Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
Ponsioen, Bas, Post, Jasmin B, Buissant des Amorie, Julian R, Laskaris, Dimitrios, van Ineveld, Ravian L, Kersten, Simone, Bertotti, Andrea, Sassi, Francesco, Sipieter, François, Cappe, Benjamin, Mertens, Sander, Verlaan-Klink, Ingrid, Boj, Sylvia F, Vries, Rob G J, Rehmann, Holger, Vandenabeele, Peter, Riquet, Franck B, Trusolino, Livio, Bos, Johannes L, Snippert, Hugo J G
Published in Nature cell biology (01.04.2021)
Published in Nature cell biology (01.04.2021)
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Journal Article
Capturing cyclic nucleotides in action: snapshots from crystallographic studies
Rehmann, Holger, Wittinghofer, Alfred, Bos, Johannes L
Published in Nature reviews. Molecular cell biology (01.01.2007)
Published in Nature reviews. Molecular cell biology (01.01.2007)
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Journal Article
Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes
Pereira, Laëtitia, Rehmann, Holger, Lao, Dieu Hung, Erickson, Jeffrey R., Bossuyt, Julie, Chen, Ju, Bers, Donald M.
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.2015)
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Journal Article
Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators
Wang, Pingyuan, Luchowska-Stańska, Urszula, van Basten, Boy, Chen, Haiying, Liu, Zhiqing, Wiejak, Jolanta, Whelan, Padraic, Morgan, David, Lochhead, Emma, Barker, Graeme, Rehmann, Holger, Yarwood, Stephen J, Zhou, Jia
Published in Journal of medicinal chemistry (28.05.2020)
Published in Journal of medicinal chemistry (28.05.2020)
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Journal Article
Treatment of ARS deficiencies with specific amino acids
Kok, Gautam, Tseng, Laura, Schene, Imre F, Dijsselhof, Monique E, Salomons, Gajja, Mendes, Marisa I, Smith, Desiree E C, Wiedemann, Arnaud, Canton, Marie, Feillet, François, de Koning, Tom J, Boothe, Megan, Dean, Joy, Kassel, Rachel, Ferreira, Elise A, van den Born, Margreet, Nieuwenhuis, Edward E S, Rehmann, Holger, Terheggen-Lagro, Suzanne W J, van Karnebeek, Clara D M, Fuchs, Sabine A
Published in Genetics in medicine (01.11.2021)
Published in Genetics in medicine (01.11.2021)
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Journal Article
Structure-guided design of selective Epac1 and Epac2 agonists
Schwede, Frank, Bertinetti, Daniela, Langerijs, Carianne N, Hadders, Michael A, Wienk, Hans, Ellenbroek, Johanne H, de Koning, Eelco J P, Bos, Johannes L, Herberg, Friedrich W, Genieser, Hans-Gottfried, Janssen, Richard A J, Rehmann, Holger
Published in PLoS biology (01.01.2015)
Published in PLoS biology (01.01.2015)
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Journal Article
cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects
Beckert, Ulrike, Grundmann, Manuel, Wolter, Sabine, Schwede, Frank, Rehmann, Holger, Kaever, Volkhard, Kostenis, Evi, Seifert, Roland
Published in Biochemical and biophysical research communications (05.09.2014)
Published in Biochemical and biophysical research communications (05.09.2014)
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Journal Article
Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state
Bos, Johannes L, Rehmann, Holger, Das, Joost, Knipscheer, Puck, Wittinghofer, Alfred
Published in Nature (02.02.2006)
Published in Nature (02.02.2006)
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Journal Article
Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1
Parnell, Euan, McElroy, Stuart P, Wiejak, Jolanta, Baillie, Gemma L, Porter, Alison, Adams, David R, Rehmann, Holger, Smith, Brian O, Yarwood, Stephen J
Published in Scientific reports (22.03.2017)
Published in Scientific reports (22.03.2017)
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Journal Article
Selectivity of CDC25 Homology Domain-Containing Guanine Nucleotide Exchange Factors
Popovic, Milica, Rensen-de Leeuw, Marije, Rehmann, Holger
Published in Journal of molecular biology (09.08.2013)
Published in Journal of molecular biology (09.08.2013)
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Journal Article
Direct Spatial Control of Epac1 by Cyclic AMP
Ponsioen, Bas, Gloerich, Martijn, Ritsma, Laila, Rehmann, Holger, Bos, Johannes L., Jalink, Kees
Published in Molecular and Cellular Biology (01.05.2009)
Published in Molecular and Cellular Biology (01.05.2009)
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Journal Article
Functional characterisation of a novel class of in-frame insertion variants of KRAS and HRAS
Eijkelenboom, Astrid, van Schaik, Frederik M A, van Es, Robert M, Ten Broek, Roel W, Rinne, Tuula, van der Vleuten, Carine, Flucke, Uta, Ligtenberg, Marjolijn J L, Rehmann, Holger
Published in Scientific reports (03.06.2019)
Published in Scientific reports (03.06.2019)
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Journal Article
FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer
Tavares, Sandra, Liv, Nalan, Pasolli, Milena, Opdam, Mark, Rätze, Max A.K., Saornil, Manuel, Sluimer, Lilian M., Hengeveld, Rutger C.C., van Es, Robert, van Werkhoven, Erik, Vos, Harmjan, Rehmann, Holger, Burgering, Boudewijn M.T., Oosterkamp, Hendrika M., Lens, Susanne M.A., Klumperman, Judith, Linn, Sabine C., Derksen, Patrick W.B.
Published in Cell reports (Cambridge) (05.04.2022)
Published in Cell reports (Cambridge) (05.04.2022)
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Journal Article
Rap1 and Rap2 antagonistically control endothelial barrier resistance
Pannekoek, Willem-Jan, Linnemann, Jelena R, Brouwer, Patricia M, Bos, Johannes L, Rehmann, Holger
Published in PloS one (28.02.2013)
Published in PloS one (28.02.2013)
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Journal Article
Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish
Smith, Kelly A, Noël, Emily, Thurlings, Ingrid, Rehmann, Holger, Chocron, Sonja, Bakkers, Jeroen
Published in PLoS genetics (01.09.2011)
Published in PLoS genetics (01.09.2011)
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Journal Article
Spatial Regulation of Cyclic AMP-Epac1 Signaling in Cell Adhesion by ERM Proteins
Gloerich, Martijn, Ponsioen, Bas, Vliem, Marjolein J., Zhang, Zhongchun, Zhao, Jun, Kooistra, Matthijs R., Price, Leo S., Ritsma, Laila, Zwartkruis, Fried J., Rehmann, Holger, Jalink, Kees, Bos, Johannes L.
Published in Molecular and Cellular Biology (01.11.2010)
Published in Molecular and Cellular Biology (01.11.2010)
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Journal Article
Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes
Hoogenraad, Casper C, Popa, Ioana, Futai, Kensuke, Martinez-Sanchez, Emma, Sanchez-Martinez, Emma, Wulf, Phebe S, van Vlijmen, Thijs, Dortland, Bjorn R, Oorschot, Viola, Govers, Roland, Monti, Maria, Heck, Albert J R, Sheng, Morgan, Klumperman, Judith, Rehmann, Holger, Jaarsma, Dick, Kapitein, Lukas C, van der Sluijs, Peter
Published in PLoS biology (01.01.2010)
Published in PLoS biology (01.01.2010)
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Journal Article