdy, Sandra P., Reiter, Lawrence A., Ripp, Sharon L., Shavnya, Andrei, Thomasco, Lisa M., Trevena, Kristen A.
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
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Journal Article
Pyrimidine benzamide-based thrombopoietin receptor agonists
Reiter, Lawrence A., Subramanyam, Chakrapani, Mangual, Emilio J., Jones, Christopher S., Smeets, Marc I., Brissette, William H., McCurdy, Sandra P., Lira, Paul D., Linde, Robert G., Li, Qifang, Zhang, Fangning, Antipas, Amy S., Blumberg, Laura C., Doty, Jonathan L., Driscoll, James P., Munchhof, Michael J., Ripp, Sharon L., Shavnya, Andrei, Shepard, Richard M., Sperger, Diana, Thomasco, Lisa M., Trevena, Kristen A., Wolf-Gouveia, Lilli A., Zhang, Liling
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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