Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants
Marek, Martin, Shaik, Tajith B, Heimburg, Tino, Chakrabarti, Alokta, Lancelot, Julien, Ramos-Morales, Elizabeth, Da Veiga, Cyrielle, Kalinin, Dmitrii, Melesina, Jelena, Robaa, Dina, Schmidtkunz, Karin, Suzuki, Takayoshi, Holl, Ralph, Ennifar, Eric, Pierce, Raymond J, Jung, Manfred, Sippl, Wolfgang, Romier, Christophe
Published in Journal of medicinal chemistry (21.11.2018)
Published in Journal of medicinal chemistry (21.11.2018)
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Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni
Marek, Martin, Kannan, Srinivasaraghavan, Hauser, Alexander-Thomas, Moraes Mourão, Marina, Caby, Stéphanie, Cura, Vincent, Stolfa, Diana A, Schmidtkunz, Karin, Lancelot, Julien, Andrade, Luiza, Renaud, Jean-Paul, Oliveira, Guilherme, Sippl, Wolfgang, Jung, Manfred, Cavarelli, Jean, Pierce, Raymond J, Romier, Christophe
Published in PLoS pathogens (01.09.2013)
Published in PLoS pathogens (01.09.2013)
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Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis
Heimburg, Tino, Chakrabarti, Alokta, Lancelot, Julien, Marek, Martin, Melesina, Jelena, Hauser, Alexander-Thomas, Shaik, Tajith B, Duclaud, Sylvie, Robaa, Dina, Erdmann, Frank, Schmidt, Matthias, Romier, Christophe, Pierce, Raymond J, Jung, Manfred, Sippl, Wolfgang
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets
Lancelot, Julien, Caby, Stéphanie, Dubois-Abdesselem, Florence, Vanderstraete, Mathieu, Trolet, Jacques, Oliveira, Guilherme, Bracher, Franz, Jung, Manfred, Pierce, Raymond J
Published in PLoS neglected tropical diseases (01.09.2013)
Published in PLoS neglected tropical diseases (01.09.2013)
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Journal Article
Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis
Ghazy, Ehab, Abdelsalam, Mohamed, Robaa, Dina, Pierce, Raymond J, Sippl, Wolfgang
Published in Pharmaceuticals (Basel, Switzerland) (10.01.2022)
Published in Pharmaceuticals (Basel, Switzerland) (10.01.2022)
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Journal Article
Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni
Pagliazzo, Lucile, Caby, Stéphanie, Lancelot, Julien, Salomé-Desnoulez, Sophie, Saliou, Jean-Michel, Heimburg, Tino, Chassat, Thierry, Cailliau, Katia, Sippl, Wolfgang, Vicogne, Jérôme, Pierce, Raymond J
Published in PLoS neglected tropical diseases (29.11.2021)
Published in PLoS neglected tropical diseases (29.11.2021)
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Journal Article
Discovery of Inhibitors of Schistosoma mansoni HDAC8 by Combining Homology Modeling, Virtual Screening, and in Vitro Validation
Kannan, Srinivasaraghavan, Melesina, Jelena, Hauser, Alexander-Thomas, Chakrabarti, Alokta, Heimburg, Tino, Schmidtkunz, Karin, Walter, Alexandra, Marek, Martin, Pierce, Raymond J, Romier, Christophe, Jung, Manfred, Sippl, Wolfgang
Published in Journal of chemical information and modeling (27.10.2014)
Published in Journal of chemical information and modeling (27.10.2014)
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A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing
Simoben, Conrad V, Robaa, Dina, Chakrabarti, Alokta, Schmidtkunz, Karin, Marek, Martin, Lancelot, Julien, Kannan, Srinivasaraghavan, Melesina, Jelena, Shaik, Tajith B, Pierce, Raymond J, Romier, Christophe, Jung, Manfred, Sippl, Wolfgang
Published in Molecules (Basel, Switzerland) (02.03.2018)
Published in Molecules (Basel, Switzerland) (02.03.2018)
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Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth
Chua, Ming Jang, Arnold, Megan S.J., Xu, Weijun, Lancelot, Julien, Lamotte, Suzanne, Späth, Gerald F., Prina, Eric, Pierce, Raymond J., Fairlie, David P., Skinner-Adams, Tina S., Andrews, Katherine T.
Published in International journal for parasitology -- drugs and drug resistance (01.04.2017)
Published in International journal for parasitology -- drugs and drug resistance (01.04.2017)
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Corrigendum: Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction
Coelho, Fernanda Sales, Gava, Sandra Grossi, Andrade, Luiza Freire, Geraldo, Juliana Assis, Tavares, Naiara Clemente, Lunkes, Felipe Miguel Nery, Neves, Renata Heisler, Machado-Silva, José Roberto, Pierce, Raymond J, Oliveira, Guilherme, Mourão, Marina Moraes
Published in Frontiers in microbiology (29.03.2023)
Published in Frontiers in microbiology (29.03.2023)
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Journal Article
Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction
Coelho, Fernanda Sales, Gava, Sandra Grossi, Andrade, Luiza Freire, Geraldo, Juliana Assis, Tavares, Naiara Clemente, Lunkes, Felipe Miguel Nery, Neves, Renata Heisler, Machado-Silva, José Roberto, Pierce, Raymond J, Oliveira, Guilherme, Mourão, Marina Moraes
Published in Frontiers in microbiology (24.02.2023)
Published in Frontiers in microbiology (24.02.2023)
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Journal Article
Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni
Baeza Garcia, Alvaro, Pierce, Raymond J, Gourbal, Benjamin, Werkmeister, Elisabeth, Colinet, Dominique, Reichhart, Jean-Marc, Dissous, Colette, Coustau, Christine
Published in PLoS pathogens (01.09.2010)
Published in PLoS pathogens (01.09.2010)
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Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis
Carneiro, Vitor Coutinho, de Abreu da Silva, Isabel Caetano, Torres, Eduardo José Lopes, Caby, Stephany, Lancelot, Julien, Vanderstraete, Mathieu, Furdas, Silviya D, Jung, Manfred, Pierce, Raymond J, Fantappié, Marcelo Rosado
Published in PLoS pathogens (01.05.2014)
Published in PLoS pathogens (01.05.2014)
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Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis
Bayer, Theresa, Chakrabarti, Alokta, Lancelot, Julien, Shaik, Tajith B., Hausmann, Kristin, Melesina, Jelena, Schmidtkunz, Karin, Marek, Martin, Erdmann, Frank, Schmidt, Matthias, Robaa, Dina, Romier, Christophe, Pierce, Raymond J., Jung, Manfred, Sippl, Wolfgang
Published in ChemMedChem (10.08.2018)
Published in ChemMedChem (10.08.2018)
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Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism
Pereira, Adriana S A, Amaral, Murilo S, Vasconcelos, Elton J R, Pires, David S, Asif, Huma, daSilva, Lucas F, Morales-Vicente, David A, Carneiro, Vitor C, Angeli, Claudia B, Palmisano, Giuseppe, Fantappie, Marcelo R, Pierce, Raymond J, Setubal, João C, Verjovski-Almeida, Sergio
Published in PLoS neglected tropical diseases (01.10.2018)
Published in PLoS neglected tropical diseases (01.10.2018)
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Journal Article
Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni
Dubois, Florence, Caby, Stéphanie, Oger, Frédérik, Cosseau, Céline, Capron, Monique, Grunau, Christoph, Dissous, Colette, Pierce, Raymond J.
Published in Molecular and biochemical parasitology (01.11.2009)
Published in Molecular and biochemical parasitology (01.11.2009)
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Journal Article
Isophthalic Acid‐Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni
Stenzel, Katharina, Chakrabarti, Alokta, Melesina, Jelena, Hansen, Finn K., Lancelot, Julien, Herkenhöhner, Simon, Lungerich, Beate, Marek, Martin, Romier, Christophe, Pierce, Raymond. J., Sippl, Wolfgang, Jung, Manfred, Kurz, Thomas
Published in Archiv der Pharmazie (Weinheim) (01.08.2017)
Published in Archiv der Pharmazie (Weinheim) (01.08.2017)
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