Five computational developability guidelines for therapeutic antibody profiling
Raybould, Matthew I. J., Marks, Claire, Krawczyk, Konrad, Taddese, Bruck, Nowak, Jaroslaw, Lewis, Alan P., Bujotzek, Alexander, Shi, Jiye, Deane, Charlotte M.
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2019)
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Journal Article
Epitope profiling using computational structural modelling demonstrated on coronavirus-binding antibodies
Robinson, Sarah A, Raybould, Matthew I J, Schneider, Constantin, Wong, Wing Ki, Marks, Claire, Deane, Charlotte M
Published in PLoS computational biology (13.12.2021)
Published in PLoS computational biology (13.12.2021)
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Journal Article
Structural diversity of B-cell receptor repertoires along the B-cell differentiation axis in humans and mice
Kovaltsuk, Aleksandr, Raybould, Matthew I J, Wong, Wing Ki, Marks, Claire, Kelm, Sebastian, Snowden, James, Trück, Johannes, Deane, Charlotte M
Published in PLoS computational biology (18.02.2020)
Published in PLoS computational biology (18.02.2020)
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Journal Article
Contextualising the developability risk of antibodies with lambda light chains using enhanced therapeutic antibody profiling
Raybould, Matthew I. J., Turnbull, Oliver M., Suter, Annabel, Guloglu, Bora, Deane, Charlotte M.
Published in Communications biology (08.01.2024)
Published in Communications biology (08.01.2024)
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Journal Article
Thera-SAbDab: the Therapeutic Structural Antibody Database
Raybould, Matthew I J, Marks, Claire, Lewis, Alan P, Shi, Jiye, Bujotzek, Alexander, Taddese, Bruck, Deane, Charlotte M
Published in Nucleic acids research (08.01.2020)
Published in Nucleic acids research (08.01.2020)
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Journal Article
The Patent and Literature Antibody Database (PLAbDab): an evolving reference set of functionally diverse, literature-annotated antibody sequences and structures
Abanades, Brennan, Olsen, Tobias H, Raybould, Matthew I J, Aguilar-Sanjuan, Broncio, Wong, Wing Ki, Georges, Guy, Bujotzek, Alexander, Deane, Charlotte M
Published in Nucleic acids research (05.01.2024)
Published in Nucleic acids research (05.01.2024)
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Journal Article
Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures
Galson, Jacob D, Schaetzle, Sebastian, Bashford-Rogers, Rachael J M, Raybould, Matthew I J, Kovaltsuk, Aleksandr, Kilpatrick, Gavin J, Minter, Ralph, Finch, Donna K, Dias, Jorge, James, Louisa K, Thomas, Gavin, Lee, Wing-Yiu Jason, Betley, Jason, Cavlan, Olivia, Leech, Alex, Deane, Charlotte M, Seoane, Joan, Caldas, Carlos, Pennington, Daniel J, Pfeffer, Paul, Osbourn, Jane
Published in Frontiers in immunology (15.12.2020)
Published in Frontiers in immunology (15.12.2020)
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Journal Article
Prospects for the computational humanization of antibodies and nanobodies
Gordon, Gemma L, Raybould, Matthew I J, Wong, Ashley, Deane, Charlotte M
Published in Frontiers in immunology (15.05.2024)
Published in Frontiers in immunology (15.05.2024)
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Journal Article
Looking for therapeutic antibodies in next-generation sequencing repositories
Krawczyk, Konrad, Raybould, Matthew I J, Kovaltsuk, Aleksandr, Deane, Charlotte M
Published in mAbs (03.10.2019)
Published in mAbs (03.10.2019)
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Journal Article
A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs
Condado-Morales, Itzel, Dingfelder, Fabian, Waibel, Isabel, Turnbull, Oliver M, Patel, Bhargav, Cao, Zheng, Rose Bjelke, Jais, Nedergaard Grell, Susanne, Bennet, Anja, Hummer, Alissa M, Raybould, Matthew I J, Deane, Charlotte M, Egebjerg, Thomas, Lorenzen, Nikolai, Arosio, Paolo
Published in mAbs (31.12.2024)
Published in mAbs (31.12.2024)
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Journal Article
Antibody-antigen complex modelling in the era of immunoglobulin repertoire sequencing
Raybould, Matthew I. J, Wong, Wing Ki, Deane, Charlotte M
Published in Molecular systems design & engineering (05.08.2019)
Published in Molecular systems design & engineering (05.08.2019)
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Journal Article
Improved computational epitope profiling using structural models identifies a broader diversity of antibodies that bind to the same epitope
Spoendlin, Fabian C, Abanades, Brennan, Raybould, Matthew I J, Wong, Wing Ki, Georges, Guy, Deane, Charlotte M
Published in Frontiers in molecular biosciences (18.09.2023)
Published in Frontiers in molecular biosciences (18.09.2023)
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Journal Article
CoV-AbDab: the coronavirus antibody database
Raybould, Matthew I J, Kovaltsuk, Aleksandr, Marks, Claire, Deane, Charlotte M
Published in Bioinformatics (05.05.2021)
Published in Bioinformatics (05.05.2021)
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Journal Article
Web Resource
Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells
Fischer, Katrin, Lulla, Aleksei, So, Tsz Y, Pereyra-Gerber, Pehuén, Raybould, Matthew I J, Kohler, Timo N, Yam-Puc, Juan Carlos, Kaminski, Tomasz S, Hughes, Robert, Pyeatt, Gwendolyn L, Leiss-Maier, Florian, Brear, Paul, Matheson, Nicholas J, Deane, Charlotte M, Hyvönen, Marko, Thaventhiran, James E D, Hollfelder, Florian
Published in Nature biotechnology (14.08.2024)
Published in Nature biotechnology (14.08.2024)
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Journal Article
Ultrahigh frequencies of peripherally matured LGI1- and CASPR2-reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis
Theorell, Jakob, Harrison, Ruby, Williams, Robyn, Raybould, Matthew I J, Zhao, Meng, Fox, Hannah, Fower, Andrew, Miller, Georgina, Wu, Zoe, Browne, Eleanor, Mgbachi, Victor, Sun, Bo, Mopuri, Rohini, Li, Ying, Waters, Patrick, Deane, Charlotte M, Handel, Adam, Makuch, Mateusz, Irani, Sarosh R
Published in Proceedings of the National Academy of Sciences - PNAS (13.02.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (13.02.2024)
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Journal Article
The Observed T Cell Receptor Space database enables paired-chain repertoire mining, coherence analysis, and language modeling
Raybould, Matthew I.J., Greenshields-Watson, Alexander, Agarwal, Parth, Aguilar-Sanjuan, Broncio, Olsen, Tobias H., Turnbull, Oliver M., Quast, Nele P., Deane, Charlotte M.
Published in Cell reports (Cambridge) (24.09.2024)
Published in Cell reports (Cambridge) (24.09.2024)
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Journal Article