TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis
Xia, Yuhan, Inoue, Kazuki, Du, Yong, Baker, Stacey J, Reddy, E Premkumar, Greenblatt, Matthew B, Zhao, Baohong
Published in Nature communications (07.07.2022)
Published in Nature communications (07.07.2022)
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Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease
Sato, Katsutoshi, Padgaonkar, Amol A, Baker, Stacey J, Cosenza, Stephen C, Rechkoblit, Olga, Subbaiah, D R C Venkata, Domingo-Domenech, Josep, Bartkowski, Alison, Port, Elisa R, Aggarwal, Aneel K, Ramana Reddy, M V, Irie, Hanna Y, Reddy, E Premkumar
Published in Nature communications (03.08.2021)
Published in Nature communications (03.08.2021)
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A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling
Athuluri-Divakar, Sai Krishna, Vasquez-Del Carpio, Rodrigo, Dutta, Kaushik, Baker, Stacey J., Cosenza, Stephen C., Basu, Indranil, Gupta, Yogesh K., Reddy, M.V. Ramana, Ueno, Lynn, Hart, Jonathan R., Vogt, Peter K., Mulholland, David, Guha, Chandan, Aggarwal, Aneel K., Reddy, E. Premkumar
Published in Cell (21.04.2016)
Published in Cell (21.04.2016)
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Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia
Kotini, Andriana G., Chang, Chan-Jung, Chow, Arthur, Yuan, Han, Ho, Tzu-Chieh, Wang, Tiansu, Vora, Shailee, Solovyov, Alexander, Husser, Chrystel, Olszewska, Malgorzata, Teruya-Feldstein, Julie, Perumal, Deepak, Klimek, Virginia M., Spyridonidis, Alexandros, Rampal, Raajit K., Silverman, Lewis, Reddy, E. Premkumar, Papaemmanuil, Elli, Parekh, Samir, Greenbaum, Benjamin D., Leslie, Christina S., Kharas, Michael G., Papapetrou, Eirini P.
Published in Cell stem cell (02.03.2017)
Published in Cell stem cell (02.03.2017)
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Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade
Yan, Chi, Saleh, Nabil, Yang, Jinming, Nebhan, Caroline A, Vilgelm, Anna E, Reddy, E Premkumar, Roland, Joseph T, Johnson, Douglas B, Chen, Sheau-Chiann, Shattuck-Brandt, Rebecca L, Ayers, Gregory D, Richmond, Ann
Published in Molecular cancer (06.06.2021)
Published in Molecular cancer (06.06.2021)
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Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors
Reddy, M.V. Ramana, Billa, Vinay K., Pallela, Venkat R., Mallireddigari, Muralidhar R., Boominathan, Rengasamy, Gabriel, Jerome L., Reddy, E. Premkumar
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas
Divakar, S K A, Ramana Reddy, M V, Cosenza, S C, Baker, S J, Perumal, D, Antonelli, A C, Brody, J, Akula, B, Parekh, S, Reddy, E Premkumar
Published in Leukemia (01.01.2016)
Published in Leukemia (01.01.2016)
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Discovery of a Clinical Stage Multi-Kinase Inhibitor Sodium (E)-2-{2-Methoxy-5-[(2′,4′,6′-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): Synthesis, Structure–Activity Relationship, and Biological Activity
Reddy, M. V. Ramana, Venkatapuram, Padmavathi, Mallireddigari, Muralidhar R, Pallela, Venkat R, Cosenza, Stephen C, Robell, Kimberly A, Akula, Balaiah, Hoffman, Benjamin S, Reddy, E. Premkumar
Published in Journal of medicinal chemistry (22.09.2011)
Published in Journal of medicinal chemistry (22.09.2011)
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Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression
Chen, Xu-Qiao, Barrero, Carlos A, Vasquez-Del Carpio, Rodrigo, Reddy, E Premkumar, Fecchio, Chiara, Merali, Salim, Deglincerti, Alessia, Fang, Cheng, Rogers, Jack, Maccecchini, Maria L
Published in Pharmaceutics (07.12.2021)
Published in Pharmaceutics (07.12.2021)
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ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent
Gumireddy, Kiranmai, Reddy, M.V. Ramana, Cosenza, Stephen C., Nathan, R. Boomi, Baker, Stacey J., Papathi, Nabisa, Jiang, Jiandong, Holland, James, Reddy, E. Premkumar
Published in Cancer cell (01.03.2005)
Published in Cancer cell (01.03.2005)
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Drugging the 'undruggable' cancer targets
Dang, Chi V, Reddy, E Premkumar, Shokat, Kevan M, Soucek, Laura
Published in Nature reviews. Cancer (01.08.2017)
Published in Nature reviews. Cancer (01.08.2017)
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Journal Article
Myb Permits Multilineage Airway Epithelial Cell Differentiation
Pan, Jie-Hong, Adair-Kirk, Tracy L., Patel, Anand C., Huang, Tao, Yozamp, Nicholas S., Xu, Jian, Reddy, E. Premkumar, Byers, Derek E., Pierce, Richard A., Holtzman, Michael J., Brody, Steven L.
Published in Stem cells (Dayton, Ohio) (01.12.2014)
Published in Stem cells (Dayton, Ohio) (01.12.2014)
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