Abstract 4042: Cbl inhibition increases the response of cytotoxic T cells to sub-optimal stimulation and drives enhanced anti-tumor responses alone or in combination with PD-1 blockade
Yamashiro, Livia, Marubayashi, Sachie, Rayaji, Rameshwari, Battsooj, Anudari, Mrouj, Karim, Singh, Hema, Lee, Yue Tong, Chen, Ada, Shen, Lunda, Mailyan, Artur, Yu, Kai, Podunavac, Masha, Yu, Julie, Liu, Dongdong, Hardman, Clayton, Yin, Johnny, Gangam, Srikanth, Lawson, Ken, Leleti, Manmohan, Walters, Matthew, DiRenzo, Daniel
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
854 HPK1 inhibition relieves suppression downstream of TCR activation to drive enhanced cytokine production and antigen-specific killing, an effect that is further enhanced by immune checkpoint blockade
Singh, Rajesh, Patel, Bindi, Rayaji, Rameshwari, Marubayashi, Sachie, Cho, Sean, Garrido-Shaqfeh, Stefan, Kulusich, Joseph, Meleza, Cesar, Tibrewal, Nidhi, Joice, Thomas, Nareddy, Pradeep, Sharif, Ehesan, Zhao, Sharon, Green, Dave, Leleti, Manmohan, Powers, Jay, Walters, Matt, DiRenzo, Daniel
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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Journal Article
Abstract 1367: HPK1 inhibition enhances T cell activation and relieves the immunosuppressive phenotype of inhibitory signals found in the tumor microenvironment
Singh, Rajesh K., Rayaji, Rameshwari, Patel, Bindi, Zhang, Kristen, Marubayashi, Sachie, Cho, Soonweng, Garrido-Shaqfeh, Stefan, Kulusich, Joseph, Meleza, Cesar, Tibrewal, Nidhi, Thomas, Joice, Nareddy, Pradeep, Sharif, Ehesan, Zhao, Sharon, Green, David, Leleti, Manmohan R., Powers, Jay P., DiRenzo, Daniel, Walters, Matthew J.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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