Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Harris, Noah J, Jenkins, Meredith L, Nam, Sung-Eun, Rathinaswamy, Manoj K, Parson, Matthew A H, Ranga-Prasad, Harish, Dalwadi, Udit, Moeller, Brandon E, Sheeky, Eleanor, Hansen, Scott D, Yip, Calvin K, Burke, John E
Published in eLife (07.07.2023)
Published in eLife (07.07.2023)
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Journal Article
Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus
Jenkins, Meredith L., Ranga-Prasad, Harish, Parson, Matthew A. H., Harris, Noah J., Rathinaswamy, Manoj K., Burke, John E.
Published in Nature communications (12.01.2023)
Published in Nature communications (12.01.2023)
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Journal Article
Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs
Rathinaswamy, Manoj K., Jenkins, Meredith L., Duewell, Benjamin R., Zhang, Xuxiao, Harris, Noah J., Evans, John T., Stariha, Jordan T.B., Dalwadi, Udit, Fleming, Kaelin D., Ranga-Prasad, Harish, Yip, Calvin K., Williams, Roger L., Hansen, Scott D., Burke, John E.
Published in Cell reports (Cambridge) (28.03.2023)
Published in Cell reports (Cambridge) (28.03.2023)
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Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite's Liver Stage Development
Balasubramanian, Lakshmi, Zuzarte-Luís, Vanessa, Syed, Tabish, Mullick, Debakshi, Deb, Saptarathi, Ranga-Prasad, Harish, Meissner, Jana, Almeida, Ana, Furstenhaupt, Tobias, Siddiqi, Kaleem, Prudêncio, Miguel, Rodrigues, Cecilia M P, Mota, Maria, Sundaramurthy, Varadharajan
Published in Frontiers in cellular and infection microbiology (17.01.2020)
Published in Frontiers in cellular and infection microbiology (17.01.2020)
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Journal Article
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Harris, Noah J, Jenkins, Meredith L, Nam, Sung-Eun, Rathinaswamy, Manoj K, Parson, Matthew AH, Ranga-Prasad, Harish, Dalwadi, Udit, Moeller, Brandon E, Sheeky, Eleanor, Hansen, Scott D, Yip, Calvin K, Burke, John E
Published in eLife (07.07.2023)
Published in eLife (07.07.2023)
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Journal Article
Allosteric activation or inhibition of PI3K[gamma] mediated through conformational changes in the p110[gamma] helical domain
Harris, Noah J, Jenkins, Meredith L, Nam, Sung-Eun, Rathinaswamy, Manoj K, Parson, Matthew AH, Ranga-Prasad, Harish, Dalwadi, Udit, Moeller, Brandon E, Sheeky, Eleanor, Hansen, Scott D, Yip, Calvin K, Burke, John E
Published in eLife (07.07.2023)
Published in eLife (07.07.2023)
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Journal Article
Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cells
Setua, Sonali, Enguita, Francisco J., Chora, Ângelo Ferreira, Ranga-prasad, Harish, Lahree, Aparajita, Marques, Sofia, Sundaramurthy, Varadharajan, Mota, Maria M.
Published in Communications biology (19.11.2020)
Published in Communications biology (19.11.2020)
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Journal Article
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Harris, Noah J, Jenkins, Meredith L, Nam, Sung-Eun, Rathinaswamy, Manoj K, Parson, Matthew Ah, Ranga-Prasad, Harish, Dalwadi, Udit, Moeller, Brandon E, Sheekey, Eleanor, Hansen, Scott D, Yip, Calvin K, Burke, John E
Published in bioRxiv : the preprint server for biology (23.05.2023)
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Published in bioRxiv : the preprint server for biology (23.05.2023)
Journal Article
ANTI-MALARIAL COMPOUNDS
RANGA-PRASAD, Harish, SUNDARAMURTHY, Varadharajan, DIAS DA MOTA, Maria, ENGUITA, Francisco, SETUA, Sonali
Year of Publication 27.05.2022
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Year of Publication 27.05.2022
Patent
ANTI MALARIAL COMPOUNDS
DIAS DA MOTA, Maria Manuel, RANGA-PRASAD, Harish, SUNDARAMURTHY, Varadharajan, ENGUITA, Francisco Javier, SETUA, Sonali
Year of Publication 07.07.2022
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Year of Publication 07.07.2022
Patent