2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
Sulkowski, Parker L, Corso, Christopher D, Robinson, Nathaniel D, Scanlon, Susan E, Purshouse, Karin R, Bai, Hanwen, Liu, Yanfeng, Sundaram, Ranjini K, Hegan, Denise C, Fons, Nathan R, Breuer, Gregory A, Song, Yuanbin, Mishra-Gorur, Ketu, De Feyter, Henk M, de Graaf, Robin A, Surovtseva, Yulia V, Kachman, Maureen, Halene, Stephanie, Günel, Murat, Glazer, Peter M, Bindra, Ranjit S
Published in Science translational medicine (01.02.2017)
Published in Science translational medicine (01.02.2017)
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Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair
Sulkowski, Parker L., Sundaram, Ranjini K., Oeck, Sebastian, Corso, Christopher D., Liu, Yanfeng, Noorbakhsh, Seth, Niger, Monica, Boeke, Marta, Ueno, Daiki, Kalathil, Aravind Nambiar, Bao, Xun, Li, Jing, Shuch, Brian, Bindra, Ranjit S., Glazer, Peter M.
Published in Nature genetics (01.08.2018)
Published in Nature genetics (01.08.2018)
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PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
Fons, Nathan R., Sundaram, Ranjini K., Breuer, Gregory A., Peng, Sen, McLean, Ryan L., Kalathil, Aravind N., Schmidt, Mark S., Carvalho, Diana M., Mackay, Alan, Jones, Chris, Carcaboso, Ángel M., Nazarian, Javad, Berens, Michael E., Brenner, Charles, Bindra, Ranjit S.
Published in Nature communications (22.08.2019)
Published in Nature communications (22.08.2019)
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Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity
Garbarino, Jennifer, Eckroate, Jillian, Sundaram, Ranjini K., Jensen, Ryan B., Bindra, Ranjit S.
Published in Translational oncology (01.09.2021)
Published in Translational oncology (01.09.2021)
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PARG inhibition induces nuclear aggregation of PARylated PARP1
Paradkar, Sateja, Purcell, Julia, Cui, Annie, Friedman, Sam, Noronha, Katelyn J., Murray, Matthew A., Sundaram, Ranjini K., Bindra, Ranjit S., Jensen, Ryan B.
Published in Structure (London) (07.11.2024)
Published in Structure (London) (07.11.2024)
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Fracture toughness of fibrin gels as a function of protein volume fraction: Mechanical origins
Garyfallogiannis, Konstantinos, Ramanujam, Ranjini K., Litvinov, Rustem I., Yu, Tony, Nagaswami, Chandrasekaran, Bassani, John L., Weisel, John W., Purohit, Prashant K., Tutwiler, Valerie
Published in Acta biomaterialia (15.03.2023)
Published in Acta biomaterialia (15.03.2023)
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Temozolomide Sensitizes MGMT-Deficient Tumor Cells to ATR Inhibitors
Jackson, Christopher B, Noorbakhsh, Seth I, Sundaram, Ranjini K, Kalathil, Aravind N, Ganesa, Sachita, Jia, Lanqi, Breslin, Hank, Burgenske, Danielle M, Gilad, Oren, Sarkaria, Jann N, Bindra, Ranjit S
Published in Cancer research (Chicago, Ill.) (01.09.2019)
Published in Cancer research (Chicago, Ill.) (01.09.2019)
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TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor
Jo, Ukhyun, Murai, Yasuhisa, Agama, Keli K, Sun, Yilun, Saha, Liton Kumar, Yang, Xi, Arakawa, Yasuhiro, Gayle, Sophia, Jones, Kelli, Paralkar, Vishwas, Sundaram, Ranjini K, Van Doorn, Jinny, Vasquez, Juan C, Bindra, Ranjit S, Choi, Woo Suk, Pommier, Yves
Published in Molecular cancer therapeutics (05.07.2022)
Published in Molecular cancer therapeutics (05.07.2022)
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Design and development of automated high temperature motor test facility
GEORGE, SAJI JACOB, RANJINI, K S SREE, RAJAGOPALAN, C, MURUGAN, S
Published in Sadhana (Bangalore) (01.12.2020)
Published in Sadhana (Bangalore) (01.12.2020)
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Biodegradable PEG-poly(ω-pentadecalactone-co-p-dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors
Chen, Evan M, Quijano, Amanda R, Seo, Young-Eun, Jackson, Christopher, Josowitz, Alexander D, Noorbakhsh, Seth, Merlettini, Andrea, Sundaram, Ranjini K, Focarete, Maria Letizia, Jiang, Zhaozhong, Bindra, Ranjit S, Saltzman, W Mark
Published in Biomaterials (01.09.2018)
Published in Biomaterials (01.09.2018)
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Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors
Murray, Matthew A, Noronha, Katelyn J, Wang, Yazhe, Friedman, Anna P, Paradkar, Sateja, Suh, Hee-Won, Sundaram, Ranjini K, Brenner, Charles, Saltzman, W M, Bindra, Ranjit S
Published in Molecular cancer therapeutics (01.08.2024)
Published in Molecular cancer therapeutics (01.08.2024)
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Rupture mechanics of blood clots: Influence of fibrin network structure on the rupture resistance
Ramanujam, Ranjini K., Maksudov, Farkhad, Risman, Rebecca A., Litvinov, Rustem I., Weisel, John W., Bassani, John L., Barsegov, Valeri, Purohit, Prashant K., Tutwiler, Valerie
Published in Acta biomaterialia (10.10.2024)
Published in Acta biomaterialia (10.10.2024)
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NAPRT silencing in FH-deficient renal cell carcinoma confers therapeutic vulnerabilities via NAD+ depletion
Noronha, Katelyn J, Lucas, Karlie N, Paradkar, Sateja, Edmonds, Joseph, Friedman, Sam, Murray, Matthew A, Liu, Samantha, Sajed, Dipti P, Sachs, Chana, Spurrier, Josh, Raponi, Mitch, Liang, Jiayu, Zeng, Hao, Sundaram, Ranjini K, Shuch, Brian, Vasquez, Juan C, Bindra, Ranjit S
Published in Molecular cancer research (02.10.2024)
Published in Molecular cancer research (02.10.2024)
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Biomechanics, Energetics, and Structural Basis of Rupture of Fibrin Networks
Ramanujam, Ranjini K, Maksudov, Farkhad, Litvinov, Rustem I, Nagaswami, Chandrasekaran, Weisel, John W, Tutwiler, Valerie, Barsegov, Valeri
Published in Advanced healthcare materials (01.10.2023)
Published in Advanced healthcare materials (01.10.2023)
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Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay
Surovtseva, Yulia V, Jairam, Vikram, Salem, Ahmed F, Sundaram, Ranjini K, Bindra, Ranjit S, Herzon, Seth B
Published in Journal of the American Chemical Society (23.03.2016)
Published in Journal of the American Chemical Society (23.03.2016)
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SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination
Daddacha, Waaqo, Koyen, Allyson E., Bastien, Amanda J., Head, PamelaSara E., Dhere, Vishal R., Nabeta, Geraldine N., Connolly, Erin C., Werner, Erica, Madden, Matthew Z., Daly, Michele B., Minten, Elizabeth V., Whelan, Donna R., Schlafstein, Ashley J., Zhang, Hui, Anand, Roopesh, Doronio, Christine, Withers, Allison E., Shepard, Caitlin, Sundaram, Ranjini K., Deng, Xingming, Dynan, William S., Wang, Ya, Bindra, Ranjit S., Cejka, Petr, Rothenberg, Eli, Doetsch, Paul W., Kim, Baek, Yu, David S.
Published in Cell reports (Cambridge) (22.08.2017)
Published in Cell reports (Cambridge) (22.08.2017)
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Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen
Risman, Rebecca A, Belcher, Heather A, Ramanujam, Ranjini K, Weisel, John W, Hudson, Nathan E, Tutwiler, Valerie
Published in Biomolecules (Basel, Switzerland) (01.02.2024)
Published in Biomolecules (Basel, Switzerland) (01.02.2024)
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