Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction
England, Elizabeth, Rees, D. Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T. Y., Chaillan Huntington, Catherine E., Houslay, Kirsty F., Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B., Rapley, Laura, Sims, Dorothy A., Hollins, Claire, Hinchy, Elizabeth C., Strain, Martin D., Kemp, Benjamin P., Corkill, Dominic J., May, Richard D., Vousden, Katherine A., Butler, Robin J., Mustelin, Tomas, Vaughan, Tristan J., Lowe, David C., Colley, Caroline, Cohen, E. Suzanne
Published in Scientific reports (17.06.2023)
Published in Scientific reports (17.06.2023)
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A simeprevir-inducible molecular switch for the control of cell and gene therapies
Chin, Stacey E., Schindler, Christina, Vinall, Lisa, Dodd, Roger B., Bamber, Lisa, Legg, Sandrine, Sigurdardottir, Anna, Rees, D. Gareth, Malcolm, Tim I. M., Spratley, Samantha J., Granéli, Cecilia, Sumner, Jonathan, Tigue, Natalie J.
Published in Nature communications (27.11.2023)
Published in Nature communications (27.11.2023)
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Chitosan microparticles for the controlled delivery of fluoride
Keegan, Gemma M, Smart, John D, Ingram, Matthew J, Barnes, Lara-Marie, Burnett, Gary R, Rees, Gareth D
Published in Journal of dentistry (01.03.2012)
Published in Journal of dentistry (01.03.2012)
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A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding
Douthwaite, Julie, Moisan, Jacques, Privezentzev, Cyril, Soskic, Blagoje, Sabbah, Shereen, Cohen, Suzanne, Collinson, Andie, England, Elizabeth, Huntington, Catherine, Kemp, Ben, Zhuang, Li, Hudak, Suzanne, Rees, D Gareth, Goldberg, Debbie, Barton, Chris, Chang, Linda, Vainshtein, Inna, Liang, Meina, Iciek, Laurie, Ambery, Philip, Peakman, Mark, Vaughan, Tristan J, Tree, Tim I M, Sansom, David M, Bowen, Michael A, Minter, Ralph R, Jermutus, Lutz
Published in The Journal of immunology (1950) (01.01.2017)
Published in The Journal of immunology (1950) (01.01.2017)
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Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes
Taylor, Jonathan D., Barrett, Nathalie, Martinez Cuesta, Sergio, Cassidy, Katelyn, Pachl, Fiona, Dodgson, James, Patel, Radhika, Eriksson, Tuula M., Riley, Aidan, Burrell, Matthew, Bauer, Christin, Rees, D. Gareth, Cimbro, Raffaello, Zhang, Andrew X., Minter, Ralph R., Hunt, James, Legg, Sandrine
Published in Communications biology (19.09.2024)
Published in Communications biology (19.09.2024)
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Correction: A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding
Douthwaite, Julie, Moisan, Jacques, Privezentzev, Cyril, Soskic, Blagoje, Sabbah, Shereen, Cohen, Suzanne, Collinson, Andie, England, Elizabeth, Huntington, Catherine, Kemp, Ben, Zhuang, Li, Hudak, Suzanne, Rees, D Gareth, Goldberg, Debbie, Barton, Chris, Chang, Linda, Vainshtein, Inna, Liang, Meina, Iciek, Laurie, Ambery, Philip, Peakman, Mark, Vaughan, Tristan J, Tree, Tim I M, Sansom, David M, Bowen, Michael A, Minter, Ralph R, Jermutus, Lutz
Published in The Journal of immunology (1950) (01.09.2017)
Published in The Journal of immunology (1950) (01.09.2017)
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MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential
Tigue, Natalie J., Bamber, Lisa, Andrews, John, Ireland, Samantha, Hair, James, Carter, Edward, Sridharan, Sudharsan, Jovanović, Jelena, Rees, D. Gareth, Springall, Jeremy S., Solier, Emilie, Li, Yi-Ming, Chodorge, Matthieu, Perez-Martinez, David, Higazi, Daniel R., Oberst, Michael, Kennedy, Maureen, Black, Chelsea M., Yan, Li, Schwickart, Martin, Maguire, Shaun, Cann, Jennifer A., de Haan, Lolke, Young, Lesley L., Vaughan, Tristan, Wilkinson, Robert W., Stewart, Ross
Published in Oncoimmunology (04.03.2017)
Published in Oncoimmunology (04.03.2017)
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1169 AZD5863: a specific, potent, affinity-optimized claudin 18.2 and CD3 binding T cell-engager that elicits low cytokine release and is capable of bystander killing
Gaspar, Miguel, Natoli, Marina, Castan, Laure, Rahmy, Sharif, Kelton, Cathryn, Mulgrew, Kathy, Korade, Martin, Huhn, Oisin, Gareth Rees, D, Sigurdardottir, Anna, Lloyd, Christopher, He, Yun, Rong, Yiping, Pollizzi, Kristen, Hammond, Scott, Cemerski, Saso, Dovedi, Simon, Cobbold, Mark, Ridgway, Benjamin, Broggi, Maria AS, Palmer, Douglas C, Ball, Kathryn, McFarlane, Mary, Vargas, Fred Arce, Ceaicovscaia, Natalia, Pouliot, Gayle, Szekeres, Philip, Fitzgerald, Jonathan, Kumar, Rakesh
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma
Cohen, E Suzanne, Dobson, Claire L, Käck, Helena, Wang, Bing, Sims, Dorothy A, Lloyd, Christopher O, England, Elizabeth, Rees, D Gareth, Guo, Hongwei, Karagiannis, Sophia N, O'Brien, Siobhan, Persdotter, Sofia, Ekdahl, Helena, Butler, Robin, Keyes, Feenagh, Oakley, Sarah, Carlsson, Mats, Briend, Emmanuel, Wilkinson, Trevor, Anderson, Ian K, Monk, Phillip D, von Wachenfeldt, Karin, Eriksson, Per-Olof F, Gould, Hannah J, Vaughan, Tristan J, May, Richard D
Published in mAbs (01.05.2014)
Published in mAbs (01.05.2014)
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Fluoropolymers as low-surface-energy tooth coatings for oral care
Churchley, David, Rees, Gareth D., Barbu, Eugen, Nevell, Thomas G., Tsibouklis, John
Published in International journal of pharmaceutics (20.03.2008)
Published in International journal of pharmaceutics (20.03.2008)
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Formation and Morphology of Calcium Sulfate Nanoparticles and Nanowires in Water-in-Oil Microemulsions
Rees, Gareth D, Evans-Gowing, Richard, Hammond, Stephen J, Robinson, Brian H
Published in Langmuir (16.03.1999)
Published in Langmuir (16.03.1999)
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In vitro evolution of antibody affinity via insertional scanning mutagenesis of an entire antibody variable region
Skamaki, Kalliopi, Emond, Stephane, Chodorge, Matthieu, Andrews, John, Rees, D. Gareth, Cannon, Daniel, Popovic, Bojana, Buchanan, Andrew, Minter, Ralph R., Hollfelder, Florian
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2020)
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Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex
Strickson, Sam, Houslay, Kirsty F, Negri, Victor A, Ohne, Yoichiro, Ottosson, Tomas, Dodd, Roger B, Huntington, Catherine Chaillan, Baker, Tina, Li, Jingjing, Stephenson, Katherine E, O'Connor, Andy J, Sagawe, J Sophie, Killick, Helen, Moore, Tom, Rees, D Gareth, Koch, Sofia, Sanden, Caroline, Wang, Yixin, Gubbins, Elise, Ghaedi, Mahboobe, Kolbeck, Roland, Saumyaa, Saumyaa, Erjefält, Jonas S, Sims, Gary P, Humbles, Alison A, Scott, Ian C, Romero Ros, Xavier, Cohen, E Suzanne
Published in The European respiratory journal (01.09.2023)
Published in The European respiratory journal (01.09.2023)
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Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas
Published in Nature communications (14.09.2015)
Published in Nature communications (14.09.2015)
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