Development and characterization of canine‐specific computational models to predict pulsatile arterial hemodynamics and ventricular‐arterial coupling
Hotek, Julia C., Chirinos, Julio A., Detwiler, Theodore J., Regan, Hillary K., Regan, Christopher P.
Published in Physiological reports (01.06.2023)
Published in Physiological reports (01.06.2023)
Get full text
Journal Article
Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve
Klein, Rebecca M., Layton, Mark E., Regan, Hillary, Regan, Christopher P., Li, Yuxing, Filzen, Tracey, Cato, Matt, Clements, Michelle K., Wang, Jixin, Sanoja, Raul, Greshock, Thomas J., Roecker, Anthony J., Pero, Joseph E., Kim, Ron, Burgey, Christopher, John, Christopher T., Wang, Ying-Hong, Bhandari, Neetesh, Struyk, Arie, Kraus, Richard L., Henze, Darrell A., Houghton, Andrea K.
Published in Channels (Austin, Tex.) (31.12.2022)
Published in Channels (Austin, Tex.) (31.12.2022)
Get full text
Journal Article
Erk5 Null Mice Display Multiple Extraembryonic Vascular and Embryonic Cardiovascular Defects
Regan, Christopher P., Li, Wei, Boucher, Diane M., Spatz, Stephen, Su, Michael S., Kuida, Keisuke
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2002)
Get full text
Journal Article
Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation
Trotter, B. Wesley, Nanda, Kausik K, Kett, Nathan R, Regan, Christopher P, Lynch, Joseph J, Stump, Gary L, Kiss, Laszlo, Wang, Jixin, Spencer, Robert H, Kane, Stefanie A, White, Rebecca B, Zhang, Rena, Anderson, Kenneth D, Liverton, Nigel J, McIntyre, Charles J, Beshore, Douglas C, Hartman, George D, Dinsmore, Christopher J
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
Get full text
Journal Article
Smooth Muscle–Targeted Knockout of Connexin43 Enhances Neointimal Formation in Response to Vascular Injury
Liao, Yongbo, Regan, Christopher P, Manabe, Ichiro, Owens, Gary K, Day, Kathy H, Damon, Dave N, Duling, Brian R
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2007)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2007)
Get full text
Journal Article
Calcitonin Gene-Related Peptide Receptor Antagonism Does Not Affect the Severity of Myocardial Ischemia during Atrial Pacing in Dogs with Coronary Artery Stenosis
Regan, Christopher P, Stump, Gary L, Kane, Stefanie A, Lynch, Jr, Joseph J
Published in The Journal of pharmacology and experimental therapeutics (01.02.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2009)
Get full text
Journal Article
In Vivo Antiarrhythmic and Cardiac Electrophysiologic Effects of a Novel Diphenylphosphine Oxide IKur Blocker (2-Isopropyl-5-methylcyclohexyl) Diphenylphosphine Oxide
Stump, Gary L, Wallace, Audrey A, Regan, Christopher P, Lynch, Jr, Joseph J
Published in The Journal of pharmacology and experimental therapeutics (01.12.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2005)
Get full text
Journal Article
Autonomic Dysfunction Linked to Inhibition of the Nav1.7 Sodium Channel
Regan, Christopher P, Morissette, Pierre, Kraus, Richard L, Wang, Erjia, Arrington, Leticia, Vavrek, Marissa, de Hoon, Jan, Depre, Marleen, Lodeweyck, Thomas, Demeyer, Ignace, Laethem, Tine, Stoch, Aubrey, Struyk, Arie
Published in Circulation (New York, N.Y.) (23.04.2024)
Published in Circulation (New York, N.Y.) (23.04.2024)
Get full text
Journal Article
Atrial Antifibrillatory Effects of Structurally Distinct IKur Blockers 3-[(Dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-Phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in Dogs with Underlying Heart Failure
Regan, Christopher P, Kiss, Laszlo, Stump, Gary L, McIntyre, Charles J, Beshore, Douglas C, Liverton, Nigel J, Dinsmore, Christopher J, Lynch, Jr, Joseph J
Published in The Journal of pharmacology and experimental therapeutics (01.01.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2008)
Get full text
Journal Article
Autonomic Dysfunction Linked to Inhibition of the Na v 1.7 Sodium Channel
Regan, Christopher P, Morissette, Pierre, Kraus, Richard L, Wang, Erjia, Arrington, Leticia, Vavrek, Marissa, de Hoon, Jan, Depre, Marleen, Lodeweyck, Thomas, Demeyer, Ignace, Laethem, Tine, Stoch, Aubrey, Struyk, Arie
Published in Circulation (New York, N.Y.) (23.04.2024)
Published in Circulation (New York, N.Y.) (23.04.2024)
Get full text
Journal Article
Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor
Moore, Eric, Fraley, Mark E, Bell, Ian M, Burgey, Christopher S, White, Rebecca B, Li, Chi-Chung, Regan, Christopher P, Danziger, Andrew, Stranieri Michener, Maria, Hostetler, Eric, Banerjee, Pradeep, Salvatore, Christopher
Published in The Journal of pharmacology and experimental therapeutics (28.01.2020)
Published in The Journal of pharmacology and experimental therapeutics (28.01.2020)
Get full text
Journal Article
A generalized canine transfer function accurately reconstructs central aortic pressure waveforms to enable enhanced pulse wave analysis
Hotek, Julia C, Detwiler, Theodore J, Chirinos, Julio A, Regan, Christopher P
Published in Journal of pharmacological and toxicological methods (01.11.2023)
Published in Journal of pharmacological and toxicological methods (01.11.2023)
Get full text
Journal Article
Attenuation of edema and infarct volume following focal cerebral ischemia by early but not delayed administration of a novel small molecule KDR kinase inhibitor
Foster, Kelley A., Regan, Hillary K., Danziger, Andrew P., Detwiler, Theodore, Kwon, Nancy, Rickert, Keith, Lynch, Joseph J., Regan, Christopher P.
Published in Neuroscience research (2009)
Published in Neuroscience research (2009)
Get full text
Journal Article
In Vivo Cardiac Electrophysiologic Effects of a Novel Diphenylphosphine Oxide IKur Blocker, (2-Isopropyl-5-methylcyclohexyl) Diphenylphosphine Oxide, in Rat and Nonhuman Primate
Regan, Christopher P, Wallace, Audrey A, Cresswell, Hillary K, Atkins, Charity L, Lynch, Jr, Joseph J
Published in The Journal of pharmacology and experimental therapeutics (01.02.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2006)
Get full text
Journal Article
Pharmacologic characterization of atogepant: A potent and selective calcitonin gene–related peptide receptor antagonist
Moore, Eric, Bell, Ian M, Fraley, Mark E, Burgey, Christopher S, White, Rebecca B, Li, Chi-Chung, Regan, Christopher P, Danziger, Andrew, McGaraughty, Steve P, Naseri Kouzehgarani, Ghazal, Salvatore, Christopher, Banerjee, Pradeep
Published in Cephalalgia (01.01.2024)
Published in Cephalalgia (01.01.2024)
Get full text
Journal Article
Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel
Beshore, Douglas C., Liverton, Nigel J., McIntyre, Charles J., Claiborne, Christopher F., Libby, Brian, Culberson, J. Christopher, Salata, Joseph J., Regan, Christopher P., Lynch, Joseph J., Kiss, Laszlo, Spencer, Robert H., Kane, Stephanie A., White, Rebecca B., Yeh, Suzie, Hartman, George D., Dinsmore, Christopher J.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Get full text
Journal Article
Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues
Bennett, Frank, Huang, Yuhua, Dong, Shuzhi, Jiang, Jinlong, Hunter, David, Zhao, Zhiqiang, Gu, Xin, Scott, Jack D., Tang, Haiqun, Yang, Dexi, Xiao, Li, Scapin, Giovanna, Fischmann, Thierry, Mirza, Asra, Dayananth, Priya, Painter, Ronald E., Villafania, Artjohn, Garlisi, Charles G., Zhang, Rumin, Mayhood, Todd W., Si, Qian, Li, Nianyu, Amin, Rupesh P., Chen, Feifei, Bhatt, Bhavana, Regan, Christopher P., Regan, Hilary, Lin, Xinjie, Wu, Jin, Leithead, Andrew, Young, Katherine, Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (01.12.2024)
Published in Bioorganic & medicinal chemistry letters (01.12.2024)
Get full text
Journal Article
Characterization of ascending dose canine telemetry model supports its use in E14/S7B QT integrated risk assessments
Chaves, Alysia A., Ferraro, Jude W., Yu, Jing, Moye, Matthew J., Yee, Ka Lai, Li, Fangbiao, Steve, Desiree L., Lengel, David J., Regan, Christopher P.
Published in Journal of pharmacological and toxicological methods (01.07.2024)
Published in Journal of pharmacological and toxicological methods (01.07.2024)
Get full text
Journal Article
Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration
Dong, Shuzhi, Zhao, Zhiqiang, Tang, Haiqun, Li, Guoqing, Pan, Jianping, Gu, Xin, Jiang, Jinlong, Xiao, Li, Scapin, Giovanna, Hunter, David N., Yang, Dexi, Huang, Yuhua, Bennett, Frank, Yang, Shu-Wei, Mandal, Mihirbaran, Tang, Haifeng, Su, Jing, Tudge, Clare, deJesus, Reynalda Keh, Ding, Fa-Xiang, Lombardo, Matthew, Hicks, Jacqueline D., Fischmann, Thierry, Mirza, Asra, Dayananth, Priya, Painter, Ronald E., Villafania, Artjohn, Garlisi, Charles G., Zhang, Rumin, Mayhood, Todd W., Si, Qian, Li, Nianyu, Amin, Rupesh P., Bhatt, Bhavana, Chen, Feifei, Regan, Christopher P., Regan, Hillary, Lin, Xinjie, Wu, Jin, Leithead, Andrew, Pollack, Scott R., Scott, Jack D., Nargund, Ravi P., Therien, Alex G., Black, Todd, Young, Katherine, Pasternak, Alexander
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
Get full text
Journal Article