Design, Synthesis, Docking, DFT, MD Simulation Studies of a New Nicotinamide-Based Derivative: In Vitro Anticancer and VEGFR-2 Inhibitory Effects
Elkaeed, Eslam B., Yousef, Reda G., Elkady, Hazem, Gobaara, Ibraheem M. M., Alsfouk, Bshra A., Husein, Dalal Z., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.
Published in Molecules (Basel, Switzerland) (19.07.2022)
Published in Molecules (Basel, Switzerland) (19.07.2022)
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Journal Article
New Anticancer Theobromine Derivative Targeting EGFRWT and EGFRT790M: Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies
Elkaeed, Eslam B., Yousef, Reda G., Elkady, Hazem, Alsfouk, Aisha A., Husein, Dalal Z., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.
Published in Molecules (Basel, Switzerland) (09.09.2022)
Published in Molecules (Basel, Switzerland) (09.09.2022)
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( E )- N -(3-(1-(2-(4-(2,2,2-Trifluoroacetamido)benzoyl)hydrazono)ethyl)phenyl)nicotinamide: A Novel Pyridine Derivative for Inhibiting Vascular Endothelial Growth Factor Receptor-2: Synthesis, Computational, and Anticancer Studies
Yousef, Reda G, Elkady, Hazem, Elkaeed, Eslam B, Gobaara, Ibraheem M M, Al-Ghulikah, Hanan A, Husein, Dalal Z, Ibrahim, Ibrahim M, Metwaly, Ahmed M, Eissa, Ibrahim H
Published in Molecules (Basel, Switzerland) (09.11.2022)
Published in Molecules (Basel, Switzerland) (09.11.2022)
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Journal Article
New quinoxaline-2(1)-ones as potential VEGFR-2 inhibitors: design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations
Yousef, Reda G, Sakr, Helmy M, Eissa, Ibrahim H, Mehany, Ahmed. B. M, Metwaly, Ahmed M, Elhendawy, Mostafa A, Radwan, Mohamed M, ElSohly, Mahmoud A, Abulkhair, Hamada S, El-Adl, Khaled
Published in New journal of chemistry (28.09.2021)
Published in New journal of chemistry (28.09.2021)
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Journal Article
Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies
Yousef, Reda G., Ibrahim, Albaraa, Khalifa, Mohamed M., Eldehna, Wagdy M., Gobaara, Ibraheem M. M., Mehany, Ahmed B. M., Elkaeed, Eslam B., Alsfouk, Aisha A., Metwaly, Ahmed M., Eissa, Ibrahim H.
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2022)
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2022)
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Journal Article
Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies
Elkaeed, Eslam B, Yousef, Reda G, Khalifa, Mohamed M, Ibrahim, Albaraa, Mehany, Ahmed B M, Gobaara, Ibraheem M M, Alsfouk, Bshra A, Eldehna, Wagdy M, Metwaly, Ahmed M, Eissa, Ibrahim H, El-Zahabi, Mohamed Ayman
Published in Molecules (Basel, Switzerland) (21.09.2022)
Published in Molecules (Basel, Switzerland) (21.09.2022)
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Journal Article
Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies
Yousef, Reda G., Elwan, Alaa, Gobaara, Ibraheem M. M., Mehany, Ahmed B. M., Eldehna, Wagdy M., El-Metwally, Souad A., A. Alsfouk, Bshra, Elkaeed, Eslam B., Metwaly, Ahmed M., Eissa, Ibrahim H.
Published in Journal of enzyme inhibition and medicinal chemistry (31.12.2022)
Published in Journal of enzyme inhibition and medicinal chemistry (31.12.2022)
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Journal Article
Anticancer derivative of the natural alkaloid, theobromine, inhibiting EGFR protein: Computer-aided drug discovery approach
Eissa, Ibrahim H, Yousef, Reda G, Elkaeed, Eslam B, Alsfouk, Aisha A, Husein, Dalal Z, Ibrahim, Ibrahim M, Alesawy, Mohamed S, Elkady, Hazem, Metwaly, Ahmed M
Published in PloS one (09.03.2023)
Published in PloS one (09.03.2023)
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Journal Article
Discovery of new quinoxaline-2(1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation
El-Adl, Khaled, Sakr, Helmy M., Yousef, Reda G., Mehany, Ahmed B.M., Metwaly, Ahmed M., Elhendawy, Mostafa A., Radwan, Mohamed M., ElSohly, Mahmoud A., Abulkhair, Hamada S., Eissa, Ibrahim H.
Published in Bioorganic chemistry (01.09.2021)
Published in Bioorganic chemistry (01.09.2021)
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Journal Article
Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2
Yousef, Reda G., Eldehna, Wagdy M., Elwan, Alaa, Abdelaziz, Abdelaziz S., Mehany, Ahmed B. M., Gobaara, Ibraheem M. M., Alsfouk, Bshra A., Elkaeed, Eslam B., Metwaly, Ahmed M., Eissa, Ibrahim H.
Published in Molecules (Basel, Switzerland) (24.06.2022)
Published in Molecules (Basel, Switzerland) (24.06.2022)
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Journal Article
Design, Molecular Modeling, MD Simulations, Essential Dynamics, ADMET, DFT, Synthesis, Anti-proliferative, and Apoptotic Evaluations of a New Anti-VEGFR-2 Nicotinamide Analogue
Eissa, Ibrahim H, Elkaeed, Eslam B, Elkady, Hazem, Yousef, Reda G, Alsfouk, Bshra A, Elzahabi, Heba S A, Ibrahim, Ibrahim M, Metwaly, Ahmed M, Husein, Dalal Z
Published in Current pharmaceutical design (01.01.2023)
Published in Current pharmaceutical design (01.01.2023)
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Journal Article
Identification of new theobromine-based derivatives as potent VEGFR-2 inhibitors: design, semi-synthesis, biological evaluation, and in silico studies
Eissa, Ibrahim H, Yousef, Reda G, Elkady, Hazem, Elkaeed, Eslam B, Alsfouk, Aisha A, Husein, Dalal Z, Ibrahim, Ibrahim M, Elhendawy, Mostafa A, Godfrey, Murrell, Metwaly, Ahmed M
Published in RSC advances (26.07.2023)
Published in RSC advances (26.07.2023)
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Journal Article
In silico, in vitro VEGFR-2 inhibition, and anticancer activity of a 3-(hydrazonomethyl)naphthalene-2-ol derivative
Elkaeed, Eslam B., Yousef, Reda G., Elkady, Hazem, Mehany, Ahmed B. M., Alsfouk, Bshra A., Husein, Dalal Z., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.
Published in Journal of biomolecular structure & dynamics (02.11.2023)
Published in Journal of biomolecular structure & dynamics (02.11.2023)
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Journal Article
Design, semi-synthesis, anti-cancer assessment, docking, MD simulation, and DFT studies of novel theobromine-based derivatives as VEGFR-2 inhibitors and apoptosis inducers
Eissa, Ibrahim H., Yousef, Reda G., Elkady, Hazem, Elkaeed, Eslam B., Alsfouk, Aisha A., Husein, Dalal Z., Ibrahim, Ibrahim M., Elhendawy, Mostafa.A., Godfrey, Murrell, Metwaly, Ahmed M.
Published in Computational biology and chemistry (01.12.2023)
Published in Computational biology and chemistry (01.12.2023)
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Journal Article
Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation
Ran, Feng, Li, Wendong, Qin, Yi, Yu, Tong, Liu, Zhao, Zhou, Min, Liu, Cheng, Qiao, Tong, Li, Xiaoqiang, Yousef, Reda G., Eissa, Ibrahim H., Khalifa, Mohamed M.
Published in Oxidative medicine and cellular longevity (2021)
Published in Oxidative medicine and cellular longevity (2021)
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Journal Article
A Theobromine Derivative with Anticancer Properties Targeting VEGFR-2: Semisynthesis, in silico and in vitro Studies
Eissa, Ibrahim H, Yousef, Reda G, Elkady, Hazem, Elkaeed, Eslam B, Alsfouk, Aisha A, Husein, Dalal Z, Ibrahim, Ibrahim M, Radwan, Mohamed M, Metwaly, Ahmed M
Published in ChemistryOpen (Weinheim) (01.10.2023)
Published in ChemistryOpen (Weinheim) (01.10.2023)
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Journal Article
A New Anticancer Semisynthetic Theobromine Derivative Targeting EGFR Protein: CADDD Study
Eissa, Ibrahim H, Yousef, Reda G, Elkady, Hazem, Alsfouk, Aisha A, Alsfouk, Bshra A, Husein, Dalal Z, Ibrahim, Ibrahim M, Elkaeed, Eslam B, Metwaly, Ahmed M
Published in Life (Basel, Switzerland) (01.01.2023)
Published in Life (Basel, Switzerland) (01.01.2023)
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Journal Article
The Assessment of Anticancer and VEGFR-2 Inhibitory Activities of a New 1H-Indole Derivative: In Silico and In Vitro Approaches
Elkaeed, Eslam B., Yousef, Reda G., Elkady, Hazem, Gobaara, Ibraheem M. M., Alsfouk, Aisha A., Husein, Dalal Z., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.
Published in Processes (01.07.2022)
Published in Processes (01.07.2022)
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Journal Article
Computer-assisted drug discovery (CADD) of an anti-cancer derivative of the theobromine alkaloid inhibiting VEGFR-2
Eissa, Ibrahim H., Yousef, Reda G., Asmaey, Mostafa A., Elkady, Hazem, Husein, Dalal Z., Alsfouk, Aisha A., Ibrahim, Ibrahim M., Elkady, Mohamed A., Elkaeed, Eslam B., Metwaly, Ahmed M.
Published in Saudi pharmaceutical journal (01.12.2023)
Published in Saudi pharmaceutical journal (01.12.2023)
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Journal Article
Anti-breast cancer potential of a new xanthine derivative: In silico, antiproliferative, selectivity, VEGFR-2 inhibition, apoptosis induction and migration inhibition studies
Eissa, Ibrahim H., Yousef, Reda G., Elkady, Hazem, Elkaeed, Eslam B., Alsfouk, Bshra A., Husein, Dalal Z., Asmaey, Mostafa A., Ibrahim, Ibrahim M., Metwaly, Ahmed M.
Published in Pathology, research and practice (01.11.2023)
Published in Pathology, research and practice (01.11.2023)
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