Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP
Mukherjee, Rajarshi, Mareninova, Olga A, Odinokova, Irina V, Huang, Wei, Murphy, John, Chvanov, Michael, Javed, Muhammad A, Wen, Li, Booth, David M, Cane, Matthew C, Awais, Muhammad, Gavillet, Bruno, Pruss, Rebecca M, Schaller, Sophie, Molkentin, Jeffery D, Tepikin, Alexei V, Petersen, Ole H, Pandol, Stephen J, Gukovsky, Ilya, Criddle, David N, Gukovskaya, Anna S, Sutton, Robert
Published in Gut (01.08.2016)
Published in Gut (01.08.2016)
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Early deficits in glycolysis are specific to striatal neurons from a rat model of huntington disease
Gouarné, Caroline, Tardif, Gwenaëlle, Tracz, Jennifer, Latyszenok, Virginie, Michaud, Magali, Clemens, Laura Emily, Yu-Taeger, Libo, Nguyen, Huu Phuc, Bordet, Thierry, Pruss, Rebecca M
Published in PloS one (26.11.2013)
Published in PloS one (26.11.2013)
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Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results
Atar, Dan, Arheden, Håkan, Berdeaux, Alain, Bonnet, Jean-Louis, Carlsson, Marcus, Clemmensen, Peter, Cuvier, Valérie, Danchin, Nicolas, Dubois-Randé, Jean-Luc, Engblom, Henrik, Erlinge, David, Firat, Hüseyin, Halvorsen, Sigrun, Hansen, Henrik Steen, Hauke, Wilfried, Heiberg, Einar, Koul, Sasha, Larsen, Alf-Inge, Le Corvoisier, Philippe, Nordrehaug, Jan Erik, Paganelli, Franck, Pruss, Rebecca M, Rousseau, Hélène, Schaller, Sophie, Sonou, Giles, Tuseth, Vegard, Veys, Julien, Vicaut, Eric, Jensen, Svend Eggert
Published in European heart journal (07.01.2015)
Published in European heart journal (07.01.2015)
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Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons
Richter, Franziska, Gao, Fuying, Medvedeva, Vera, Lee, Patrick, Bove, Nicholas, Fleming, Sheila M, Michaud, Magali, Lemesre, Vincent, Patassini, Stefano, De La Rosa, Krystal, Mulligan, Caitlin K, Sioshansi, Pedrom C, Zhu, Chunni, Coppola, Giovanni, Bordet, Thierry, Pruss, Rebecca M, Chesselet, Marie-Françoise
Published in Neurobiology of disease (01.09.2014)
Published in Neurobiology of disease (01.09.2014)
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Olesoxime accelerates myelination and promotes repair in models of demyelination
Magalon, Karine, Zimmer, Celine, Cayre, Myriam, Khaldi, Joseph, Bourbon, Clarisse, Robles, Isabelle, Tardif, Gwenaëlle, Viola, Angèle, Pruss, Rebecca M., Bordet, Thierry, Durbec, Pascale
Published in Annals of neurology (01.02.2012)
Published in Annals of neurology (01.02.2012)
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TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition
Schaller, Sophie, Paradis, Stéphanie, Ngoh, Gladys A, Assaly, Rana, Buisson, Bruno, Drouot, Cyrille, Ostuni, Mariano A, Lacapere, Jean-Jacques, Bassissi, Firas, Bordet, Thierry, Berdeaux, Alain, Jones, Steven P, Morin, Didier, Pruss, Rebecca M
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
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Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat
Clemens, Laura E, Weber, Jonasz J, Wlodkowski, Tanja T, Yu-Taeger, Libo, Michaud, Magali, Calaminus, Carsten, Eckert, Schamim H, Gaca, Janett, Weiss, Andreas, Magg, Janine C D, Jansson, Erik K H, Eckert, Gunter P, Pichler, Bernd J, Bordet, Thierry, Pruss, Rebecca M, Riess, Olaf, Nguyen, Huu P
Published in Brain (London, England : 1878) (01.12.2015)
Published in Brain (London, England : 1878) (01.12.2015)
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Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis
Bordet, Thierry, Buisson, Bruno, Michaud, Magali, Drouot, Cyrille, Galéa, Pascale, Delaage, Pierre, Akentieva, Natalia P, Evers, Alex S, Covey, Douglas F, Ostuni, Mariano A, Lacapère, Jean-Jacques, Massaad, Charbel, Schumacher, Michael, Steidl, Esther-Marie, Maux, Delphine, Delaage, Michel, Henderson, Christopher E, Pruss, Rebecca M
Published in The Journal of pharmacology and experimental therapeutics (01.08.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2007)
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Journal Article
Olesoxime (cholest-4-en-3-one, oxime): Analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel
Xiao, Wen Hua, Zheng, Felix Y., Bennett, Gary J., Bordet, Thierry, Pruss, Rebecca M.
Published in Pain (Amsterdam) (15.12.2009)
Published in Pain (Amsterdam) (15.12.2009)
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Olesoxime (TRO19622): A Novel Mitochondrial-Targeted Neuroprotective Compound
Bordet, Thierry, Berna, Patrick, Abitbol, Jean-Louis, Pruss, Rebecca M
Published in Pharmaceuticals (28.01.2010)
Published in Pharmaceuticals (28.01.2010)
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Book Review
Differences in the profile of protection afforded by TRO40303 and mild hypothermia in models of cardiac ischemia/reperfusion injury
Hansson, Magnus J., Llwyd, Osian, Morin, Didier, de Paulis, Damien, Arnoux, Thomas, Gouarné, Caroline, Koul, Sasha, Engblom, Henrik, Bordet, Thierry, Tissier, Renaud, Arheden, Haakan, Erlinge, David, Halestrap, Andrew P., Berdeaux, Alain, Pruss, Rebecca M., Schaller, Sophie
Published in European journal of pharmacology (05.08.2015)
Published in European journal of pharmacology (05.08.2015)
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Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy
Michaud, Magali, Arnoux, Thomas, Bielli, Serena, Durand, Estelle, Rotrou, Yann, Jablonka, Sibylle, Robert, Fabrice, Giraudon-Paoli, Marc, Riessland, Markus, Mattei, Marie-Geneviève, Andriambeloson, Emile, Wirth, Brunhilde, Sendtner, Michael, Gallego, Jorge, Pruss, Rebecca M, Bordet, Thierry
Published in Neurobiology of disease (01.04.2010)
Published in Neurobiology of disease (01.04.2010)
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Journal Article
Mitochondrial Membrane Fluidity is Consistently Increased in Different Models of Huntington Disease: Restorative Effects of Olesoxime
Eckmann, Janett, Clemens, Laura E., Eckert, Schamim H., Hagl, Stephanie, Yu-Taeger, Libo, Bordet, Thierry, Pruss, Rebecca M., Muller, Walter E., Leuner, Kristina, Nguyen, Huu P., Eckert, Gunter P.
Published in Molecular neurobiology (01.08.2014)
Published in Molecular neurobiology (01.08.2014)
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Tissue- and cell-specific mitochondrial defect in Parkin-deficient mice
Damiano, Maria, Gautier, Clément A, Bulteau, Anne-Laure, Ferrando-Miguel, Rosa, Gouarne, Caroline, Paoli, Marc Giraudon, Pruss, Rebecca, Auchère, Françoise, L'Hermitte-Stead, Caroline, Bouillaud, Frédéric, Brice, Alexis, Corti, Olga, Lombès, Anne
Published in PloS one (24.06.2014)
Published in PloS one (24.06.2014)
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Journal Article
Olesoxime protects embryonic cortical neurons from camptothecin intoxication by a mechanism distinct from BDNF
Gouarné, Caroline, Giraudon‐Paoli, Marc, Seimandi, Mathieu, Biscarrat, Clotilde, Tardif, Gwenaëlle, Pruss, Rebecca M, Bordet, Thierry
Published in British journal of pharmacology (01.04.2013)
Published in British journal of pharmacology (01.04.2013)
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Journal Article
Specific Antinociceptive Activity of Cholest-4-en-3-one, Oxime (TRO19622) in Experimental Models of Painful Diabetic and Chemotherapy-Induced Neuropathy
Bordet, Thierry, Buisson, Bruno, Michaud, Magali, Abitbol, Jean-Louis, Marchand, Fabien, Grist, John, Andriambeloson, Emile, Malcangio, Marzia, Pruss, Rebecca M
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
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Journal Article
Dysfunction of the Cholesterol Biosynthetic Pathway in Huntington's Disease
Valenza, Marta, Rigamonti, Dorotea, Goffredo, Donato, Zuccato, Chiara, Fenu, Simone, Jamot, Laure, Strand, Andrew, Tarditi, Alessia, Woodman, Ben, Racchi, Marco, Mariotti, Caterina, Di Donato, Stefano, Corsini, Alberto, Bates, Gillian, Pruss, Rebecca, Olson, James M, Sipione, Simonetta, Tartari, Marzia, Cattaneo, Elena
Published in The Journal of neuroscience (26.10.2005)
Published in The Journal of neuroscience (26.10.2005)
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Mitochondrial translocator protein (TSPO) ligands prevent doxorubicin-induced mechanical dysfunction and cell death in isolated cardiomyocytes
de Tassigny, Alexandra d'Anglemont, Assaly, Rana, Schaller, Sophie, Pruss, Rebecca M, Berdeaux, Alain, Morin, Didier
Published in Mitochondrion (01.11.2013)
Published in Mitochondrion (01.11.2013)
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