An Optimized Approach for Serial Crystallography Using Chips
Galchenkova, Marina, Rahmani Mashhour, Aida, Reinke, Patrick Y. A., Günther, Sebastian, Meyer, Jan, Chapman, Henry N., Yefanov, Oleksandr M.
Published in Crystals (Basel) (01.08.2023)
Published in Crystals (Basel) (01.08.2023)
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Journal Article
Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia
Latham, Sharissa L., Ehmke, Nadja, Reinke, Patrick Y. A., Taft, Manuel H., Eicke, Dorothee, Reindl, Theresia, Stenzel, Werner, Lyons, Michael J., Friez, Michael J., Lee, Jennifer A., Hecker, Ramona, Frühwald, Michael C., Becker, Kerstin, Neuhann, Teresa M., Horn, Denise, Schrock, Evelin, Niehaus, Indra, Sarnow, Katharina, Grützmann, Konrad, Gawehn, Luzie, Klink, Barbara, Rump, Andreas, Chaponnier, Christine, Figueiredo, Constanca, Knöfler, Ralf, Manstein, Dietmar J., Di Donato, Nataliya
Published in Nature communications (12.10.2018)
Published in Nature communications (12.10.2018)
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Structural and Biochemical Characterization of a Dye-Decolorizing Peroxidase from Dictyostelium discoideum
Rai, Amrita, Klare, Johann P., Reinke, Patrick Y. A., Englmaier, Felix, Fohrer, Jörg, Fedorov, Roman, Taft, Manuel H., Chizhov, Igor, Curth, Ute, Plettenburg, Oliver, Manstein, Dietmar J.
Published in International journal of molecular sciences (10.06.2021)
Published in International journal of molecular sciences (10.06.2021)
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Journal Article
Hydrazones and Thiosemicarbazones Targeting Protein-Protein-Interactions of SARS-CoV-2 Papain-like Protease
Ewert, Wiebke, Günther, Sebastian, Miglioli, Francesca, Falke, Sven, Reinke, Patrick Y A, Niebling, Stephan, Günther, Christian, Han, Huijong, Srinivasan, Vasundara, Brognaro, Hévila, Lieske, Julia, Lorenzen, Kristina, Garcia-Alai, Maria M, Betzel, Christian, Carcelli, Mauro, Hinrichs, Winfried, Rogolino, Dominga, Meents, Alke
Published in Frontiers in chemistry (11.04.2022)
Published in Frontiers in chemistry (11.04.2022)
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Author Correction: Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia
Latham, Sharissa L., Ehmke, Nadja, Reinke, Patrick Y. A., Taft, Manuel H., Eicke, Dorothee, Reindl, Theresia, Stenzel, Werner, Lyons, Michael J., Friez, Michael J., Lee, Jennifer A., Hecker, Ramona, Frühwald, Michael C., Becker, Kerstin, Neuhann, Teresa M., Horn, Denise, Schrock, Evelin, Niehaus, Indra, Sarnow, Katharina, Grützmann, Konrad, Gawehn, Luzie, Klink, Barbara, Rump, Andreas, Chaponnier, Christine, Figueiredo, Constanca, Knöfler, Ralf, Manstein, Dietmar J., Di Donato, Nataliya
Published in Nature communications (19.11.2018)
Published in Nature communications (19.11.2018)
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Journal Article
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
Günther, Sebastian, Reinke, Patrick Y A, Fernández-García, Yaiza, Lieske, Julia, Lane, Thomas J, Ginn, Helen M, Koua, Faisal H M, Ehrt, Christiane, Ewert, Wiebke, Oberthuer, Dominik, Yefanov, Oleksandr, Meier, Susanne, Lorenzen, Kristina, Krichel, Boris, Kopicki, Janine-Denise, Gelisio, Luca, Brehm, Wolfgang, Dunkel, Ilona, Seychell, Brandon, Gieseler, Henry, Norton-Baker, Brenna, Escudero-Pérez, Beatriz, Domaracky, Martin, Saouane, Sofiane, Tolstikova, Alexandra, White, Thomas A, Hänle, Anna, Groessler, Michael, Fleckenstein, Holger, Trost, Fabian, Galchenkova, Marina, Gevorkov, Yaroslav, Li, Chufeng, Awel, Salah, Peck, Ariana, Barthelmess, Miriam, Schlünzen, Frank, Lourdu Xavier, P, Werner, Nadine, Andaleeb, Hina, Ullah, Najeeb, Falke, Sven, Srinivasan, Vasundara, França, Bruno Alves, Schwinzer, Martin, Brognaro, Hévila, Rogers, Cromarte, Melo, Diogo, Zaitseva-Doyle, Joanna J, Knoska, Juraj, Peña-Murillo, Gisel E, Mashhour, Aida Rahmani, Hennicke, Vincent, Fischer, Pontus, Hakanpää, Johanna, Meyer, Jan, Gribbon, Philip, Ellinger, Bernhard, Kuzikov, Maria, Wolf, Markus, Beccari, Andrea R, Bourenkov, Gleb, von Stetten, David, Pompidor, Guillaume, Bento, Isabel, Panneerselvam, Saravanan, Karpics, Ivars, Schneider, Thomas R, Garcia-Alai, Maria Marta, Niebling, Stephan, Günther, Christian, Schmidt, Christina, Schubert, Robin, Han, Huijong, Boger, Juliane, Monteiro, Diana C F, Zhang, Linlin, Sun, Xinyuanyuan, Pletzer-Zelgert, Jonathan, Wollenhaupt, Jan, Feiler, Christian G, Weiss, Manfred S, Schulz, Eike-Christian, Mehrabi, Pedram, Karničar, Katarina, Usenik, Aleksandra, Loboda, Jure, Tidow, Henning, Chari, Ashwin, Hilgenfeld, Rolf, Uetrecht, Charlotte, Cox, Russell, Zaliani, Andrea, Beck, Tobias, Rarey, Matthias, Günther, Stephan, Turk, Dusan, Hinrichs, Winfried, Chapman, Henry N, Pearson, Arwen R
Published in Science (07.05.2021)
Published in Science (07.05.2021)
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Crystal structures of cables formed by the acetylated and unacetylated forms of the Schizosaccharomyces pombe tropomyosin ortholog TpmCdc8
Reinke, Patrick Y.A., Heiringhoff, Robin S., Reindl, Theresia, Baker, Karen, Taft, Manuel H., Meents, Alke, Mulvihill, Daniel P., Davies, Owen R., Fedorov, Roman, Zahn, Michael, Manstein, Dietmar J.
Published in The Journal of biological chemistry (01.12.2024)
Published in The Journal of biological chemistry (01.12.2024)
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Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors
Falke, Sven, Lieske, Julia, Herrmann, Alexander, Loboda, Jure, Karničar, Katarina, Günther, Sebastian, Reinke, Patrick Y. A., Ewert, Wiebke, Usenik, Aleksandra, Lindič, Nataša, Sekirnik, Andreja, Dretnik, Klemen, Tsuge, Hideaki, Turk, Vito, Chapman, Henry N., Hinrichs, Winfried, Ebert, Gregor, Turk, Dušan, Meents, Alke
Published in Journal of medicinal chemistry (09.05.2024)
Published in Journal of medicinal chemistry (09.05.2024)
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Time-resolved crystallography captures light-driven DNA repair
Christou, Nina-Eleni, Apostolopoulou, Virginia, Melo, Diogo V M, Ruppert, Matthias, Fadini, Alisia, Henkel, Alessandra, Sprenger, Janina, Oberthuer, Dominik, Günther, Sebastian, Pateras, Anastasios, Rahmani Mashhour, Aida, Yefanov, Oleksandr M, Galchenkova, Marina, Reinke, Patrick Y A, Kremling, Viviane, Scheer, T Emilie S, Lange, Esther R, Middendorf, Philipp, Schubert, Robin, De Zitter, Elke, Lumbao-Conradson, Koya, Herrmann, Jonathan, Rahighi, Simin, Kunavar, Ajda, Beale, Emma V, Beale, John H, Cirelli, Claudio, Johnson, Philip J M, Dworkowski, Florian, Ozerov, Dmitry, Bertrand, Quentin, Wranik, Maximilian, Bacellar, Camila, Bajt, Saša, Wakatsuki, Soichi, Sellberg, Jonas A, Huse, Nils, Turk, Dušan, Chapman, Henry N, Lane, Thomas J
Published in Science (American Association for the Advancement of Science) (01.12.2023)
Published in Science (American Association for the Advancement of Science) (01.12.2023)
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Mechanochemical properties of human myosin-1C are modulated by isoform-specific differences in the N-terminal extension
Giese, Sven, Reindl, Theresia, Reinke, Patrick Y.A., Zattelman, Lilach, Fedorov, Roman, Henn, Arnon, Taft, Manuel H., Manstein, Dietmar J.
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms
Zattelman, Lilach, Regev, Ronit, Ušaj, Marko, Reinke, Patrick Y.A., Giese, Sven, Samson, Abraham O., Taft, Manuel H., Manstein, Dietmar J., Henn, Arnon
Published in The Journal of biological chemistry (27.10.2017)
Published in The Journal of biological chemistry (27.10.2017)
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Journal Article
SARS-CoV-2 Mpro responds to oxidation by forming disulfide and NOS/SONOS bonds
Reinke, Patrick Y. A., Schubert, Robin, Oberthür, Dominik, Galchenkova, Marina, Rahmani Mashhour, Aida, Günther, Sebastian, Chretien, Anaïs, Round, Adam, Seychell, Brandon Charles, Norton-Baker, Brenna, Kim, Chan, Schmidt, Christina, Koua, Faisal H. M., Tolstikova, Alexandra, Ewert, Wiebke, Peña Murillo, Gisel Esperanza, Mills, Grant, Kirkwood, Henry, Brognaro, Hévila, Han, Huijong, Koliyadu, Jayanath, Schulz, Joachim, Bielecki, Johan, Lieske, Julia, Maracke, Julia, Knoska, Juraj, Lorenzen, Kristina, Brings, Lea, Sikorski, Marcin, Kloos, Marco, Vakili, Mohammad, Vagovic, Patrik, Middendorf, Philipp, de Wijn, Raphael, Bean, Richard, Letrun, Romain, Han, Seonghyun, Falke, Sven, Geng, Tian, Sato, Tokushi, Srinivasan, Vasundara, Kim, Yoonhee, Yefanov, Oleksandr M., Gelisio, Luca, Beck, Tobias, Doré, Andrew S., Mancuso, Adrian P., Betzel, Christian, Bajt, Saša, Redecke, Lars, Chapman, Henry N., Meents, Alke, Turk, Dušan, Hinrichs, Winfried, Lane, Thomas J.
Published in Nature communications (07.05.2024)
Published in Nature communications (07.05.2024)
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Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease
Srinivasan, Vasundara, Brognaro, Hévila, Prabhu, Prince R., de Souza, Edmarcia Elisa, Günther, Sebastian, Reinke, Patrick Y. A., Lane, Thomas J., Ginn, Helen, Han, Huijong, Ewert, Wiebke, Sprenger, Janina, Koua, Faisal H. M., Falke, Sven, Werner, Nadine, Andaleeb, Hina, Ullah, Najeeb, Franca, Bruno Alves, Wang, Mengying, Barra, Angélica Luana C., Perbandt, Markus, Schwinzer, Martin, Schmidt, Christina, Brings, Lea, Lorenzen, Kristina, Schubert, Robin, Machado, Rafael Rahal Guaragna, Candido, Erika Donizette, Oliveira, Danielle Bruna Leal, Durigon, Edison Luiz, Niebling, Stephan, Garcia, Angelica Struve, Yefanov, Oleksandr, Lieske, Julia, Gelisio, Luca, Domaracky, Martin, Middendorf, Philipp, Groessler, Michael, Trost, Fabian, Galchenkova, Marina, Mashhour, Aida Rahmani, Saouane, Sofiane, Hakanpää, Johanna, Wolf, Markus, Alai, Maria Garcia, Turk, Dusan, Pearson, Arwen R., Chapman, Henry N., Hinrichs, Winfried, Wrenger, Carsten, Meents, Alke, Betzel, Christian
Published in Communications biology (11.08.2022)
Published in Communications biology (11.08.2022)
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Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections
Reinke, Patrick Y. A., de Souza, Edmarcia Elisa, Günther, Sebastian, Falke, Sven, Lieske, Julia, Ewert, Wiebke, Loboda, Jure, Herrmann, Alexander, Rahmani Mashhour, Aida, Karničar, Katarina, Usenik, Aleksandra, Lindič, Nataša, Sekirnik, Andreja, Botosso, Viviane Fongaro, Santelli, Gláucia Maria Machado, Kapronezai, Josana, de Araújo, Marcelo Valdemir, Silva-Pereira, Taiana Tainá, Filho, Antônio Francisco de Souza, Tavares, Mariana Silva, Flórez-Álvarez, Lizdany, de Oliveira, Danielle Bruna Leal, Durigon, Edison Luiz, Giaretta, Paula Roberta, Heinemann, Marcos Bryan, Hauser, Maurice, Seychell, Brandon, Böhler, Hendrik, Rut, Wioletta, Drag, Marcin, Beck, Tobias, Cox, Russell, Chapman, Henry N., Betzel, Christian, Brehm, Wolfgang, Hinrichs, Winfried, Ebert, Gregor, Latham, Sharissa L., Guimarães, Ana Marcia de Sá, Turk, Dusan, Wrenger, Carsten, Meents, Alke
Published in Communications biology (18.10.2023)
Published in Communications biology (18.10.2023)
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Structure of SARS-CoV-2 papain-like protease PLpro reveals a framework for antiviral inhibitor design
Srinivasan, Vasundara, Werner, Nadine, Falke, Sven, Brognaro, Hévilla, Günther, Sebastian, Reinke, Patrick Y. A., Atia-tul-Wahab, Choudhary, Iqbal, Meents, Alke, Betzel, Christian
Published in Acta crystallographica. Section A, Foundations and advances (14.08.2021)
Published in Acta crystallographica. Section A, Foundations and advances (14.08.2021)
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Crystal structures of cables formed by the acetylated and unacetylated forms of the Schizosaccharomyces pombe tropomyosin ortholog Tpm Cdc8
Reinke, Patrick Y A, Heiringhoff, Robin S, Reindl, Theresia, Baker, Karen, Taft, Manuel H, Meents, Alke, Mulvihill, Daniel P, Davies, Owen R, Fedorov, Roman, Zahn, Michael, Manstein, Dietmar J
Published in The Journal of biological chemistry (25.10.2024)
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Published in The Journal of biological chemistry (25.10.2024)
Journal Article
SARS-CoV-2 M pro responds to oxidation by forming disulfide and NOS/SONOS bonds
Reinke, Patrick Y A, Schubert, Robin, Oberthür, Dominik, Galchenkova, Marina, Rahmani Mashhour, Aida, Günther, Sebastian, Chretien, Anaïs, Round, Adam, Seychell, Brandon Charles, Norton-Baker, Brenna, Kim, Chan, Schmidt, Christina, Koua, Faisal H M, Tolstikova, Alexandra, Ewert, Wiebke, Peña Murillo, Gisel Esperanza, Mills, Grant, Kirkwood, Henry, Brognaro, Hévila, Han, Huijong, Koliyadu, Jayanath, Schulz, Joachim, Bielecki, Johan, Lieske, Julia, Maracke, Julia, Knoska, Juraj, Lorenzen, Kristina, Brings, Lea, Sikorski, Marcin, Kloos, Marco, Vakili, Mohammad, Vagovic, Patrik, Middendorf, Philipp, de Wijn, Raphael, Bean, Richard, Letrun, Romain, Han, Seonghyun, Falke, Sven, Geng, Tian, Sato, Tokushi, Srinivasan, Vasundara, Kim, Yoonhee, Yefanov, Oleksandr M, Gelisio, Luca, Beck, Tobias, Doré, Andrew S, Mancuso, Adrian P, Betzel, Christian, Bajt, Saša, Redecke, Lars, Chapman, Henry N, Meents, Alke, Turk, Dušan, Hinrichs, Winfried, Lane, Thomas J
Published in Nature communications (07.05.2024)
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Published in Nature communications (07.05.2024)
Journal Article
SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design
Srinivasan, Vasundara, Brognaro, Hevila, Prince Rajaiah Prabhu, De Souza, Edmarci Elisa, Guenther, Sebastian, Reinke, Patrick Y A, Lane, Thomas J, Ginn, Helen, Han, Huijong, Ewert, Wiebke, Sprenger, Janina, Koua, Faisal H M, Falke, Sven, Werner, Nadine, Andaleeb, Hina, Ullah, Najeeb, Bruno Alves Franca, Wang, Mengying, Angelica Luana C Barra, Perbandt, Markus, Schwinzer, Martin, Schmidt, Christina, Brings, Lea, Lorenzen, Kristina, Schubert, Robin, Rafael Rahal Guaragna Machado, Candido, Erika Donizette, Danielle Bruna Leal Oliveira, Durigon, Edison Luiz, Yefanov, Oleksandr, Lieske, Julia, Gelisio, Luca, Domaracky, Martin, Middendorf, Philipp, Groessler, Michael, Trost, Fabian, Galchenkova, Marina, Saouane, Sofiane, Hakanpaeae, Johanna, Wolf, Markus, Turk, Dusan, Pearson, Arwen R, Chapman, Henry N, Hinrichs, Winfried, Wrenger, Carsten, Meents, Alke, Betzel, Christian
Published in bioRxiv (22.11.2021)
Published in bioRxiv (22.11.2021)
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Inhibition of SARS-CoV-2 main protease by allosteric drug-binding
Günther, Sebastian, Reinke, Patrick Y A, Fernández-García, Yaiza, Lieske, Julia, Lane, Thomas J, Koua, Faisal H M, Ehrt, Christiane, Ewert, Wiebke, Oberthuer, Dominik, Yefanov, Oleksandr, Meier, Susanne, Lorenzen, Kristina, Krichel, Boris, Janine-Denise Kopicki, Gelisio, Luca, Brehm, Wolfgang, Dunkel, Ilona, Seychell, Brandon, Gieseler, Henry, Norton-Baker, Brenna, Escudero-Pérez, Beatriz, Domaracky, Martin, Saouane, Sofiane, Tolstikova, Alexandra, White, Thomas A, Hänle, Anna, Groessler, Michael, Fleckenstein, Holger, Trost, Fabian, Galchenkova, Marina, Gevorkov, Yaroslav, Li, Chufeng, Awel, Salah, Peck, Ariana, Barthelmess, Miriam, Schlünzen, Frank, Xavier, P Lourdu, Werner, Nadine, Ullah, Najeeb, Falke, Sven, Srinivasan, Vasundara, Bruno Alves Franca, Schwinzer, Martin, Brognaro, Hévila, Rogers, Cromarte, Melo, Diogo, Zaitsev-Doyle, Jo J, Knoska, Juraj, Peña Murillo, Gisel E, Aida Rahmani Mashhour, Guicking, Filip, Hennicke, Vincent, Fischer, Pontus, Hakanpää, Johanna, Meyer, Jan, Gribbon, Phil, Ellinger, Bernhard, Kuzikov, Maria, Wolf, Markus, Beccari, Andrea R, Bourenkov, Gleb, David Von Stetten, Pompidor, Guillaume, Bento, Isabel, Panneerselvam, Saravanan, Karpics, Ivars, Schneider, Thomas R, Garcia Alai, Maria Marta, Niebling, Stephan, Günther, Christian, Schmidt, Christina, Schubert, Robin, Han, Huijong, Boger, Juliane, Monteiro, Diana C F, Zhang, Linlin, Sun, Xinyuanyuan, Pletzer-Zelgert, Jonathan, Wollenhaupt, Jan, Feiler, Christian G, Weiss, Manfred S, Schulz, Eike-Christian, Mehrabi, Pedram, Karničar, Katarina, Usenik, Aleksandra, Loboda, Jure, Tidow, Henning, Chari, Ashwin, Hilgenfeld, Rolf, Uetrecht, Charlotte, Cox, Russell, Beck, Tobias, Rarey, Matthias, Günther, Stephan, Turk, Dusan, Hinrichs, Winfried, Chapman, Henry N, Pearson, Arwen R, Betzel, Christian, Meents, Alke
Published in bioRxiv (23.11.2020)
Published in bioRxiv (23.11.2020)
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