Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
Southam, Lorraine, Gilly, Arthur, Süveges, Dániel, Farmaki, Aliki-Eleni, Schwartzentruber, Jeremy, Tachmazidou, Ioanna, Matchan, Angela, Rayner, Nigel W., Tsafantakis, Emmanouil, Karaleftheri, Maria, Xue, Yali, Dedoussis, George, Zeggini, Eleftheria
Published in Nature communications (26.05.2017)
Published in Nature communications (26.05.2017)
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Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
Gilly, Arthur, Suveges, Daniel, Kuchenbaecker, Karoline, Pollard, Martin, Southam, Lorraine, Hatzikotoulas, Konstantinos, Farmaki, Aliki-Eleni, Bjornland, Thea, Waples, Ryan, Appel, Emil V. R., Casalone, Elisabetta, Melloni, Giorgio, Kilian, Britt, Rayner, Nigel W., Ntalla, Ioanna, Kundu, Kousik, Walter, Klaudia, Danesh, John, Butterworth, Adam, Barroso, Inês, Tsafantakis, Emmanouil, Dedoussis, George, Moltke, Ida, Zeggini, Eleftheria
Published in Nature communications (07.11.2018)
Published in Nature communications (07.11.2018)
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Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk
GROVES, Christopher J, ZEGGINI, Eleftheria, MCCARTHY, Mark I, MINTON, Jayne, FRAYLING, Timothy M, WEEDON, Michael N, RAYNER, Nigel W, HITMAN, Graham A, WALKER, Mark, WILTSHIRE, Steven, HATTERSLEY, Andrew T
Published in Diabetes (New York, N.Y.) (01.09.2006)
Published in Diabetes (New York, N.Y.) (01.09.2006)
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A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates
Tachmazidou, Ioanna, Dedoussis, George, Southam, Lorraine, Farmaki, Aliki-Eleni, Ritchie, Graham R. S., Xifara, Dionysia K., Matchan, Angela, Hatzikotoulas, Konstantinos, Rayner, Nigel W., Chen, Yuan, Pollin, Toni I., O’Connell, Jeffrey R., Yerges-Armstrong, Laura M., Kiagiadaki, Chrysoula, Panoutsopoulou, Kalliope, Schwartzentruber, Jeremy, Moutsianas, Loukas, Tsafantakis, Emmanouil, Tyler-Smith, Chris, McVean, Gil, Xue, Yali, Zeggini, Eleftheria
Published in Nature communications (17.12.2013)
Published in Nature communications (17.12.2013)
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Author Correction: Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
Gilly, Arthur, Suveges, Daniel, Kuchenbaecker, Karoline, Pollard, Martin, Southam, Lorraine, Hatzikotoulas, Konstantinos, Farmaki, Aliki-Eleni, Bjornland, Thea, Waples, Ryan, Appel, Emil V. R., Casalone, Elisabetta, Melloni, Giorgio, Kilian, Britt, Rayner, Nigel W., Ntalla, Ioanna, Kundu, Kousik, Walter, Klaudia, Danesh, John, Butterworth, Adam, Barroso, Inês, Tsafantakis, Emmanouil, Dedoussis, George, Moltke, Ida, Zeggini, Eleftheria
Published in Nature communications (19.12.2018)
Published in Nature communications (19.12.2018)
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Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study
Mamakou, Vasiliki, Hackinger, Sophie, Zengini, Eleni, Tsompanaki, Evgenia, Marouli, Eirini, Serafetinidis, Ioannis, Prins, Bram, Karabela, Athina, Glezou, Eirini, Southam, Lorraine, Rayner, Nigel W, Kuchenbaecker, Karoline, Lamnissou, Klea, Kontaxakis, Vassilis, Dedoussis, George, Gonidakis, Fragiskos, Thanopoulou, Anastasia, Tentolouris, Nikolaos, Zeggini, Eleftheria
Published in BMC psychiatry (02.08.2018)
Published in BMC psychiatry (02.08.2018)
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MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven
Rantalainen, Mattias, Herrera, Blanca M, Nicholson, George, Bowden, Rory, Wills, Quin F, Min, Josine L, Neville, Matt J, Barrett, Amy, Allen, Maxine, Rayner, Nigel W, Fleckner, Jan, McCarthy, Mark I, Zondervan, Krina T, Karpe, Fredrik, Holmes, Chris C, Lindgren, Cecilia M
Published in PloS one (15.11.2011)
Published in PloS one (15.11.2011)
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BMI-associated alleles do not constitute risk alleles for polycystic ovary syndrome independently of BMI: a case-control study
Louwers, Yvonne V, Rayner, Nigel W, Herrera, Blanca M, Stolk, Lisette, Groves, Christopher J, Barber, Thomas M, Uitterlinden, Andre G, Franks, Stephen, Laven, Joop S E, McCarthy, Mark I
Published in PloS one (31.01.2014)
Published in PloS one (31.01.2014)
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THOC5: a novel gene involved in HDL-cholesterol metabolism[S]
Keller, Maria, Schleinitz, Dorit, Förster, Julia, Tönjes, Anke, Böttcher, Yvonne, Fischer-Rosinsky, Antje, Breitfeld, Jana, Weidle, Kerstin, Rayner, Nigel W., Burkhardt, Ralph, Enigk, Beate, Müller, Ines, Halbritter, Jan, Koriath, Moritz, Pfeiffer, Andreas, Krohn, Knut, Groop, Leif, Spranger, Joachim, Stumvoll, Michael, Kovacs, Peter
Published in Journal of lipid research (01.11.2013)
Published in Journal of lipid research (01.11.2013)
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Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes
Boraska, Vesna, Rayner, Nigel W, Groves, Christopher J, Frayling, Timothy M, Diakite, Mahamadou, Rockett, Kirk A, Kwiatkowski, Dominic P, Day-Williams, Aaron G, McCarthy, Mark I, Zeggini, Eleftheria
Published in BMC genetics (06.05.2010)
Published in BMC genetics (06.05.2010)
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Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study
Zeggini, Eleftheria, Panoutsopoulou, Kalliope, Southam, Lorraine, Rayner, Nigel W, Day-Williams, Aaron G, Lopes, Margarida C, Boraska, Vesna, Esko, Tonu, Evangelou, Evangelos, Hoffman, Albert, Houwing-Duistermaat, Jeanine J, Ingvarsson, Thorvaldur, Jonsdottir, Ingileif, Jonnson, Helgi, Kerkhof, Hanneke J, Kloppenburg, Margreet, Bos, Steffan D, Mangino, Massimo, Metrustry, Sarah, Slagboom, P Eline, Thorleifsson, Gudmar, Raine, Emma V A, Ratnayake, Madhushika, Ricketts, Michelle, Beazley, Claude, Blackburn, Hannah, Bumpstead, Suzannah, Elliott, Katherine S, Hunt, Sarah E, Potter, Simon C, Shin, So-Youn, Yadav, Vijay K, Zhai, Guangju, Sherburn, Kate, Dixon, Kate, Arden, Elizabeth, Aslam, Nadim, Battley, Phillippa-kate, Carluke, Ian, Doherty, Sally, Gordon, Andrew, Joseph, John, Keen, Richard, Koller, Nicola C, Mitchell, Sheryl, O'Neill, Fiona, Paling, Ellen, Reed, Mike R, Rivadeneira, Fernando, Swift, Diane, Walker, Kirsten, Watkins, Bridget, Wheeler, Maggie, Birrell, Fraser, Ioannidis, John P A, Meulenbelt, Ingrid, Metspalu, Andres, Rai, Ashok, Salter, Donald, Stefansson, Kari, Stykarsdottir, Unnur, Uitterlinden, André G, van Meurs, Joyce B J, Chapman, Kay, Deloukas, Panos, Ollier, William E R, Wallis, Gillian A, Arden, Nigel, Carr, Andrew, Doherty, Michael, McCaskie, Andrew, Willkinson, J Mark, Ralston, Stuart H, Valdes, Ana M, Spector, Tim D, Loughlin, John
Published in The Lancet (British edition) (01.09.2012)
Published in The Lancet (British edition) (01.09.2012)
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70-OR: Identification of 489 Type 2 Diabetes Shared and Tissue-Specific Effector Genes by Integrating eQTL Data with a Multiancestry GWAS of 2.5 Million Individuals
MANDLA, RAVI, LORENZ, KIMBERLY, YIN, XIANYONG, SOUTHAM, LORRAINE, SUZUKI, KEN, HATZIKOTOULAS, KONSTANTINOS, TAYLOR, HENRY J., HUERTA, ALICIA, RAYNER, NIGEL W., CONSORTIUM, DIAMANTE, MILLION VETERAN PROGRAM, VA, MEIGS, JAMES B., MCCARTHY, MARK I., MAHAJAN, ANUBHA, SPRACKLEN, CASSANDRA, BOEHNKE, MICHAEL, VUJKOVIC, MARIJANA, ROTTER, JEROME I., VOIGHT, BENJAMIN F., ZEGGINI, ELEFTHERIA, MORRIS, ANDREW, MERCADER, JOSEP M., 2 DIABETES GLOBAL GENOMICS INITIATIVE, TYPE
Published in Diabetes (New York, N.Y.) (20.06.2023)
Published in Diabetes (New York, N.Y.) (20.06.2023)
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69-OR: Multiancestry Genome-Wide Association Study Reveals Distinct Biological Pathways and Cell Types Driving Type 2 Diabetes Risk with Heterogeneous Effects across Diverse Populations
SUZUKI, KEN, HATZIKOTOULAS, KONSTANTINOS, SOUTHAM, LORRAINE, YIN, XIANYONG, LORENZ, KIMBERLY, MANDLA, RAVI, TAYLOR, HENRY J., HUERTA, ALICIA, RAYNER, NIGEL W., CONSORTIUM, DIAMANTE, MILLION VETERAN PROGRAM, VA, MEIGS, JAMES B., MCCARTHY, MARK I., MAHAJAN, ANUBHA, MERCADER, JOSEP M., SPRACKLEN, CASSANDRA, BOEHNKE, MICHAEL, VUJKOVIC, MARIJANA, ROTTER, JEROME I., VOIGHT, BENJAMIN F., ZEGGINI, ELEFTHERIA, MORRIS, ANDREW, 2 DIABETES GLOBAL GENOMICS INITIATIVE, TYPE
Published in Diabetes (New York, N.Y.) (20.06.2023)
Published in Diabetes (New York, N.Y.) (20.06.2023)
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A common variant of HMGA2 is associated with adult and childhood height in the general population
Shields, Beverley, Salomaa, Veikko, Burtt, Noel P, Weedon, Michael N, Voight, Benjamin F, Tobias, Jonathan H, Guiducci, Candace, Morris, Andrew D, Perry, John R B, Ness, Andrew R, Lango, Hana, Frayling, Timothy M, Lettre, Guillaume, Elliott, Katherine S, Groop, Leif C, Palmer, Colin N A, Hirschhorn, Joel N, Zeggini, Eleftheria, Lindgren, Cecilia M, Freathy, Rachel M, Timpson, Nicholas J, Peltonen, Leena, Hackett, Rachel, Lyssenko, Valeriya, Rayner, Nigel W, McCarthy, Mark I, Ardlie, Kristin, Ring, Susan M, Saxena, Richa, Smith, George Davey, Hattersley, Andrew T
Published in Nature genetics (01.10.2007)
Published in Nature genetics (01.10.2007)
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A Dietary Pattern with High Sugar Content Is Associated with Cardiometabolic Risk Factors in the Pomak Population
Farmaki, Aliki-Eleni, Rayner, Nigel W, Kafyra, Maria, Matchan, Angela, Ntaoutidou, Kyriaki, Feritoglou, Pournar, Athanasiadis, Antonis, Gilly, Arthur, Mamakou, Vasiliki, Zengini, Eleni, Karaleftheri, Maria, Zeggini, Eleftheria, Dedoussis, George
Published in Nutrients (13.12.2019)
Published in Nutrients (13.12.2019)
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Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants
Panoutsopoulou, Kalliope, Hatzikotoulas, Konstantinos, Xifara, Dionysia Kiara, Colonna, Vincenza, Farmaki, Aliki-Eleni, Ritchie, Graham R. S., Southam, Lorraine, Gilly, Arthur, Tachmazidou, Ioanna, Fatumo, Segun, Matchan, Angela, Rayner, Nigel W., Ntalla, Ioanna, Mezzavilla, Massimo, Chen, Yuan, Kiagiadaki, Chrysoula, Zengini, Eleni, Mamakou, Vasiliki, Athanasiadis, Antonis, Giannakopoulou, Margarita, Kariakli, Vassiliki-Eirini, Nsubuga, Rebecca N., Karabarinde, Alex, Sandhu, Manjinder, McVean, Gil, Tyler-Smith, Chris, Tsafantakis, Emmanouil, Karaleftheri, Maria, Xue, Yali, Dedoussis, George, Zeggini, Eleftheria
Published in Nature communications (06.11.2014)
Published in Nature communications (06.11.2014)
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A Variant in MCF2L Is Associated with Osteoarthritis
Day-Williams, Aaron G., Southam, Lorraine, Panoutsopoulou, Kalliope, Rayner, Nigel W., Esko, Tonu, Estrada, Karol, Helgadottir, Hafdis T., Hofman, Albert, Ingvarsson, Throvaldur, Jonsson, Helgi, Keis, Aime, Kerkhof, Hanneke J.M., Thorleifsson, Gudmar, Arden, Nigel K., Carr, Andrew, Chapman, Kay, Deloukas, Panos, Loughlin, John, McCaskie, Andrew, Ollier, William E.R., Ralston, Stuart H., Spector, Timothy D., Wallis, Gillian A., Wilkinson, J. Mark, Aslam, Nadim, Birell, Fraser, Carluke, Ian, Joseph, John, Rai, Ashok, Reed, Mike, Walker, Kirsten, Doherty, Sally A., Jonsdottir, Ingileif, Maciewicz, Rose A., Muir, Kenneth R., Metspalu, Andres, Rivadeneira, Fernando, Stefansson, Kari, Styrkarsdottir, Unnur, Uitterlinden, Andre G., van Meurs, Joyce B.J., Zhang, Weiya, Valdes, Ana M., Doherty, Michael, Zeggini, Eleftheria
Published in American journal of human genetics (09.09.2011)
Published in American journal of human genetics (09.09.2011)
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Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany
TÖNJES, Anke, ZEGGINI, Eleftheria, ESZLINGER, Markus, KEMPPINEN, Anu, PROKOPENKO, Inga, HOFFMANN, Katrin, TEUPSER, Daniel, THIERY, Joachim, KROHN, Knut, MCCARTHY, Mark I, STUMVOLL, Michael, KOVACS, Peter, BÖTTCHER, Yvonne, SCHLEINITZ, Dorit, DIETRICH, Kerstin, MORRIS, Andrew P, ENIGK, Beate, RAYNER, Nigel W, KORIATH, Moritz
Published in European journal of human genetics : EJHG (01.01.2010)
Published in European journal of human genetics : EJHG (01.01.2010)
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Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs
Tönjes, Anke, Koriath, Moritz, Schleinitz, Dorit, Dietrich, Kerstin, Böttcher, Yvonne, Rayner, Nigel W., Almgren, Peter, Enigk, Beate, Richter, Olaf, Rohm, Silvio, Fischer-Rosinsky, Antje, Pfeiffer, Andreas, Hoffmann, Katrin, Krohn, Knut, Aust, Gabriela, Spranger, Joachim, Groop, Leif, Blüher, Matthias, Kovacs, Peter, Stumvoll, Michael
Published in Human molecular genetics (01.12.2009)
Published in Human molecular genetics (01.12.2009)
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Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes
Min, Josine L, Nicholson, George, Halgrimsdottir, Ingileif, Almstrup, Kristian, Petri, Andreas, Barrett, Amy, Travers, Mary, Rayner, Nigel W, Mägi, Reedik, Pettersson, Fredrik H, Broxholme, John, Neville, Matt J, Wills, Quin F, Cheeseman, Jane, Allen, Maxine, Holmes, Chris C, Spector, Tim D, Fleckner, Jan, McCarthy, Mark I, Karpe, Fredrik, Lindgren, Cecilia M, Zondervan, Krina T
Published in PLoS genetics (01.02.2012)
Published in PLoS genetics (01.02.2012)
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