The proline-rich domain promotes Tau liquid-liquid phase separation in cells
Zhang, Xuemei, Vigers, Michael, McCarty, James, Rauch, Jennifer N, Fredrickson, Glenn H, Wilson, Maxwell Z, Shea, Joan-Emma, Han, Songi, Kosik, Kenneth S
Published in The Journal of cell biology (02.11.2020)
Published in The Journal of cell biology (02.11.2020)
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Journal Article
Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)
Rauch, Jennifer N., Chen, John J., Sorum, Alexander W., Miller, Gregory M., Sharf, Tal, See, Stephanie K., Hsieh-Wilson, Linda C., Kampmann, Martin, Kosik, Kenneth S.
Published in Scientific reports (23.04.2018)
Published in Scientific reports (23.04.2018)
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Journal Article
Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions
Lin, Yanxian, McCarty, James, Rauch, Jennifer N, Delaney, Kris T, Kosik, Kenneth S, Fredrickson, Glenn H, Shea, Joan-Emma, Han, Songi
Published in eLife (05.04.2019)
Published in eLife (05.04.2019)
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Journal Article
Cofactors are essential constituents of stable and seeding-active tau fibrils
Fichou, Yann, Lin, Yanxian, Rauch, Jennifer N., Vigers, Michael, Zeng, Zhikai, Srivastava, Madhur, Keller, Timothy J., Freed, Jack H., Kosik, Kenneth S., Han, Songi
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2018)
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Journal Article
A Scalable, Easy-to-Deploy Protocol for Cas13-Based Detection of SARS-CoV-2 Genetic Material
Rauch, Jennifer N, Valois, Eric, Solley, Sabrina C, Braig, Friederike, Lach, Ryan S, Audouard, Morgane, Ponce-Rojas, Jose Carlos, Costello, Michael S, Baxter, Naomi J, Kosik, Kenneth S, Arias, Carolina, Acosta-Alvear, Diego, Wilson, Maxwell Z
Published in Journal of clinical microbiology (19.03.2021)
Published in Journal of clinical microbiology (19.03.2021)
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Journal Article
Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate
Carrettiero, Daniel C., Almeida, Maria C., Longhini, Andrew P., Rauch, Jennifer N., Han, Dasol, Zhang, Xuemei, Najafi, Saeed, Gestwicki, Jason E., Kosik, Kenneth S.
Published in Nature communications (02.06.2022)
Published in Nature communications (02.06.2022)
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Journal Article
BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins
Rauch, Jennifer N., Tse, Eric, Freilich, Rebecca, Mok, Sue-Ann, Makley, Leah N., Southworth, Daniel R., Gestwicki, Jason E.
Published in Journal of molecular biology (06.01.2017)
Published in Journal of molecular biology (06.01.2017)
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Journal Article
Hsp70 protein complexes as drug targets
Assimon, Victoria A, Gillies, Anne T, Rauch, Jennifer N, Gestwicki, Jason E
Published in Current pharmaceutical design (2013)
Published in Current pharmaceutical design (2013)
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Journal Article
RNA stores tau reversibly in complex coacervates
Zhang, Xuemei, Lin, Yanxian, Eschmann, Neil A, Zhou, Hongjun, Rauch, Jennifer N, Hernandez, Israel, Guzman, Elmer, Kosik, Kenneth S, Han, Songi
Published in PLoS biology (06.07.2017)
Published in PLoS biology (06.07.2017)
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Journal Article
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation
Mok, Sue-Ann, Condello, Carlo, Freilich, Rebecca, Gillies, Anne, Arhar, Taylor, Oroz, Javier, Kadavath, Harindranath, Julien, Olivier, Assimon, Victoria A., Rauch, Jennifer N., Dunyak, Bryan M., Lee, Jungsoon, Tsai, Francis T. F., Wilson, Mark R., Zweckstetter, Markus, Dickey, Chad A., Gestwicki, Jason E.
Published in Nature structural & molecular biology (01.05.2018)
Published in Nature structural & molecular biology (01.05.2018)
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Journal Article
Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer
Li, Xiaokai, Colvin, Teresa, Rauch, Jennifer N, Acosta-Alvear, Diego, Kampmann, Martin, Dunyak, Bryan, Hann, Byron, Aftab, Blake T, Murnane, Megan, Cho, Min, Walter, Peter, Weissman, Jonathan S, Sherman, Michael Y, Gestwicki, Jason E
Published in Molecular cancer therapeutics (01.03.2015)
Published in Molecular cancer therapeutics (01.03.2015)
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Journal Article
Hsp70-Bag3 Interactions Regulate Cancer-Related Signaling Networks
COLVIN, Teresa A, GABAI, Vladimir L, GARCIA-MARCOS, Mikel, XIAOKAI LI, YOUNG, Z. T, RAUCH, Jennifer N, GESTWICKI, Jason E, TAKAYAMA, Shinichi, SHERMAN, Michael Y, JIANLIN GONG, CALDERWOOD, Stuart K, HU LI, GUMMULURU, Suryaram, MATCHUK, Olga N, SMIRNOVA, Svetlana G, ORLOVA, Nina V, ZAMULAEVA, Irina A
Published in Cancer research (Chicago, Ill.) (01.09.2014)
Published in Cancer research (Chicago, Ill.) (01.09.2014)
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Journal Article
Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy
Young, Zapporah T., Rauch, Jennifer N., Assimon, Victoria A., Jinwal, Umesh K., Ahn, Misol, Li, Xiaokai, Dunyak, Bryan M., Ahmad, Atta, Carlson, George A., Srinivasan, Sharan R., Zuiderweg, Erik R.P., Dickey, Chad A., Gestwicki, Jason E.
Published in Cell chemical biology (18.08.2016)
Published in Cell chemical biology (18.08.2016)
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Journal Article
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
Eftekharzadeh, Bahareh, Banduseela, Varuna C., Chiesa, Giulio, Martínez-Cristóbal, Paula, Rauch, Jennifer N., Nath, Samir R., Schwarz, Daniel M. C., Shao, Hao, Marin-Argany, Marta, Di Sanza, Claudio, Giorgetti, Elisa, Yu, Zhigang, Pierattelli, Roberta, Felli, Isabella C., Brun-Heath, Isabelle, García, Jesús, Nebreda, Ángel R., Gestwicki, Jason E., Lieberman, Andrew P., Salvatella, Xavier
Published in Nature communications (08.08.2019)
Published in Nature communications (08.08.2019)
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Journal Article
Non-canonical Interactions between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release
Rauch, Jennifer N., Zuiderweg, Erik R.P., Gestwicki, Jason E.
Published in The Journal of biological chemistry (16.09.2016)
Published in The Journal of biological chemistry (16.09.2016)
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Journal Article
Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks
Meister-Broekema, Melanie, Freilich, Rebecca, Jagadeesan, Chandhuru, Rauch, Jennifer N., Bengoechea, Rocio, Motley, William W., Kuiper, E. F. Elsiena, Minoia, Melania, Furtado, Gabriel V., van Waarde, Maria A. W. H., Bird, Shawn J., Rebelo, Adriana, Zuchner, Stephan, Pytel, Peter, Scherer, Steven S., Morelli, Federica F., Carra, Serena, Weihl, Conrad C., Bergink, Steven, Gestwicki, Jason E., Kampinga, Harm H.
Published in Nature communications (17.12.2018)
Published in Nature communications (17.12.2018)
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Journal Article
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy
Hernandez, Israel, Luna, Gabriel, Rauch, Jennifer N, Reis, Surya A, Giroux, Michel, Karch, Celeste M, Boctor, Daniel, Sibih, Youssef E, Storm, Nadia J, Diaz, Antonio, Kaushik, Susmita, Zekanowski, Cezary, Kang, Alexander A, Hinman, Cassidy R, Cerovac, Vesna, Guzman, Elmer, Zhou, Honjun, Haggarty, Stephen J, Goate, Alison M, Fisher, Steven K, Cuervo, Ana M, Kosik, Kenneth S
Published in Science translational medicine (27.03.2019)
Published in Science translational medicine (27.03.2019)
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Journal Article
LRP1 is a master regulator of tau uptake and spread
Rauch, Jennifer N., Luna, Gabriel, Guzman, Elmer, Audouard, Morgane, Challis, Collin, Sibih, Youssef E., Leshuk, Carolina, Hernandez, Israel, Wegmann, Susanne, Hyman, Bradley T., Gradinaru, Viviana, Kampmann, Martin, Kosik, Kenneth S.
Published in Nature (London) (01.04.2020)
Published in Nature (London) (01.04.2020)
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Journal Article