Development of LC-MS/MS-Based Receptor Occupancy Tracers and Positron Emission Tomography Radioligands for the Nociceptin/Orphanin FQ (NOP) Receptor
Pedregal, Concepción, Joshi, Elizabeth M, Toledo, Miguel A, Lafuente, Celia, Diaz, Nuria, Martinez-Grau, Maria A, Jiménez, Alma, Benito, Ana, Navarro, Antonio, Chen, Zhaogen, Mudra, Daniel R, Kahl, Steven D, Rash, Karen S, Statnick, Michael A, Barth, Vanessa N
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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In Vitro and in Vivo Evidence for a Lack of Interaction with Dopamine D2 Receptors by the Metabotropic Glutamate 2/3 Receptor Agonists 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-bicaroxylate Monohydrate (LY354740) and (â)-2-Oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic Acid (LY379268)
Fell, Matthew J, Perry, Kenneth W, Falcone, Julie F, Johnson, Bryan G, Barth, Vanessa N, Rash, Karen S, Lucaites, Virginia L, Threlkeld, Penny G, Monn, James A, McKinzie, David L, Marek, Gerard J, Svensson, Kjell A, Nelson, David L
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
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Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer
Barth, Vanessa N., Chernet, Eyassu, Martin, Laura J., Need, Anne B., Rash, Karen S., Morin, Michelle, Phebus, Lee A.
Published in Life sciences (1973) (22.05.2006)
Published in Life sciences (1973) (22.05.2006)
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Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: Dopamine D2, serotonin 2A and NK-1 receptors as examples
Chernet, Eyassu, Martin, Laura J., Li, Dominic, Need, Anne B., Barth, Vanessa N., Rash, Karen S., Phebus, Lee A.
Published in Life sciences (1973) (12.12.2005)
Published in Life sciences (1973) (12.12.2005)
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Brain and whole-body imaging in rhesus monkeys of 11C-NOP-1A, a promising PET radioligand for nociceptin/orphanin FQ peptide receptors
Kimura, Yasuyuki, Fujita, Masahiro, Hong, Jinsoo, Lohith, Talakad G, Gladding, Robert L, Zoghbi, Sami S, Tauscher, Johannes A, Goebl, Nancy, Rash, Karen S, Chen, Zhaogen, Pedregal, Concepcion, Barth, Vanessa N, Pike, Victor W, Innis, Robert B
Published in The Journal of nuclear medicine (1978) (01.10.2011)
Published in The Journal of nuclear medicine (1978) (01.10.2011)
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Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer
Mitch, Charles H, Quimby, Steven J, Diaz, Nuria, Pedregal, Concepcion, de la Torre, Marta G, Jimenez, Alma, Shi, Qing, Canada, Emily J, Kahl, Steven D, Statnick, Michael A, McKinzie, David L, Benesh, Dana R, Rash, Karen S, Barth, Vanessa N
Published in Journal of medicinal chemistry (08.12.2011)
Published in Journal of medicinal chemistry (08.12.2011)
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Discovery of a Novel Series of Orally Active Nociceptin/Orphanin FQ (NOP) Receptor Antagonists Based on a Dihydrospiro(piperidine-4,7′-thieno[2,3‑c]pyran) Scaffold
Toledo, Miguel A, Pedregal, Concepción, Lafuente, Celia, Diaz, Nuria, Martinez-Grau, Maria Angeles, Jiménez, Alma, Benito, Ana, Torrado, Alicia, Mateos, Carlos, Joshi, Elizabeth M, Kahl, Steven D, Rash, Karen S, Mudra, Daniel R, Barth, Vanessa N, Shaw, David B, McKinzie, David, Witkin, Jeffrey M, Statnick, Michael A
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
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Synthesis and Evaluation of Radioligands for Imaging Brain Nociceptin/Orphanin FQ Peptide (NOP) Receptors with Positron Emission Tomography
Pike, Victor W, Rash, Karen S, Chen, Zhaogen, Pedregal, Concepción, Statnick, Michael A, Kimura, Yasuyuki, Hong, Jinsoo, Zoghbi, Sami S, Fujita, Masahiro, Toledo, Miguel A, Diaz, Nuria, Gackenheimer, Susan L, Tauscher, Johannes T, Barth, Vanessa N, Innis, Robert B
Published in Journal of medicinal chemistry (28.04.2011)
Published in Journal of medicinal chemistry (28.04.2011)
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Brain and Whole-Body Imaging in Rhesus Monkeys of ^sup 11^C-NOP-1A, a Promising PET Radioligand for Nociceptin/Orphanin FQ Peptide Receptors
Kimura, Yasuyuki, Fujita, Masahiro, Hong, Jinsoo, Lohith, Talakad G, Gladding, Robert L, Zoghbi, Sami S, Tauscher, Johannes A, Goebl, Nancy, Rash, Karen S, Chen, Zhaogen, Pedregal, Concepcion, Barth, Vanessa N, Pike, Victor W, Innis, Robert B
Published in The Journal of nuclear medicine (1978) (01.10.2011)
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Published in The Journal of nuclear medicine (1978) (01.10.2011)
Journal Article
Brain and Whole-Body Imaging in Rhesus Monkeys of 11 C-NOP-1A, a Promising PET Radioligand for Nociceptin/Orphanin FQ Peptide Receptors
Kimura, Yasuyuki, Fujita, Masahiro, Hong, Jinsoo, Lohith, Talakad G., Gladding, Robert L., Zoghbi, Sami S., Tauscher, Johannes A., Goebl, Nancy, Rash, Karen S., Chen, Zhaogen, Pedregal, Concepcion, Barth, Vanessa N., Pike, Victor W., Innis, Robert B.
Published in Journal of Nuclear Medicine (01.10.2011)
Published in Journal of Nuclear Medicine (01.10.2011)
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Journal Article
In Vitro and in Vivo Evidence for a Lack of Interaction with Dopamine D 2 Receptors by the Metabotropic Glutamate 2/3 Receptor Agonists 1 S ,2 S ,5 R ,6 S -2-Aminobicyclo[3.1.0]hexane-2,6-bicaroxylate Monohydrate (LY354740) and (−)-2-Oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic Acid (LY379268)
Fell, Matthew J., Perry, Kenneth W., Falcone, Julie F., Johnson, Bryan G., Barth, Vanessa N., Rash, Karen S., Lucaites, Virginia L., Threlkeld, Penny G., Monn, James A., McKinzie, David L., Marek, Gerard J., Svensson, Kjell A., Nelson, David L.
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
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Journal Article