Synthesis and Conformational Dynamics of Tricyclic Pyridones Containing a Fused Seven-Membered Ring
Gibson, Karl R, Hitzel, Laure, Mortishire-Smith, Russell J, Gerhard, Ute, Jelley, Richard A, Reeve, Austin J, Rowley, Michael, Nadin, Alan, Owens, Andrew P
Published in Journal of organic chemistry (27.12.2002)
Published in Journal of organic chemistry (27.12.2002)
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Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition
Chambers, Mark S, Atack, John R, Broughton, Howard B, Collinson, Neil, Cook, Susan, Dawson, Gerard R, Hobbs, Sarah C, Marshall, George, Maubach, Karen A, Pillai, Goplan V, Reeve, Austin J, MacLeod, Angus M
Published in Journal of medicinal chemistry (22.05.2003)
Published in Journal of medicinal chemistry (22.05.2003)
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Selective, Orally Active γ-Aminobutyric AcidA α5 Receptor Inverse Agonists as Cognition Enhancers
Sternfeld, Francine, Carling, Robert W, Jelley, Richard A, Ladduwahetty, Tamara, Merchant, Kevin J, Moore, Kevin W, Reeve, Austin J, Street, Leslie J, O'Connor, Desmond, Sohal, Bindi, Atack, John R, Cook, Susan, Seabrook, Guy, Wafford, Keith, Tattersall, F. David, Collinson, Neil, Dawson, Gerard R, Castro, José L, MacLeod, Angus M
Published in Journal of medicinal chemistry (22.04.2004)
Published in Journal of medicinal chemistry (22.04.2004)
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Synthesis and Biological Evaluation of 3-Heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and Analogues as Subtype-Selective Inverse Agonists for the GABAAα5 Benzodiazepine Binding Site
Street, Leslie J, Sternfeld, Francine, Jelley, Richard A, Reeve, Austin J, Carling, Robert W, Moore, Kevin W, McKernan, Ruth M, Sohal, Bindi, Cook, Susan, Pike, Andrew, Dawson, Gerard R, Bromidge, Frances A, Wafford, Keith A, Seabrook, Guy R, Thompson, Sally A, Marshall, George, Pillai, Goplan V, Castro, José L, Atack, John R, MacLeod, Angus M
Published in Journal of medicinal chemistry (01.07.2004)
Published in Journal of medicinal chemistry (01.07.2004)
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Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors
Street, Leslie J, Baker, Raymond, Castro, Jose L, Chambers, Mark S, Guiblin, Alexander R, Hobbs, Sarah C, Matassa, Victor G, Reeve, Austin J, Beer, Margaret S
Published in Journal of medicinal chemistry (01.05.1993)
Published in Journal of medicinal chemistry (01.05.1993)
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6,7-Dihydro-2-benzothiophen-4(5H)-ones: A Novel Class of GABA-A α5 Receptor Inverse Agonists
Chambers, Mark S, Atack, John R, Bromidge, Frances A, Broughton, Howard B, Cook, Susan, Dawson, Gerard R, Hobbs, Sarah C, Maubach, Karen A, Reeve, Austin J, Seabrook, Guy R, Wafford, Keith, MacLeod, Angus M
Published in Journal of medicinal chemistry (14.03.2002)
Published in Journal of medicinal chemistry (14.03.2002)
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Synthesis and Serotonergic Activity of 3-[2-(Pyrrolidin-1-yl)ethyl]indoles: Potent Agonists for the h5-HT1D Receptor with High Selectivity over the h5-HT1B Receptor
Sternfeld, Francine, Guiblin, Alexander R, Jelley, Richard A, Matassa, Victor G, Reeve, Austin J, Hunt, Peter A, Beer, Margaret S, Heald, Anne, Stanton, Josephine A, Sohal, Bindi, Watt, Alan P, Street, Leslie J
Published in Journal of medicinal chemistry (25.02.1999)
Published in Journal of medicinal chemistry (25.02.1999)
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Journal Article
Synthesis and Serotonergic Activity of N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and Analogs: Potent Agonists for 5-HT1D Receptors
Street, Leslie J, Baker, Raymond, Davey, William B, Guiblin, Alexander R, Jelley, Richard A, Reeve, Austin J, Routledge, Helen, Sternfeld, Francine, Watt, Alan P
Published in Journal of medicinal chemistry (01.05.1995)
Published in Journal of medicinal chemistry (01.05.1995)
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Journal Article
3-(Piperazinylpropyl)indoles: Selective, Orally Bioavailable h5-HT1D Receptor Agonists as Potential Antimigraine Agents
Chambers, Mark S, Street, Leslie J, Goodacre, Simon, Hobbs, Sarah C, Hunt, Peter, Jelley, Richard A, Matassa, Victor G, Reeve, Austin J, Sternfeld, Francine, Beer, Margaret S, Stanton, Josephine A, Rathbone, Denise, Watt, Alan P, MacLeod, Angus M
Published in Journal of medicinal chemistry (25.02.1999)
Published in Journal of medicinal chemistry (25.02.1999)
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Journal Article
Selective, Orally Active 5-HT1D Receptor Agonists as Potential Antimigraine Agents
MacLeod, Angus M, Street, Leslie J, Reeve, Austin J, Jelley, Richard A, Sternfeld, Francine, Beer, Margaret S, Stanton, Josephine A, Watt, Alan P, Rathbone, Denise, Matassa, Victor G
Published in Journal of medicinal chemistry (24.10.1997)
Published in Journal of medicinal chemistry (24.10.1997)
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Journal Article
Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives
Street, Leslie J, Baker, Raymond, Book, Tracey, Reeve, Austin J, Saunders, John, Willson, Timothy, Marwood, Rosemarie S, Patel, Shailendra, Freedman, Stephen B
Published in Journal of medicinal chemistry (01.01.1992)
Published in Journal of medicinal chemistry (01.01.1992)
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Synthesis of azabicyclic pyrazine derivatives as muscarinic agonists and the preparation of a chloropyrazine analogue with functional selectivity at sub-types of the muscarinic receptor
BAKER, R, STREET, L. J, REEVE, A. J, SAUNDERS, J
Published in Journal of the Chemical Society. Chemical communications (1991)
Published in Journal of the Chemical Society. Chemical communications (1991)
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Synthesis and Biological Evaluation of 3-Heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4- a ]phthalazines and Analogues as Subtype-Selective Inverse Agonists for the GABA A α5 Benzodiazepine Binding Site
Street, Leslie J., Sternfeld, Francine, Jelley, Richard A., Reeve, Austin J., Carling, Robert W., Moore, Kevin W., McKernan, Ruth M., Sohal, Bindi, Cook, Susan, Pike, Andrew, Dawson, Gerard R., Bromidge, Frances A., Wafford, Keith A., Seabrook, Guy R., Thompson, Sally A., Marshall, George, Pillai, Goplan V., Castro, José L., Atack, John R., MacLeod, Angus M.
Published in Journal of medicinal chemistry (01.07.2004)
Published in Journal of medicinal chemistry (01.07.2004)
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Journal Article
Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site
Street, Leslie J, Sternfeld, Francine, Jelley, Richard A, Reeve, Austin J, Carling, Robert W, Moore, Kevin W, McKernan, Ruth M, Sohal, Bindi, Cook, Susan, Pike, Andrew, Dawson, Gerard R, Bromidge, Frances A, Wafford, Keith A, Seabrook, Guy R, Thompson, Sally A, Marshall, George, Pillai, Goplan V, Castro, José L, Atack, John R, MacLeod, Angus M
Published in Journal of medicinal chemistry (01.07.2004)
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Published in Journal of medicinal chemistry (01.07.2004)
Journal Article
Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition
Chambers, Mark S, Atack, John R, Broughton, Howard B, Collinson, Neil, Cook, Susan, Dawson, Gerard R, Hobbs, Sarah C, Marshall, George, Maubach, Karen A, Pillai, Goplan V, Reeve, Austin J, MacLeod, Angus M
Published in Journal of medicinal chemistry (22.05.2003)
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Published in Journal of medicinal chemistry (22.05.2003)
Journal Article
Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers
Sternfeld, Francine, Carling, Robert W, Jelley, Richard A, Ladduwahetty, Tamara, Merchant, Kevin J, Moore, Kevin W, Reeve, Austin J, Street, Leslie J, O'Connor, Desmond, Sohal, Bindi, Atack, John R, Cook, Susan, Seabrook, Guy, Wafford, Keith, Tattersall, F David, Collinson, Neil, Dawson, Gerard R, Castro, José L, MacLeod, Angus M
Published in Journal of medicinal chemistry (22.04.2004)
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Published in Journal of medicinal chemistry (22.04.2004)
Journal Article
Identification of a Novel, Selective GABA A α5 Receptor Inverse Agonist Which Enhances Cognition
Chambers, Mark S., Atack, John R., Broughton, Howard B., Collinson, Neil, Cook, Susan, Dawson, Gerard R., Hobbs, Sarah C., Marshall, George, Maubach, Karen A., Pillai, Goplan V., Reeve, Austin J., MacLeod, Angus M.
Published in Journal of medicinal chemistry (01.05.2003)
Published in Journal of medicinal chemistry (01.05.2003)
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Journal Article
Selective, Orally Active γ-Aminobutyric Acid A α5 Receptor Inverse Agonists as Cognition Enhancers
Sternfeld, Francine, Carling, Robert W., Jelley, Richard A., Ladduwahetty, Tamara, Merchant, Kevin J., Moore, Kevin W., Reeve, Austin J., Street, Leslie J., O'Connor, Desmond, Sohal, Bindi, Atack, John R., Cook, Susan, Seabrook, Guy, Wafford, Keith, Tattersall, F. David, Collinson, Neil, Dawson, Gerard R., Castro, José L., MacLeod, Angus M.
Published in Journal of medicinal chemistry (01.04.2004)
Published in Journal of medicinal chemistry (01.04.2004)
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Journal Article
Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazin es and analogues as subtype-selective inverse agonists for the GABAAα5 benzodiazepine binding site
STREET, Leslie J, STERNFELD, Francine, DAWSON, Gerard R, BROMIDGE, Frances A, WAFFORD, Keith A, SEABROOK, Guy R, THOMPSON, Sally A, MARSHALL, George, PILLAI, Goplan V, CASTRO, Josh L, ATACK, John R, MACLEOD, Angus M, JELLEY, Richard A, REEVE, Austin J, CARLING, Robert W, MOORE, Kevin W, MCKERNAN, Ruth M, SOHAL, Bindi, COOK, Susan, PIKE, Andrew
Published in Journal of medicinal chemistry (2004)
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Published in Journal of medicinal chemistry (2004)
Journal Article
Identification of a novel, selective GABAA a5 receptor inverse agonist which enhances cognition
CHAMBERS, Mark S, ATACK, John R, REEVE, Austin J, MACLEOD, Angus M, BROUGHTON, Howard B, COLLINSON, Neil, COOK, Susan, DAWSON, Gerard R, HOBBS, Sarah C, MARSHALL, George, MAUBACH, Karen A, PILLAI, Goplan V
Published in Journal of medicinal chemistry (2003)
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Published in Journal of medicinal chemistry (2003)
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