Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis
Zille, Marietta, Karuppagounder, Saravanan S, Chen, Yingxin, Gough, Peter J, Bertin, John, Finger, Joshua, Milner, Teresa A, Jonas, Elizabeth A, Ratan, Rajiv R
Published in Stroke (1970) (01.04.2017)
Published in Stroke (1970) (01.04.2017)
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Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate
Sleiman, Sama F, Henry, Jeffrey, Al-Haddad, Rami, El Hayek, Lauretta, Abou Haidar, Edwina, Stringer, Thomas, Ulja, Devyani, Karuppagounder, Saravanan S, Holson, Edward B, Ratan, Rajiv R, Ninan, Ipe, Chao, Moses V
Published in eLife (02.06.2016)
Published in eLife (02.06.2016)
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Journal Article
Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases
Rroji, Orjon, Kumar, Amit, Karuppagounder, Saravanan S., Ratan, Rajiv R.
Published in Neurobiology of disease (01.01.2021)
Published in Neurobiology of disease (01.01.2021)
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Journal Article
Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition: Robust New Target or Another Big Bust for Stroke Therapeutics?
Karuppagounder, Saravanan S, Ratan, Rajiv R
Published in Journal of Cerebral Blood Flow & Metabolism (01.07.2012)
Published in Journal of Cerebral Blood Flow & Metabolism (01.07.2012)
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Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways
Siddiq, Ambreena, Aminova, Leila R, Troy, Carol M, Suh, Kyungsun, Messer, Zachary, Semenza, Gregg L, Ratan, Rajiv R
Published in The Journal of neuroscience (08.07.2009)
Published in The Journal of neuroscience (08.07.2009)
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Journal Article
Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease
Kaidery, Navneet Ammal, Banerjee, Rebecca, Yang, Lichuan, Smirnova, Natalya A, Hushpulian, Dmitry M, Liby, Karen T, Williams, Charlotte R, Yamamoto, Masayuki, Kensler, Thomas W, Ratan, Rajiv R, Sporn, Michael B, Beal, M Flint, Gazaryan, Irina G, Thomas, Bobby
Published in Antioxidants & redox signaling (10.01.2013)
Published in Antioxidants & redox signaling (10.01.2013)
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Journal Article
The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease
Aimé, Pascaline, Karuppagounder, Saravanan S., Rao, Apeksha, Chen, Yingxin, Burke, Robert E., Ratan, Rajiv R., Greene, Lloyd A.
Published in Neurobiology of disease (01.03.2020)
Published in Neurobiology of disease (01.03.2020)
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Journal Article
Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice
Ferrante, Robert J, Kubilus, James K, Lee, Junghee, Ryu, Hoon, Beesen, Ayshe, Zucker, Birgit, Smith, Karen, Kowall, Neil W, Ratan, Rajiv R, Luthi-Carter, Ruth, Hersch, Steven M
Published in The Journal of neuroscience (15.10.2003)
Published in The Journal of neuroscience (15.10.2003)
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Journal Article
Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes
Chen, Y., Wang, J. J., Li, J., Hosoya, K. I., Ratan, R., Townes, T., Zhang, S. X.
Published in Diabetologia (01.09.2012)
Published in Diabetologia (01.09.2012)
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Journal Article
Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases
Gibson, Gary E., Starkov, Anatoly, Blass, John P., Ratan, Rajiv R., Beal, M. Flint
Published in Biochimica et biophysica acta (01.01.2010)
Published in Biochimica et biophysica acta (01.01.2010)
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Journal Article
Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke
Speer, Rachel E., Karuppagounder, Saravanan S., Basso, Manuela, Sleiman, Sama F., Kumar, Amit, Brand, David, Smirnova, Natalya, Gazaryan, Irina, Khim, Soah J., Ratan, Rajiv R.
Published in Free radical biology & medicine (01.09.2013)
Published in Free radical biology & medicine (01.09.2013)
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Journal Article
Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons
Brochier, Camille, Dennis, Gretel, Rivieccio, Mark A, McLaughlin, Kathryn, Coppola, Giovanni, Ratan, Rajiv R, Langley, Brett
Published in The Journal of neuroscience (15.05.2013)
Published in The Journal of neuroscience (15.05.2013)
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Journal Article
Neuroprotective Effects of Phenylbutyrate in the N171-82Q Transgenic Mouse Model of Huntington's Disease
Gardian, Gabriella, Browne, Susan E., Choi, Dong-Kug, Klivenyi, Peter, Gregorio, Jason, Kubilus, James K., Ryu, Hoon, Langley, Brett, Ratan, Rajiv R., Ferrante, Robert J., Beal, M. Flint
Published in The Journal of biological chemistry (07.01.2005)
Published in The Journal of biological chemistry (07.01.2005)
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Journal Article
Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury
Huie, J R, Ferguson, A R, Kyritsis, N, Pan, J Z, Irvine, K-A, Nielson, J L, Schupp, P G, Oldham, M C, Gensel, J C, Lin, A, Segal, M R, Ratan, R R, Bresnahan, J C, Beattie, M S
Published in Scientific reports (09.02.2021)
Published in Scientific reports (09.02.2021)
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Journal Article
HDAC6 is a target for protection and regeneration following injury in the nervous system
Rivieccio, Mark A, Brochier, Camille, Willis, Dianna E, Walker, Breset A, D'Annibale, Melissa A, McLaughlin, Kathryn, Siddiq, Ambreena, Kozikowski, Alan P, Jaffrey, Samie R, Twiss, Jeffery L, Ratan, Rajiv R, Langley, Brett
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2009)
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Journal Article
Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats
Ferguson, Adam R, Irvine, Karen-Amanda, Gensel, John C, Nielson, Jessica L, Lin, Amity, Ly, Johnathan, Segal, Mark R, Ratan, Rajiv R, Bresnahan, Jacqueline C, Beattie, Michael S
Published in PloS one (27.03.2013)
Published in PloS one (27.03.2013)
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Journal Article
Translational Control of Inducible Nitric Oxide Synthase Expression by Arginine Can Explain the Arginine Paradox
Lee, Junghee, Ryu, Hoon, Ferrante, Robert J., Morris, Sidney M., Ratan, Rajiv R.
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.2003)
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