Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorder
Foley, Andrew G., Gannon, Shane, Rombach-Mullan, Nanette, Prendergast, Alison, Barry, Claire, Cassidy, Andrew W., Regan, Ciaran M.
Published in Neuropharmacology (01.09.2012)
Published in Neuropharmacology (01.09.2012)
Get full text
Journal Article
AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity
McKee, Alex G, Loscher, Jennifer S, O'Sullivan, Niamh C, Chadderton, Naomi, Palfi, Arpad, Batti, Laura, Sheridan, Graham K, O'Shea, Sean, Moran, Mary, McCabe, Olive, Fernández, Alfonso Blanco, Pangalos, Menelas N, O'Connor, John J, Regan, Ciaran M, O'Connor, William T, Humphries, Peter, Farrar, G. Jane, Murphy, Keith J
Published in Journal of neurochemistry (01.02.2010)
Published in Journal of neurochemistry (01.02.2010)
Get full text
Journal Article
Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats
Medhurst, Andrew D, Briggs, Michael A, Bruton, Gordon, Calver, Andrew R, Chessell, Iain, Crook, Barry, Davis, John B, Davis, Robert P, Foley, Andrew G, Heslop, Teresa, Hirst, Warren D, Medhurst, Stephen J, Ociepka, Sandrine, Ray, Alison, Regan, Ciaran M, Sargent, Becky, Schogger, Joanne, Stean, Tania O, Trail, Brenda K, Upton, Neil, White, Trevor, Orlek, Barry, Wilson, David M
Published in Biochemical pharmacology (15.04.2007)
Published in Biochemical pharmacology (15.04.2007)
Get full text
Journal Article
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Selkoe, Dennis J, Shankar, Ganesh M, Li, Shaomin, Mehta, Tapan H, Garcia-Munoz, Amaya, Shepardson, Nina E, Smith, Imelda, Brett, Francesca M, Farrell, Michael A, Rowan, Michael J, Lemere, Cynthia A, Regan, Ciaran M, Walsh, Dominic M, Sabatini, Bernardo L
Published in Nature medicine (01.08.2008)
Published in Nature medicine (01.08.2008)
Get full text
Journal Article
Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning
O’Sullivan, Niamh C., McGettigan, Paul A., Sheridan, Graham K., Pickering, Mark, Conboy, Lisa, O’Connor, John J., Moynagh, Paul N., Higgins, Desmond G., Regan, Ciaran M., Murphy, Keith J.
Published in Journal of neurochemistry (01.05.2007)
Published in Journal of neurochemistry (01.05.2007)
Get full text
Journal Article
Aβ oligomers inhibit synapse remodelling necessary for memory consolidation
Freir, Darragh B, Fedriani, Rocio, Scully, Darren, Smith, Imelda M, Selkoe, Dennis J, Walsh, Dominic M, Regan, Ciaran M
Published in Neurobiology of aging (01.12.2011)
Published in Neurobiology of aging (01.12.2011)
Get full text
Journal Article
Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation
Borlikova, Gilyana G, Trejo, Margarita, Mably, Alexandra J, Mc Donald, Jessica M, Sala Frigerio, Carlo, Regan, Ciaran M, Murphy, Keith J, Masliah, Eliezer, Walsh, Dominic M
Published in Neurobiology of aging (01.05.2013)
Published in Neurobiology of aging (01.05.2013)
Get full text
Journal Article
SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models
HIRST, Warren D, STEAN, Tania O, HEIDBREDER, Christian A, ATKINS, Alan R, LACROIX, Laurent P, DAWSON, Lee A, FOLEY, Andrew G, REGAN, Ciaran M, UPTON, Neil, ROGERS, Derek C, SUNTER, David, PUGH, Pippa, MOSS, Stephen F, BROMIDGE, Steven M, RILEY, Graham, SMITH, Douglas R, BARTLETT, Sarah
Published in European journal of pharmacology (28.12.2006)
Published in European journal of pharmacology (28.12.2006)
Get full text
Journal Article
GSK189254, a Novel H3 Receptor Antagonist That Binds to Histamine H3 Receptors in Alzheimer's Disease Brain and Improves Cognitive Performance in Preclinical Models
Medhurst, Andrew D, Atkins, Alan R, Beresford, Isabel J, Brackenborough, Kim, Briggs, Michael A, Calver, Andrew R, Cilia, Jackie, Cluderay, Jane E, Crook, Barry, Davis, John B, Davis, Rebecca K, Davis, Robert P, Dawson, Lee A, Foley, Andrew G, Gartlon, Jane, Gonzalez, M Isabel, Heslop, Teresa, Hirst, Warren D, Jennings, Carol, Jones, Declan N C, Lacroix, Laurent P, Martyn, Abbe, Ociepka, Sandrine, Ray, Alison, Regan, Ciaran M, Roberts, Jennifer C, Schogger, Joanne, Southam, Eric, Stean, Tania O, Trail, Brenda K, Upton, Neil, Wadsworth, Graham, Wald, Jeffrey A, White, Trevor, Witherington, Jason, Woolley, Marie L, Worby, Angela, Wilson, David M
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
Get full text
Journal Article
Curcumin-induced degradation of PKCδ is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats
Conboy, Lisa, Foley, Andrew G., O’Boyle, Noel M., Lawlor, Marie, Gallagher, Helen C., Murphy, Keith J., Regan, Ciaran M.
Published in Biochemical pharmacology (01.04.2009)
Published in Biochemical pharmacology (01.04.2009)
Get full text
Journal Article
Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat
Lukasz, Bartlomiej, O’Sullivan, Niamh C, Loscher, Jennifer S, Pickering, Mark, Regan, Ciaran M, Murphy, Keith J
Published in Brain, behavior, and immunity (01.01.2013)
Published in Brain, behavior, and immunity (01.01.2013)
Get full text
Journal Article
Temporal proteomic profile of memory consolidation in the rat hippocampal dentate gyrus
Monopoli, Marco P., Raghnaill, Michelle Nic, Loscher, Jennifer S., O'Sullivan, Niamh C., Pangalos, Menelas N., Ring, Robert H., von Schack, David, Dunn, Michael J., Regan, Ciaran M., Pennington, Stephen, Murphy, Keith J.
Published in Proteomics (Weinheim) (01.11.2011)
Published in Proteomics (Weinheim) (01.11.2011)
Get full text
Journal Article
Valproate activates phosphodiesterase-mediated cAMP degradation: relevance to C6 glioma G1 phase progression
Gallagher, Helen C., Bacon, Christopher L., Odumeru, Oladapo A., Gallagher, Kevin F., Fitzpatrick, Thérèse, Regan, Ciaran M.
Published in Neurotoxicology and teratology (01.01.2004)
Published in Neurotoxicology and teratology (01.01.2004)
Get full text
Journal Article
The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats
Foley, Andrew G, Hirst, Warren D, Gallagher, Helen C, Barry, Claire, Hagan, Jim J, Upton, Neil, Walsh, Frank S, Hunter, A Jackie, Regan, Ciaran M
Published in Neuropharmacology (01.06.2008)
Published in Neuropharmacology (01.06.2008)
Get full text
Journal Article
The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats
FOLEY, Andrew G, MURPHY, Keith J, HIRST, Warren D, GALLAGHER, Helen C, HAGAN, Jim J, UPTON, Neil, WALSH, Frank S, REGAN, Ciaran M
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2004)
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2004)
Get full text
Journal Article
Reduced reelin protein synthesis in ventral hippocampus of isolation reared Wistar rats accompanies impaired avoidance conditioning
Cassidy, Andrew W., Mulvany, Sean K., Pangalos, Menelas N., Murphy, Keith J., Regan, Ciaran M.
Published in Behavioural brain research (12.11.2010)
Published in Behavioural brain research (12.11.2010)
Get full text
Journal Article
Chronic Exposure of Rats to Cognition Enhancing Drugs Produces a Neuroplastic Response Identical to that Obtained by Complex Environment Rearing
MURPHY, Keith J, FOLEY, Andrew G, O'CONNELL, Alan W, REGAN, Ciaran M
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2006)
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2006)
Get full text
Journal Article