AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer
Cross, Darren A E, Ashton, Susan E, Ghiorghiu, Serban, Eberlein, Cath, Nebhan, Caroline A, Spitzler, Paula J, Orme, Jonathon P, Finlay, M Raymond V, Ward, Richard A, Mellor, Martine J, Hughes, Gareth, Rahi, Amar, Jacobs, Vivien N, Red Brewer, Monica, Ichihara, Eiki, Sun, Jing, Jin, Hailing, Ballard, Peter, Al-Kadhimi, Katherine, Rowlinson, Rachel, Klinowska, Teresa, Richmond, Graham H P, Cantarini, Mireille, Kim, Dong-Wan, Ranson, Malcolm R, Pao, William
Published in Cancer discovery (01.09.2014)
Published in Cancer discovery (01.09.2014)
Get full text
Journal Article
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
Red Brewer, Monica, Choi, Sung Hee, Alvarado, Diego, Moravcevic, Katarina, Pozzi, Ambra, Lemmon, Mark A., Carpenter, Graham
Published in Molecular cell (26.06.2009)
Published in Molecular cell (26.06.2009)
Get full text
Journal Article
HER2 missense mutations have distinct effects on oncogenic signaling and migration
Zabransky, Daniel J, Yankaskas, Christopher L, Cochran, Rory L, Wong, Hong Yuen, Croessmann, Sarah, Chu, David, Kavuri, Shyam M, Brewer, Monica Red, Rosen, D Marc, Dalton, W Brian, Cimino-Mathews, Ashley, Cravero, Karen, Button, Berry, Kyker-Snowman, Kelly, Cidado, Justin, Erlanger, Bracha, Parsons, Heather A, Manto, Kristen M, Bose, Ron, Lauring, Josh, Arteaga, Carlos L, Konstantopoulos, Konstantinos, Park, Ben Ho
Published in Proceedings of the National Academy of Sciences - PNAS (10.11.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (10.11.2015)
Get full text
Journal Article
JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors
Gao, Sizhi P, Chang, Qing, Mao, Ninghui, Daly, Laura A, Vogel, Robert, Chan, Tyler, Liu, Shu Hui, Bournazou, Eirini, Schori, Erez, Zhang, Haiying, Brewer, Monica Red, Pao, William, Morris, Luc, Ladanyi, Marc, Arcila, Maria, Manova-Todorova, Katia, de Stanchina, Elisa, Norton, Larry, Levine, Ross L, Altan-Bonnet, Gregoire, Solit, David, Zinda, Michael, Huszar, Dennis, Lyden, David, Bromberg, Jacqueline F
Published in Science signaling (29.03.2016)
Published in Science signaling (29.03.2016)
Get more information
Journal Article
Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
Hanker, Ariella B., Brown, Benjamin P., Meiler, Jens, Marín, Arnaldo, Jayanthan, Harikrishna S., Ye, Dan, Lin, Chang-Ching, Akamatsu, Hiroaki, Lee, Kyung-Min, Chatterjee, Sumanta, Sudhan, Dhivya R., Servetto, Alberto, Brewer, Monica Red, Koch, James P., Sheehan, Jonathan H., He, Jie, Lalani, Alshad S., Arteaga, Carlos L.
Published in Cancer cell (09.08.2021)
Published in Cancer cell (09.08.2021)
Get full text
Journal Article
Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer
Lovly, Christine M, McDonald, Nerina T, Chen, Heidi, Ortiz-Cuaran, Sandra, Heukamp, Lukas C, Yan, Yingjun, Florin, Alexandra, Ozretić, Luka, Lim, Diana, Wang, Lu, Chen, Zhao, Chen, Xi, Lu, Pengcheng, Paik, Paul K, Shen, Ronglai, Jin, Hailing, Buettner, Reinhard, Ansén, Sascha, Perner, Sven, Brockmann, Michael, Bos, Marc, Wolf, Jürgen, Gardizi, Masyar, Wright, Gavin M, Solomon, Benjamin, Russell, Prudence A, Rogers, Toni-Maree, Suehara, Yoshiyuki, Red-Brewer, Monica, Tieu, Rudy, de Stanchina, Elisa, Wang, Qingguo, Zhao, Zhongming, Johnson, David H, Horn, Leora, Wong, Kwok-Kin, Thomas, Roman K, Ladanyi, Marc, Pao, William
Published in Nature medicine (01.09.2014)
Published in Nature medicine (01.09.2014)
Get full text
Journal Article
Structure-function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting
Du, Zhenfang, Brown, Benjamin P, Kim, Soyeon, Ferguson, Donna, Pavlick, Dean C, Jayakumaran, Gowtham, Benayed, Ryma, Gallant, Jean-Nicolas, Zhang, Yun-Kai, Yan, Yingjun, Red-Brewer, Monica, Ali, Siraj M, Schrock, Alexa B, Zehir, Ahmet, Ladanyi, Marc, Smith, Adam W, Meiler, Jens, Lovly, Christine M
Published in Nature communications (02.03.2021)
Published in Nature communications (02.03.2021)
Get full text
Journal Article
Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers
Sudhan, Dhivya R., Guerrero-Zotano, Angel, Won, Helen, González Ericsson, Paula, Servetto, Alberto, Huerta-Rosario, Mariela, Ye, Dan, Lee, Kyung-min, Formisano, Luigi, Guo, Yan, Liu, Qi, Kinch, Lisa N., Red Brewer, Monica, Dugger, Teresa, Koch, James, Wick, Michael J., Cutler, Richard E., Lalani, Alshad S., Bryce, Richard, Auerbach, Alan, Hanker, Ariella B., Arteaga, Carlos L.
Published in Cancer cell (10.02.2020)
Published in Cancer cell (10.02.2020)
Get full text
Journal Article
EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib
Gallant, Jean-Nicolas, Sheehan, Jonathan H, Shaver, Timothy M, Bailey, Mark, Lipson, Doron, Chandramohan, Raghu, Red Brewer, Monica, York, Sally J, Kris, Mark G, Pietenpol, Jennifer A, Ladanyi, Marc, Miller, Vincent A, Ali, Siraj M, Meiler, Jens, Lovly, Christine M
Published in Cancer discovery (01.11.2015)
Published in Cancer discovery (01.11.2015)
Get full text
Journal Article
Functional Effects of Glycosylation at Asn-579 of the Epidermal Growth Factor Receptor
Whitson, Kristin B, Whitson, Stefanie R, Red-Brewer, Monica L, McCoy, Austin J, Vitali, Angela A, Walker, Francesca, Johns, Terrance G, Beth, Albert H, Staros, James V
Published in Biochemistry (Easton) (15.11.2005)
Published in Biochemistry (Easton) (15.11.2005)
Get full text
Journal Article
Abstract P4-01-02: A spectrum of secondary mutations in HER2 augment breast cancer cell growth and reduce neratinib sensitivity in HER2 -mutant breast cancer
Marin, Arnaldo Andres, Mamun, Abdullah Al, Akamatsu, Hiroaki, Ye, Dan, Sudhan, Dhivya, Brown, Benjamin, Brewer, Monica Red, Eli, Lisa, Meiler, Jens, Arteaga, Carlos L, Hanker, Ariella B
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Get full text
Journal Article
Abstract 867: EGFR kinase domain duplication (EGFR-KDD) is activated by asymmetric intra-molecular dimerization
Du, Zhenfang, Gallant, Jean-Nicolas, Red-Brewer, Monica, Brown, Benjamin, Sheehan, Jonathan, Meiler, Jens, Lovly, Christine M.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Abstract GS6-04: Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, breast cancer progression, and HER2 inhibitor sensitivity
Hanker, Ariella B., Jayanthan, Harikrishna Sekar, Ye, Dan, Lin, Chang-Ching, Akamatsu, Hiroaki, Sheehan, Jonathan H., Koch, James P., Sudhan, Dhivya R., Brewer, Monica Red, Servetto, Alberto, He, Jie, Miller, Vincent A., Lalani, Alshad S., Meiler, Jens, Arteaga, Carlos L.
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Get full text
Journal Article
An ERBB1-3 Neutralizing Antibody Mixture With High Activity Against Drug-Resistant HER2+ Breast Cancers With ERBB Ligand Overexpression
Schwarz, Luis J, Hutchinson, Katherine E, Rexer, Brent N, Estrada, Mónica Valeria, Gonzalez Ericsson, Paula I, Sanders, Melinda E, Dugger, Teresa C, Formisano, Luigi, Guerrero-Zotano, Angel, Red-Brewer, Monica, Young, Christian D, Lantto, Johan, Pedersen, Mikkel W, Kragh, Michael, Horak, Ivan D, Arteaga, Carlos L
Published in JNCI : Journal of the National Cancer Institute (01.11.2017)
Published in JNCI : Journal of the National Cancer Institute (01.11.2017)
Get full text
Journal Article
Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA ^sup H1047R^ in HER2/ER-positive breast cancer
Cheng, Feixiong, Zhao, Junfei, Hanker, Ariella B, Brewer, Monica Red, Arteaga, Carlos L, Zhao, Zhongming
Published in Breast cancer research and treatment (01.12.2016)
Published in Breast cancer research and treatment (01.12.2016)
Get full text
Journal Article
Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA super(H1047R) in HER2/ER-positive breast cancer
Cheng, Feixiong, Zhao, Junfei, Hanker, Ariella B, Brewer, Monica Red, Arteaga, Carlos L, Zhao, Zhongming
Published in Breast cancer research and treatment (01.12.2016)
Published in Breast cancer research and treatment (01.12.2016)
Get full text
Journal Article
Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA.sup.H1047R in HER2/ER-positive breast cancer
Cheng, Feixiong, Zhao, Junfei, Hanker, Ariella B, Brewer, Monica Red, Arteaga, Carlos L, Zhao, Zhongming
Published in Breast cancer research and treatment (01.12.2016)
Published in Breast cancer research and treatment (01.12.2016)
Get full text
Journal Article