Light-controlled modulation of gene expression by chemical optoepigenetic probes
Reis, Surya A, Ghosh, Balaram, Hendricks, J Adam, Szantai-Kis, D Miklos, Törk, Lisa, Ross, Kenneth N, Lamb, Justin, Read-Button, Willis, Zheng, Baixue, Wang, Hongtao, Salthouse, Christopher, Haggarty, Stephen J, Mazitschek, Ralph
Published in Nature chemical biology (01.05.2016)
Published in Nature chemical biology (01.05.2016)
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Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
Rosenthal, Zachary C, Fass, Daniel M, Payne, N Connor, She, Angela, Patnaik, Debasis, Hennig, Krista M, Tesla, Rachel, Werthmann, Gordon C, Guhl, Charlotte, Reis, Surya A, Wang, Xiaoyu, Chen, Yueting, Placzek, Michael, Williams, Noelle S, Hooker, Jacob, Herz, Joachim, Mazitschek, Ralph, Haggarty, Stephen J
Published in Scientific reports (20.04.2024)
Published in Scientific reports (20.04.2024)
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TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling
Martin, Pauline, Wagh, Vilas, Reis, Surya A, Erdin, Serkan, Beauchamp, Roberta L, Shaikh, Ghalib, Talkowski, Michael, Thiele, Elizabeth, Sheridan, Steven D, Haggarty, Stephen J, Ramesh, Vijaya
Published in Molecular autism (06.01.2020)
Published in Molecular autism (06.01.2020)
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High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy
Cheng, Chialin, Reis, Surya A., Adams, Emily T., Fass, Daniel M., Angus, Steven P., Stuhlmiller, Timothy J., Richardson, Jared, Olafson, Hailey, Wang, Eric T., Patnaik, Debasis, Beauchamp, Roberta L., Feldman, Danielle A., Silva, M. Catarina, Sur, Mriganka, Johnson, Gary L., Ramesh, Vijaya, Miller, Bruce L., Temple, Sally, Kosik, Kenneth S., Dickerson, Bradford C., Haggarty, Stephen J.
Published in Scientific reports (23.08.2021)
Published in Scientific reports (23.08.2021)
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Journal Article
Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability
Lalonde, Jasmin, Reis, Surya A, Sivakumaran, Sudhir, Holland, Carl S, Wesseling, Hendrik, Sauld, John F, Alural, Begum, Zhao, Wen-Ning, Steen, Judith A, Haggarty, Stephen J
Published in Nature communications (21.11.2017)
Published in Nature communications (21.11.2017)
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Journal Article
Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin
Fass, Daniel M, Shah, Rishita, Ghosh, Balaram, Hennig, Krista, Norton, Stephanie, Zhao, Wen-Ning, Reis, Surya A, Klein, Peter S, Mazitschek, Ralph, Maglathlin, Rebecca L, Lewis, Timothy A, Haggarty, Stephen J
Published in ACS medicinal chemistry letters (13.01.2011)
Published in ACS medicinal chemistry letters (13.01.2011)
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Journal Article
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy
Hernandez, Israel, Luna, Gabriel, Rauch, Jennifer N, Reis, Surya A, Giroux, Michel, Karch, Celeste M, Boctor, Daniel, Sibih, Youssef E, Storm, Nadia J, Diaz, Antonio, Kaushik, Susmita, Zekanowski, Cezary, Kang, Alexander A, Hinman, Cassidy R, Cerovac, Vesna, Guzman, Elmer, Zhou, Honjun, Haggarty, Stephen J, Goate, Alison M, Fisher, Steven K, Cuervo, Ana M, Kosik, Kenneth S
Published in Science translational medicine (27.03.2019)
Published in Science translational medicine (27.03.2019)
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Journal Article
Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia
She, Angela, Kurtser, Iren, Reis, Surya A., Hennig, Krista, Lai, Jenny, Lang, Audrey, Zhao, Wen-Ning, Mazitschek, Ralph, Dickerson, Bradford C., Herz, Joachim, Haggarty, Stephen J.
Published in Cell chemical biology (20.07.2017)
Published in Cell chemical biology (20.07.2017)
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Journal Article
Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery
Bernard-Gauthier, Vadim, Mossine, Andrew V, Knight, Ashley, Patnaik, Debasis, Zhao, Wen-Ning, Cheng, Chialin, Krishnan, Hema S, Xuan, Lucius L, Chindavong, Peter S, Reis, Surya A, Chen, Jinshan Michael, Shao, Xia, Stauff, Jenelle, Arteaga, Janna, Sherman, Phillip, Salem, Nicolas, Bonsall, David, Amaral, Brenda, Varlow, Cassis, Wells, Lisa, Martarello, Laurent, Patel, Shil, Liang, Steven H, Kurumbail, Ravi G, Haggarty, Stephen J, Scott, Peter J. H, Vasdev, Neil
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
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Journal Article
Monoalkoxy BODIPYsA Fluorophore Class for Bioimaging
Courtis, Alexandra M, Santos, Sofia A, Guan, Yinghua, Hendricks, J. Adam, Ghosh, Balaram, Szantai-Kis, D. Miklos, Reis, Surya A, Shah, Jagesh V, Mazitschek, Ralph
Published in Bioconjugate chemistry (18.06.2014)
Published in Bioconjugate chemistry (18.06.2014)
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Journal Article
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors
Wagner, Florence F., Weïwer, Michel, Steinbacher, Stefan, Schomburg, Adrian, Reinemer, Peter, Gale, Jennifer P., Campbell, Arthur J., Fisher, Stewart L., Zhao, Wen-Ning, Reis, Surya A., Hennig, Krista M., Thomas, Méryl, Müller, Peter, Jefson, Martin R., Fass, Daniel M., Haggarty, Stephen J., Zhang, Yan-Ling, Holson, Edward B.
Published in Bioorganic & medicinal chemistry (15.09.2016)
Published in Bioorganic & medicinal chemistry (15.09.2016)
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Journal Article
An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors
Marcaurelle, Lisa A, Comer, Eamon, Dandapani, Sivaraman, Duvall, Jeremy R, Gerard, Baudouin, Kesavan, Sarathy, Lee, Maurice D, Liu, Haibo, Lowe, Jason T, Marie, Jean-Charles, Mulrooney, Carol A, Pandya, Bhaumik A, Rowley, Ann, Ryba, Troy D, Suh, Byung-Chul, Wei, Jingqiang, Young, Damian W, Akella, Lakshmi B, Ross, Nathan T, Zhang, Yan-Ling, Fass, Daniel M, Reis, Surya A, Zhao, Wen-Ning, Haggarty, Stephen J, Palmer, Michelle, Foley, Michael A
Published in Journal of the American Chemical Society (01.12.2010)
Published in Journal of the American Chemical Society (01.12.2010)
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Journal Article
Dissecting structure–activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation
Ghosh, Balaram, Zhao, Wen-Ning, Reis, Surya A., Patnaik, Debasis, Fass, Daniel M., Tsai, Li-Huei, Mazitschek, Ralph, Haggarty, Stephen J.
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
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Journal Article
Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity
Fass, Daniel M., Reis, Surya A., Ghosh, Balaram, Hennig, Krista M., Joseph, Nadine F., Zhao, Wen-Ning, Nieland, Thomas J.F., Guan, Ji-Song, Groves Kuhnle, Chelsea E., Tang, Weiping, Barker, Douglas D., Mazitschek, Ralph, Schreiber, Stuart L., Tsai, Li-Huei, Haggarty, Stephen J.
Published in Neuropharmacology (01.01.2013)
Published in Neuropharmacology (01.01.2013)
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Journal Article
Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling
Garza, Jacob C, Qi, Xiaoli, Gjeluci, Klaudio, Leussis, Melanie P, Basu, Himanish, Reis, Surya A, Zhao, Wen Ning, Piguel, Nicolas H, Penzes, Peter, Haggarty, Stephen J, Martens, Gerard J, Poelmans, Geert, Petryshen, Tracey L
Published in Translational psychiatry (25.07.2018)
Published in Translational psychiatry (25.07.2018)
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Journal Article
Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis
REIS, Surya A, THOMPSON, Morgan N, MACDONALD, Marcy E, SIK SEONG, Ihn, LEE, Jong-Min, FOSSALE, Elisa, KIM, Hyung-Hwan, LIAO, James K, MOSKOWITZ, Michael A, SHAW, Stanley Y, LINDA DONG, HAGGARTY, Stephen J
Published in Human molecular genetics (15.06.2011)
Published in Human molecular genetics (15.06.2011)
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An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration
Petcherski, Anton, Chandrachud, Uma, Butz, Elisabeth S, Klein, Madeleine C, Zhao, Wen-Ning, Reis, Surya A, Haggarty, Stephen J, Ruonala, Mika O, Cotman, Susan L
Published in Cells (Basel, Switzerland) (27.11.2019)
Published in Cells (Basel, Switzerland) (27.11.2019)
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Journal Article
Isolation of mouse neuritic mRNAs
Reis, Surya A, Oostra, Ben A, Willemsen, Rob
Published in Journal of Molecular Histology (01.01.2006)
Published in Journal of Molecular Histology (01.01.2006)
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Journal Article
Prospects of TAT-mediated protein therapy for fragile X syndrome
Reis, Surya A, Willemsen, Rob, van Unen, Leontine, Hoogeveen, Andre T, Oostra, Ben A
Published in Journal of molecular histology (01.05.2004)
Published in Journal of molecular histology (01.05.2004)
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Journal Article
Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin
Fass, Daniel M, Shah, Rishita, Ghosh, Balaram, Hennig, Krista, Norton, Stephanie, Zhao, Wen-Ning, Reis, Surya A, Klein, Peter S, Mazitschek, Ralph, Maglathlin, Rebecca L, Lewis, Timothy A, Haggarty, Stephen J
Published in ACS medicinal chemistry letters (08.10.2010)
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Published in ACS medicinal chemistry letters (08.10.2010)
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