Discovery of GSK345931A : An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain
HALL, Adrian, BROWN, Susan H, SCOCCITTI, Tiziana, WILSON, Alexander W, WINCHESTER, Wendy J, BUDD, Christopher, CLAYTON, Nicholas M, GIBLIN, Gerard M. P, GOLDSMITH, Paul, HAYHOW, Thomas G, HURST, David N, NAYLOR, Alan, RAWLINGS, D. Anthony
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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Discovery of 2-[(2,4-Dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a Selective CB2 Receptor Agonist for the Treatment of Inflammatory Pain
Giblin, Gerard M. P, O'Shaughnessy, Celestine T, Naylor, Alan, Mitchell, William L, Eatherton, Andrew J, Slingsby, Brian P, Rawlings, D. Anthony, Goldsmith, Paul, Brown, Andrew J, Haslam, Carl P, Clayton, Nick M, Wilson, Alex W, Chessell, Iain P, Wittington, Andrew R, Green, Richard
Published in Journal of medicinal chemistry (31.05.2007)
Published in Journal of medicinal chemistry (31.05.2007)
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Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists
ALLAN, Amanda C, BILLINTON, Andy, NAYLOR, Alan, RAWLINGS, D. Anthony, SIME, Mairi, SCOCCITTI, Tiziana, THEOBALD, Pamela J, BROWN, Susan H, CHOWDHURY, Anita, EATHERTON, Andrew J, FIELDHOUSE, Charlotte, GIBLIN, Gerard M. P, GOLDSMITH, Paul, HALL, Adrian, HURST, David N
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
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Journal Article
6-Aryl-pyrazolo[3,4- b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason, Bordas, Vincent, Gaiba, Alessandra, Garton, Neil S., Naylor, Antoinette, Rawlings, Anthony D., Slingsby, Brian P., Smith, David G., Takle, Andrew K., Ward, Robert W.
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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Journal Article
6-Heteroaryl-pyrazolo[3,4- b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason, Bordas, Vincent, Gaiba, Alessandra, Naylor, Antoinette, Rawlings, Anthony D., Slingsby, Brian P., Smith, David G., Takle, Andrew K., Ward, Robert W.
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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Journal Article
Pyridine-3-carboxamides as novel CB(2) agonists for analgesia
Mitchell, William L, Giblin, Gerard M P, Naylor, Alan, Eatherton, Andrew J, Slingsby, Brian P, Rawlings, Anthony D, Jandu, Karamjit S, Haslam, Carl P, Brown, Andrew J, Goldsmith, Paul, Clayton, Nick M, Wilson, Alex W, Chessell, Iain P, Green, Richard H, Whittington, Andrew R, Wall, Ian D
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
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Journal Article
Pyridine-3-carboxamides as novel CB2 agonists for analgesia
MITCHELL, William L, GIBLIN, Gerard M. P, CLAYTON, Nick M, WILSON, Alex W, CHESSELL, Iain P, GREEN, Richard H, WHITTINGTON, Andrew R, WALL, Ian D, NAYLOR, Alan, EATHERTON, Andrew J, SLINGSBY, Brian P, RAWLINGS, Anthony D, JANDU, Karamjit S, HASLAM, Carl P, BROWN, Andrew J, GOLDSMITH, Paul
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Journal Article
Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists
Hall, Adrian, Billinton, Andy, Bristow, Alan K, Brown, Susan H, Chowdhury, Anita, Cutler, Leanne, Giblin, Gerard M P, Goldsmith, Paul, Hayhow, Thomas G, Kilford, Ian R, Naylor, Alan, Passingham, Barry, Rawlings, D Anthony
Published in Bioorganic & medicinal chemistry letters (15.07.2008)
Published in Bioorganic & medicinal chemistry letters (15.07.2008)
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Journal Article
Identification and optimization of novel 1,3,4-oxadiazole EP1 receptor antagonists
Hall, Adrian, Brown, Susan H., Chowdhury, Anita, Giblin, Gerard M.P., Gibson, Mairi, Healy, Mark P., Livermore, David G., McArthur Wilson, Richard J., Naylor, Alan, Rawlings, D. Anthony, Roman, Shilina, Ward, Emma, Willay, Caroline
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Journal Article
5-Aryl-pyrazolo[3,4- b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason, Bordas, Vincent, Haigh, David, Hickey, Deirdre M.B, Ife, Robert J, Rawlings, Anthony D, Slingsby, Brian P, Smith, David G, Ward, Robert W
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
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Journal Article
Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K
FENWICK, Ashley E, GARNIER, Bénédicte, GRIBBLE, Andrew D, IFE, Robert J, RAWLINGS, Anthony D, WITHERINGTON, Jason
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
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Journal Article
Discovery of a novel series of nonacidic benzofuran EP 1 receptor antagonists
Allan, Amanda C., Billinton, Andy, Brown, Susan H., Chowdhury, Anita, Eatherton, Andrew J., Fieldhouse, Charlotte, Giblin, Gerard M.P., Goldsmith, Paul, Hall, Adrian, Hurst, David N., Naylor, Alan, Rawlings, D. Anthony, Sime, Mairi, Scoccitti, Tiziana, Theobald, Pamela J.
Published in Bioorganic & medicinal chemistry letters (2011)
Published in Bioorganic & medicinal chemistry letters (2011)
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Journal Article
Discovery of GSK345931A: An EP 1 receptor antagonist with efficacy in preclinical models of inflammatory pain
Hall, Adrian, Brown, Susan H., Budd, Christopher, Clayton, Nicholas M., Giblin, Gerard M.P., Goldsmith, Paul, Hayhow, Thomas G., Hurst, David N., Naylor, Alan, Anthony Rawlings, D., Scoccitti, Tiziana, Wilson, Alexander W., Winchester, Wendy J.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Journal Article
Pyridine-3-carboxamides as novel CB sub(2) agonists for analgesia
Mitchell, William L, Giblin, Gerard MP, Naylor, Alan, Eatherton, Andrew J, Slingsby, Brian P, Rawlings, Anthony D, Jandu, Karamjit S, Haslam, Carl P, Brown, Andrew J, Goldsmith, Paul, Clayton, Nick M, Wilson, Alex W, Chessell, Iain P, Green, Richard H, Whittington, Andrew R, Wall, Ian D
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
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Journal Article
Pyridine-3-carboxamides as novel CB 2 agonists for analgesia
Mitchell, William L., Giblin, Gerard M.P., Naylor, Alan, Eatherton, Andrew J., Slingsby, Brian P., Rawlings, Anthony D., Jandu, Karamjit S., Haslam, Carl P., Brown, Andrew J., Goldsmith, Paul, Clayton, Nick M., Wilson, Alex W., Chessell, Iain P., Green, Richard H., Whittington, Andrew R., Wall, Ian D.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Journal Article
Discovery of brain penetrant, soluble, pyrazole amide EP 1 receptor antagonists
Hall, Adrian, Billinton, Andy, Bristow, Alan K., Brown, Susan H., Chowdhury, Anita, Cutler, Leanne, Giblin, Gerard M.P., Goldsmith, Paul, Hayhow, Thomas G., Kilford, Ian R., Naylor, Alan, Passingham, Barry, Rawlings, D. Anthony
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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Journal Article
Discovery of brain penetrant, soluble, pyrazole amide EP1receptor antagonists
HALL, Adrian, BILLINTON, Andy, NAYLOR, Alan, PASSINGHAM, Barry, RAWLINGS, D. Anthony, BRISTOW, Alan K, BROWN, Susan H, CHOWDHURY, Anita, CUTLER, Leanne, GIBLIN, Gerard M. P, GOLDSMITH, Paul, HAYHOW, Thomas G, KILFORD, Ian R
Published in Bioorganic & medicinal chemistry letters (2008)
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Published in Bioorganic & medicinal chemistry letters (2008)
Journal Article
Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones
Boyd, Helen F, Fell, Stephen C M, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Macphee, Colin H, Milliner, Kevin J, Pinto, Ivan L, Rawlings, D Anthony, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Theobald, Colin J, Whittaker, Caroline M
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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Journal Article
Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones
BOYD, Helen F, FELL, Stephen C. M, STANSFIELD, Ian G, STANWAY, Steven J, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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Journal Article
6-Aryl-pyrazolo[3,4-b]pyridines: Potent inhibitors of glycogen synthase kinase-3 (GSK-3): Recent advances in the design of kinase inhibitors as novel therapeutic agents
WITHERINGTON, Jason, BORDAS, Vincent, GAIBA, Alessandra, GARTON, Neil S, NAYLOR, Antoinette, RAWLINGS, Anthony D, SLINGSBY, Brian P, SMITH, David G, TAKLE, Andrew K, WARD, Robert W
Published in Bioorganic & medicinal chemistry letters (2003)
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Published in Bioorganic & medicinal chemistry letters (2003)
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